Basic Information

Gene Symbol
-
Assembly
None
Location
GL501484.1:723301-725948[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 7.9 6.6e+02 1.4 0.4 1 23 192 214 192 215 0.70
2 15 2.3e-05 0.0019 18.9 2.1 2 23 222 243 222 243 0.98
3 15 0.00057 0.048 14.4 1.1 2 22 248 268 247 268 0.96
4 15 0.52 44 5.1 0.1 2 23 364 384 363 384 0.83
5 15 0.00017 0.014 16.1 0.3 2 23 391 412 390 412 0.96
6 15 0.00076 0.063 14.1 0.2 1 23 419 442 419 442 0.95
7 15 0.00012 0.0098 16.6 7.8 1 23 490 512 490 512 0.99
8 15 0.027 2.2 9.2 1.6 1 23 517 540 517 540 0.95
9 15 0.001 0.086 13.7 3.2 1 23 547 569 547 569 0.96
10 15 1.3e-05 0.0011 19.6 3.7 1 21 576 596 576 598 0.96
11 15 3.1e-07 2.6e-05 24.7 1.6 3 23 613 633 611 633 0.96
12 15 0.0096 0.81 10.6 6.2 1 23 639 661 639 661 0.99
13 15 2.3e-06 0.00019 22.0 0.4 5 23 670 688 667 688 0.97
14 15 6.1e-05 0.0051 17.5 5.3 1 23 694 718 694 718 0.98
15 15 0.0016 0.14 13.0 1.4 6 23 728 747 726 747 0.90

