Mdil012195.1
Basic Information
- Insect
- Megalocaria dilatata
- Gene Symbol
- topi
- Assembly
- GCA_034642435.1
- Location
- CM067856.1:44893636-44903413[+]
Transcription Factor Domain
- TF Family
- zf-C2H2
- Domain
- zf-C2H2 domain
- PFAM
- PF00096
- TF Group
- Zinc-Coordinating Group
- Description
- The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 13 0.0031 0.35 12.6 2.1 2 21 126 145 125 146 0.94 2 13 7.9e-05 0.0089 17.6 2.4 1 20 171 190 171 193 0.94 3 13 0.013 1.5 10.6 2.0 3 23 201 221 200 221 0.95 4 13 0.014 1.6 10.5 0.5 2 20 240 258 239 260 0.90 5 13 2.1e-05 0.0024 19.4 1.0 2 23 317 338 316 338 0.97 6 13 0.0016 0.18 13.5 2.7 2 22 381 401 380 404 0.89 7 13 0.76 86 5.0 0.1 1 23 522 545 522 545 0.91 8 13 0.18 20 7.0 0.9 1 23 549 571 549 571 0.91 9 13 1e-06 0.00012 23.5 2.4 1 23 577 599 577 599 0.98 10 13 0.029 3.3 9.5 0.2 1 23 605 630 605 630 0.96 11 13 0.49 55 5.7 2.5 1 23 636 658 636 658 0.85 12 13 6.6e-05 0.0074 17.8 1.5 3 23 666 686 664 686 0.97 13 13 9.3e-07 0.0001 23.7 1.0 1 23 692 715 692 715 0.98
Sequence Information
- Coding Sequence
- ATGAGAAACTCGGATAATCTTATTTTTAAAGTATATAAGATCAACCAGAATGGAATTATTTCAGCAGTGGAATATGAACAAGATTTTTATACTCGCGAAGTTCTATCTAAAAGGCatatttcaactcaagaacCATCTCCAAATTTACTTTTTGATTCAGAAAAGTTAAAATTGAGCTTCAGTAACTTCGAATGTGAAGATGAGGATAATCCCTTAGTAAGTTTTgtgaaaatcgaaaatattaGCGATGTTAGTTTAATACAGAACAGCGGATATTCATGTccaacaaatttcatttttcgcGGTAAAAGGAGTGTTTCACCATGTTATTTACACCACCAGATGAGGATATCTCTTAATATTCCCACCATGATAAGATGCCAAAATTGTGAAACCAATTTTCCAACAAAATATCAGTATCAGAGGCATCAGTGTGAATTTAATGCAGAAAAAGTAGTTTTAAAAGCAAATGCTGATTTGAAAGATATAAATAAAGGTATGAGAATAAAGTATGATTGTGACAGATGTGGGAAACAGTTCGTAAGTAAAAATAATTTGGAGAGGCATCAAATTTGTCATGATAATTCTAGAGAAAATATTTGTGAACATTGTAATAAACAGTTTGTTAGTGAAAATAGATTAAGAATTCATAAGGAAAATCACTGTAAAAAAGTTGGAGATATATCAAAGTTTTATCGCAGTGATGTTGCTGTATGGAAATGTAAAAAATGTCATGAAGTATTTTCTTCCTTGAATTCTGCAAACACTCATGTTGAATCTTGTGAAGAAgctatatttcaatttgatcagaATAATGCCAAGACAGATGCTGATTGCCAAAAAGAGAAATTGTCTAGCATGACATCTGTATCTGCTATTAATGATGAGACAAATGCAAAGTTATTAGATGAAAGCCAAATTGAGAAAATTCTCACAGAAATTCTATTACAATGTGAATTTTGCAATCGAACATATGCAGATAAAAGTTTACTTCTGTTACATCAAAGAAAACATTCAACCACTAAGAACTATGAATGTGTTAATtgtaatagtaactttgaatcATATGCTATTGCTGCTCAGCATTGGTTAAAAATATGTTCCGAAACTTCAAATATGTTTTATCTTCCCAAATTAACTTATTGTGAGTACTGCGACCGTACCTTCAAATCACACGAATTATTATATGCACATAAAATCAAGAAGAAACATTATACGGTTAAACTACATAAAAATGATTTATCTTCAAATAAggataaagaaaaacaaattgaCAGTAGTGAAGCTATCAATAAACTCATTGAAGATGTTTTAATAACATTAGATAGGCCAATAGGTAAAATCTGCCAGCTATCGAAACttaattatgaaaattcaagtaaggaaaatattgaaagagAGGAAACTTATACGGCGAGTAATTTCAACGATGTAGTTGAAGAATCTAGTCATAATAAGATTTTAGATAAAGCTGATAAAAGGAAAAGGGGACGGAAGCGTAAATGCACCAAGCCAGGAATAAGGAGTAAGAAGatacataatttaattaatgaagGATACAAATATCAGTGTGAACGTTGCCCGCTTGTATGGGATAATGTAACTGATTTAGAAAAGCACAGGGATGAAGAGCATGCTGCAAGTTTTAGCTGTGAAGACTGTGGGCAGATATTACACAGTGCTAAAGCTTTGCTTATACATTGTCGGGCTCATAAATGTTTGAAGCCATACGTTTGTGATACTTGTGGAAGAAGTTATTCGCAAACGTCTCATTTATGGCAACATATGAGATTCCATCAAGGTATAAAACCTTTCGCGTGTCCACACGAAGGTTGTGAAGCTAGATATACTATTCGTCCAGACCTGAAAGACCATATAAGGAAAGTGCATACAAGAGAAAGGCCCTTCAAATGCGCTGTATGCAATAAATGCTTCTTGACGGGTTCCGTGTATTATCAACATCGTTTAATACACACTAATGATAGAAGATATGGTTGTGAAGTATGCCATAAGAGATTTTTCAGGGCTGATGCCTTGAATAATCATAAGAGAATTCACACTGATGAGCGTCCATATCCCTGCACAGTGTGTGGGAGAGAATTCAGGCAGAAGGGAGACCGTAATAAGCATATGCGTACTCAACATCCTGAAGCTGTTATTCAGTGA
- Protein Sequence
- MRNSDNLIFKVYKINQNGIISAVEYEQDFYTREVLSKRHISTQEPSPNLLFDSEKLKLSFSNFECEDEDNPLVSFVKIENISDVSLIQNSGYSCPTNFIFRGKRSVSPCYLHHQMRISLNIPTMIRCQNCETNFPTKYQYQRHQCEFNAEKVVLKANADLKDINKGMRIKYDCDRCGKQFVSKNNLERHQICHDNSRENICEHCNKQFVSENRLRIHKENHCKKVGDISKFYRSDVAVWKCKKCHEVFSSLNSANTHVESCEEAIFQFDQNNAKTDADCQKEKLSSMTSVSAINDETNAKLLDESQIEKILTEILLQCEFCNRTYADKSLLLLHQRKHSTTKNYECVNCNSNFESYAIAAQHWLKICSETSNMFYLPKLTYCEYCDRTFKSHELLYAHKIKKKHYTVKLHKNDLSSNKDKEKQIDSSEAINKLIEDVLITLDRPIGKICQLSKLNYENSSKENIEREETYTASNFNDVVEESSHNKILDKADKRKRGRKRKCTKPGIRSKKIHNLINEGYKYQCERCPLVWDNVTDLEKHRDEEHAASFSCEDCGQILHSAKALLIHCRAHKCLKPYVCDTCGRSYSQTSHLWQHMRFHQGIKPFACPHEGCEARYTIRPDLKDHIRKVHTRERPFKCAVCNKCFLTGSVYYQHRLIHTNDRRYGCEVCHKRFFRADALNNHKRIHTDERPYPCTVCGREFRQKGDRNKHMRTQHPEAVIQ
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00349527;
- 90% Identity
- -
- 80% Identity
- -