Basic Information

Gene Symbol
-
Assembly
GCA_949319885.1
Location
OX439425.1:21982613-21983473[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 8 0.011 0.97 10.9 3.9 1 23 53 76 53 76 0.93
2 8 0.0034 0.3 12.5 0.2 2 23 84 106 83 106 0.95
3 8 0.046 4.1 9.0 0.5 2 19 111 128 110 131 0.93
4 8 0.0007 0.062 14.7 0.5 3 23 139 160 138 160 0.95
5 8 0.00024 0.021 16.2 1.3 3 23 168 189 168 189 0.96
6 8 0.0013 0.11 13.8 1.4 2 23 194 216 193 216 0.91
7 8 2.8e-05 0.0025 19.1 4.4 2 23 222 244 221 244 0.96
8 8 0.011 1 10.9 0.1 1 23 254 277 254 277 0.95

Sequence Information

Coding Sequence
atgaGTGAGTTGGTCGAAGCTGAAATCGAGGTAGACATTGAGAGGTTAGATTCTGATGCGATAGATGAGCATCTTCGGTCTTCAACGAGTGTGCTACAGCAAATATTGCAAAGCGACCCGGAGAGCACCGAGGGGCCAACGGGCGATGCGGAGGTCCATGTCTGCGTCCACTGCGGGAAACTGTACAAAACAGCGACGACCCTTCATATGCACGTCCTGCTCAAACACCCAGACAATAAGGTCGAAGTTCGCTGCACAGCCTGCGATAAGCAGTACGCCTCACTTCTAAGTCTTGAGAAGCACGTGCGGTACATGCATCGCTACCCGTGCCGCTGCAAAGCTTGCTACCGGACCTTCGAGACGCCAGAACTGCTCGCCGAGCACAACACAGTCTGCTCCAAGGCCGCGAGACCCTGCCCCTCTTGCGGGAAGTTCTACGACTCATCGCTTTCTCTCCGAAACCACGTGAAGTACAAACATCCCGAGCGCAAGACCAACTGGTGCGAGATATGCCGGCGGACGTTCTACTCCCCTCACAACTTGGCTAATCACTTCGCCACTATGCACCCAGACGGGACGTCTTGCAGCAAATGCGATAAGCAATTCAACTCTATTGCGTCGCTGCAAAGTCACTTTTTGTACAAACACGCGGAGAATGGTAAGCGGTGTCACGTGTGCAAGAAAGTTTTCGCCTCCCGCAGGAGTCTGACTCGTCACCTGACCAAAAACCACGACGTTGTGGTCTCTGTAGGAGAAAAGTATACGTGCGGTATTTGCGATGCCAATTTCCAAGGATCCCAGAAGTTAATAGACCACGTTATGGAGAAGCATACTGGAAAAGACACTAAGCAATCGTCGTAG
Protein Sequence
MSELVEAEIEVDIERLDSDAIDEHLRSSTSVLQQILQSDPESTEGPTGDAEVHVCVHCGKLYKTATTLHMHVLLKHPDNKVEVRCTACDKQYASLLSLEKHVRYMHRYPCRCKACYRTFETPELLAEHNTVCSKAARPCPSCGKFYDSSLSLRNHVKYKHPERKTNWCEICRRTFYSPHNLANHFATMHPDGTSCSKCDKQFNSIASLQSHFLYKHAENGKRCHVCKKVFASRRSLTRHLTKNHDVVVSVGEKYTCGICDANFQGSQKLIDHVMEKHTGKDTKQSS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-