Basic Information

Gene Symbol
-
Assembly
GCA_030765055.1
Location
CM060950.1:451863290-451960473[-]

Transcription Factor Domain

TF Family
Runt
Domain
Runt domain
PFAM
PF00853
TF Group
Beta-Scaffold Factors
Description
The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 0.0022 35 6.4 0.1 46 67 91 112 71 125 0.80
2 7 0.0019 30 6.6 0.1 44 67 134 157 125 171 0.81
3 7 0.0021 33 6.4 0.1 41 67 177 202 170 215 0.79
4 7 0.002 32 6.5 0.1 41 67 222 247 214 262 0.79
5 7 0.0022 35 6.4 0.1 41 67 267 292 259 302 0.79
6 7 0.0021 33 6.4 0.1 41 67 312 337 302 348 0.79
7 7 0.086 1.4e+03 1.2 0.1 12 103 398 487 390 496 0.69

Sequence Information

Coding Sequence
ATGTTAATACATACAGACTCAAAACCATATCAGTGTGATCAATGCGACCAGTCTTTCAGACAAAAACAGTTATTAAGAAGACATCAAAATCTTTATCATAATCCTAATTATGTGCCCCCTCCAACTCGGGAGAAGACTTACGAATGTGCTGAATGTGGTAGAGCTTTCAGACATAAAGGAAATCTCATCAGGCATATGGCAATACACGATCCTGAATCATCAGCACAAGAAAAGGCTCTTGCTTTAAAACTAGGACGACAAAAGAAAATTCAGATCATAGATGGTCAGCAAGTAGAAGTAATGGCAGGAGAAGATGAAGACGAGGATGAAGATATGGATGGGGAAATGAAGGCTGTGGATGGGCAAGATGGACAGCAGTATGTTGTGCCGGAGGTTATACAACAACAGATCATAGATGGTCCGCAAGTAGAAGTAATGGCAGGAGAAGATGAAGACAAGGATGAAGATATGGATGTGGAAATGAAGGCTGTGGATGGGCAAGATGGACAGCAGTATGTTGTGCCGGAGGTTATACAACTACAGATCATAGATGGTCCGCAAGTAGAAGTAATGGCAGGAGAAGATGAAGACAAGGATGAAGATATGGATGTGGAAATGAAGGCTGTGGATGGGCAAGATGGACAGCAGTATGTTGTGCCGGAGGTTATACAACTACAGATCATAGATGGTCCGCAAGTAGAAGTAATGGCAGGAGAAGATGAAGACAAGGATGAAGATATGGATGTGGAAATGAAGGCTGTGGATGGGCAAGATGGACAGCAGTATGTTGTGCCGGAGGTTATACAACTACAGATCATAGATGGTCCGCAAGTAGAAGTAATGGCAGGAGAAGATGAAGACAAGGATGAAGATATGGATGTGGAAATGAAGGCTGTGGATGGGCAAGATGGACAGCAGTATGTTGTGCCAGAGGTTATACAACTACAGATCATAGATGGTCCGCAAGTAGAAGTAATGGCAGGAGAAGATGAAGACAAGGATGAAGATATGGATGTGGAAATGAAGGCTGTGGATGGGCAAGATGGACAGCAGTATGTTGTGCCGGAGGTTATACAACTACAGATGGATAACTTGGGTTTTCAACACGAAGAAGCATCCCTCGCAATGGGAGGCGAAGCTGCCCCACGTAGTCCACCCCTACTCCCCTTGATCACCGACGGTTCCAGGCTACTCACGGCCACCCATACTCCCAAGCTATCCTCGTCTTCCGTGCCTTCCTCGTGCTCCCCCAAGAAGAATAATAACGAGGTGGTCAGGGATACCTCTCTAGACATTCTCTCGCCCAAGTGTCTCGTCAAGAACAACAACAATACGTATTGCAGTAATACCCCTGAGAGCCCGACGCTGCTCAAGAAACATCAGCAGGGGCTCAACAACTTGAGAAGCAGCGAGGGGAAGGTCCTCAGTAGGTCCACAACACTGCCCACCATCACGATCAATAACATGGTGCCCAGCGTCTCCGGGAATGTGCCCTACTTCTACCCAGGGTTTGCTGGAGGTTCTCAACAGGACGTAGCGCCGCCGTCGCCTCAACCCCACGCCGAGAACCGCCAGAACATGAGGCGGACCTCCAGGTATCTGCGGGAGTCTGGTGAGGGTGTCGAGGGTAGAGGCGCCACGCTCAGGAAGCTGCGGGCTGGAGGCTGGAACCTTGCCTTCTGTTGTTTTCTGCTGGTATTCTGCATCCTTGCTGCAGCCGCCACGGTTGCTCTAGTCGTCTACATGACCACAGgCATGAAGTCCGTACCGATGAAGTTGGAAGGAGTCCAGGACTCTGCCGGAGAAAGTGGTGAGTTGTCCGAAGAAAACTTTTTAGCAATTCCTTAA
Protein Sequence
MLIHTDSKPYQCDQCDQSFRQKQLLRRHQNLYHNPNYVPPPTREKTYECAECGRAFRHKGNLIRHMAIHDPESSAQEKALALKLGRQKKIQIIDGQQVEVMAGEDEDEDEDMDGEMKAVDGQDGQQYVVPEVIQQQIIDGPQVEVMAGEDEDKDEDMDVEMKAVDGQDGQQYVVPEVIQLQIIDGPQVEVMAGEDEDKDEDMDVEMKAVDGQDGQQYVVPEVIQLQIIDGPQVEVMAGEDEDKDEDMDVEMKAVDGQDGQQYVVPEVIQLQIIDGPQVEVMAGEDEDKDEDMDVEMKAVDGQDGQQYVVPEVIQLQIIDGPQVEVMAGEDEDKDEDMDVEMKAVDGQDGQQYVVPEVIQLQMDNLGFQHEEASLAMGGEAAPRSPPLLPLITDGSRLLTATHTPKLSSSSVPSSCSPKKNNNEVVRDTSLDILSPKCLVKNNNNTYCSNTPESPTLLKKHQQGLNNLRSSEGKVLSRSTTLPTITINNMVPSVSGNVPYFYPGFAGGSQQDVAPPSPQPHAENRQNMRRTSRYLRESGEGVEGRGATLRKLRAGGWNLAFCCFLLVFCILAAAATVALVVYMTTGMKSVPMKLEGVQDSAGESGELSEENFLAIP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00955918;
90% Identity
iTF_00955918;
80% Identity
iTF_00955918;