Basic Information

Gene Symbol
-
Assembly
GCA_936440415.1
Location
CAKZFH010000145.1:1109748-1120549[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.0023 0.18 12.4 2.4 1 23 281 303 281 303 0.96
2 12 3.5e-05 0.0027 18.2 0.6 2 23 311 332 310 332 0.94
3 12 0.49 38 5.1 0.2 1 23 336 358 336 358 0.94
4 12 0.0011 0.084 13.5 1.5 1 23 363 386 363 386 0.98
5 12 0.00045 0.035 14.7 0.2 1 23 390 413 390 413 0.94
6 12 0.0074 0.58 10.8 0.1 2 20 429 447 429 449 0.93
7 12 0.0012 0.09 13.4 1.8 3 23 464 485 464 485 0.98
8 12 0.12 9.2 7.0 0.4 2 23 505 527 505 527 0.97
9 12 1.1e-06 8.5e-05 22.9 0.5 1 23 538 560 538 560 0.99
10 12 0.00031 0.024 15.2 6.0 1 21 566 586 566 588 0.95
11 12 7.8e-05 0.006 17.1 0.5 1 23 594 616 594 616 0.98
12 12 4.1e-06 0.00031 21.1 0.3 1 23 622 645 622 645 0.98

Sequence Information

Coding Sequence
ATGGAGAAAAATCAAGTAGATATTAAAGTGTGCCGCATGTGTTTGAAGATGCAACAGAATAATATATTTAGACTTGATCAGCACCCTTTGGAGACCTATTACTTTGAACTTCTCTTAGGCTCCAGTCCTATCACAGCTAAAGTTGGAAATAACATGGCTTGCCAAGAGTGTTTGACTTCGATAAAGGAATATTACCAGTTTAGGTTAAAATGTATTCAAAGTCAGTCTATACTGGACAACATGGCGGTTGATGGAGTGATAACATCTAAAATATTATTACGGCTCCGACGAAGTAAAGCTATTGCAAACAACATTAGTCAGTCTAGCACAATACATCAAGACAATAAAGAAACACCTAATATACAACCAACTTCAGACCCTGTGTCTCCTGAGAGTGTGTCACACAAAGAGCCAGTTCAATTTGTGACTACTGAAGCTACAACTGAACCTACAGTCTTAGCAATAAAAATAGAAGCACCCGATTCTCCAAAAGAGGACAATTATGATGTCGAAGATGTAGTAGTAAAGGAAGAAGATGATATAGATTCTTATGAACCTCCCATGGATCCAGTGACATCTAGTGATGATGACCAGCCTTTAGCTAAGCAGAAGAGAAAGAAAGAAAAGGAGAAAATTAAAAAGATAAAAGTTAGAGGTTCTGCAAAGAAGCAGGGAAGAAAGAAAAGTGAAACTAGTGGGGATGACACCAAAAGTAAAGCCTTAGCTTGTGGTGTTGATCTGCCAATAGAAGACTACATGACAGTCATCAATTTGACAGTAGAAGAACAGCTGGAAGAGATAAACAAGCGGAAGGAGACGTCCAACTATCTCAACTCGCCGTTTCAATGCAACCAGTGCTACAAGGGATTCATTGACGCGCATGCGTGGAAACATCACGTCGGCAAACACTCACCCAGCGCAGGTGACATAGAGTGCCCGATTTGTAAGTTCCGATTCAAAACAAAGCGCGCTCTTCAGAAGCACGCTATCAATCACGAGAAGAAATATGCTTGCAAAGCTTGTCCATATGTTTCAACAAATACGACTCAAGCTAAACAACACCAAGGCTGGCACAAGGGAGTTACGTACAAATGTAATCATTGCGAAGATGTCTTCAGTGTTTGGACTTCATACATGAGCCACGTTCGCATCAAGCACCCGTCTGAGTTCATCTGTGGAATCTGCGGGTATTCCTTTATCAGCAAGCTCGGCTTAACTATGCACAAGACCATGATGCATAAGGACCATAATAACTCTGAAGATATGAAAAAGGAGGAGGGTCCGTATTGCAAAGAGTGTGATGTGAAGTTCGTGTCGGAAGAAGCTTACAAACGTCACACTGTCATGTCTGCTAAACACACACCGCCGGATACTAAGGCTATCAAAGGGTGTCGAACCTGTGGCGAACAGTTCGAGAGTTCAGAAGAGTTGCGGCTACATCACCGGCGGGAGCACGCGCGGTCACGGCCGAAGAACTACGGGAAGAAACCGAGCACTACCAACTGGCCCGCTAAGTGCGAACATTGTACGGAAGAGGTGGGCAGTGCTCGCGAGTACTGGGCTCACTTCCGCCGCGCACATCCCGACAAGAAGTACCCCATACAGAAGGATTACGTCTGCGATATCTGTGGGAAGAGCTTCCGGGGCAACGCGTTCTTGATATATCACAGGAGAACTCACTTCGATGAAAAGCCGTTCAAGTGTACTCAATGTGACAAAGCGTTCTTCAACCGAAGCAATCTGGTGCACCACGAGCGATGTCACTCCGACTCGCGGCCTTACCCTTGCTCTGTCTGCTTCAAGGCGTTCAAGAGTAAAGCGGCGGTTGTTAGGCACTTCAGAAGCCACACCGGTCAGAAGCCTTACGAGTGTGAAGTATGCGGTAAAGCGTTCAGTCAGTCAAATAGTAGAAAGTTGCACGTCAGAACTGTTCACTTGAAGCAGCCCGCGCCTTATATAAGCCGCAGTAGGTTGGAGAGGAGGAAACAAATCGCTCCCTACAAGGAAATAGCACAGCAGCCGTTTAGCTTTTAA
Protein Sequence
MEKNQVDIKVCRMCLKMQQNNIFRLDQHPLETYYFELLLGSSPITAKVGNNMACQECLTSIKEYYQFRLKCIQSQSILDNMAVDGVITSKILLRLRRSKAIANNISQSSTIHQDNKETPNIQPTSDPVSPESVSHKEPVQFVTTEATTEPTVLAIKIEAPDSPKEDNYDVEDVVVKEEDDIDSYEPPMDPVTSSDDDQPLAKQKRKKEKEKIKKIKVRGSAKKQGRKKSETSGDDTKSKALACGVDLPIEDYMTVINLTVEEQLEEINKRKETSNYLNSPFQCNQCYKGFIDAHAWKHHVGKHSPSAGDIECPICKFRFKTKRALQKHAINHEKKYACKACPYVSTNTTQAKQHQGWHKGVTYKCNHCEDVFSVWTSYMSHVRIKHPSEFICGICGYSFISKLGLTMHKTMMHKDHNNSEDMKKEEGPYCKECDVKFVSEEAYKRHTVMSAKHTPPDTKAIKGCRTCGEQFESSEELRLHHRREHARSRPKNYGKKPSTTNWPAKCEHCTEEVGSAREYWAHFRRAHPDKKYPIQKDYVCDICGKSFRGNAFLIYHRRTHFDEKPFKCTQCDKAFFNRSNLVHHERCHSDSRPYPCSVCFKAFKSKAAVVRHFRSHTGQKPYECEVCGKAFSQSNSRKLHVRTVHLKQPAPYISRSRLERRKQIAPYKEIAQQPFSF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-