Basic Information

Gene Symbol
-
Assembly
GCA_905333055.1
Location
HG995236.1:2648554-2655182[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 1.4e-05 0.00066 20.4 2.5 1 23 451 473 451 473 0.98
2 15 0.18 8.5 7.4 6.8 3 23 481 501 479 501 0.97
3 15 7.3e-06 0.00034 21.3 1.3 2 23 508 529 507 529 0.97
4 15 2.4e-06 0.00011 22.8 1.5 1 23 535 557 535 557 0.99
5 15 0.00013 0.0062 17.3 2.2 2 23 564 585 563 585 0.97
6 15 2.5e-05 0.0011 19.6 4.3 1 23 591 613 591 613 0.99
7 15 3.5e-05 0.0016 19.1 2.8 1 23 619 641 619 641 0.98
8 15 0.00015 0.007 17.1 3.4 1 23 647 669 647 669 0.96
9 15 7.1e-06 0.00033 21.3 0.2 1 23 675 697 675 697 0.99
10 15 0.00033 0.015 16.1 3.7 2 23 704 725 703 725 0.97
11 15 7.1e-06 0.00033 21.3 0.2 1 23 731 753 731 753 0.99
12 15 0.00033 0.015 16.1 3.7 2 23 760 781 759 781 0.97
13 15 3.7e-05 0.0017 19.1 3.9 1 23 787 809 787 809 0.99
14 15 0.00021 0.0099 16.7 3.4 1 23 815 837 815 837 0.96
15 15 0.00054 0.025 15.4 6.2 1 23 843 865 843 865 0.98

