Mrel000742.1
Basic Information
- Insect
- Mantis religiosa
- Gene Symbol
- -
- Assembly
- GCA_030765055.1
- Location
- CM060947.1:39071774-39077870[-]
Transcription Factor Domain
- TF Family
- GCM
- Domain
- GCM domain
- PFAM
- PF03615
- TF Group
- Beta-Scaffold Factors
- Description
- GCM transcription factors are a family of proteins which contain a GCM motif. The GCM motif is a domain that has been identified in proteins belonging to a family of transcriptional regulators involved in fundamental developmental processes which comprise Drosophila melanogaster GCM and its mammalian homologues [PMID: 8962155, PMID: 9114061, PMID: 9580683, PMID: 10671510]. IN GCM transcription factors the N-terminal moiety contains a DNA-binding domain of 150 residues. Sequence conservation is highest in this GCM domain. In contrast, the C-terminal moiety contains one or two transactivating regions and is only poorly conserved.The GCM motif has been shown to be a DNA binding domain that recognises preferentially the nonpalindromic octamer 5'-ATGCGGGT-3' [PMID: 8962155, PMID: 9114061, PMID: 9580683]. The GCM motif contains many conserved basic amino acid residues, seven cysteine residues, and four histidine residues [PMID: 8962155]. The conserved cysteines are involved in shaping the overall conformation of the domain, in the process of DNA binding and in the redox regulation of DNA binding [PMID: 9580683]. The GCM domain as a new class of Zn-containing DNA-binding domain with no similarity to any other DNA-binding domain [PMID: 12682016]. The GCM domain consists of a large and a small domain tethered together by one of the two Zn ions present in the structure. The large and the small domains comprise five- and three-stranded beta-sheets, respectively, with three small helical segments packed against the same side of the two beta-sheets. The GCM domain exercises a novel mode of sequence-specific DNA recognition, where the five-stranded beta-pleated sheet inserts into the major groove of the DNA. Residues protruding from the edge strand of the beta-pleated sheet and the following loop and strand contact the bases and backbone of both DNA strands, providing specificity for its DNA target site.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 14 0.0091 4.4e+02 3.1 0.0 113 130 126 143 112 152 0.84 2 14 0.012 5.6e+02 2.8 0.1 114 131 160 177 148 187 0.84 3 14 0.015 7.3e+02 2.4 0.0 114 131 193 210 185 219 0.84 4 14 0.01 4.8e+02 3.0 0.0 114 130 226 242 214 251 0.85 5 14 0.26 1.2e+04 -1.6 0.0 117 130 261 274 257 285 0.81 6 14 0.012 5.5e+02 2.8 0.0 114 130 291 307 279 318 0.84 7 14 0.014 6.5e+02 2.6 0.0 114 130 324 340 312 348 0.84 8 14 0.0099 4.7e+02 3.0 0.1 114 130 357 373 345 383 0.84 9 14 0.011 5.4e+02 2.8 0.0 114 130 390 406 377 415 0.85 10 14 0.01 4.8e+02 3.0 0.0 114 130 423 439 413 450 0.84 11 14 0.015 7e+02 2.5 0.0 114 130 456 472 449 482 0.84 12 14 0.016 7.4e+02 2.4 0.0 114 130 489 505 482 513 0.84 13 14 0.0084 4e+02 3.2 0.0 112 130 585 603 561 613 0.83 14 14 0.014 6.5e+02 2.6 0.0 114 130 620 636 612 644 0.84
Sequence Information
- Coding Sequence
