Basic Information

Gene Symbol
-
Assembly
GCA_905333055.1
Location
HG995236.1:5144924-5159416[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 25 0.0069 0.32 11.9 3.0 1 23 296 318 296 318 0.98
2 25 3.3e-05 0.0015 19.2 3.5 1 23 510 532 510 532 0.98
3 25 0.0017 0.076 13.9 4.6 1 23 538 560 538 560 0.99
4 25 2.7e-05 0.0012 19.5 3.9 1 23 566 588 566 588 0.99
5 25 0.00092 0.043 14.7 2.2 1 23 594 616 594 616 0.98
6 25 7.1e-05 0.0033 18.2 3.7 1 23 622 644 622 644 0.99
7 25 0.00092 0.043 14.7 2.2 1 23 650 672 650 672 0.98
8 25 7.1e-05 0.0033 18.2 3.7 1 23 678 700 678 700 0.99
9 25 1.9e-05 0.00088 20.0 2.4 1 23 706 728 706 728 0.99
10 25 6.7e-05 0.0031 18.2 3.8 1 23 734 756 734 756 0.98
11 25 0.00092 0.043 14.7 2.2 1 23 762 784 762 784 0.98
12 25 7.1e-05 0.0033 18.2 3.7 1 23 790 812 790 812 0.99
13 25 0.00092 0.043 14.7 2.2 1 23 818 840 818 840 0.98
14 25 4e-05 0.0018 19.0 3.7 1 23 846 868 846 868 0.99
15 25 1.9e-05 0.00088 20.0 2.4 1 23 874 896 874 896 0.99
16 25 9.1e-05 0.0042 17.8 5.2 1 23 902 924 902 924 0.97
17 25 0.00015 0.0068 17.2 2.2 1 23 930 952 930 952 0.98
18 25 4.2e-05 0.0019 18.9 5.1 1 23 958 980 958 980 0.99
19 25 0.00019 0.0089 16.8 3.2 1 23 1148 1170 1148 1170 0.98
20 25 0.55 25 5.9 0.6 6 23 1181 1198 1179 1198 0.86
21 25 5.7e-07 2.6e-05 24.8 1.8 1 23 1204 1226 1204 1226 0.99
22 25 0.0021 0.098 13.5 2.3 1 23 1232 1254 1232 1254 0.98
23 25 8.6e-05 0.004 17.9 5.2 1 23 1260 1282 1260 1282 0.99
24 25 0.0019 0.087 13.7 3.0 1 23 1288 1310 1288 1310 0.98
25 25 7.1e-05 0.0033 18.2 1.6 1 23 1316 1338 1316 1338 0.98

Sequence Information

Coding Sequence
ATGCGTTGTTGTGTGCCATTCTGCACAAATACTCCCACCAATGTGTCAACATCTGAGTCGAAGGGGATCAGTTTTCACGCTCTCCCCAGTGATGTGCGTCTGCGCGCTGCTTGGCTCAGAGCCCTCGGCAAACAAGACAGTCAGCTACCAGACTCTGCTGTGGTCTGCTCCCAGCATTTTCTTGATGATGAAATGTATGAAACAGAAAGTGGCTTAAGGCAGATTGCTACTGGTGCTGTTCCTTCAACAGTGCAGGTTTGCATGATATGTCTAAACACTGACAACAAGCTGTATCTAATGAGTAAACACAAATTGGAAGAAGCATATGAGCGGTTAACCGGATATCCATTGTATGATCAAGGAAACCTGAAACGAACACTTTGTGTACAATGTGCTCAGAGACTAATAAACTTTAGTAGATTCAGAGACAAGAGCTTGAGAGCCCGTGCACTGATGATGGACTTAGTTGAAAAACATGAATTAATAACACGGCGACATATCAAAGGGATAAACCGCACAAAGAACCAACTAAAGAGTAATTTTGTGATGAAAACTCTAGGACCTGACCACTGTGACTTATACATACTGGACTCCTCAGACAAACAGACAGAATCAGAGCCAATCGGCTATAGTGCTGTTGTGAAGAATGAAGAAAGTTTTGACTCGCCAATTGATGAAGACATGGAAGTGGCAGAGGAAGATGACAATACTGCAGATAATGTCAATGATGAGTTGGTTGCATTTAACGAGGAGTGCTTCTCTGACGATAGCATAATGTTGGAAACAAAACTGCTGGATGATGTTATTTGCAAAGCTCTGGAGAACCCAGTATTTGCAGAACAAGTGGCTGAAATACCGGATTTGTTGAAGTGTGAAAGTGCTGCCTTCCAATGTACTTTATGTTCTGAGGAGTTTGTTAGTGAACATGCGTACATGCAACATATGCACATGCATGACCAGCAGAACAGTGACGGAAATGCTGACTGTAGCACGTCTCAAGTATGCAAGCCTCATACAGCCGTGAGCTCCTCACACTCTCCATGCCTCACTGAGAACAAGCAGGCCATTCCTCTGAGCCAGGCCTCGAGCCTGTCTGCACACAGCCCGTCTGCACACTCACCTCAAACTGCAGTCGCTCCTCTGTCCGCGAGACTTGCGACGAGTAACGGAAACAAAGTGCAAGCTGAAGACGCCGATACAGTCCAGAAGAGTGAACCACTATTTAAAATTAACAATGTCGGATTAAACAACCAACTATTCGATACCAACAATATAACTGACATTAATAGATTGACTGATTGTGTGGTCATATTATATGATATTTTCAAAAAGCCCGAAGTAGGTGTACCAATACAAGGTGAATCACTGGCGACAATGAGACCAAGTATTAGTTCTTGGGACAGTCAGCGTCCAGTTACTAACAAACTGAAAGTTACTGAGCTTAATGCTACGAAAACTTCACAAAGTAAAACTTATTGTTCAAATAATTACAACAGTGAAGATAGTTTGCTTACTGAAAAGAATGGGTATATTTGTGATGTATGTAGACATAAGTTTAAACGGAAAAGTCTCTTAGTTAAACACATAAAGACTCACAGTGAAGTAGAACCGTTCACTTGCAAGTATTGCCAATTCAAAGCTATATATAAATTTAGTTTAAAGAAACATATGCGAACTCACACGGCTGACAAACCATTTACTTGCGAGTTATGCGACTACAAATGTAAACAAAGTAGAGATCTAGTGCGACACATGAGAACTCACACGGGTGAAAAACCTTTTACTTGCGAGTTATGCGATTACAAATGTGCACTTAAGTCTAATCTGGCGAGGCACAAAATAACTCACACGGGTGAAAAACCTTACGTTTGTAAGTTATGTGATCATAAATTTGCACTATCAAGTCATTTAGTGAGACACATGAGTACTCACACGGGTGAAAAACCTTTTACTTGCGAGTTATGCGATTACAAATGTGCACTTAAGTCTAATCTGGCGAGGCACAAAATAACTCACACGGGTGAAAAACCTTATGTTTGTAAGTTATGTGATCACAAATTTGCACTATCAAGTCATTTAGTGAGACACATGAGTACTCACACGGGTGAAAAACCTTTTACTTGCGAGTTATGCGACTACAAATGTGCACAAAATAGTAGTTTAGTGCAGCACATGAGAACTCACACGGGTGAAAAACCTTACGTTTGTAAGTTATGTGATCATAAATTTTCACTATCAAGTCATTTAGTGAGACACATGAGTATTCACACGGGTGAAAAACCTTTTACTTGCGAGTTATGCGATTACAAATGTGCACTTAAGTCTAATCTGGCGAGGCACAAAATAACTCACACGGGTGAAAAACCTTACGTTTGTAAGTTATGTGATCATAAATTTGCACTATCAAGTCATTTAGTGAGACACATGAGTACTCACACGGGTGAAAAACCTTTTACTTGCGAGTTATGCGATTACAAATGTGCACTTAAGTCTAATCTGGCGAGGCACAAAATAACTCACACAGGTGAAAAACCTTACGTTTGTAAGTTATGTGATCATAAATTTGCACTATCAAGTCATTTAGTGAGCCACATGAGAACTCACACGGGTGAAAAACCTTTTACTTGCGAGTTATGCGACTACAAATGTGCACAAAATAGTAGTTTAGTGCAACACATGAGAACTCACACGGGTGAAAAACCTCACATTTGTAAGTTATGTGATCATAAATTTGCACAAGCTAGTCATTTAGTGAGACACATGAGTACTCACACGGGTGAGAAACCTTTTACTTGCGAGTTATGCGACTACAAATGTGCACAAAATAGTAGTTTAGTGCAACACATGACAACTCACACTGGTGACAAACCTTTTACTTGCGAGTTATGCGACTACAAATGTGCATATTCTAGTCATTTAGTGCGACACATGAGAACTCACACGGGTGAAAAACCTTACATTTTCGCTCCTCTGTCCGCGAGACTTGCGACGAATAACGGAAACAAATTGCAAGCTGAAGACGCCGATACAGTCCAGAAGAGAAAACAACTACTTAAAATTAACAATGTCGAATTAAACAACCAATTATTCGATACCAACAATATAAGTAACAGTAATAGATTAACAGATTGTGTGGTCATATTATATGATATTTTCAAAAAGCCTGAAGAAGGTGTACCAATACAAGGTGAATCACTGGCGACAATGCGACCAAGTGTTAGTTCTTGGAACAGTCAGTGTCATATTGAAAAGGCCTCTAAAGATTTTAACTGTCAGGCAGTTACTTGGAATGAAGCCACTAGACATACGATAGGAGACATTCAACCAGCTACTAACAAACTGAAAGTTACTGAGCTTAATGCTACGAAAACTTCACAAAGTAAAACTTATTTTTCAAATAATTACAACAGTGAAGATAGTTTGCTTACTGACAAGAATGGGTATATTTGTGATGTATGTAGACATAAGTTTAAACGGAAAAGTGTCTTAGTTAAACACATAAAGACTCACAGTGAAGTGAAACCGTTCACTCGCGAGTTTTGCCAATTCAAAGCTATATATAAATTTAGTTTAAAGAAACATATGCAAACTCACACGGCTGACAAACCATTTACTTGCGAGTTATGCGACTACAAATTTACACAAAGTAGAGATCTAGTGCGACACATGAGAACTCACACGGGTGAAAAACCTTTTACTTGCGAGATTTGCGATTACAAATGTGCACTTAAGTTTAATCTGGCGAGGCACAAAATAACTCACACGGGTGAAAAACCTTTTACTTGCGAGTTATGCGACTACAAATGTGCACACAGTAGTAAACTAGTGCGACACATGAGAACTCACACGGGTGAAAAACCTTTTACTTGCGAGTTTTGCGATTACAAATGTGCACTTAAGTCTAATCTGGCGAGGCACAAAATAACTCACACGGGTGAAAAACCTTTTAATTGCGAGTTATGTGACTACAAATGTGCACAAAATAGTAGTTTAGTGCAACACATGAGAATTCACGCGGGTGAAAAACCTTACATTTATCTCAGCCTTAGACCTGTTATGGTGGGCTGGCGATGGGGTGAGAATGATGATGATTTGGTTTGGTTAACAGACTATGTGACCCCCCGGCTGTAA
Protein Sequence
MRCCVPFCTNTPTNVSTSESKGISFHALPSDVRLRAAWLRALGKQDSQLPDSAVVCSQHFLDDEMYETESGLRQIATGAVPSTVQVCMICLNTDNKLYLMSKHKLEEAYERLTGYPLYDQGNLKRTLCVQCAQRLINFSRFRDKSLRARALMMDLVEKHELITRRHIKGINRTKNQLKSNFVMKTLGPDHCDLYILDSSDKQTESEPIGYSAVVKNEESFDSPIDEDMEVAEEDDNTADNVNDELVAFNEECFSDDSIMLETKLLDDVICKALENPVFAEQVAEIPDLLKCESAAFQCTLCSEEFVSEHAYMQHMHMHDQQNSDGNADCSTSQVCKPHTAVSSSHSPCLTENKQAIPLSQASSLSAHSPSAHSPQTAVAPLSARLATSNGNKVQAEDADTVQKSEPLFKINNVGLNNQLFDTNNITDINRLTDCVVILYDIFKKPEVGVPIQGESLATMRPSISSWDSQRPVTNKLKVTELNATKTSQSKTYCSNNYNSEDSLLTEKNGYICDVCRHKFKRKSLLVKHIKTHSEVEPFTCKYCQFKAIYKFSLKKHMRTHTADKPFTCELCDYKCKQSRDLVRHMRTHTGEKPFTCELCDYKCALKSNLARHKITHTGEKPYVCKLCDHKFALSSHLVRHMSTHTGEKPFTCELCDYKCALKSNLARHKITHTGEKPYVCKLCDHKFALSSHLVRHMSTHTGEKPFTCELCDYKCAQNSSLVQHMRTHTGEKPYVCKLCDHKFSLSSHLVRHMSIHTGEKPFTCELCDYKCALKSNLARHKITHTGEKPYVCKLCDHKFALSSHLVRHMSTHTGEKPFTCELCDYKCALKSNLARHKITHTGEKPYVCKLCDHKFALSSHLVSHMRTHTGEKPFTCELCDYKCAQNSSLVQHMRTHTGEKPHICKLCDHKFAQASHLVRHMSTHTGEKPFTCELCDYKCAQNSSLVQHMTTHTGDKPFTCELCDYKCAYSSHLVRHMRTHTGEKPYIFAPLSARLATNNGNKLQAEDADTVQKRKQLLKINNVELNNQLFDTNNISNSNRLTDCVVILYDIFKKPEEGVPIQGESLATMRPSVSSWNSQCHIEKASKDFNCQAVTWNEATRHTIGDIQPATNKLKVTELNATKTSQSKTYFSNNYNSEDSLLTDKNGYICDVCRHKFKRKSVLVKHIKTHSEVKPFTREFCQFKAIYKFSLKKHMQTHTADKPFTCELCDYKFTQSRDLVRHMRTHTGEKPFTCEICDYKCALKFNLARHKITHTGEKPFTCELCDYKCAHSSKLVRHMRTHTGEKPFTCEFCDYKCALKSNLARHKITHTGEKPFNCELCDYKCAQNSSLVQHMRIHAGEKPYIYLSLRPVMVGWRWGENDDDLVWLTDYVTPRL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00954593;
90% Identity
iTF_00954593;
80% Identity
iTF_00954593;