Basic Information

Gene Symbol
Zfy1
Assembly
GCA_936440415.1
Location
CAKZFH010000250.1:334429-339074[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.0079 0.61 10.8 6.4 1 23 138 161 138 161 0.96
2 17 2.8e-06 0.00021 21.6 0.8 1 23 170 193 170 193 0.96
3 17 0.022 1.7 9.4 0.4 2 23 206 228 206 228 0.97
4 17 0.00044 0.034 14.7 2.7 1 23 237 260 237 260 0.96
5 17 9.8e-05 0.0076 16.8 1.0 1 23 271 294 271 294 0.96
6 17 2.5e-05 0.0019 18.6 0.6 2 23 320 342 319 342 0.97
7 17 0.0025 0.2 12.3 1.1 2 23 352 374 351 374 0.96
8 17 0.16 13 6.6 0.8 1 19 378 396 378 398 0.87
9 17 0.0001 0.0078 16.7 0.1 2 23 404 426 403 426 0.96
10 17 0.0003 0.023 15.2 0.2 3 23 436 457 435 457 0.97
11 17 0.0074 0.57 10.8 4.5 1 23 462 485 462 485 0.96
12 17 0.0013 0.1 13.2 1.2 3 23 499 520 497 520 0.96
13 17 0.059 4.6 8.0 1.7 1 23 542 565 542 565 0.94
14 17 0.042 3.3 8.5 0.2 2 23 570 591 569 591 0.95
15 17 0.11 8.7 7.1 1.2 2 23 597 618 596 618 0.97
16 17 0.0066 0.51 11.0 0.2 1 23 684 706 684 706 0.97
17 17 0.096 7.4 7.3 2.5 1 23 712 735 712 735 0.96

