Basic Information

Transcription Factor Domain

TF Family: TEA
Domain: TEA domain
PFAM: PF01285
TF Group: Helix-turn-helix
Description: The TEA domain is a DNA-binding region of about 66 to 68 amino acids that has been named after the two proteins that originally defined the domain: TEF-1 and AbaA. The TEA domain is located toward the N terminus of eukaryotic transcription factors of the TEA/ATTS family. It shows a three-helix bundle with a homeodomain fold [3, 1]. Two α-helices are nearly anti-parallel and pack on either side of the third one, which is the DNA-recognition helix of the TEA domain. Phosphorylation of one or both of the two conserved serines found on the DNA-binding surface could interfere with DNA-binding activity, by introducing electrostatic repulsion and/or steric hindrance, and help regulate the transcription factor activity of the proteins [2, 1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 1.5 3.5e+04 -2.5 0.0 16 29 12 25 11 33 0.75

2 6 0.0026 63 6.3 0.0 11 40 42 73 40 85 0.83

3 6 0.011 2.6e+02 4.3 0.0 11 30 100 119 98 131 0.81

4 6 0.0026 63 6.3 0.0 11 40 135 166 133 178 0.83

5 6 0.011 2.6e+02 4.3 0.0 11 30 193 212 191 224 0.81

6 6 0.013 3.1e+02 4.1 0.0 11 29 228 246 226 258 0.82

#	of	c-Evalue	i-Evalue	score	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	1.5	3.5e+04	-2.5	16	29	12	25	11	33	0.75
2	6	0.0026	63	6.3	11	40	42	73	40	85	0.83
3	6	0.011	2.6e+02	4.3	11	30	100	119	98	131	0.81
4	6	0.0026	63	6.3	11	40	135	166	133	178	0.83
5	6	0.011	2.6e+02	4.3	11	30	193	212	191	224	0.81
6	6	0.013	3.1e+02	4.1	11	29	228	246	226	258	0.82

Coding Sequence: ATGTCGAAGTTTACCCTTAACAACACTCCAGAAAGCTTCGAAGTTTACCCTCAACAACACTCCAAAAAGCTCTCGAAGTTTACCCTCAACAACACTCCAAAAAGCTCTCGAAGTTTACCCTCAACAACACTCCAAAAAGCTCTCGAAGTTTACCCTCAACAACACTCCAAAAAGCTCTCGACGTTTATCCTCAACAACACTCCAAAAAGATGTCGAAGTTTACCCTTAACAACACTCCAGAAAGCTTCGAAGTTTACCCTCAACAACACTCCAAAAAGCTCTCGAAGTTTACCCTCAACAACACTCCAAAAAGCTCTCGAAGTTTACCCTCAACAACACTCTAAAAAGCTCTCGAAGTTTAAGCTCAACAACACTCCAAAAAGTTCTCGATGTTTACCCTCAACAACACTCCAAAAAGCTCTCGAAGTTTACCCTCAACAACACTCCAAAAAGCTCTCGACGTTTATCCTCAACAACACTCCAAAAAGATGTCGAAGTTTACCCTTAACAACACTCCAGAAAGCTTCGAAGTTTACCCTCAACAACACTCCAAAAAGCTCTCGAAGTTTACCCTCAACAACACTCCAAAAAGCTCTCGAAGTTTACCCTCAACAACACTCTAAAAAGCTCTCGAAGTTTAAGCTCAACAACACTCCAAAAAGTTCTCGATGTTTACCCTCAACAACACTCCAAAAAGCTCTCGAAGTTTACCCTCAACAACACTCCAAAAAGCTCTCGAAGTTTACCCTCAACAACACTCCAAAAAGCTCTCGAAGTTTACCCTTAACAACACTCTAA
Protein Sequence: MSKFTLNNTPESFEVYPQQHSKKLSKFTLNNTPKSSRSLPSTTLQKALEVYPQQHSKKLSTFILNNTPKRCRSLPLTTLQKASKFTLNNTPKSSRSLPSTTLQKALEVYPQQHSKKLSKFKLNNTPKSSRCLPSTTLQKALEVYPQQHSKKLSTFILNNTPKRCRSLPLTTLQKASKFTLNNTPKSSRSLPSTTLQKALEVYPQQHSKKLSKFKLNNTPKSSRCLPSTTLQKALEVYPQQHSKKLSKFTLNNTPKSSRSLPLTTL

Sequence clustering based on sequence similarity using MMseqs2