Sequence Information

Coding Sequence
ATGCGGTGCTGTGTGCCTTTCTGCCAAAATGCTTCGGACAATATATCTAAATCAGAGGCAGAAGGAATTAGTTTTCATGGTTTCCCCAGTAAAATGCATCTCCGTGCTACTTGGCTCAAAGCTCTCGGCAAACAAGACAATCTACCAGACTCTGCGGTGGTCTGCTCGCAGCATTTTCTAAATGATGACATTTATGAAACAGAAAGTGGTTTAAGGCAAATTCGTACTGGTGCAATTCCTTCCATGGTGCAGATTTGCATGATATGCCTTGACACTGACAGCAAGCTGTTGCTAATGAACAAATATAAATTAGATAAAGCATATGAAAAGTTAACAGGACATCCTTTGTGTGATCAAGGAAACCTAAAACAAACACTTTGTGTACAATGTGCTCAGAGATTGACTAACTTTAGTAGATTTAGAGAAAAGAGCTTGAGAGCTCGTGCACTGATGATGGACTTAATTAACAAACATGAATTAATAACAAGACAACATATCGAAATGTTAAATAGCACGAAACACCAATTAAAGAGTAATATGGTGGTGACAACGCTAGGACCTGACCACTGCAACTTATACATATTAGAACAGCCCTCAGAAGACAAACAAACCGAATTAGAGGAAACAGGCCACCAAGTTCTAGTGAAAACTGAAGGAAGTGATGACCCTATGTCAGTTGATGAGGACACAGGAGTGATAAATGAAGATTACAATATTGCAGACACTGTCAAAGATGTGTTTGTAACTTGTAACGATGAAAACATATCTGATTATAGCATTATGATGGAAGAAAAAGCAATGGATGAAGATCTTTACAAAGCTCTCAAGATGAAACAGGCATACATGCGACATACAAGTGCCGAGCAGAACAGTGACGGTGATGGTGAATGTGAGACGTCACAAGTATGCAAGCCTCATACAGCTGTGAGCTCTAGCTCTTCACACTCTTCACTCCTCACTGAGAACAAGCAGGCAGGCCCCAGCCCTTCTGCACATTCTGCTCAGACCTTGGTTGCTCCTCTTCCCGCAACAAGTAACGAAATAAAAGCACCGTCAACTGAAGAAGCCGATACAACCGCCAGTTGCCGATATGAAAGATTAACAGATTGTTTTGTCAAACTATATGATATTTTCTCTAAGAAAGTTATACCAAGTGAGGAAAACACTGTTAGGTCGTCTGTAAGTCAAAACATTCAGAATGAAGTCCCTACAACAGAATATGTTGAACCAGGCAATGAAACAGTAAAAGTAATTGTATCAAAAACTGTACAAAGTGAAGCTGATTGTTTGAAAAATGTTGTTAATGTACAATCTTCGTCGCAAAACAGTTCACACACTGAAGTAAGCAGGTTTATCTGTGATATTTGTCGAAAAGTGTGTATACGAAAAAGAAACTTAGTTAAACACATAAAGACTCACACTGAAGTAAGATGGATCAATTGCAAGATGTGCCAGTACACATGTAAATGTCAAAGTGTTTTGAAGCAGCATATGAGAACACACACTGGTATAAAACCCTCCTCGTGTAAGATATGCGATTACAAATGTGCACAAAATAGCGATCTAGTGGCGCACATGAGAACCCACACTGGTGAAAAGCCATATTCCTGTAAGGTATGCGATTACAAATGTGCACAAAATAGCGATCTAGTGGCGCACATGAGAACCCACACTGGTATAAAACCTTTGTCATGTGAGTTATGTAATTACAAATGTGCAAAAAAAAGCAATCTAGTGACGCACATGAGAATCCACACTGGTGAAAAGCCATATTCCTGTAAGGTATGCGATTACAAATGTGCACGAAATGCCCATCTAGTGACGCATATGAGAACCCACACTGGTATAAAACCTTTCTCATGTGAGTTGTGTAGTTACAAATGTGCTCAAAATAGCAATCTAGTGACGCACATGAGAACTCACACTGGTATAAAACCTTTCTTGTGTAAGTTATGTAGTTACAAATGTGCACAAAATAGCAATCTAGTGACGCATATGAGAACACACACTGGTGACAAGCCATACTCCTGTAAGATATGCGATTACAAAGGTGTACAAAATAGCGATCTTGTGGCGCACATGAGAACCCACACTGGTATAAAACCTATCTCATGTGAGTTATGTAGTTACAAATGTGCACAAAATAGCCATCTAGTGACGCACATGAGAACACACACTGGTGACAAGCCATACTCCTGTAACATATGCGATTACAAAGGTGTACAAAATAGCGATCTAGTGGCGCACATGAGAACCCACACTGGTATAAAACCTATCTCATGTGAATTATGTAGTTACAAATGTGCACAAAATAGCCATCTAGTGACGCACATGAGAACACACACTGGTGAAAAGCCATATTCCTGTAAGGTATGCGATTACAAATGTGCACGAAATGCCCATCTAGTGATGCATATGAGAACCCACACTGGTATAAAACCTTTCTTATGTGAGTTATGTAGTTACAAATGTGCTCAAAGTAGCCATCTAGTGGCGCACATGAGAACACACACTGGAATAAAACCTTTCTCATGTCAGTTATGTAGTTACAAATGTGCAAGAAATAACCATCTAGTGAGGCACATGCGAACCCACACGGTGATAAGCCATATTCCTGTAGACCGACTTGAAGCGACGTCCAGTAAACTTGATGGTGTATAG
Protein Sequence
MRCCVPFCQNASDNISKSEAEGISFHGFPSKMHLRATWLKALGKQDNLPDSAVVCSQHFLNDDIYETESGLRQIRTGAIPSMVQICMICLDTDSKLLLMNKYKLDKAYEKLTGHPLCDQGNLKQTLCVQCAQRLTNFSRFREKSLRARALMMDLINKHELITRQHIEMLNSTKHQLKSNMVVTTLGPDHCNLYILEQPSEDKQTELEETGHQVLVKTEGSDDPMSVDEDTGVINEDYNIADTVKDVFVTCNDENISDYSIMMEEKAMDEDLYKALKMKQAYMRHTSAEQNSDGDGECETSQVCKPHTAVSSSSSHSSLLTENKQAGPSPSAHSAQTLVAPLPATSNEIKAPSTEEADTTASCRYERLTDCFVKLYDIFSKKVIPSEENTVRSSVSQNIQNEVPTTEYVEPGNETVKVIVSKTVQSEADCLKNVVNVQSSSQNSSHTEVSRFICDICRKVCIRKRNLVKHIKTHTEVRWINCKMCQYTCKCQSVLKQHMRTHTGIKPSSCKICDYKCAQNSDLVAHMRTHTGEKPYSCKVCDYKCAQNSDLVAHMRTHTGIKPLSCELCNYKCAKKSNLVTHMRIHTGEKPYSCKVCDYKCARNAHLVTHMRTHTGIKPFSCELCSYKCAQNSNLVTHMRTHTGIKPFLCKLCSYKCAQNSNLVTHMRTHTGDKPYSCKICDYKGVQNSDLVAHMRTHTGIKPISCELCSYKCAQNSHLVTHMRTHTGDKPYSCNICDYKGVQNSDLVAHMRTHTGIKPISCELCSYKCAQNSHLVTHMRTHTGEKPYSCKVCDYKCARNAHLVMHMRTHTGIKPFLCELCSYKCAQSSHLVAHMRTHTGIKPFSCQLCSYKCARNNHLVRHMRTHTVISHIPVDRLEATSSKLDGV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
-
80% Identity
-