Sequence Information

Coding Sequence
ATGTCTGATATAACTATAAAAGTAGAAAGTACAATTGAAAGAAAAGATCCTACCTCATTTTTGCCTGAAGAGCCAATGTCTTATGAGATAAAGAAGAAGAAAAAAAAGAAAAAGAAAACTCAAGAGGATCCTTTTAAGGATATAGAAGAGAAAGTTCTTAAAACAGAAGTTGTGACAGCTTTAGATCCTGAAGTTAATATTAAAGCTGAAAATATTGAAGTTGAATTAGATTTTAATGATTTCACTGATAACTCTGGGTTTTTGGTGGAAGGGACAGCAGTAGATAATGAAGAACCAGCCATCAGAATAGAGTCACAAGCTCATGATGCGCTCTTACTTACATTTGAAAGTGTTGTCAGCGATAACCCAGTTATTTGTAAAACCGAAGTTACTAAACAGCCAGCCCCCTGCCATATCTGTAAAGTATGTCATCTACTCTTCAAATCACAGAAAACTTTACAAATGCACCAGAAACGGAAACACAAATCATTCAGAAAGTATTTCAATCATATCTGTAAAGACTGTGGCATGGCTTATGAGAACAAAAGTAGCCTAGCAGCTCATATGAAGCGTAAACACGGACCGAATTCAATGCCTGATGACAAAGAAGAAAGGACTTGTGATATCTGTGCACTTGTTTTCAAAGGTATGCCAAGATTACGTATGCATATGAGACGAAAGCATAACTCTTTCGAAGACGCCTTCACACATGCCTGCAAATTCTGTGGGCTTACTTATGACAGGAGTACAAGTTTATTAACACATATAAAAAGAAAACATTCAGGTACTAAAAAAGAAGTGACTCAGTGGTTTAACTGCCCCTTTTGCGCTAAAATCTTTTCTAGACAAGAATCTTACGCTAGGCATGTTCAACGAAAACACCAAGTTTCTGAAGATTCTATAAAAAATGCTTCAGAGGATATAGGAAGTTCTGTAAATGAACAAACCGGAGAAGTCACTTGTAAAGAGTGCCCACTAGTTTTTTCGTCAGTGAATTATTTGAAACTTCATATGCGGAGGAAGCATAATGCTTTAAGAGAAAACTTTAGATTAAAATGTAGGATTTGTAACTTGTCTTATGACAAAATTGAAAGCTTGAAACGACATGTACAACGAAAACATGAAGAGAAATATCGATGTGATGTCTGTAACAAACAATTTCTTACTAGAGAAGGTTATGCTAACCATTCACACTTAAAACTGGTTAAGGAATGTTCAGTTTGTGGCCTCATTTTCGCTAGCCAAGGAGGTTTAGCGAAACACTTAAGACTTAAACATAAAGTAGAATCGCCGAAGGTTGCTTTTTGTAATATATGTGAAGAAGGGTTTGGTGATAAACGACAACTAAAGGTCCATTTGATGAAAGTTCATTGGAAAGTGTCTTACACTTGTCGGTATTGCCAAAAAGTGTTTAAAATGAAGGAAACGCACCGCCGCCATATTTTAATCAAACATCCAAATGGAAACCAACCCATAAACTCAACAAAACAAAACTGTGAACAATGTTCTGAAACATTTAACGATGAATTCGAGCTCTGTCAGCATATTTACACAGTTCACGGGAAAGAAACGAAACCATCTTTATTAAAAATAAAGAAAGAGGAATCCGATCCTCAAGAGAACTTTCAATGCACAAAATGTTCAGATAGTTATCCTACTTTTGAACAATTGAAGGTGCATTTCGATAAAAGCCACAGTCCAGATACACAATGTCAAATCTGTGGTGACATGGTGTCCGCTAATGAACTACAGAAACATATAAAAACTCAGCATACAAATAAAGATCTGCAATGCAAGTTCTGTGAGTTCAAAACTGACGTAAAACTGAGCTTGACTCAGCATATATTACGACATAAAAACGCTTCAACGTTGCATTGTGACTACGCTGGTTGTAGATACAAGACATATTTTGATCTAGCAATGCAGAAACATAAAAGAAGACATCTAGATTTAGGAGTAAAACTTCAATGCGCACATTGTCCGTTCCAATCTATGAATAAATACATACTAAAATATCATGAAGAAGCTCATGAAACGGGGAAAAAACGATATACCTGTGATCAATGTGACTATGCGACGATACTTCCCGCCAATTTGGTACAACATAAGTATAAACATTCAGCAGAAAAGCGATTTAAGTGCGATGTATGCGATTTTGCCACTAAATATAATACATCGCTACGTTTTCATGTGAAAAAGAAACACTGTGATCTCCCAACTTTCAGTTAA
Protein Sequence
MSDITIKVESTIERKDPTSFLPEEPMSYEIKKKKKKKKKTQEDPFKDIEEKVLKTEVVTALDPEVNIKAENIEVELDFNDFTDNSGFLVEGTAVDNEEPAIRIESQAHDALLLTFESVVSDNPVICKTEVTKQPAPCHICKVCHLLFKSQKTLQMHQKRKHKSFRKYFNHICKDCGMAYENKSSLAAHMKRKHGPNSMPDDKEERTCDICALVFKGMPRLRMHMRRKHNSFEDAFTHACKFCGLTYDRSTSLLTHIKRKHSGTKKEVTQWFNCPFCAKIFSRQESYARHVQRKHQVSEDSIKNASEDIGSSVNEQTGEVTCKECPLVFSSVNYLKLHMRRKHNALRENFRLKCRICNLSYDKIESLKRHVQRKHEEKYRCDVCNKQFLTREGYANHSHLKLVKECSVCGLIFASQGGLAKHLRLKHKVESPKVAFCNICEEGFGDKRQLKVHLMKVHWKVSYTCRYCQKVFKMKETHRRHILIKHPNGNQPINSTKQNCEQCSETFNDEFELCQHIYTVHGKETKPSLLKIKKEESDPQENFQCTKCSDSYPTFEQLKVHFDKSHSPDTQCQICGDMVSANELQKHIKTQHTNKDLQCKFCEFKTDVKLSLTQHILRHKNASTLHCDYAGCRYKTYFDLAMQKHKRRHLDLGVKLQCAHCPFQSMNKYILKYHEEAHETGKKRYTCDQCDYATILPANLVQHKYKHSAEKRFKCDVCDFATKYNTSLRFHVKKKHCDLPTFS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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