Basic Information

Insect: Megalopta genalis
Gene Symbol: br
Assembly: GCA_011865705.1
Location: NW:3001055-3069248[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 1.8e-07 9.5e-06 24.9 1.9 1 23 629 651 629 651 0.98

2 8 2.2e-05 0.0012 18.3 2.0 1 23 657 679 657 679 0.98

3 8 1.4e-06 7.3e-05 22.1 0.3 2 23 688 709 688 709 0.98

4 8 4.5e-05 0.0024 17.3 0.1 3 23 717 737 715 737 0.97

5 8 1.4e-07 7.7e-06 25.2 3.0 1 23 743 765 743 765 0.98

6 8 2.5e-06 0.00013 21.3 0.7 1 23 771 793 771 793 0.98

7 8 5.2e-05 0.0028 17.1 7.5 1 23 799 821 799 821 0.98

8 8 6.4e-06 0.00034 20.0 1.0 1 21 827 847 827 848 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	1.8e-07	9.5e-06	24.9	1.9	1	23	629	651	629	651	0.98
2	8	2.2e-05	0.0012	18.3	2.0	1	23	657	679	657	679	0.98
3	8	1.4e-06	7.3e-05	22.1	0.3	2	23	688	709	688	709	0.98
4	8	4.5e-05	0.0024	17.3	0.1	3	23	717	737	715	737	0.97
5	8	1.4e-07	7.7e-06	25.2	3.0	1	23	743	765	743	765	0.98
6	8	2.5e-06	0.00013	21.3	0.7	1	23	771	793	771	793	0.98
7	8	5.2e-05	0.0028	17.1	7.5	1	23	799	821	799	821	0.98
8	8	6.4e-06	0.00034	20.0	1.0	1	21	827	847	827	848	0.95

