Basic Information

Gene Symbol
PRDM7
Assembly
GCA_034642435.1
Location
CM067861.1:31134088-31175467[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 19 0.035 4 9.2 0.2 3 20 1851 1868 1851 1870 0.96
2 19 0.00026 0.029 16.0 0.8 1 23 1944 1966 1944 1966 0.98
3 19 0.24 26 6.7 0.6 1 23 1972 1994 1972 1994 0.96
4 19 0.24 27 6.6 0.0 3 23 2080 2101 2078 2101 0.96
5 19 0.16 18 7.2 2.4 1 23 2136 2159 2136 2159 0.94
6 19 0.023 2.6 9.8 4.3 1 23 2165 2188 2165 2188 0.93
7 19 0.71 80 5.1 0.2 6 23 2199 2217 2197 2217 0.90
8 19 0.016 1.8 10.3 3.9 1 23 2223 2246 2223 2246 0.94
9 19 0.0012 0.13 13.9 2.2 1 23 2252 2275 2252 2275 0.94
10 19 0.002 0.22 13.2 2.6 1 23 2281 2304 2281 2304 0.94
11 19 0.00069 0.078 14.6 2.8 1 23 2310 2333 2310 2333 0.94
12 19 0.0056 0.63 11.8 1.2 1 23 2339 2362 2339 2362 0.94
13 19 0.00069 0.078 14.6 2.8 1 23 2368 2391 2368 2391 0.94
14 19 0.0013 0.15 13.7 4.2 1 23 2397 2420 2397 2420 0.94
15 19 0.032 3.6 9.4 1.9 1 23 2426 2449 2426 2449 0.94
16 19 0.023 2.6 9.8 4.4 1 23 2455 2478 2455 2478 0.94
17 19 0.002 0.22 13.2 2.6 1 23 2484 2507 2484 2507 0.94
18 19 0.0014 0.16 13.7 2.4 1 23 2513 2536 2513 2536 0.94
19 19 0.17 19 7.1 0.7 1 18 2542 2559 2542 2559 0.95

Sequence Information

Coding Sequence
ATGAAACGATCAAGAAAAAGGTTATCTGGggatttcaaaaaacatttaactAACAAAAGTAAAAATGAATGTAAAGAAATTATACAGAAAAGGGATCATCTTTCTAATAATGTTGTATTAGATTCAACaattgaaaaagagaaaaaaacacTGAACATCTGTAGAAAAAAATCATCTGAAAAAGAGGAATGTTCTTGGAGTTCagattttgtgaaaaatttctttgaagaaagaaaagaaCCTATGGAAAGTCCAAGTGAAAAGCAACTCAAGAAAATGCCTCCAGATGATCTAATAAGTGATGGTTCTAGAATACCTTTTGAAAAAAGAGAAAACAATAGTTATTATCCCTTTAAAAAACGCTTCAAAGCGGTTTACTATGATGATGatcctgaaaaaataaataaagaacagGAAAAAATTAAGAGAGAATTAGAAGTTCTAACAGAAGAAAAACTAGCAGATTTTTATTTTCCACCACTTAATATTAAGAAAGATGAAGAAAGTAAAGATGAGACGAAATTTGTATTGATAGAAAAATCATTGAATAGTtatgataaaaaatttgttgctgTTGGTAATGTATCAGACAATTATGAGAGAATGACACAAGATAGCCGCAAattaaataatgttaatttcgcagaaaaaattagtgcagttgaaTATAATGGTCGAATAAAGGAAAAGGTTGAACCAAGTCTGGTAAAAAATCCAACAGATGTAGAATTCAATAATCCTTCCATAGAACAAAGTGATGACACTCCCACTTTAGAGAAACagtttcaagaaatatttttcccaGCAGAACACATGGGGGGTATGGATATTTTTGTACCTGTTCCACACATAGAAATAGAAGTCGAAATTGAAACTAGCCCAGAAATCATTCCACCAATGAAGAATGTTGTTAATAACAATTTTTCACCATCAAGAAATTGTGAACAGATTGCAAATGATACCGGGGATATAACAAATTGTCTTGAGTCCATTGTCAACGAAGAACAAATAAATGATACTCTGGTAGTATCAAAACATTTTACAGAGTGTAGCGATGACAAACAACAGAAACCGAATGATACTTTGAGAGTATTGAAACGTTCTGTAGAACCAAGTATTTGTGAAGAGCAGATAGGAATTAATACTTCGAATGCAGAAAAAAATGTTGCTCTATCAAAACAAGAAACTTGTTTATCTAAGTCACATGATGATATACAAACTGAAATCAGTAATACTCTAGAAACAGAAACTCTAGATTGTCTATCTTCAGTGTGTAACAATGAGATAAGATGTAATAAGGAGATATCAAATAAAATCAATGAGGTTAAAATGACTGCACAACTTCCTCCAGAGACTACAATTGATCTACAACAAGTAACGAAAGATTATTTGGGAATAACCAAACATTCTTTGGATCTTAAAGATGTCCTGTGTCcaaaaaatacttttaaaataaCCAATTATTCTCCAAACTCTAATATCCATGAAGAGTATACAACAAATAGTACTGTAGGAACAATAGATCATTCTGTGAAGTCTACTAATAATGAACAGCAGATAACGAAAGACACTTTGGGAAAGATAGAACATTCTCAAGACCATTGCAATCATAAATGGTATACAAACAAACAAGTTTTGAATATCTTCAGTCGTTCTCCCCAGccttataatgaaattctaagAGGATCAAATTATTCTCTACAACCTAATAATAATGAACATCTAATGAGAAGAGATGAATCAGGAAATTCTCCAAACGCAGGAAAACAACCATAtggatggtttatgataaacaGAATTAGGCAAAAATTTAAAGAATCTATGAGCTCCATTAAGGACAAagatcaaatagaaaaaaatactttggaatttgaaaaaactttagAACCTCATAAAAATGAAGGGCAAGTAGAAACAAACTCTCTACCCCATCTTTTATCTGATATTAATGAAGGCTGTCTATCAAAAGATGAACCAAAAAAACCGAAATTTTCTCTAGAACCTTATAAGAGTAAACAGCAGATTAAGAAAGAGAATGTATTAAGATCGAAACATTGCTTAGAGGAAAATATTCTGGACGggaaaatgatgaaattaaataaacatcGTGTAGAGACTCACAATTGTGCGCTGCAGGAAGCAATTGATAGTTGGAGAACAAAAAAACATTGTATACAGTCAAGAATTGATGAACATCAGcgaaaaacagatatattaGGAATACCAAAATGTTCACTCCAAAATTACAAAGATGAGCAGCAGATGATAAAAGACATAGCAGAGCCTTCACCAGAAATCATCAATAAAAAATGTCTGATTAGAAAGGAATCTCAAAAAATATCAGAACATTCTTTAGAGATGAATGTGGATGAACAGCCAATTAATAGAGACACTTTGAATGCAACAGAACATTCTACGCAGTCTAACAAAGATAAACAGCAAATAATAAGTGATATGTCTGAAATGCTAGAATATTATCTACCACATATAAAGAAAAAGCAACAAGCTATAATGGGACATTCACTAACACTTCATAATAAGGAATGTCGGATACCAAACCCGTCCCAAAAATCTGAATATTCTTTAGATACACACAGTGAAAAACAACAGATTaagaaatataatatagaaCCTTTGAAGTCTAGTAATAGTCAACAAAAATTAACTAAGGactctctgataataacaaaacatCATCTAGAACTTGATAATGTTGAGTTACAGAAAATAAGAGGTACACTTAGAATATCGGAACATcctttaaaattcataaaagaaGACCAGCAGTTAACACAAAGTACTTTgggaataattaaaaattctctAGAGCCTAATAAAGTTGAGCAACAGAGAACAAGAATATTAGAATGTTCTCTAGAACACAACAAGGAAGAGCGGCAGATTGAAAGAGATACTATGAGAATAATAGAACATTCGCTGGAATCCAAAAATGACGAATGTCAGATAAGGAAAGAGTTTAAGAACATGTCTGAACAATTTCAACAGGTAGATAGTGATGAGCACCAGATTATGAGAGATAAATTCAGATTATCTGAATATTCTTCAGAATACAGAAAAGAACAGcaaaaaacaaaacaacatTCTCTAGGAGCAGATAAATCATTAGAGTctccttataatgaatgttcgaTAACAAAAAGACCCCAGAAAATATCTGAACAATATTTAGAGGTGCATAGAGATAACCAGCAGATTAAGACTAATTTCAGATTATCAGaaaatactcaaaaaaaaattaatgaagagACAAAAGATTTCCTAAGAATAACAGATCATTCATTGAAATCTCATAACGATAAATGTCTGATAGCAAAAGCGTCCCAGAAAATATATGAACAATATTTAGAGGTAGATATTGCCGAACAGCAGATCGAGAGAGATAATATAACACACAATTCTGAGAAGTTTAATAAGAATGGACAAGAGATAACAGGAAATATGTTGAGATTATTAAAACATTCTCTAGAACACAAGAAACAAGAGCAGAAGGTAACTTCACACCCTGACCTTCAGGTCGATTCTACCTCAGTGCAGAAGGTAAATGTAGATTCTTTAAGAACAATAGATCATTCGCTAAAGTTTAAAACTGACGGATGTCAGTTAATAAAGGAGTTCCAAAACATATCCAAACAATGTATAGTAGAGATTAACAGTGCCAAACAGCAGATTAAGAAAGACAGTATAACACAATATTCTGAGGAGCCGAATAATGATGAACATCAGGAAAAAACAGATAAGTTTAGATTGACAGAACATTCTCTAGAACACAGTAAAGCAGATCGGCAGATGAAAGTATATTCTCCGAAAGCGATTAATCATTCACTAGAGTTCAATAATGATGAATCTCGGATAACAAAAGAGTGTGAGAAAATATCCGAACAATCTTTAGAGATGGATAGTGGAAAACAGCAGAAAGAGATATATATAACACAACACTTCAAGGAACCTAATAACGATGAAAATCAGACAAGAGATACCTCCACATTGATAGGACGTTCTTTAGaatctagaaaaaaagaacatcCGATTAAAAAGGATTCCCCTGGTATAATGAATTATCTGCAGGCAGATAGTGATGAACAGTACAAAACAAGAGAAAGTTCTCAAAACGCTACAAATAATGAACAGCGGATTAAGAGAGACATTTtgaatataacagaatattgtgtagaacttaataatgataaacAGCAGATAATGGTAAAAGATCATCCGAAAATATCAGAATATTCTTCACAGCCTTATATCGATGAACATGGgaaaacacaaaatattttgaaaataactgaatGTTCTATAGAACCTAATAACGATGAACAACAGATAATGGAAGACATTACTAAATTATCAAAAGAATCTCTGCAGGCTGAAAATAATGAACAGCATATAACAAATAAACTTGTGAAGTTAACAGATCATTTTATAGAGTCTAACAATGACGAACCACAgATAACAGATACTTTGATACTTCCAGTACAGTctgtagaaaataaaaattgtgaagaaCAGATACTAGTTGATACTATAGAGAAAGGCAAAGATTTGCgggtaataaaaaaacagaatcATTGTGTGGAGAAACAACCGATAACAAGAGATAGTCCTAGAAGAGAAGAAGAGGAGATAATCAAAGAAACTTCAACAGTAACAAAGCATTCTTCAGAGTTTAGCAATGAAGAAGACAATTATGCAGAATTGCTGAATATTTCCTTACTAGAACAGAATAATGGAATAGAAAATTGTTTATTCCCAGAACATGTTAAAGTAAAAATTGAAGACAATGTTGACACACAAATATCAATGAGGGAACAATCCCTCGATAATAGTTCTCTGAAGTCTAACTGCAATGGTAAACTGGTAAACTCATCTAGAAAAGACGAAGATAAGGATTTCAAGATAAAAAGAGTTGTTTTCGGGAAGTCTGAAGtccGCCGTAATCCGAAAAGGCAAGTCGAGGTCAAAAACTATAAGGAAACTGAAGAACCACAAGATGATAGATATGTCTATTGTGATTTTTGCGAGGAAGTTTTTGTGGACAATTGCATGAAATGTGGCCAGCTGGCATTTTTGCAGGATGCCGAGGTAGAAATGGGAATTGAGAACAGAGCCAAGATGACTATACCGAATACTCATTTGATCATACTACCTTCACCTATTCATGGTTTGGGTGTGTTTGCGCAAGTTCTCTTGAAGCAAGGCATCAAGATGGGCCCTTATGAAGGAAAAATAACCAGATTTGAAAGCAATACTGGATACAGTTGGAAGCTGAGGGATGGCAGACTGGTTGATGCAGCCGACGAGAAGTTTTCCAACTGGATGAGGTACATAAACTGTGCTAGACATTTCAACGAGCAAAATTTGGTGGCATTCCAATACAAGGGCAACCTGTACTACAGAACATGTAAGGATATTAAGATCGGAGAAGAACTTCTTGTGTATTATGGACAAAGTTTCGCCAGTATCTTGGGAATCGACATAAAGAATTACTTTAAACCGAAAGAGGAGCAAATATCGGATAATCCCCAATGGTGTCAGTACTGTTATTATGGATACACAGATTCATCCAAATTGAAAAGCCATATCGCTTTGTGCAAATTGAACCCTGCAAGTAAAAAGAAAATTCCAGTTAAGGTTTACCATTGTCGATTTTGCTTTTTCGATACTGCTGATgaagaaaattatcaaaaacatGAGAAGAAATGTGAAAAATGGCAAGAGGGGAAGAAAGAGAATGAgAATATAAGAGATGAAGCTGTGAGACGTCATGAAGAGATGAAAACGAGAAGCTGTAAGAAGAATGATGTTCTGTTTAAATGTCAGGATTGTGATTATTCATCGCGTTACGAAGATTATTTGGAGAAACACCAGATAATTCACAGAAAAGTTTTCACTTTTTCCTGTACAATATGTTCTGAAGGTTTAAATTTCGAATACAGTTTGAAAGGCCACATGTTTAACCATTTGAGTGAATCTACCAGTACAACTATGCTACAAACCACTAAAGTGATGGATGGAAAGGCTGTTAGAAATCATCAAAAAGTGTTGATATTTGTTTGTTGTTTATGCGAATTCAACTCCACTGAATTGAATGTAGTCCAATCGCACCTTAGTCAGATTCATTGGACTGAAAACATTCCATGTTGCCAACATTGTGAAAAACGAGAATTCTGCAAAAGACAcgtgaaaaaaatattgatatatgACACAGAACAGATTTGTGCTATTTGTGGCTACATTGCTCCACGAAAAAGTATTTTGAAAGAACACATAAACACGATCCATTTGCAAAGAAGAAACCGCAAGTGCTGTTTGTATGACAATTCTGCAAGTAGAAATTCAGATGTCGAAAGACACACAAGTGCGGTGCATATGAAGGAAACAAATCATAAGTGTCATTTGTGTGACTTTTACgcaagtttaaaaaaaaacctaaaaGCACACATAAGTGCGGTGCACCTGAAGGAAAGAAGCCACAATTGTCATTTGTGTGACTATTCTGCAAGTAGAAAAATGCATCTCAAAACACACATAAGTGCGGTGCATTTAAAGGAAAGAAGTCACAAGTATTATTTGTGTGACTATCCTGCAAGTACAAAAACGCACCTCAAAACACACATAAGTGCGGTGCATCTGAAGGAAAGGAGCCACAAGTGTCATTTGTGTGATAATTCTGCAAGTACAAAACCGCACCTCAAAAAACACATAAGTGCAGTGCATCTGAAGGAAAGAAGCCACAAGTGTCATTTGTGTGACTATTCTGCAAGTAGAAAAATTGACCTTAAAAGACACATAAGTGCAGTGCATCTGAAGGAGAGAAGCCACAAGTGTCATTTGTGTGACTATTCTGCAAGTACAAAAATGAACCTCAAAACACACATAAGTGCGGTGCATCTGAATGAAAGAAGCCACAAGTGTCATTTGTGTGACTATTCTGCAAGTACAAAAATGAACCTCAAAAGACACATAAGTGCAGTGCATCTGAAGGAGAGAAGCCACAAGTGTTATTTGTGTGACTATTCTGCAAGTACAAAAATGGACCTCAAAAAACACATAAGTGCAGTGCATCTGAAGGAAAGAAGCCACAAGTGTCATTTGTGTGACTATTCTGCAAGTACAAAAATGAACCTCAAAAGACACATAAGTGCAGTGCATCTGAAGGAGAGAAGCCACAAGTGTCATTTGTGTGACTATTCTGCAAGTACAAAAGCGCACCTCAAAAAACACATAAGTGCAGTGCATCTGAAGGAGAGAAGCCACAAGTGTCATTTGTGTGACTATTCTGCAAGCACAAATACGGTCCTCAAAACACACATAAGTGCGGTGCATCTGAAGGAAAGAAGCCACAAGTGTCATTTGTGTGACTATTCTGCAAGTACAAAACTGCACCTCAAAACACACATAAGTGCGGTGCATCTGAAGGAAAGAAGCCACAAGTGTCATTTGTGTGACTATTCTGCAAGTACAAAAATGAACCTCAAAACACACATAAGTGCGGTGCATCTGAAGGAAAGAAGCCACAAGTGTCATTTGTGTGACTATTCTGCAAGTACAAAAATGGACCTCAAAAGACACATAAGTGCAGTGCATCTGAAGGAAAGAAGCCACAAGTGTCATTTGTGTGACTATTCTGCAAGTACAAAACCGCACCTCAAAAGATACATAAGTACAGTGCATCTGAAGGAAAGAAGCCACATTTGTGTGACTATTCTGCAAGTACAAAAACGCTCCTCAAAACATACATAA
Protein Sequence
MKRSRKRLSGDFKKHLTNKSKNECKEIIQKRDHLSNNVVLDSTIEKEKKTLNICRKKSSEKEECSWSSDFVKNFFEERKEPMESPSEKQLKKMPPDDLISDGSRIPFEKRENNSYYPFKKRFKAVYYDDDPEKINKEQEKIKRELEVLTEEKLADFYFPPLNIKKDEESKDETKFVLIEKSLNSYDKKFVAVGNVSDNYERMTQDSRKLNNVNFAEKISAVEYNGRIKEKVEPSLVKNPTDVEFNNPSIEQSDDTPTLEKQFQEIFFPAEHMGGMDIFVPVPHIEIEVEIETSPEIIPPMKNVVNNNFSPSRNCEQIANDTGDITNCLESIVNEEQINDTLVVSKHFTECSDDKQQKPNDTLRVLKRSVEPSICEEQIGINTSNAEKNVALSKQETCLSKSHDDIQTEISNTLETETLDCLSSVCNNEIRCNKEISNKINEVKMTAQLPPETTIDLQQVTKDYLGITKHSLDLKDVLCPKNTFKITNYSPNSNIHEEYTTNSTVGTIDHSVKSTNNEQQITKDTLGKIEHSQDHCNHKWYTNKQVLNIFSRSPQPYNEILRGSNYSLQPNNNEHLMRRDESGNSPNAGKQPYGWFMINRIRQKFKESMSSIKDKDQIEKNTLEFEKTLEPHKNEGQVETNSLPHLLSDINEGCLSKDEPKKPKFSLEPYKSKQQIKKENVLRSKHCLEENILDGKMMKLNKHRVETHNCALQEAIDSWRTKKHCIQSRIDEHQRKTDILGIPKCSLQNYKDEQQMIKDIAEPSPEIINKKCLIRKESQKISEHSLEMNVDEQPINRDTLNATEHSTQSNKDKQQIISDMSEMLEYYLPHIKKKQQAIMGHSLTLHNKECRIPNPSQKSEYSLDTHSEKQQIKKYNIEPLKSSNSQQKLTKDSLIITKHHLELDNVELQKIRGTLRISEHPLKFIKEDQQLTQSTLGIIKNSLEPNKVEQQRTRILECSLEHNKEERQIERDTMRIIEHSLESKNDECQIRKEFKNMSEQFQQVDSDEHQIMRDKFRLSEYSSEYRKEQQKTKQHSLGADKSLESPYNECSITKRPQKISEQYLEVHRDNQQIKTNFRLSENTQKKINEETKDFLRITDHSLKSHNDKCLIAKASQKIYEQYLEVDIAEQQIERDNITHNSEKFNKNGQEITGNMLRLLKHSLEHKKQEQKVTSHPDLQVDSTSVQKVNVDSLRTIDHSLKFKTDGCQLIKEFQNISKQCIVEINSAKQQIKKDSITQYSEEPNNDEHQEKTDKFRLTEHSLEHSKADRQMKVYSPKAINHSLEFNNDESRITKECEKISEQSLEMDSGKQQKEIYITQHFKEPNNDENQTRDTSTLIGRSLESRKKEHPIKKDSPGIMNYLQADSDEQYKTRESSQNATNNEQRIKRDILNITEYCVELNNDKQQIMVKDHPKISEYSSQPYIDEHGKTQNILKITECSIEPNNDEQQIMEDITKLSKESLQAENNEQHITNKLVKLTDHFIESNNDEPQITDTLILPVQSVENKNCEEQILVDTIEKGKDLRVIKKQNHCVEKQPITRDSPRREEEEIIKETSTVTKHSSEFSNEEDNYAELLNISLLEQNNGIENCLFPEHVKVKIEDNVDTQISMREQSLDNSSLKSNCNGKLVNSSRKDEDKDFKIKRVVFGKSEVRRNPKRQVEVKNYKETEEPQDDRYVYCDFCEEVFVDNCMKCGQLAFLQDAEVEMGIENRAKMTIPNTHLIILPSPIHGLGVFAQVLLKQGIKMGPYEGKITRFESNTGYSWKLRDGRLVDAADEKFSNWMRYINCARHFNEQNLVAFQYKGNLYYRTCKDIKIGEELLVYYGQSFASILGIDIKNYFKPKEEQISDNPQWCQYCYYGYTDSSKLKSHIALCKLNPASKKKIPVKVYHCRFCFFDTADEENYQKHEKKCEKWQEGKKENENIRDEAVRRHEEMKTRSCKKNDVLFKCQDCDYSSRYEDYLEKHQIIHRKVFTFSCTICSEGLNFEYSLKGHMFNHLSESTSTTMLQTTKVMDGKAVRNHQKVLIFVCCLCEFNSTELNVVQSHLSQIHWTENIPCCQHCEKREFCKRHVKKILIYDTEQICAICGYIAPRKSILKEHINTIHLQRRNRKCCLYDNSASRNSDVERHTSAVHMKETNHKCHLCDFYASLKKNLKAHISAVHLKERSHNCHLCDYSASRKMHLKTHISAVHLKERSHKYYLCDYPASTKTHLKTHISAVHLKERSHKCHLCDNSASTKPHLKKHISAVHLKERSHKCHLCDYSASRKIDLKRHISAVHLKERSHKCHLCDYSASTKMNLKTHISAVHLNERSHKCHLCDYSASTKMNLKRHISAVHLKERSHKCYLCDYSASTKMDLKKHISAVHLKERSHKCHLCDYSASTKMNLKRHISAVHLKERSHKCHLCDYSASTKAHLKKHISAVHLKERSHKCHLCDYSASTNTVLKTHISAVHLKERSHKCHLCDYSASTKLHLKTHISAVHLKERSHKCHLCDYSASTKMNLKTHISAVHLKERSHKCHLCDYSASTKMDLKRHISAVHLKERSHKCHLCDYSASTKPHLKRYISTVHLKERSHICVTILQVQKRSSKHT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-