Mdol011313.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Megamerina dolium
Gene Symbol
pros
Assembly
GCA_963854835.1
Location
OY978526.1:60383766-60390793[-]

Transcription Factor Domain

TF Family
HPD
Domain
HPD domain
PFAM
PF05044
TF Group
Helix-turn-helix
Description
Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. Homologues of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here [1]. This homeo-prospero domain binds to DNA.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 0.88 1.5e+04 -3.4 0.1 108 146 547 585 527 589 0.72
2 2 9.8e-29 1.7e-24 87.4 2.5 1 50 1785 1834 1785 1834 0.99

Sequence Information

Coding Sequence
ATGATGTCATCAGAGGAGGACACAGACTGTTTTGAGTTGTACAGTGATGATAAGTTACTGttaaagacaacaacaacaacaacactgccTACGTCAACGTCATCGCCATCACTATTAACTGAATTGGAATTTCAACAGCAACCACCTTCAACATCAGCGCTACGCACAAACAAGACAACCACCACTACTACGACGTTGTCGTCATTGTTGTCTACTACAACAAAAAGAACTACAACGCCACCAAAGTGCAATACGAACCTAAAGGAAGAGGCAAACGAAAACGATAACGACGACGTTATCGTCGTACTCGAaggcagtagcagcagcaacagcagctctGTCAGCTTTAGTGGTGGCAGTCGTCGTAAGCGAAGTGGCAATAGACAACAAGTCGTACAAGCAGTTGATCGCTCGAGCAAAAGTAGTCAGTGTGGTGCCGTCAACAAGGCAACAGCGTGTATCGCGCCCAACTTAAAAACGCATtgtcaaaataagaaaaagaaggcGAACGTGTCCTTAAAATCGTCTTCATTGTCGCCATCATCGTTGTCGTGTGAGTTATTACCAACATTAAATGCAAGTGCCGCGTTAGAAGTGAAAAGTGAACAACTCGAACAAGAATCTCATCAATCGCCACTGTCACAAAAATCTTCTAGTGAAAATAAACCATTTTCGGCCGTGTCGTTCAATTCACAAAtactaccaacaacaacaaaaacaagtcCGACATCGGCAGCCTCCACGTCGCCGTCAACAGCTGCTGCCTTCATGAGTAGTGCTGCTGCGGCTACTGCGGGTGCCGCTGGAGGAGCTCTGTATGGAGCCGTACTAAATCAACAAAGTACAACATCACTTGTGTCCGCGGTGTCATCCAACAGTAATAGTGCAGTAGTGAACGCCATTATAAACAATCACAGTAGTTCGCCGGCATCTGGTTCGGCATCCTCGTCGCCAACAGCATCGCTGCTGTCGGGAAATTTTACAACCGCTCTCGGTAATCTGTTCGGCGCCAACGGTTTTGGTTCGGCTAAAATGTTAAATGAACTATTTGGACGTCAAATGAAACAAGCTCAAGATGCTACCAGTGGTTTGCCCACCACGCTGGACAATGCAATGCTAGCGGCTGCCATGGAATCGGCCACAAGTGCCGAATTGCTAAGCGCAGCCGGTTTAGTGAATAGTTTAAGTTTGAATACGACCAGTAAATTGctcaacaataatacaataaatagttTGAACAGCTTAAGTAATGCCGCTGGTGGCGGTTGTGCGGCGACTACCAGTAATGGTGTTGTTGGTGATAACCAACAACCAAATATCTCACAATCGCCAAAAAATCGTCGTATCAGTAACTGTAGTGACCGATCCTTAGAAGCCGACTCTGGTTCTCAGGTAGCTGATGCCAGCTCATCACCACGAGCACCTTCAGCGAGCTCTGCAATTACGACTGCAGCCAGTGTGGTAACAAACACCACCACGGCTACAGCTACAGGTGCTGCTTCACCAACCACACAACAGCACCACAGTGATTTGGCACATCATATGCTGCGTAATATTTTGCAAGGTAAAAAGGAGCTTATGCAATTGGATCAGGAGCTACGCTCTGTTATAAATCAGCAACAGCAGAAGGATAATCATCAGAATAATctgaaacacaacaacaacaactcttctgccacaaataacaataatgtCGCCGACAAGACATCCCAAAATGATGTCATAAATCTGCTGGAGGACACTATGCCTGAGATTAAAATTAAAGCAGAGCCCCAAACACCATCCAACAACATGGATACGTCGATGTCGGCGGATCGACGCAAATCGTCAGATTCTGAAGTCAATGGAGCACAACAAGATGATGATCAAAGATCTGAAATAGATAATGAAATGGACCAACAAGATGTAGAGCAACAGGATGAACAACGAATCAATTCGGGCCTGTCGGTTGGTGTGACGAAGAAAGAAGCGGATGATATACTCGAAGACGTTGAGCTAATGGGATTAAATTCACGCTCCGATTTGGAATCACTAGCATCGCCCAGTCATTCAGACATGATGTTGCTTGACAACAGCAAAGATGAGCTAGAGGAGGAAATCGAGAAGGATGTTGCTGCGACCATGACTAAGAAACCAGCCATGGATATGAAGCGGGCGCGTGTTGAGAATATAGTGTCGTCAATGCGTTCGAGTCCTTCTTCGCACCAGCCCCATTTACAGGTGAATGGTTGCAAAAAGCGAAAGCTCTATCAGCCACAACAACACGCAATGGAGCGATATGTTGCGGCGGCTGCTGGCTTAAATTTTGGCCTCAATTTACACTCAATGATGCTAGATGATGAGGAATCGGATGAGCTGGAATCACCGCAAATTCAACAGAAGCGTGTCGAGAAAAATGCTCTCAAGTCGCAGTTGCGATCTATGCAAGAGCAGTTGGCCGAAATGCAGCAAAAGTATGTGCAATTATGCACTCGTATGGAACAAGAATCAGAATGCCATGAAATCGATGACACAGCCAGTGACAGTTTAGAGCAGGACGATAATGGTGGCGATCTCTCGCCATCGCCATCACTCACAGGTGAGTCTGGTGTTCATGATAAACAtctacagcagcaacaacagcaacagctgcAAGAAAACGAACGACCAAGTTCCACATCGCCTAACCTACGACTGAAGAATCAAAAGCATTTGAGCACAACTAATCCAATGGCGGCATTAGACAATACGCCCAATATGCTTTCACAGATGATGAGCAAGATGATGTCATCGAAGATGCACAATCCCATGGTTGGGCATCCGCATATGCAACAACCGTTCAACGGTCCATTACCTTTGCTGCAGCATATGCCACAGTTACAAGCCGAACCTACGCTGTCGCATCCAGCCATCAGTAATGCTGCTGCCATGTATCTAGGCCAACAGTTCTTCTTCGAGCAAGAGGCACGTATGGCAAAAGAGGCGGCTGAACAGCAAGAacggcaacagcaacaacagcagcaacagcaacaattgcaacagcagcagcaacaacaacaacaacagcagcaacagcagcaggaaCAACAGGAACAGCAGCGTCGTTTTGaacacgaacaacaacaattgaggCGTAAagaagaacaacagcaacaacaagcgCAACatcaagcacaacaacaattacaaaggcaacagcagctgcaacaacaactgcagcaacaacaacaattggaaCAACACAACACGCCAACAACACCAATCAATCAGCCCACCCGCCCACAGTTGCATCACAATCGCCTGCAGCACCGTCACGCCAATCACTCGGTCCTCAAGTCAGAGCTGTCGGAGAAATTCAACATGTTGCGCTCCAACTCCAACTCGATAATGCGTATGTCCGGCTCAGATTTGGAAGGTCTGGCCGATGTACTCAAATCAGAGATCACCACCTCATTGTCGGCTCTCGTGGACACCATTGTGACACGATTTGTACATCAGCGACGACTGTTTAGCAAACAGTCCGATTCGGTGGCCGCAGCAGCCGAGCAACTAAACAAAGACTTGCTTATGGCCTCGCAGATACTCGATCGCAAATCGCCACGAACAAAAGTCGCCGATCGTTCACAGTCAAGCAGTCAATCGAGCGGTAGCAGCAACGCAATCGCAACATCTGGAGCACCTATTGCAATAGGCAGTAACAACATTGTCACAGCCACTGCAGCTCAATCAGGTAATAATGGTTCTCTACTTCTAGTTAATAATACCTCTTCAACTAACCACAATATCAACCAAACCACGAATGGCAATCACCTAGGCCACATGCAAACATCCGTACCGAACGGTATGCAATTGCATGTTGGCACTTCTGGTGTAGTGAATGTACCACAACATGCACTCACCAACAGTCAGAATGCCGCTATTATGACTAATAATAACCAGGTCAGTCAGCAGCATACGCAACCAATGACTCAGTTAAGTGCGATGAATGCGCCCAATTGTCAGAGTCTAATTGCTGCGCCACGCCTCAACGGCAATCAGTTGTCGTTTCCTTCACCGGCAGCTGCAGCGGCTGCTGCTATGGGCCTACAAATGCATCATGCAGCGGCTGCAGCTGCCAtgtcagcagcagcagttagTCAACAGAATCATAACCAGCACCAAACAGATGGAGTTGGTCAAAATATTAACCCTCAAAACCCGATTAATACTAACAACAATAGCTTAAATACCATTAATATACCACCTCCTCATATACGTCCTTCGCCCACAGCGGCAGCAATTTTTCAGGCACCAAAGACGCCACAAGGGATTAACCCTGTTGCTGCAGCTGCGCTTTACAACTCGATGACAGGTGGTGGCCCCACTCAAATGAATGCGTTTGGCATACCGGATCCacaacaccagcagcagcagcaacagcaacaacagcagcagcaacaacagcaacagcaacagcagcagcagcaacaacaccagcagcaacaacagcaacaacaacagcaacagcaattggAACAGAACGAAGCACTAAGTTTGGTGGTAACGCCAAAAAAGAAGCGACACAAGGTAACAGACACTCGCATAACTCCGCGTACCGTTAGTCGCATACTGGCCCAAGATGGAATTGCTCCACCCAATTCGACTGCCGCTACAAATGCACTACTCGATAACAATGGTAAATTTAGTGCGATCGGCTCACAGTCCAATAATGCTCCTTCACAGGGACTACAGAATCAAATTCCAAATCAGATTAATTGCAATGCCAACagcatgggggctgcaatatCTGCAACACCTGCCACTGCGAACAATGCAAACACAACGCCTGCACAGAGTCCCTCGCCGCGTGCTCAAGCACCTGCTTACCatccaccgccaccaccaccaccaccatccaTGATGCCCGTATCGTTGCCTACCTCCGTAGCTATACCAAATCCTTCATTGCATGAGTCACAAGTCTTCTCGCCGTACAGTCCATTCTTTAATCCACATCCACCGCATGCACCACCACCGCCTCCATCCGGCCCTCACGGCCCGCTTGGTGGTTCGCATGCACCGCCTACAGCTGCTCAACTGCATCACATGAAAATGTCATCGAGCCCTCCCGGTTTAGGTACTCTAATGGATTCGCGCGACTCTCCGCCACTGCCACACCCGCCAACTATGCTACATCCCGCCTTGCTAGCAGCCGCCCATCATGGTGGCTCACCCGATTACAGCGCGCACTTACGTGCAGCGATGGATGCTCAGGATCGTAACTCTGATTGTAATTCAGCCGAAATGCAATTTGAGGGAATGCAACCTACTATATCCTTTTTGAAACAGCAAATGATCAAAAATAGCGATTCCTTAACTCCATTGCACTCGTCAACATTGACTCCGATGCACCTGCGCAAAGCTAAATTGATGTTCTTTTGGGTGCGTTATCCGAGCTCAGCCGTATTGAAGATGTATTTTCCCgatatcaaattcaataagaATAATACAGCACAATTGGTGAAATGGTTCTCGAATTTCCGGTAA
