Basic Information

Gene Symbol
HIVEP1
Assembly
GCA_963576845.1
Location
OY756250.1:9739136-9745765[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 8 0.0024 0.36 12.3 0.4 1 23 104 126 104 126 0.98
2 8 0.015 2.3 9.8 2.1 1 21 132 152 132 156 0.86
3 8 0.048 7.2 8.2 0.0 1 21 352 372 352 373 0.93
4 8 1.1e-06 0.00017 22.8 1.6 1 23 1088 1110 1088 1110 0.99
5 8 3.6e-05 0.0054 18.0 3.5 1 23 1116 1140 1116 1140 0.92
6 8 1.6e-06 0.00023 22.3 0.1 2 23 1406 1427 1405 1427 0.97
7 8 0.00061 0.092 14.2 1.8 1 23 1433 1457 1433 1457 0.92
8 8 0.0011 0.16 13.4 3.3 1 23 1478 1502 1478 1502 0.93

Sequence Information

Coding Sequence
ATGACAGACCCACAGTTAGCGAACAACaataacagcaacaacaacaacaacaataataataacaataacaataacaacgaTGGCGAGCAAAAGTACCTGCACAAAAAGTTCAAGAAGATGGCGACAACCGAAGTCTCGCCGAAGGTGGAGCCGAAGAAGGACACCGCGGTCAGCAACGATTCTTTGGAACCACCTAAAAAGAAAGATTCGACCAAGGACTTCCGAGAGTCGCCTAAAGATCCGATCAAGATCGAGGCGTCCCCGGAATCCGTGGATGGAGACCCCGCAGCCGAGTCCAGGAAAAGCGGCTACGTGTGCCCTTATTGCAGGCTATTGTGCGCTAAGCCAAGCGTCTTGCAGAAACACATCAGGGCACACACGAACGAGAGGCCGTATCCTTGCGTGCCTTGCGGTTTCGCCTTTAAAACCAAATCGAACCTCTACAAACACTGCAGGTCACGAGCTCATGCCCTGAAAATGGAGGGTGGTGATGCCAGCAAGGTATCAGAAGATTCGGACATAAGTTTGTCCGACAGCGCGAGCAACGGTACCGgcacaccaccaccaccaccttcGTCAACTCCCACGACCACCGTATCCAGCGTGAAAACGATCAAAACCGGGAAAATCTACAAGCCAAAATTCCACACGGCGCTCCAGTGCGTTAACAACGATATCGAAACGTCTTCCTTATCCTCCGTTTCTTCCACGAACAGTTCTTCCTCAACCGCAGCTGTCACTCCTAAACCTAACCCTGAACAGGTGCAGGAACACATCGACAAAATTATCACCGACAACCAGGCGATCGTCGAAGCGGTAGATCCGCGACTTCACAAGCTGATTCAAAGGCAGCAAAGTCTCGTAGAGATGAAAGAATCCGACCAACCGTTGAATCTCTCCTCGGCCGAAGAATTTGCCTCCAGGAAACGTTGTTACAGCGACACCTTCGCGGAGGACAAAGATTGTCCGAACAATTCCGAAGGTTCCATAATAAAGGACCTGTTGCTGAAGAATCAAAATTCGAGCCAAGATGGTAGCACGGAGAGCGAGAATTATCTTTGTCCCTCTTGCAACATCCCCTACTCGAGCATCGACAACCTGGACGCCCACCGGAGATACTACTGCAAAGGTAGCCTAAGTCCGCGCAGGGAGTATCCTTTGGAGATCGATAAAAGAGAGTCCGAGTTCGATTCAAAGTCTTCCGATTATTACAACACGTTGCAACCTCTGCCCTCGCCTGGACCACTTCTGGGGAACACTCGGCTGGTCGACGCGTACACGCCACCCGTAAAGAAACAGAGGTCAGAATCCGTGCCCACCACGTTGCGATCCCTGGAGGAACTCAGCAAGTATCCTCGACCCAACTCGTTGCAGATGTTCGGCGGAGAGGTGAGGATACTGGACAACACCGGCGAGACAAAAACCATGAGGATCGAGCCGCGGCAAACCAAGTCCCCGACCAGCGAACACATCGTGAGCAGCAAGTGCGTCACCTCGGAGACCGCTTCCATCGTGGTCAGATCTGGCCTCCACTCGGGTGGCACTATGGTGCACAAACCGCCAGGCACTCCCGTCAGTACGGCCAGTACCTCCATATCCTTGCCCAACACGCCTAAGATGTTGGCACCCATCATACCGAACATATCAACCCCGAACATAGCACCCAGTATGTCCTGCTACAACTACATGGAGCCTCATCTGAATCCCCTGACCAGCATCACTGCCTACAACCCGTTGACTCTGCCCCAGCCAGGACAAATCACGAGCATCCTCCACGGCGGTAAAGTCATACCCTACGTTCCCGGCATGCCTGGACCACACACTCTGACACCGACCATAGACATATCCTCGAGTATAGCGACTGGTGAAGCCGGCTACAAGGTAATACCTGGCCTACCCGGCTTGCATATGATCCCTCAACCTCTGGACCTGGCCAGTCCGGTTAAAATACAGACACCGAGTGTACCTGGAATCCCAGGACCCATGTCTAGTGGGCATGTGCCCATGATGGGTCAACCCTTGGACCTGGCTAGTCCTGCTAAGGACTCGAAACTCGGCTTTAAAACACCTGGAAACGACGTCATGAAAGCTGGCTTGACCAGTCAAAAAGTTCCTATCGTTAAGGTCGAAAATTCTGGGGAGAAGTATCGGAGGGGAGTGCCGTCTGTCGTGGAGGTGACGAAGGTAGAGCTTGACCGTCATATCAAGAACAGCATGGCTATCAAGTACAAGGGTATGGAGGGCCTCAGGGACAGGCGGGAGTTCGCGTACGAGCGGAGCCCGAAGGCGGAGAAAAGTTTCGGTTACACGAACGGGATCGATGCGGGAGTCGCTTCCTCGATCTCCTACAGTAAACTTAGATACTCGCCGAAGGAGTCTTCCGAGAATAGAAAGAGACTGTTGACGTGGAACGTGAACGAAGTGGAAGCTGGAAGGGTGATGGTTGAATCTCTGGGACACAACGCGAAGTACGATTCGCCTACGACTCTAGAGAATGGGCGGCTGAAGGCGAGTCTTAATGAAACGAGGAGCAAGCAGACCGAGTATTACGGTACCTTTAATGGAGCCAAGGCTAAGCCCGATCCCGTGTCGCCGATAGTGCTCCTCAACGTAGATACCTCGAAAACAGATGTGCCAAACAAAGCTTCCGTAGATTTAATTAGCAAGGTGGACAAACCCGAAGCGAAGTCGCCGAAGAACGGAGACGCCACGAAGGAGGAGACGAATTCGAGCAAGTTCTTGAGACCCACCTCTCTGCCGCTGAAGCCGGGCACCTTCACCCCGAAGAAGCATCACGGAATTACGCCGACGGCGAACACGCTTCCACTCATCAGCCCAGAAACCCCCAGGCCGAAGAAATCGTACGGGCAACTTTACCTGAACGGGCATGCTTACACATATCTGGGCTTGAAGTGTTCTACCAGAGTGTTTTATTGTACTCTGAACAGACCACAGCCCATGTACGTCACGCAGCAACACGGGTTATCGATGTACTCCAATTGGAAAATATGCGAGGAAGCACCACCTGATGTAGATATGGCGCATTATGACTCGAGGCATAGATCGTTTAATTATACCACCGCCTGGAAAAAGCAGGAGGACATCTTGACACACTCCTCGCAGAGACCCACCACCCCTACGAGCCCGGATAGCGGCTTGGACGGTGACATGCAAGAGAAGGCGAAGAGAGTCAAGATTTTCGATGGGGGATTCGAGAGTAATGAGGACTATACGTATGTTAGGGGCAGAGGTCGAGGTCGATACGTTTGTGAAGAATGCGGCATTCGTTGTAAAAAGCCATCCATGTTAAAGAAACATATCAGAACTCACACAGATGTAAGACCATACACATGCAAGCACTGCGCTTTTGGTTTCAAAACCAAGGGCAACCTGACAAAGCATATGAAATCAAAGGCCCATTACAAGAAATGCGTGGAGCTGGGAGTGGTTCCTGTGCCAACAATTGTTTGCGACGAGAACATCGATAAGGAAGCTATTGCCCGTTTAGCGGCAGGTGGCAACACGGAAGAGTCCTCGGACGAAGAGGAAGAGAGCGAAGGAGAAGAAAGCGAAGAATCCGGTAGCGAGGAACAGGAAGTGGCTCAAAGTTTACTGAGTCTGTCTCAACGGAATACAAACAGGTTGCCAGGACTTTTGCCATCAGGAAGGCCAACTACTTACCCCTATACACTCACTTTTCCTACAACCTCCACGTCCGTGAGCGTGTCCATTACGATAGCCAGCACCCCCATAAGTACCCAAACGATTGCCAGTACCCAGGAGACTACCGTTGTTCGAAACGAATTGTCGCATCGCTATTACTTTCCTTCAAATCGAAGCGCTCCGGAGGAGATAAGAACGACCGTGATCCAATCGTCGAAAAAGGAGACCCCTGAAGTAGAAATGAACAAGAGCGAACAAGATTCGCGGAGCACCTCTTCTCAACCCATGGATCTTACAACGAAGGCTGTTGTACAATCGTTGCCTGCCCCTGTGCCGCAAAGAGCGAGACCAACGGACATTTTGACCCCTGTCTCGGAACCAGTCTTGCTGCAAACGATAGTTCAAACCATGGAAAGGTTACCGATACAAGGGAGAGAATGGAAACCGGACGCCGAGGGTCACGTGTTGCCGGCTTACCTGAAAGAAATAACTTTCGCCGAAAGGAGCGAGTCCAACAAATGTAGTTACAGTGTGACTGAGGATGGGAAAAGTGTCTGCGGTATTTGTAACAAGGTGTTCAGCAAACCTAGTCAGTTACGGTTGCATATCAATATTCATTACTTCGAGAGACCATTTAGATGCGAGAGCTGCGCGGTGTCTTTCCGGACCAAGGGTCATTTGACAAAGCACGAGAGATCTGTTTCACATCACAACAAGGTCAGTATGACTTCCACGTTCGGGGCTGCGACGACTAGCAACCCACGACCATTCAAATGTACCGACTGTAAGATAGCGTTCAGGATACATGGTCACTTGGCGAAACATCTTCGTAGCAAAATGCATATTATGAAATTAGAGTGTTTAGGTAAATTGCCATTCGGGACGTACGCTGAAATGGAAAGGTCTGGTGTCAATTTGAATGACATCGATACGACCGACTGTGATAATAGTCTTACTAGTCTTCAGATGTTGGCTCAAAGACTTTGCGAGAAAGATCCTAATAAAGTAGGACAGTGGGAACCTGAAACTATTCCAAGTCAAGTGATCAGCGGAGGTGAAACTTCCTCAAACGATGGTGAGCCTATGCCGCCATGA
Protein Sequence
MTDPQLANNNNSNNNNNNNNNNNNNNDGEQKYLHKKFKKMATTEVSPKVEPKKDTAVSNDSLEPPKKKDSTKDFRESPKDPIKIEASPESVDGDPAAESRKSGYVCPYCRLLCAKPSVLQKHIRAHTNERPYPCVPCGFAFKTKSNLYKHCRSRAHALKMEGGDASKVSEDSDISLSDSASNGTGTPPPPPSSTPTTTVSSVKTIKTGKIYKPKFHTALQCVNNDIETSSLSSVSSTNSSSSTAAVTPKPNPEQVQEHIDKIITDNQAIVEAVDPRLHKLIQRQQSLVEMKESDQPLNLSSAEEFASRKRCYSDTFAEDKDCPNNSEGSIIKDLLLKNQNSSQDGSTESENYLCPSCNIPYSSIDNLDAHRRYYCKGSLSPRREYPLEIDKRESEFDSKSSDYYNTLQPLPSPGPLLGNTRLVDAYTPPVKKQRSESVPTTLRSLEELSKYPRPNSLQMFGGEVRILDNTGETKTMRIEPRQTKSPTSEHIVSSKCVTSETASIVVRSGLHSGGTMVHKPPGTPVSTASTSISLPNTPKMLAPIIPNISTPNIAPSMSCYNYMEPHLNPLTSITAYNPLTLPQPGQITSILHGGKVIPYVPGMPGPHTLTPTIDISSSIATGEAGYKVIPGLPGLHMIPQPLDLASPVKIQTPSVPGIPGPMSSGHVPMMGQPLDLASPAKDSKLGFKTPGNDVMKAGLTSQKVPIVKVENSGEKYRRGVPSVVEVTKVELDRHIKNSMAIKYKGMEGLRDRREFAYERSPKAEKSFGYTNGIDAGVASSISYSKLRYSPKESSENRKRLLTWNVNEVEAGRVMVESLGHNAKYDSPTTLENGRLKASLNETRSKQTEYYGTFNGAKAKPDPVSPIVLLNVDTSKTDVPNKASVDLISKVDKPEAKSPKNGDATKEETNSSKFLRPTSLPLKPGTFTPKKHHGITPTANTLPLISPETPRPKKSYGQLYLNGHAYTYLGLKCSTRVFYCTLNRPQPMYVTQQHGLSMYSNWKICEEAPPDVDMAHYDSRHRSFNYTTAWKKQEDILTHSSQRPTTPTSPDSGLDGDMQEKAKRVKIFDGGFESNEDYTYVRGRGRGRYVCEECGIRCKKPSMLKKHIRTHTDVRPYTCKHCAFGFKTKGNLTKHMKSKAHYKKCVELGVVPVPTIVCDENIDKEAIARLAAGGNTEESSDEEEESEGEESEESGSEEQEVAQSLLSLSQRNTNRLPGLLPSGRPTTYPYTLTFPTTSTSVSVSITIASTPISTQTIASTQETTVVRNELSHRYYFPSNRSAPEEIRTTVIQSSKKETPEVEMNKSEQDSRSTSSQPMDLTTKAVVQSLPAPVPQRARPTDILTPVSEPVLLQTIVQTMERLPIQGREWKPDAEGHVLPAYLKEITFAERSESNKCSYSVTEDGKSVCGICNKVFSKPSQLRLHINIHYFERPFRCESCAVSFRTKGHLTKHERSVSHHNKVSMTSTFGAATTSNPRPFKCTDCKIAFRIHGHLAKHLRSKMHIMKLECLGKLPFGTYAEMERSGVNLNDIDTTDCDNSLTSLQMLAQRLCEKDPNKVGQWEPETIPSQVISGGETSSNDGEPMPP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01123249;
90% Identity
iTF_01122646;
80% Identity
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