Basic Information

Gene Symbol
zfy1
Assembly
GCA_949319885.1
Location
OX439421.1:5824348-5837677[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.26 23 6.6 0.1 1 23 339 361 339 363 0.96
2 10 6 5.2e+02 2.3 1.0 1 23 365 388 365 388 0.92
3 10 0.55 49 5.6 2.0 1 23 395 417 395 417 0.77
4 10 0.00024 0.021 16.2 1.3 2 23 422 444 421 444 0.93
5 10 7.9e-05 0.0069 17.7 2.1 1 23 450 472 450 473 0.95
6 10 0.00015 0.013 16.8 0.7 2 21 483 502 483 507 0.93
7 10 0.0011 0.093 14.1 1.5 1 23 515 538 515 538 0.94
8 10 4.9e-05 0.0043 18.3 0.8 1 23 543 566 543 566 0.98
9 10 5.3e-07 4.7e-05 24.5 3.2 2 23 574 595 573 595 0.97
10 10 1.3e-05 0.0012 20.1 1.4 1 23 601 624 601 624 0.95

Sequence Information

Coding Sequence
ATGGAAAAGAAACAACAtgtaaacaatttaattaataaaatgctGTGCAATGCATGTTTGTGTGTGGGTCGCACGCTACACAAGATTACGGATGATAAATTATCCAGATTCTATTTAGATGCACTAAGAGAAGTACCTCTTTGCAACATGCCAGTTACATGCCCGAGTATGTGTTGGGAATGCAAGGCAACCCTGAAGAAAGCTGTTACGTTTAAGGAACAAGTTCAAGATTCCTACAGGATACTGCAGACTTACACGAATGAGAACTTCCACGAATGTCTTCTAAGCGACATTGAGAGGTCGTCTCGGTTGAGCGTCCGCGCCGTCTCGCCTGTCACCATTAGTCCTGAAGATGGTGGGGACCAGGCGCTTGGGTACAAGGAGGAGTTGAAGTTCGAGTGGGTCGGGAAAGAATCAAACGAGGATCTTGAAGACAATTCTCCAACCAATGGATCACTGGATGTGACTCCTCAGCAGAAACTACCGATAGTAGGTGCTTGGCGTCAAGACGAGGATGATAGTCCCCTGTCTCCGAGACCTGCACGGAGCGATTCTACTATCATTGACCCTGAAGAGAAGGTGGAAAGAAGTCGGAACCTAGATTGTAAAGATGACCTTAACTGGATTGGGAAGGATTTGACTGCTTGCTCGACACCAGACCATCACTCATCTGACTTTGATACTCAAGATTTGGAAACAAACATgcagtttacaaaaaagaagAGAAAGAAAAAAACCGTGAAGACGAAACTTAATAAAActgataaagttaaaaaaagacTGGGAAATTTGATTAAGAATATAAAACCGAAACAACCCAGACCCGTACCGAACAGCAAGTACGTAACCCTACAGTTGTCCTTCGAGGACATGGTGCGAGAGAGACAGGCGCAGGCGAGCAGGACGGCGTATGTGAAGAGCGCGGTCAAGTGCGAGTCGTGTCTCGTCGGGTTTGAGTGTAAGAAGATGCTCGATGCGCATAATGCTGCTAAGCATAGTACGGATCTAGGTAACTATATCTGCCCTATATGTAAAACGATCATACCGTCCGTGGAAAGATATATGGCCCACTATAAGCGACATATGAGAAGgTACGAGTGTATTATTTGTCAGAAAAGAACAATGGACGTCACATCTATGAGACAACACTATTTTTCCACGCACGAAACATCGCTCAAGCAATATAAATGTGACATATGTGGAAAGATATCCtaCTCAATCGATACCCACAGATACCACAAAGACACACACAAAGCCAGGGTTCAGTGTGGGCAGTGCGACAAAACCTTCACACATCGGGCAGGCTTGTCTAACCATAAATATTCGGTGCACGATCTTCGAAACGAGTTTCCCTGTTCAGTATGCAACAAAGTCTTCCGGTGGAAGACCAGTCTCAAGAGACACTTGGAGATGCACCACGCCAAGAACAAATCGTCGTCGGCCGCATACTGCGAGCAGTGCGGGGTGACATTCTCCTCGGTCAGCTCGTACCAGCGACACATGAAGAACAGCCTCAAGCACGTTACCCAGGACCAACTAAGGTACATATGTGATCATTGCAACCGCCGGTTTGCTGATAAAACCAAGATTAGGGACCACATTGAAGAGAAACATCTGCATAAGACTTACCAATGCCATATTTGTAACAAGCCGTCCAAAAACCGCGTGGCGTTAGACCAACACATTCGCAATGTGCACAAAGGAAGACCGAACAACAAAATGTGCCATCACTGCGGTAAAGGATTCCCAACCAAAGGCCAACTGGAGTCTCACATCAGGACCCACACCGGGGAGCGGCCTTTCATATGCGAGTTCTGCCCCACCACCTTCTCGCAGCAGTCCAACCTGTACAAGCACAACAGACAGGTCCACCTGAACATAAAGTCTAAACGCTACCCCATGTGCAAGAAGAGGAAGGACGAGAGCTCCGAGCCGCCGCAGCCGCTAGCGGAGCCCTACCGACCCCAGGCAGTACTGCATTACGAGCCCGAGAGGGGACTCATTATGTAA
Protein Sequence
MEKKQHVNNLINKMLCNACLCVGRTLHKITDDKLSRFYLDALREVPLCNMPVTCPSMCWECKATLKKAVTFKEQVQDSYRILQTYTNENFHECLLSDIERSSRLSVRAVSPVTISPEDGGDQALGYKEELKFEWVGKESNEDLEDNSPTNGSLDVTPQQKLPIVGAWRQDEDDSPLSPRPARSDSTIIDPEEKVERSRNLDCKDDLNWIGKDLTACSTPDHHSSDFDTQDLETNMQFTKKKRKKKTVKTKLNKTDKVKKRLGNLIKNIKPKQPRPVPNSKYVTLQLSFEDMVRERQAQASRTAYVKSAVKCESCLVGFECKKMLDAHNAAKHSTDLGNYICPICKTIIPSVERYMAHYKRHMRRYECIICQKRTMDVTSMRQHYFSTHETSLKQYKCDICGKISYSIDTHRYHKDTHKARVQCGQCDKTFTHRAGLSNHKYSVHDLRNEFPCSVCNKVFRWKTSLKRHLEMHHAKNKSSSAAYCEQCGVTFSSVSSYQRHMKNSLKHVTQDQLRYICDHCNRRFADKTKIRDHIEEKHLHKTYQCHICNKPSKNRVALDQHIRNVHKGRPNNKMCHHCGKGFPTKGQLESHIRTHTGERPFICEFCPTTFSQQSNLYKHNRQVHLNIKSKRYPMCKKRKDESSEPPQPLAEPYRPQAVLHYEPERGLIM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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