Basic Information

Gene Symbol
HIVEP1
Assembly
GCA_945859635.1
Location
CAMAOE010000071.1:48871-55542[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 8 0.0019 0.25 12.3 0.4 1 23 104 126 104 126 0.98
2 8 0.012 1.6 9.8 2.1 1 21 132 152 132 156 0.86
3 8 0.1 13 6.8 0.0 1 21 353 373 353 374 0.93
4 8 8.8e-07 0.00011 22.8 1.6 1 23 1090 1112 1090 1112 0.99
5 8 2.8e-05 0.0036 18.0 3.5 1 23 1118 1142 1118 1142 0.92
6 8 1.2e-06 0.00016 22.3 0.1 2 23 1408 1429 1407 1429 0.97
7 8 0.00047 0.062 14.2 1.8 1 23 1435 1459 1435 1459 0.92
8 8 0.00082 0.11 13.4 3.3 1 23 1480 1504 1480 1504 0.93

Sequence Information

Coding Sequence
ATGACAGAcccacagttagcgaacaataataacagcaacaacaacaacaacaataataataataataacaataacaacgaTGGCGAGCAAAAGTACCTGCACAAAAAGTTCAAGAAGATGGCGACAACCGAGGTCTCGCCGAAGGTGGAGCCGAAGAAGGACACCGCGGTCAGCAACGATTCTTTGGAACCACCTAAAAAGAAAGATTCGACCAAGGACTTCCGAGAGTCGCCTAAAGATCCGATCAAGATCGAGGCGTCCCCGGAATCCGTGGATGGAGACCCCGCAGCCGAATCCAGGAAAAGCGGCTACGTGTGCCCTTATTGCAGGCTATTGTGCGCTAAGCCAAGCGTCTTGCAGAAACACATCAGGGCACACACGAACGAGAGGCCGTATCCTTGCGTGCCTTGCGGTTTCGCCTTTAAAACCAAATCGAACCTCTACAAACACTGCAGGTCACGCGCTCATGCCCTGAAAATGGAGGGTGGTGATGCCAGCAAGGTATCAGAAGATTCGGACATAAGTTTGTCCGACAGCGCGAGCAACGGTACCGGCACACCACCACCACCACCTTCGTCAACTCCCACGACCACCGTATCCAGCGTGAAAACGATCAAAACCGGGAAAATCTACAAGCCAAAATTTCACACGGCGCTCCAGTGCGTTAACAACGATATCGAAACGTCTTCCTTATCCTCCGTTTCTTCCACGAACAGTTCTTCCTCAACGACCGCAGCTGTCACTCCTAAACCTAACCCGGAGCAGGTGCAGGAACACATCGACAAAATTATCACCGACAACCAGGCGATCGTCGAAGCGGTAGATCCGCGACTTCACAAGCTGATTCAAAGGCAGCAAAGTCTCGTAGAGATGAAAGAATCCGACCAACCGTTGAATCTCTCCTCGGCCGAAGAATTTGCCTCCAGAAAACGTTGTTACAGCGATACCTTCGCGGAGGACAAAGACTGTCCGAACAATTCCGAAGGTTCCATAATAAAGGACCTGTTGCTGAAGAATCAAAATTCGAGCCAAGACGGGAGCACGGAGAACGAGAATTATCTTTGTCCCGCTTGCAACATCCCCTACTCGAGCATCGACAACCTGGACGCCCATCGGAGATACTACTGCAAAGGTAGCCTAAGTCCACGCAGGGAGTATCCTTTGGAGATCGATAAAAGAGAGTCCGAGTTCGATTCAAAGTCTTCCGATTATTACAACACGTTACAACCTCTACCTTCGCCTGGACCACTTCTGGGGAACACTCGGCTGGTCGACGCGTACACGCCACCCGTAAAGAAACAGAGGTCAGAATCCGTGCCCACCACGTTGCGTTCCCTGGAGGAACTCAGCAAGTATCCTCGGCCCAACTCGTTGCAGATGTTCGGCGGAGAGGTGAGGATACTGGATAACACCGGCGAAACAAAAACCATGAGGATCGAGCCGCGGCAAACCAAGTCCCCGACCAGCGAACACATCGTAAGCAGCAAGTGCGTCACCTCGGAGACCGCCTCCATAGTGGTCAGATCTGGCCTCCATTCGGGTGGCACCATGGTGCACAAACCGCCAGGCACTCCCGCCAGTACGGCCAGTACCTCCATATCCTTGCCCAACACACCTAAGATGTTGGCACCCATCATACCGAACATATCAACCCCGAACATAGCACCCAGTATGTCCTGCTACAATTACATGGAGCCCCATTTGAACCCCCTGACCAGCATCACTGCCTACAACCCTTTGACTCTGCCCCAGCCAGGACAAATCACGAGCATCCTCCACGGCGGCAAGGTCATACCCTACGTCCCCGGCATGCCTGGACCACACACTCTCACACCGACCATAGACATATCCTCGAGTATAGCGACTGGCGAAGCCGGCTACAAGGTGATACCTGGCCTACCCGGCCTGCATATGATCCCTCAACCTCTGGACCTGGCCAGTCCGGTCAAGATACAGACACCGAGTGTACCTGGAATCCCAGGACCCATGTCCAGTGGACATGTGCCCATGATGGGTCAACCCTTGGATCTAGCTAGTCCTGCTAAGGACTCGAAACTCGGCTTTAAAACACCTGGAAACGACGTTATGAAAGCTGGCTTGACCAGTCAAAAAGTTCCTATCGTTAAGGTCGAAAATTCTGGAGAGAAATATCGGAGGGGAGTGCCGTCTGTCGTGGAGGTGACGAAGGTAGAGCTCGACCGTCATATCAAGAACAGCATGGCCATCAAGTACAAGGGTATGGAAGGCCTGAGGGACAGGCGGGAGTTCGCATACGAGCGGAGCCCGAAGGCGGAAAAAAGTTTCGGTTACACGAACGGGATCGATGCGGGAGTCGCTTCCTCGATCTCCTACAGTAAACTTAGATACTCGCCGAAGGAGTCTTCCGAGAATAGAAAGAGACTGTCGACGTGGAACGTGAACGAAGTGGAAGCCGGCAGGGTGATGGTTGAATCTCTGGGACACAACGCGGCGAAATACGATTCGCCCACGACCCTCGAGAATGGACGGCTAAAGGCGAGTCTTAATGAAACGAGAACCAAGCAGACCGAGTATTACGGTACCTTTAATGGAGCCAAGGCTAAGCCCGATCCTGTGTCGCCGATGGTGGTCCTCAACGTAGATACCTCGAAAACAGATGTGCCAAACAAAGCTTCCGTAGATTTAATTAGCAAGGTGGACAAACCCGAAGCGAAGTCGCCGAAGAACGGAGACGCCACGAAGGAGGAGACGAATTCAAGCAAGTTCTTGAGACCCACCTCTTTGCCGCTGAAGCCGGGCACCTTTACCCCGAAGAAGCATCACGGTATTACGCCAACGGCGAACACGCTTCCACTCATCAGTCCGGAAACCCCCAGGCCGAAGAAATCGTACGGGCAACTTTACCTGAACGGGCATGCTTACACATATCTGGGCTTGAAGTGTTCTACCAGAGTGTTTTACTGTACTCTGAACAGACCACAGCCCATGTACGTCACGCAGCAACACGGTTTATCAATGTACTCCAATTGGAAGATATGCGAGGAAGCACCACCTGATGTAGATATGGCGCATTATGACTCGAGGCACAGATCGTTTAATTATACCACCGCCTGGAAAAAACAGGAGGACATCTTGACACACTCCTCGCAGAGACCCACCACCCCAACGAGCCCGGATAGCGGCTTGGACGGTGATATGCAAGAGAAAGCGAAGAGAGTCAAGATTTTCGATGGAGGATTCGAGAGTAATGAGGACTATACGTATGTTAGGGGCAGAGGTCGAGGTCGATACGTTTGTGAAGAATGCGGCATTCGTTGTAAAAAGCCATCCATGTTAAAGAAACATATCAGAACTCACACAGATGTAAGACCATACACATGCAAGCACTGCGCTTTTGGTTTCAAAACCAAAGGCAACCTGACAAAACATATGAAATCAAAGGCCCATTACAAGAAATGCGTCGAGCTGGGAGTGGTTCCTGTACCAACTATTGTTTGCGACGAGAACATCGATAAGGAAGCCATTGCCCGTTTAGCAGCAGGTGGCAACACCGAAGAGTCCTCGGACGAAGAAGAAGAGAGCGAAGGAGAAGAAAGCGAAGAATCCGGTAGCGAGGAACAGGAAGTGGCTCAAAGTTTACTGAGTTTGTCTCAACGGAATACAAACAGGTTGCCAGGACTTTTGCCATCAGGAAGGCCAACTACTTACCCTTATACACTCACTTTTCCTACAACTTCCACGTCCGTGAGCGTGTCCATAACGATAACCAGCACCCCCATAAGTACCCAAACGATTGCCAGTACCCAAGAGACTACCGTTGTTCGAAACGAATTGTCGCATCGTTATTATTTCCCTTCAAATCGAACCGCTCCGGAGGAGATAAGAACGACCGTGATCCAATCGTCGAAGAAGGAAACCCCTGAAGTAGAAATGAACAAGAGCGAACAAGATTCGCGAAGCACCTCTTCTCAGCCCATGGATCTTACAACGAAAGCCGTTGTACAATCATTGCCTGCCCCTGTGCCGCAAAGAGCAAGACCAACGGACATTTTGACCCCTGTCTCGGAACCAGTCTTGCTGCAAACGATAGTTCAAACCATGGAAAGGTTACCGATACAAGGAAGAGAATGGAAACCGGATGCCGAGGGCCACGTGTTGCCAGCTTACCTGAAAGAAATAACTTTCGCCGAAAGAAGCGAGTCCAACAAATGTAGTTACAGTGTGACTGAAGATGGGAAAAGTGTCTGCGGTATTTGTAACAAGGTGTTCAGCAAACCTAGTCAGTTACGGTTGCATATCAATATTCATTACTTCGAGAGACCATTTAGATGCGAGAGCTGCGCGGTGTCTTTCCGGACCAAGGGTCATTTGACAAAGCACGAGAGATCTGTTTCACATCACAACAAGGTCAGTATGACTTCCACGTTCGGGGCTGCGACGACTAGCAACCCACGACCATTCAAATGTACCGACTGTAAGATAGCGTTCAGGATACATGGTCACTTGGCGAAACATCTTCGTAGCAAAATGCATATTATGAAATTAGAATGTTTAGGTAAATTGCCATTCGGGACGTACGCTGAAATGGAAAGGTCTGGTGTCAATTTGAATGACATCGATACGACCGACTGTGATAATAGTCTTACTAGTCTTCAGATGTTGGCTCAAAGACTTTGCGAGAAAGATCCTAATAAAGTAGGACAGTGGGAACCTGAAACTATTCCAAGTCAAGTGATCAGCGGAGGTGAAACTTCCTCAAACGATGGTGAGCCTATGCCGCCATGA
Protein Sequence
MTDPQLANNNNSNNNNNNNNNNNNNNDGEQKYLHKKFKKMATTEVSPKVEPKKDTAVSNDSLEPPKKKDSTKDFRESPKDPIKIEASPESVDGDPAAESRKSGYVCPYCRLLCAKPSVLQKHIRAHTNERPYPCVPCGFAFKTKSNLYKHCRSRAHALKMEGGDASKVSEDSDISLSDSASNGTGTPPPPPSSTPTTTVSSVKTIKTGKIYKPKFHTALQCVNNDIETSSLSSVSSTNSSSSTTAAVTPKPNPEQVQEHIDKIITDNQAIVEAVDPRLHKLIQRQQSLVEMKESDQPLNLSSAEEFASRKRCYSDTFAEDKDCPNNSEGSIIKDLLLKNQNSSQDGSTENENYLCPACNIPYSSIDNLDAHRRYYCKGSLSPRREYPLEIDKRESEFDSKSSDYYNTLQPLPSPGPLLGNTRLVDAYTPPVKKQRSESVPTTLRSLEELSKYPRPNSLQMFGGEVRILDNTGETKTMRIEPRQTKSPTSEHIVSSKCVTSETASIVVRSGLHSGGTMVHKPPGTPASTASTSISLPNTPKMLAPIIPNISTPNIAPSMSCYNYMEPHLNPLTSITAYNPLTLPQPGQITSILHGGKVIPYVPGMPGPHTLTPTIDISSSIATGEAGYKVIPGLPGLHMIPQPLDLASPVKIQTPSVPGIPGPMSSGHVPMMGQPLDLASPAKDSKLGFKTPGNDVMKAGLTSQKVPIVKVENSGEKYRRGVPSVVEVTKVELDRHIKNSMAIKYKGMEGLRDRREFAYERSPKAEKSFGYTNGIDAGVASSISYSKLRYSPKESSENRKRLSTWNVNEVEAGRVMVESLGHNAAKYDSPTTLENGRLKASLNETRTKQTEYYGTFNGAKAKPDPVSPMVVLNVDTSKTDVPNKASVDLISKVDKPEAKSPKNGDATKEETNSSKFLRPTSLPLKPGTFTPKKHHGITPTANTLPLISPETPRPKKSYGQLYLNGHAYTYLGLKCSTRVFYCTLNRPQPMYVTQQHGLSMYSNWKICEEAPPDVDMAHYDSRHRSFNYTTAWKKQEDILTHSSQRPTTPTSPDSGLDGDMQEKAKRVKIFDGGFESNEDYTYVRGRGRGRYVCEECGIRCKKPSMLKKHIRTHTDVRPYTCKHCAFGFKTKGNLTKHMKSKAHYKKCVELGVVPVPTIVCDENIDKEAIARLAAGGNTEESSDEEEESEGEESEESGSEEQEVAQSLLSLSQRNTNRLPGLLPSGRPTTYPYTLTFPTTSTSVSVSITITSTPISTQTIASTQETTVVRNELSHRYYFPSNRTAPEEIRTTVIQSSKKETPEVEMNKSEQDSRSTSSQPMDLTTKAVVQSLPAPVPQRARPTDILTPVSEPVLLQTIVQTMERLPIQGREWKPDAEGHVLPAYLKEITFAERSESNKCSYSVTEDGKSVCGICNKVFSKPSQLRLHINIHYFERPFRCESCAVSFRTKGHLTKHERSVSHHNKVSMTSTFGAATTSNPRPFKCTDCKIAFRIHGHLAKHLRSKMHIMKLECLGKLPFGTYAEMERSGVNLNDIDTTDCDNSLTSLQMLAQRLCEKDPNKVGQWEPETIPSQVISGGETSSNDGEPMPP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01123249;
90% Identity
iTF_01122646;
80% Identity
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