Sequence Information

Coding Sequence: ATGATGGGTGAAGTGATTCGGGTTTCCGGGAGGGCACCGGATGTTGGGGAGTTCCTGAAGGAGGCGATGCTGTCCCAGAGGTTCGCCGACGTTGCACTTTGCTGTCCCGATGGTCAAAGGTTCCTTGCGCACCGCCTCGTTTTGTCGGCTGCCAGTCCTTATCTACAGGAAGTCCTGCTGGCGCACAGTAAAACGTCGTCGCACTGCGAGCCGATCACAGTGATCCTCGCCGAGGTAGAGGCGCCGGAACTCGCGGCGATCCTCGGGTTCGTCTACACCGGAAGTGCCACGGTGCCGAGGCCCCGTCTGCAGGCGTTCTTGCGGGCAGCGGAAGCTCTGCGGATCAGACTGCCGCCGGTGCCACTGGCGATGACCTGTCCACGGCCGGACTGCAAGCAGGAGGACGTGAAGGACGTAAAGATCAGCCCCAGGTACCTGCGCTGCGATCAGTACCCGTGCTGCAATCGCTGGTACAGGGCCCAAGACGTAGATCCCGGGCTTGACAAGCGTGCTACCTGTCCGGCGATCGAGTCCTTGGATGGTTCGAGGGAAATCGGATCGCTTCCCGATCCGATGAACTTTGCCGGGCCGAGATACGGCTCGGTCAGACATTGCGCCGCCACTTGGCCCGTGCCAGCCTTCTTGAACGCCAGCAGCCAAGAGAAGAGCATCCGCGTTCTAGATCAGCTGCCCGATAAGGACAGCGTGCATCAGACGGACGTCAGACGTTATAATCCTGTCTCCGTGGTGTCGAGGATCGACAGGATCGAGGACAGCACCGCCACCAGTTCGGAGAACGCTCTCTCAACCTGCCGTTCCCCCGTGAAGCAAATGGAATTCTGTTTTTCGAGGAACAGCTACGACGTTCATAGACAGTTAGATCCTCTTGAATTGAGGATGCGGAACGATCAGACTCGTCTCCCGGGCGACGAGGACGCGAGTGCCGCGATAGATCCGCTCCGCGGCAGCCGGCCCGACGAGGACCGATGCGCCGAGGATCGCGGCAGCGTGATCCACTCGAGGATCAGTCAATCCGCGGTCTCGTTGCAGCCAGCCGAACGGACCAGGCACCACGAGAAACCAGATTACGGCGAGGATTTGACTTGCGGGGAAAGTTGCCTCGGCTGGAGGACACCGAAAAGGCACGTGGCCAATCGCGTGATCGCCTCCCCGTGGAGACAGACCGCTAGGCCTTATCACTCGCCCAAGCTGCAGCCCATCGTGCTTCTTCAGCCTCACGCGGACGATGTCGAGGCCGGAGAGAACCTGCGTCTGCCAGAAGTGCAGCAACCGGTAGTCCCCTGCGGTCCCCACGTTCCGTTCCCGAAAAGTCCAGCACCCGCAGCAGTGCATTACTATGGCGTCGAAGCTCCCGCCAGCAGAGAGATACAGTACAACCTTGGTCCAAGGTTGTTGGAAGCGAATTCAGCGCCAGCAACGAGACACCGAGAGTTTTATTCGCCGCAGATCCCATTTCCGACTGTGGAACCTGTTCCGTCCATTGTGAACGATGTTCCTACCAACGAGACCGTCTCGCAATCACAGAATAATGTTGTGTCCACAACGACCAGGCCTCCGTTGATCAGCAACGAGAACGTTCAGCCGACTATCAACAGGAAAACTGGCTACTTTGGTCAAACCCTGCCCCATCCACCGCAAAAACCAGAAATCTCACATCCGGTTAGCAGACTCTGCGATACGATCGAAACCAACGATaagatcgatcgtttcgcgagtGTGGAAGTCGAAAGGTCGGAGAGGGTACTGAAGAAGGACGATAAACTCGCGGAAAGGGTTATTAGAAATAGtgataacaacaacaacgatgCTATCGTTGGCAACGATGTTCCGCAACGTGGGAGGCCGGTCGCGAGCCAAGAAAGCCACAGATGCGATCAGTGCGGGAAGACTTTCGTTACCAGAGCCTCTCTCAAGGTGCACGTCAGGACGCACTCCGGTGAAAAGCCGTTTCGCTGCGCGGATTGCGGCAAGCAGTTCTCACAGCTGCGAAACTACAAGTACCACCGGAGCGTTCACGAGGGCACCAGGGAGTTCGCGGCCACCTGCCCGGAATGCGGCAAGTACTTCAACGACCGGGGTTACCTGAGCTCTCACATGAAGATCCACCGCAACCGGAAGGAATACGGGTGCGCGGAATGCGGGAAAAGCTTCAACCAGCGGGTCGCGTACAACATGCACGTCCGGATCCACACGGGCGTGAAGCCGCACCAGTGCGAGCAGTGCGGCAAGGCTTTCTCGCGGAAAATGTTGCTGAAGCAGCACCTGAGGACCCATTCCGGGGAGCGGCCGTACCAGTGCCAGGTCTGCCAGAAGGCTTTCGCGGACAGATCGAACATGACTCTGCACACCAGGCTTCATTCCGGATTGAAGCCGTATCAGTGCACGCTGTGCTCGAAAGCTTTCACCAAGAAGCACCACCTGAAGACCCACTTGAACTACCACACCGGCACCAAGCCGTACTCCTGCCCCAATTGCGGCCTCAGGTTCTCCCAGAGCAGCAACATGAGGACTCACTACAAGAAGTGCACGGTGAACAATCCCGGAGAAGCGAAGGAGCAGATAGAGGGCGCCACGGCGGAGTCCAAGGTTGGCCAGGCCAGAGTGCTGTCGAGGACACCGGCGGATACCCTGACACCACCGAATTCGGACCAGGAGCTCAGCATACTGACGCCAATATCGAAGAATCCGTTGGAAGCTAGCGGGAGTTAG
Protein Sequence: MMGEVIRVSGRAPDVGEFLKEAMLSQRFADVALCCPDGQRFLAHRLVLSAASPYLQEVLLAHSKTSSHCEPITVILAEVEAPELAAILGFVYTGSATVPRPRLQAFLRAAEALRIRLPPVPLAMTCPRPDCKQEDVKDVKISPRYLRCDQYPCCNRWYRAQDVDPGLDKRATCPAIESLDGSREIGSLPDPMNFAGPRYGSVRHCAATWPVPAFLNASSQEKSIRVLDQLPDKDSVHQTDVRRYNPVSVVSRIDRIEDSTATSSENALSTCRSPVKQMEFCFSRNSYDVHRQLDPLELRMRNDQTRLPGDEDASAAIDPLRGSRPDEDRCAEDRGSVIHSRISQSAVSLQPAERTRHHEKPDYGEDLTCGESCLGWRTPKRHVANRVIASPWRQTARPYHSPKLQPIVLLQPHADDVEAGENLRLPEVQQPVVPCGPHVPFPKSPAPAAVHYYGVEAPASREIQYNLGPRLLEANSAPATRHREFYSPQIPFPTVEPVPSIVNDVPTNETVSQSQNNVVSTTTRPPLISNENVQPTINRKTGYFGQTLPHPPQKPEISHPVSRLCDTIETNDKIDRFASVEVERSERVLKKDDKLAERVIRNSDNNNNDAIVGNDVPQRGRPVASQESHRCDQCGKTFVTRASLKVHVRTHSGEKPFRCADCGKQFSQLRNYKYHRSVHEGTREFAATCPECGKYFNDRGYLSSHMKIHRNRKEYGCAECGKSFNQRVAYNMHVRIHTGVKPHQCEQCGKAFSRKMLLKQHLRTHSGERPYQCQVCQKAFADRSNMTLHTRLHSGLKPYQCTLCSKAFTKKHHLKTHLNYHTGTKPYSCPNCGLRFSQSSNMRTHYKKCTVNNPGEAKEQIEGATAESKVGQARVLSRTPADTLTPPNSDQELSILTPISKNPLEASGS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00183433;
90% Identity: iTF_00183433;
80% Identity: iTF_00966125;