Protein Sequence
MMSSEEDTDCFELYSDDKLLLKTTTTTTLPTSTSSPSLLTELEFQQQPPSTSALRTNKTTTTTTTLSSLLSTTTKRTTTPPKCNTNLKEEANENDNDDVIVVLEGSSSSNSSSVSFSGGSRRKRSGNRQQVVQAVDRSSKSSQCGAVNKATACIAPNLKTHCQNKKKKANVSLKSSSLSPSSLSCELLPTLNASAALEVKSEQLEQESHQSPLSQKSSSENKPFSAVSFNSQILPTTTKTSPTSAASTSPSTAAAFMSSAAAATAGAAGGALYGAVLNQQSTTSLVSAVSSNSNSAVVNAIINNHSSSPASGSASSSPTASLLSGNFTTALGNLFGANGFGSAKMLNELFGRQMKQAQDATSGLPTTLDNAMLAAAMESATSAELLSAAGLVNSLSLNTTSKLLNNNTINSLNSLSNAAGGGCAATTSNGVVGDNQQPNISQSPKNRRISNCSDRSLEADSGSQVADASSSPRAPSASSAITTAASVVTNTTTATATGAASPTTQQHHSDLAHHMLRNILQGKKELMQLDQELRSVINQQQQKDNHQNNLKHNNNNSSATNNNNVADKTSQNDVINLLEDTMPEIKIKAEPQTPSNNMDTSMSADRRKSSDSEVNGAQQDDDQRSEIDNEMDQQDVEQQDEQRINSGLSVGVTKKEADDILEDVELMGLNSRSDLESLASPSHSDMMLLDNSKDELEEEIEKDVAATMTKKPAMDMKRARVENIVSSMRSSPSSHQPHLQVNGCKKRKLYQPQQHAMERYVAAAAGLNFGLNLHSMMLDDEESDELESPQIQQKRVEKNALKSQLRSMQEQLAEMQQKYVQLCTRMEQESECHEIDDTASDSLEQDDNGGDLSPSPSLTGESGVHDKHLQQQQQQQLQENERPSSTSPNLRLKNQKHLSTTNPMAALDNTPNMLSQMMSKMMSSKMHNPMVGHPHMQQPFNGPLPLLQHMPQLQAEPTLSHPAISNAAAMYLGQQFFFEQEARMAKEAAEQQERQQQQQQQQQQLQQQQQQQQQQQQQQQEQQEQQRRFEHEQQQLRRKEEQQQQQAQHQAQQQLQRQQQLQQQLQQQQQLEQHNTPTTPINQPTRPQLHHNRLQHRHANHSVLKSELSEKFNMLRSNSNSIMRMSGSDLEGLADVLKSEITTSLSALVDTIVTRFVHQRRLFSKQSDSVAAAAEQLNKDLLMASQILDRKSPRTKVADRSQSSSQSSGSSNAIATSGAPIAIGSNNIVTATAAQSGNNGSLLLVNNTSSTNHNINQTTNGNHLGHMQTSVPNGMQLHVGTSGVVNVPQHALTNSQNAAIMTNNNQVSQQHTQPMTQLSAMNAPNCQSLIAAPRLNGNQLSFPSPAAAAAAAMGLQMHHAAAAAAMSAAAVSQQNHNQHQTDGVGQNINPQNPINTNNNSLNTINIPPPHIRPSPTAAAIFQAPKTPQGINPVAAAALYNSMTGGGPTQMNAFGIPDPQHQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQQQQQQLEQNEALSLVVTPKKKRHKVTDTRITPRTVSRILAQDGIAPPNSTAATNALLDNNGKFSAIGSQSNNAPSQGLQNQIPNQINCNANSMGAAISATPATANNANTTPAQSPSPRAQAPAYHPPPPPPPPSMMPVSLPTSVAIPNPSLHESQVFSPYSPFFNPHPPHAPPPPPSGPHGPLGGSHAPPTAAQLHHMKMSSSPPGLGTLMDSRDSPPLPHPPTMLHPALLAAAHHGGSPDYSAHLRAAMDAQDRNSDCNSAEMQFEGMQPTISFLKQQMIKNSDSLTPLHSSTLTPMHLRKAKLMFFWVRYPSSAVLKMYFPDIKFNKNNTAQLVKWFSNFR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-