Sequence Information

Coding Sequence
ATGGATATTGATATGGATCGTGTGTGTCGGTCGTGTCTTTCGGAAAACAGTAATACATATTATAAAATCAATGAATCTGCTAAATGCCACAATGATTTGCGATTCGATTGGCGCGATTTGGATTTGACAATAGCTGATGTTATAATGGCCTGTACTGTTGTTCGGATACAACCAGATGATGTTGGACTGCCTCAAGCAATTTGCATGGAATGCTTGAATCAAGTACAGCAAGCATTTGTATTTAAAAAAATATGCGAGGCTACCGATGAAAAACTACGTAAATATGCGGCTGATGTTAAAATCAAAGACGAAAAATGTGAAGATTCGATTTGTGAGCCCGAAACAATTCATGTGGATGAACTTAATGATTCTAATGAGCTGAATGGTGAAATCGAAAATGAGTCCGTTGCTGGCTGTAATGATTGCAGCGACAAAGATTCAAATTCATATCATGAACCAATCGAAAAAGCTGAATCGATTGAAGAAATCGATGCGATAAATTTGAACAAAATTCCATTTAAAGATGTCGACGAAGAGACGTTAATGAAACAAACTCAAATTATAAATGGCAAATATCAGTGCGTTATTTGTACGAAACTTTTAGGAGCTCGAAAAAGTTATCGATTTCATCTTCGTTTACACATTGGAAGCGATAAATTAAGGCGATGTTCTGTCTGTGATCGTGGATTTGCGAGAAAAACACACCTTGATCGGCATTTGTTAACACACAAGAAAACTGTGAAATGTAACTATTGTAAGAAAGCATTCACAACGGAAGAGGAGCAACACGAACACATGAAAACATGTTCAAAATTGAAAATTCGCGATTCGAATGTAACCGTGAATAAGCCTAGCACAATGCATTCTATGCGTGAAACTGATTCAGATGTGGCTGAAATGCCATATGAAAATGTTTGTGATTCAATGGACGTTGGTGAAATGGGTAATAATTCAGATAACGCGCAGGACAGTTGTAAAAAACCTATTCGGATTGAATCTAGTGAATTAGAGCGACCAATTCGTTTACCACTCGATGAAGAGGAACTGAAATGGGTGAAAAAAGCGAAGCAGATCGGCAATGGTCGTTGGCAATGTCCACTGTGTCCGAAAACGTTGGCCAAGAAAGTGATCAGAATCCATATTCGAAGGCATGTTGGTCGAAATTTGATTGAGTGTCGTGTATGTGCGAAATCGTTTGCAATAAATTCCAAATTGAAACGGCATATGTTACTTCATCCAAAGCATGGTGACGCCTTTCCATGCAATCAATGTGATGAAATATTCAAAACACCGAATGATCAAAAGTATCACATTGAAATAACGCACACAATCAAATCTGATCAATCCAAAATCGAAGTGGAGATGAGTTCAATGCAACCGACAGACACATTGAATCGTAATGATGAAACGTTTGACAACAATGAAAATGAACGAAACAATAAAAATTCTAAATTAACAAATGATCGATATCAATGTAAGCTCTGTCAAAAATGTCTATCAAAAAAGAGCCACTTGGATCGCCACTTAAAAACACACCAAAAATCGAAACATGAATGTAAATTATGCGATGTTGAATACCAAACATATCAAGCACTTCATGCACATATGTATAGTGTTCATGGCGATAAATCAAAGTTTTTCGAATGTGACCAATGTTCAAAGATATTCCATCAAGAAGAGCATTTAACGGCGCATAAACAAGACCATTTATTACCAAAAAAAGTGTTCGAATGCGATGTGTGCCAAAGGAAATTCAGTCGATTGGATAATTTAAGAACTCATATGCGATGCCATATACCACCAGAGCAGCGTGAAGACATTTTAAAAAATCATTTATGTTCCTATTGCGGTGCGAGTTTCAACAATTCATCAAATTTAACCGTGCACATTCGAAGACATACTGGCTATTTGCCATTCAAATGCGAGAACTGTGAACGTCGGTTCCCTAGAAGTTGTGATTTGATATGCCATCGAAGGACCCATACGGGCGAAAAACCATATGTTTGCGATTGTGGGAAGGCCTTTTCCAGATCAAATCAATTGGTGCGACACATGAGAATCCATTCTGGACAAAAGCCTTATAAGTGCTCGCATGAACATTGTGACAAATCCTTTACCCAATTGAACGATTTAAAATTGCACGTTAAGCGGCACACGGGAGAGAAGCCCTTCGTTTGCAGTTGTGGTAAACGATTCATAACGAGCAGTCTTTTGAAACAACATCGCAAATCCCAAGGACATGCAGCTCAAACGATTGGGGAAACATTTAAGAACGGTAATTCTACCGAACAAACAAGCCTTAATTGA
Protein Sequence
MDIDMDRVCRSCLSENSNTYYKINESAKCHNDLRFDWRDLDLTIADVIMACTVVRIQPDDVGLPQAICMECLNQVQQAFVFKKICEATDEKLRKYAADVKIKDEKCEDSICEPETIHVDELNDSNELNGEIENESVAGCNDCSDKDSNSYHEPIEKAESIEEIDAINLNKIPFKDVDEETLMKQTQIINGKYQCVICTKLLGARKSYRFHLRLHIGSDKLRRCSVCDRGFARKTHLDRHLLTHKKTVKCNYCKKAFTTEEEQHEHMKTCSKLKIRDSNVTVNKPSTMHSMRETDSDVAEMPYENVCDSMDVGEMGNNSDNAQDSCKKPIRIESSELERPIRLPLDEEELKWVKKAKQIGNGRWQCPLCPKTLAKKVIRIHIRRHVGRNLIECRVCAKSFAINSKLKRHMLLHPKHGDAFPCNQCDEIFKTPNDQKYHIEITHTIKSDQSKIEVEMSSMQPTDTLNRNDETFDNNENERNNKNSKLTNDRYQCKLCQKCLSKKSHLDRHLKTHQKSKHECKLCDVEYQTYQALHAHMYSVHGDKSKFFECDQCSKIFHQEEHLTAHKQDHLLPKKVFECDVCQRKFSRLDNLRTHMRCHIPPEQREDILKNHLCSYCGASFNNSSNLTVHIRRHTGYLPFKCENCERRFPRSCDLICHRRTHTGEKPYVCDCGKAFSRSNQLVRHMRIHSGQKPYKCSHEHCDKSFTQLNDLKLHVKRHTGEKPFVCSCGKRFITSSLLKQHRKSQGHAAQTIGETFKNGNSTEQTSLN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-