Basic Information

Gene Symbol
ZNF646
Assembly
GCA_030765055.1
Location
CM060955.1:67677951-67689585[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 6 6.9e-05 0.031 17.0 0.3 2 23 399 420 398 420 0.98
2 6 0.0087 3.9 10.4 0.4 1 23 427 449 427 449 0.98
3 6 7.4e-06 0.0033 20.1 0.7 2 23 508 530 507 530 0.94
4 6 0.0057 2.5 11.0 0.2 1 23 647 670 647 670 0.96
5 6 1.2e-05 0.0054 19.4 1.9 2 23 704 725 703 725 0.97
6 6 0.0098 4.4 10.3 0.1 1 17 731 747 731 748 0.87

Sequence Information

Coding Sequence
ATGGATGACTCTGGGAGGCAACAAGAGCTTCTTAATGAAGTGGACATGGTACCCCACATGAGGACGGAAGTAGTGAAATTAAGCAGTGCTTCCCTAAAGGGAGATGATGAGGGGGAACCTTCCCCAGAGTTGATAAGTACACAGTATATTAATATCCATCGTGTTCCAGACACATTAACTAAAAGTTTAGTAGATTGTGGTTCTCCAGCCCCTTCCACGTTAATGAGTGGAGAATTAATTCCACACCATGTGGTTCATAGTGGAATGGTCGTAGACATGATGGTGTCTCAACCAGCAACCTCTGCAGAGTTTACACAACCAGGGCTTGACCGCACCACTCTTCCTCAGTATATAACTGATCAGTACGATGCAGATGAAGATCTCCTATCTCATGATCTGACAGAAGAAGATAGACGATTGGCTGTTCAACTGGTACAGCTTGTTCAGCAGCAAAAGCATCACCATGCAGTAGTATCTTCAGAATCCAATGTTATTGTTAGTCCAGGAGGACTGCCTGGACTAATTACCACAACAGGACATCTGTCTACTAAAGTACAGGTACCTGTATCCCTTGGAGATCATCATATGACAACAATGCAGCCACTGTCACCAGTGGCAGGTGTGCCTGTTGACAAACCAGGAATGGCAGCTATGGTTACTAGTTACATCCAGGCTGTTGAAGAAGAAGCGGCAGTAGCTGCAACCAGTACACATCAGCTCCTGGACCATACGGGGGACAGGATCATGAAAATGTATCAGCCACAGCACCAATCACAAGACATGAGACTACCTcctattgcaccactcaaaaaggtGCTGTCAAGCCAGTCCATGACCATCAGAAGCCGCTATGTGCGACCGCATCTTCAAGAAGTGGTGCACAGACAGGAAGTGATCCATCATGAGAGTGAAAGATTACAGCAGCATACACAGCAGCAGTCTACAATAGCAGGTGACATGACTAGTGGTGTAAGTGATAAAGACCTCCATGAGGAATATGATGTGAAAATTGAAGGGTTAGATGATGAAGATAGTGATGATTTAGCTCAAGATGATAATGACTCTGATTATGATGTAGACAGTGATTTGAGATCATCTCGGAAAAGCCTACCACATAAGAAACGTATTCCTCGGAAACTGAAGAACCTTAAGAAATCAGCATCTCCTTCAAGAAGTATGCATATGAAATCCAATAAGTGTTTGAAGTGTGGAGAACAATTTGCAAACCAGTCTGCATTTGCAGCACATCGTCTCACTCATAATTCTACTAAGAAGATGTTCAGTTGTGAACTTTGTGGTAAAGGTATTGCCAATCAGCTAAAATTCTTTGAACATCTGAAGTCACACTATGAACCAATGGCTCCGGCAGTGTCATTAGATCCAATTACTGTTACAAAACCACCAAACAAAGAAAAATCTTTAATTGTGGGTAATGAAGATGAGTTAAAGGACACTCCAGATAAATCTGAACCTCTTGTGTTGTCAGTAGGTTCAACAGTAGGTGCAATTCCACCACCATTAACCTGTGATCAGTGCGGGAAAACTTTCCGTCGCCAGAAGGCTTTTGAAACTCATGTTAATTTAGTTCATCCAAAACAAGAGgaaattgaagaattcagtgaacCAGAAGATTTGATGGAGGGTATTAGGGGGGTTGTAGATGTAGGCAGTGCTGATACTGGGGACGAAGCAGATATAGATTGCTTAACTTCTCCATCAGTAGTCAGAGTTTTAAAGAACAACAATGAGAAGGATTGGTATAGAGAAGAAGATCTGCATGCTGCTGAGGTTGACCTTCAGGAGAtagagcaacagcagcagcagcagcaacaacaacaacagcagcagcagcaacaacaacatcatcaccaccataatcaccatcatcaccaaccaCAGCACCTTCACCATCATTTTCATCACTTAGATGATTCTGCACACatctgtgaattgtgtggtgaTATTTATGAAAGTAAAGCGCAGTTGGAACAACATGTTCAGACAGATCATCTAGACTTTGCTCCAGATCCGGGAGGCAGGCAAGAAGTTGTGGTATCTCCCAAAAGACGTTTACATGGAAAAAAGTCCAGGCGAGCAGGACTTCATTTAACATGTCCTCAGTGTGGACGCATGTTCAATCATCGCAATTCACTGGTCTATCACCTCCGCAGTCACTCAGGGGAACGACCTCATCAGTGTGAGGTCTGTGGAAAGTCTTTCTTTGCTGCCAGTGCACTCAAGACAGCAGCACGAACAACAATGAGCACCTCAATTAAGTTACCGGATAAACCATCGACGTCAACTAATAAGGGCAAGCTGCCCGTAATTTACCAAGCACCAGAAATGAAGTTCAAGACACAGTACGATAAAACCGCCTTTCTCAAGGATAACGCCAAGTCTGCTCCTGTAAAAAGCAAGGGCAAAAGGAGCCCACGATCATCTTCGGATTCATGTGGAGATGACTCAGACCGGCGACAGTCAACTTCGTCGGTCGtagtttccaatcggttcgagccACTTGAACCGAAAGTTGCAGAAGGAAAACAGTCCTCCACAGAAAATATGGAGCAGGAAGAACCTGACCATGCTGCTGCAACGTCAGCAAAGAAAAGGCAGGAGAAACCTGCAGAAACCAGCCCAActccaaagaaaaagggcaaattgctccgaccaccgctaaaatcTACGTAA
Protein Sequence
MDDSGRQQELLNEVDMVPHMRTEVVKLSSASLKGDDEGEPSPELISTQYINIHRVPDTLTKSLVDCGSPAPSTLMSGELIPHHVVHSGMVVDMMVSQPATSAEFTQPGLDRTTLPQYITDQYDADEDLLSHDLTEEDRRLAVQLVQLVQQQKHHHAVVSSESNVIVSPGGLPGLITTTGHLSTKVQVPVSLGDHHMTTMQPLSPVAGVPVDKPGMAAMVTSYIQAVEEEAAVAATSTHQLLDHTGDRIMKMYQPQHQSQDMRLPPIAPLKKVLSSQSMTIRSRYVRPHLQEVVHRQEVIHHESERLQQHTQQQSTIAGDMTSGVSDKDLHEEYDVKIEGLDDEDSDDLAQDDNDSDYDVDSDLRSSRKSLPHKKRIPRKLKNLKKSASPSRSMHMKSNKCLKCGEQFANQSAFAAHRLTHNSTKKMFSCELCGKGIANQLKFFEHLKSHYEPMAPAVSLDPITVTKPPNKEKSLIVGNEDELKDTPDKSEPLVLSVGSTVGAIPPPLTCDQCGKTFRRQKAFETHVNLVHPKQEEIEEFSEPEDLMEGIRGVVDVGSADTGDEADIDCLTSPSVVRVLKNNNEKDWYREEDLHAAEVDLQEIEQQQQQQQQQQQQQQQQQHHHHHNHHHHQPQHLHHHFHHLDDSAHICELCGDIYESKAQLEQHVQTDHLDFAPDPGGRQEVVVSPKRRLHGKKSRRAGLHLTCPQCGRMFNHRNSLVYHLRSHSGERPHQCEVCGKSFFAASALKTAARTTMSTSIKLPDKPSTSTNKGKLPVIYQAPEMKFKTQYDKTAFLKDNAKSAPVKSKGKRSPRSSSDSCGDDSDRRQSTSSVVVSNRFEPLEPKVAEGKQSSTENMEQEEPDHAAATSAKKRQEKPAETSPTPKKKGKLLRPPLKST

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01411053; iTF_00821294;
90% Identity
iTF_00821294;
80% Identity
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