- ATGAAACAACATGGAGGCAGAGAGGCACGGGTAAAGGTGGACTGTGTGGTTTCTCGGAGAGAAAGAGTGACTGCTTCAGAAATGGACAAGAGGTCAGTGCCAAGTCGCAGGTCCGTGTTTCGTTGGGTCTCCGAATTCAGAGACTGCAAGGACAGTGCTGAAAAAATCAAAAGCACTGGGCATCCAGCAACTGAAGGGATACTGCTAGTGGATTGGCTCCCTTCCAAGCGGTACTGCAACAACTCCGCCGACGCATTCAACAATGCCACCATCAAAAATTGGGTCCGtggtgttcttctccaacaagacaatgcacgaccacctGTCAGTTACTGCAACAACTCCGCCGACGCATTCAACAATGCCGCCATCAAAATTGGGTCCGtggtgttcttctccaacaagacaatgcacgaccacatgtCAGTTACTGCAACAACTCCACCGACGCATTCAACAATGCCACCATCAAAAATTGGGTCCGtggtgttcttctccaacaagacaatACACGACCACGTGTCAGATACTGCAACAACTCCGCCGACGCATTCAACAATGCCACCATCAAAAATTGGGCCCGtggtgttcttctccaacaagacaatACACGACCACGTGTCAGATACTGCAACAACTCCGCCGACGCATTCAACAATGCCACCATCAAAAATTGGGTCCGtggtgttcttctccaacaagacaatgcacgaccacatgtCAGTTACTGCAACAACTCCGCCGACGCATTCAACAATGCCACCATCAAAAATTGGGTCCGTGGTgttctccaacaagacaatgcacgaccacatgtCAGTTACTGCAACAACTCCACCGACGCATTCAACAATGCCACCATCAAAAATTGGGCCCGtggtgttcttctccaacaagacaatgcatgACCACATGTCAGTTACTGCAACAACTCCGCCGACGCATTCAACAATGTCACCATCAAAAATTGGGCCCGtggtgttcttctccaacaagacaatgcacgaccacctGTCAGTTACTGCAACAACTCCGCCGACGCATTCAACAATGCCACCATCAAAAATTGGGTCCGtggtgttcttctccaacaagacaatgcacgaccacatgtCAGTTACTGCAACAACTCCGCCGACGCATTCAACAATGCCACCATCAAAAATTGGGTCCGtggtgttcttctccaacaagacaatgcacgaccacctGTCAGTTACTGCAACAACTCCGCCGACGCATTCAACAATGCCACCATCAAAAATTGGGTCCGtggtgttcttctccaacaagacaatgcacgaccacatgtCAGTTACTGCAACAACTCCGCCGACGCATTCAACAATGCCACCATCAAAAATTGGGCCCGtggtgttcttctccaacaagacaatgcacgaccacctGTCAGTTACTGCAACAACTCCACCGACGCATTCAACAATGCCACCATCAAAAATTGGGCCCGtggtgttcttctccaacaagacaatgcacgaccacctGTCAGTTACTGCAACAACTCCGCCGACGAATTCAACAATGCCACCATCAAAATTGGGTCCGtggtgttcttctccaacaagacaatgcatgACCACATGTCAGTTACTGCAACAACTCCACCGACGAATTCAACAATGCCACCATCAAAATTGGGTCCGtggtgttcttctccaacaagacaatgcacgaccacatgtCAGTTACTGCAACAACTCCGCCGACGAATTCAACAATGCCACCATCAAAATTGGGTCCGtggtgttcttctccaacaagacaatgcacgaccacctGTCAGTTACTGCAACAACTCCGCCGACGAATTCAACAATGCCACCATCAAAAATTGGGCCCGtggtgttcttctccaacaagacaatgcatgACCACATGTCAGTTACTGCAACAACTCCACCGACGCATTCAACAATGCCACCATCAAAATTGGGTCCGtggtgttcttctccaacaagacaatgcacgaccacatgtCAGTTACTGCAACAACTCCGCCGACGCATTCAACAATGCCACCATCAAAATTGGGTCCGtggtgttcttctccaacaagacaatgcacgaccacatgtCAGTTACTGCAACAACTCCGCCGACGCATTCAACAATGCCACCATCAAAATTGGAGACTATGTTCCATTCGTCTGGATGAAAGAGATCATGCGATGTAAGAAGTTCACTACTAATGACGAAATTCACGCAGTTgGGAAAAGCTGCACAGACATTGACGAGGAATACCTGTGA
- Protein Sequence
- MKQHGGREARVKVDCVVSRRERVTASEMDKRSVPSRRSVFRWVSEFRDCKDSAEKIKSTGHPATEGILLVDWLPSKRYCNNSADAFNNATIKNWVRGVLLQQDNARPPVSYCNNSADAFNNAAIKIGSVVFFSNKTMHDHMSVTATTPPTHSTMPPSKIGSVVFFSNKTIHDHVSDTATTPPTHSTMPPSKIGPVVFFSNKTIHDHVSDTATTPPTHSTMPPSKIGSVVFFSNKTMHDHMSVTATTPPTHSTMPPSKIGSVVFSNKTMHDHMSVTATTPPTHSTMPPSKIGPVVFFSNKTMHDHMSVTATTPPTHSTMSPSKIGPVVFFSNKTMHDHLSVTATTPPTHSTMPPSKIGSVVFFSNKTMHDHMSVTATTPPTHSTMPPSKIGSVVFFSNKTMHDHLSVTATTPPTHSTMPPSKIGSVVFFSNKTMHDHMSVTATTPPTHSTMPPSKIGPVVFFSNKTMHDHLSVTATTPPTHSTMPPSKIGPVVFFSNKTMHDHLSVTATTPPTNSTMPPSKLGPWCSSPTRQCMTTCQLLQQLHRRIQQCHHQNWVRGVLLQQDNARPHVSYCNNSADEFNNATIKIGSVVFFSNKTMHDHLSVTATTPPTNSTMPPSKIGPVVFFSNKTMHDHMSVTATTPPTHSTMPPSKLGPWCSSPTRQCTTTCQLLQQLRRRIQQCHHQNWVRGVLLQQDNARPHVSYCNNSADAFNNATIKIGDYVPFVWMKEIMRCKKFTTNDEIHAVGKSCTDIDEEYL
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -