Basic Information

Gene Symbol
-
Assembly
GCA_905333055.1
Location
HG995235.1:150526-155151[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 29 0.004 0.18 12.7 0.5 1 23 201 223 201 223 0.97
2 29 0.00062 0.029 15.2 5.8 1 23 229 251 229 251 0.97
3 29 0.07 3.2 8.7 1.6 1 19 257 275 257 279 0.94
4 29 0.13 6.1 7.9 2.6 1 23 285 307 285 307 0.97
5 29 0.089 4.1 8.4 7.2 1 23 312 334 312 334 0.90
6 29 0.16 7.6 7.6 0.8 1 23 340 362 340 362 0.98
7 29 0.00035 0.016 16.0 5.1 2 23 369 390 368 390 0.97
8 29 2.8e-05 0.0013 19.5 0.6 1 23 396 419 396 419 0.98
9 29 0.18 8.4 7.4 7.5 1 23 425 447 425 447 0.97
10 29 3.9 1.8e+02 3.3 0.6 1 23 453 475 453 475 0.75
11 29 0.0015 0.069 14.0 0.6 1 23 481 503 481 503 0.99
12 29 4.2e-05 0.0019 18.9 2.1 2 23 510 531 509 531 0.97
13 29 0.0005 0.023 15.5 1.5 1 23 537 559 537 559 0.98
14 29 0.004 0.18 12.7 6.5 1 23 565 587 565 587 0.98
15 29 5.4e-05 0.0025 18.5 2.0 1 23 593 615 593 615 0.99
16 29 0.00064 0.03 15.2 6.1 1 23 621 643 621 643 0.98
17 29 9.4e-05 0.0043 17.8 1.9 1 23 649 671 649 671 0.97
18 29 0.002 0.094 13.6 5.1 1 23 677 699 677 699 0.98
19 29 0.00056 0.026 15.3 0.9 1 23 705 727 705 727 0.98
20 29 0.011 0.52 11.2 11.7 1 23 733 755 733 755 0.98
21 29 0.026 1.2 10.1 5.2 1 23 761 783 761 783 0.99
22 29 0.00016 0.0072 17.1 4.1 1 23 789 811 789 811 0.98
23 29 0.0022 0.1 13.5 0.7 1 23 817 839 817 839 0.97
24 29 0.0048 0.22 12.4 6.3 1 23 845 867 845 867 0.98
25 29 2e-06 9.4e-05 23.0 4.5 1 23 873 895 873 895 0.98
26 29 0.00072 0.033 15.0 5.2 1 23 901 923 901 923 0.98
27 29 0.0039 0.18 12.7 2.2 1 23 929 951 929 951 0.98
28 29 0.00051 0.024 15.5 4.3 1 23 959 981 959 981 0.97
29 29 0.0005 0.023 15.5 1.3 1 23 987 1009 987 1009 0.97

Sequence Information

Coding Sequence
ATGCGGCTAGAAGCAATTCCTTCTGTGATAAACGACACAGGGCAGTCTGATCTAAACCAGAACCCATCAAATGTGGATCGACAGACAGAAATAGACACTGTACCCCGAGTCACTGACAATGTTGGAAAAACTAATGAAAAAGCAGAGAAAAGTAAGATGGTTGTGGAGGATGGCTCATTTAAACAGGAACCTTTAGGCACGGAGTCCTGTCACAATACCCACGACTCTCTCTTTGATGTGATCAAGGATGAGAATAGTCTACAAAAGGAGCATCAGAGTGGCTGCCATGTTGATACTCCTGCTACAACAGATGTCAGTGTTGGAGATGTGTCCCTAGCACATAATATGAATATTCACATTAAACCTGAACCTTCTCAAGCTGAAGTGAGTTTGCCTGTAGACCATGATCTCACGCTGGATGCTATTTCGGCAAAGGAAAATACGATGGAAGACTCAAAGATGAATGAAGGCTTTTCAGTAAAGCAAAACCGCTTCAACCCAAGAATACAACAAAGATTGATTAAATGGACAGCTGCTGTCAAACGCAAGATGGACAGAGAAGACAGTGCGCAGGGTGGCTCTCCCACTGATGATACATTCTTCGCTTGCGACAATTGCCAGTACAAGACTGTCTACAAAAGAGCCTTAGCGATACACATGAAGAGTCACACCGACATAAAACCCTTTGCATGTAACTTTTGCGACTACAAATGTTCCACAGCCACTCATCTAAAATCCCACATGAGTACCCACCCTAATTATAAACCATTCACTTGCAAGGAATGTAACATGGAATTTACATGTGCGAGTTATTTAAAACAACATGCACCAATTCACTCTGATGATATACTCTTCAGTTGCGATCAATGCTCGTACAAAACAACTAAAAAAGGCTACATCTTAAGGCATATAAAGTTTCACACCAAACCCCTCTTCTATTGCGACCATTGTTCATATAAAAATTTTAGCAAATGTAACTTGGAGAGACACATGCGAATCCATACGGGTAGAAAACCTTTTAGTTGTAAGCTTTGCAACTACAAGGGTAGATTAGCTGTCAGTGTAAGGTCTCATATGACGACTCACACTGGTGAGAAACCATGGTCGTGCAAGTACTGTTCATACAAGTGTACGACATCAAGTTATCTGAAAACCCACATGACAACTCACACTGGTTCTAGAGATTACGTTTGCGAGATCTGTAACAGTAAGTTTTCTAGAGCAAACTCTTTAAAAATCCACATTAAAAAGCTTCACACTCATCTAAAACTCTTCCATTGTGATCATTGCAAGTATAAAACAACAAAGAAAGGTCTCATCAGGAGACATATGACACGACACACTGTCAAACCAATTTTCTATTGTGACTTCTGCTCGTATAAAGATTTAGACAAAGGTCGCTTAGAGCGTCACATTCGCATTCACACTGGTGAAAAACCTTACAGTTGTAAGCTCTGCGACTACAAGGGAGCGTTACCGAACAGTCTAAAATCTCACATGAAGACTCACACTGGTGAGAAACCATGGTCATGCAAGTACTGCGATTACAAGTGTTCGCAATTGTCTGCTCTAAAAACCCACATGATGATTCACACTGGAGAAAAACCTTTCGCATGTAAATATTGCCCCTACAAGTGTACTACAGGAGGCCCTTTAAAGATCCACATGAGGACTCACACCGGTGAGAAACCATATTCGTGTAAATACTGTGACTATAAATGTTCTGTAGCGTGTTCTTTGAAAACTCATTTGAGGTCTCACTCGGGTGAAAAGCCTTATCGGTGTGAACATTGTCCGTTCAGAACTTCGACACCGGGCGCTCTTAAGACTCACACGAGGACTCACACAGGTGAAAAACCTTACAGTTGTAAATTCTGTGACTACAAGTGTTCACAAAACGTTCACTTAAAAGCCCACACAAGAATTCACACTGGATTCAAACCGTTTGCTTGTAAGCATTGCGACTATAAAAGTTCAACATCGAGCGGTCTAAAAATCCATATGGTGACTCACAGTACCGATAAACCGTTTTATTGTAAACACTGTACCTTTAAATGCGCCTTAGCAGCCAATCTAAAGATACACATGAGAACTCACACTGGTGAGCAACCGTTTTCCTGCAATTTATGCGACTACAAAAGTGCAACATCGGGTCAATTGAAAAGCCACACGCTTACACACACCGGTGAAAAACCTTATCATTGTGACCACTGTAACCATAAAAGTTCGCACAAAAGCAGTCTTAAAACGCACTTGAGGACTCACACTGGTGAAAGACCGTATAGTTGTAAGCTCTGTCACTACACATGTCTGCAAGCGAGTTACCTAGTGACACACATGCAAACTCATACAAAGGAGAAGCCTTTTTCCTGTACTCTTTGTAACTACAAGTGTGCGCGGAACACTACTCTGACAATCCATATGAGAACCCACACAGGCGAAAAACCTCACTCTTGTGAGCTTTGTGATTACAAAGGTTCTACAAAAAGCGCTGTGAAAGCCCACATGGTAACTCACTCGAGTGAAAAACCATTTTCCTGTGAGCATTGCGACTATAAATGTTCCACATCAACTGGTCTAAAATCTCACACGACTACTCATACCGGTCTTAAACCCCACACTTGCAAGGTGTGTAACACTAAATTTACTAGACCTTACTCTCTAAAACTTCACATGAGGACACACACTAATGATAAACCGTACTGTTGCGACCATTGCGACTACAAATCTTACCAATTGGGTAATTTAAGGAGCCACATACGGACTCACACTGGTGAAAAACCTTTTAGCTGTAATCATTGTAACTTTAGAAGTGCTACAGGCGGCGAATTAAAGGTCCACAGGAGAACTCACACTACGGGCAAGCACAAGCCTTTTGCCTGTAAGCTCTGTGACTATAAATGTAGGACCACAAAAACACTGAATAATCACATGAGAATTCATACTGACGGAAAACCATTTTTCTGTAACCTGTGTGATTATAAATCTGCTCAAGCAAGGGATTTGAAAACCCACATGAAGAGCCACACTGGTTAG
Protein Sequence
MRLEAIPSVINDTGQSDLNQNPSNVDRQTEIDTVPRVTDNVGKTNEKAEKSKMVVEDGSFKQEPLGTESCHNTHDSLFDVIKDENSLQKEHQSGCHVDTPATTDVSVGDVSLAHNMNIHIKPEPSQAEVSLPVDHDLTLDAISAKENTMEDSKMNEGFSVKQNRFNPRIQQRLIKWTAAVKRKMDREDSAQGGSPTDDTFFACDNCQYKTVYKRALAIHMKSHTDIKPFACNFCDYKCSTATHLKSHMSTHPNYKPFTCKECNMEFTCASYLKQHAPIHSDDILFSCDQCSYKTTKKGYILRHIKFHTKPLFYCDHCSYKNFSKCNLERHMRIHTGRKPFSCKLCNYKGRLAVSVRSHMTTHTGEKPWSCKYCSYKCTTSSYLKTHMTTHTGSRDYVCEICNSKFSRANSLKIHIKKLHTHLKLFHCDHCKYKTTKKGLIRRHMTRHTVKPIFYCDFCSYKDLDKGRLERHIRIHTGEKPYSCKLCDYKGALPNSLKSHMKTHTGEKPWSCKYCDYKCSQLSALKTHMMIHTGEKPFACKYCPYKCTTGGPLKIHMRTHTGEKPYSCKYCDYKCSVACSLKTHLRSHSGEKPYRCEHCPFRTSTPGALKTHTRTHTGEKPYSCKFCDYKCSQNVHLKAHTRIHTGFKPFACKHCDYKSSTSSGLKIHMVTHSTDKPFYCKHCTFKCALAANLKIHMRTHTGEQPFSCNLCDYKSATSGQLKSHTLTHTGEKPYHCDHCNHKSSHKSSLKTHLRTHTGERPYSCKLCHYTCLQASYLVTHMQTHTKEKPFSCTLCNYKCARNTTLTIHMRTHTGEKPHSCELCDYKGSTKSAVKAHMVTHSSEKPFSCEHCDYKCSTSTGLKSHTTTHTGLKPHTCKVCNTKFTRPYSLKLHMRTHTNDKPYCCDHCDYKSYQLGNLRSHIRTHTGEKPFSCNHCNFRSATGGELKVHRRTHTTGKHKPFACKLCDYKCRTTKTLNNHMRIHTDGKPFFCNLCDYKSAQARDLKTHMKSHTG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-