Basic Information

Gene Symbol
-
Assembly
GCA_905333055.1
Location
HG995233.1:2429804-2433279[+]

Transcription Factor Domain

TF Family
Runt
Domain
Runt domain
PFAM
PF00853
TF Group
Beta-Scaffold Factors
Description
The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 6 0.002 6.8 6.7 0.0 16 46 54 84 36 90 0.84
2 6 0.003 10 6.1 0.0 16 46 132 162 124 168 0.90
3 6 0.023 78 3.3 0.0 16 46 210 240 202 246 0.90
4 6 0.023 78 3.3 0.0 16 46 288 318 280 324 0.90
5 6 0.024 80 3.2 0.0 16 46 366 396 358 401 0.90
6 6 0.0026 8.8 6.3 0.0 16 46 450 480 443 486 0.90

Sequence Information

Coding Sequence
ATGGAGACTCAAGAAACAAAAAGTAACAGCATGATAAACAAACAGCCGAAACCTCTGGAAATAGCAATTTTTTCGTTCTCTTGTGAAGTTGCTAAATTAAAAAAAAACACTACTACAGGTAAATACTCGGACGAGTTCACGTTTACGAAGAAGCCGGACGGAAGCACGGAGTACGCGTGCAAGCACTGCCCGAGCGTGTTCCGAAGCAACAACAGCTACGTGCAGCACTACCGCCAGGTGCACCTGAAGGAGCGGCCCAAGCTGCGTGCATGCCACCTGTGCGACGTCAAAGTGCCAGGTGCACCTGAAGGAGCGGCCCAAGCTGCGTGCATGCCACCTGTGCGACGTCAAAGTGCCAGGTATATAAAATTCACGTTTACGAAGAAGCCGGACGGAAGCACGGAGTACGCGTGCAAGCACTGCCCGAGCGTGTTCCGAAGCAACAACAGCTACGTGCAGCACTACCGCCAGGTGCACCTGAAGGAGCGGCCCAAGCTGCGTGCATGCCACCTGTGCGACGTCAAAGTGCCAGGTGCACCTGAAGGAGCGGCCCAAGCTGCGTGCATGCCACCTGTGCGACGTCAAAGTGCCAGGTATATAAAATTCACGTTTACGAAGAAGCCGGACGGAAGCACGGAGTACGCGTGCAAGTACTGCCAGAGCGTTTTTCGAAGCAACAACAGCTACGTGCAACACTACCGCCAGGTGCACCTGAAGGAGCGGCCCAAGCTGCGTGCATGCCACCTGTGCGACGTCAAAGTGCCAGGTGCACCTGAAGGAGCGGCCCAAGCTGCGTGCATGCCACCTGTGCGACGTCAAAGTGCCAGGTATATAAAATTCACGTTTACGAAGAAGCCGGACGGAAGCACGGAGTACGCGTGCAAGTACTGCCAGAGCGTTTTTCGAAGCAACAACAGCTACGTGCAACACTACCGCCAGGTGCACCTGAAGGAGCGGCCCAAGCTGCGTGCATGCCACCTGTGCGACGTCAAAGTGCCAGGTGCACCTGAAGGAGCGGCCCAAGCTGCGTGCATGCCACCTGTGCGACGTCAAAGTGCCAGGTATATAAAATTCACGTTTACGAAGAAGCCGGACGGAAGCACGGAGTACGCGTGCAAGTACTGCCAGAGCGTTTTTCGAAGCAACAACAGCTACGTGCAACACTACCGCCAGGTGCACCTGAAAGAGCGGCCCAAGCTGCGTGCCTGCCACTTGTGCGACGTCAAAGTGCCAGGTGAGCTCCACAGTGACTACAGCTACGGTTTTTATTATTTACTAGTTGATGCCCGCAGCTTTGCCCGCATGGATTTAGGTTTTTTAAAATTCACGTTAATGAAGAAGCCGGACGGAAGCACGCAGTACGCGTGCAAGCACTGCCCGAGCGTGTTCCGAAGCAACAACAGCTACGTGCAACACTACCGCCAGGTGCACCTCAAGGAGCGGCCCAAGCTGCGTGCATGCCACCTGTGCGACGTCAAAGTGCCAGGTGAGCTCCACAGTGACTACAGCTACGGTTTTTATTATTTACTACACTAG
Protein Sequence
METQETKSNSMINKQPKPLEIAIFSFSCEVAKLKKNTTTGKYSDEFTFTKKPDGSTEYACKHCPSVFRSNNSYVQHYRQVHLKERPKLRACHLCDVKVPGAPEGAAQAACMPPVRRQSARYIKFTFTKKPDGSTEYACKHCPSVFRSNNSYVQHYRQVHLKERPKLRACHLCDVKVPGAPEGAAQAACMPPVRRQSARYIKFTFTKKPDGSTEYACKYCQSVFRSNNSYVQHYRQVHLKERPKLRACHLCDVKVPGAPEGAAQAACMPPVRRQSARYIKFTFTKKPDGSTEYACKYCQSVFRSNNSYVQHYRQVHLKERPKLRACHLCDVKVPGAPEGAAQAACMPPVRRQSARYIKFTFTKKPDGSTEYACKYCQSVFRSNNSYVQHYRQVHLKERPKLRACHLCDVKVPGELHSDYSYGFYYLLVDARSFARMDLGFLKFTLMKKPDGSTQYACKHCPSVFRSNNSYVQHYRQVHLKERPKLRACHLCDVKVPGELHSDYSYGFYYLLH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00955241;
90% Identity
iTF_00955241;
80% Identity
iTF_00955241;