Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 2.3e-05 0.031 18.7 0.8 1 23 79 101 79 101 0.97

2 7 7.5 1e+04 1.4 1.1 1 9 107 115 107 126 0.78

3 7 0.7 9.2e+02 4.6 2.7 1 13 130 142 130 144 0.87

4 7 0.0081 11 10.7 1.1 2 23 183 203 183 203 0.85

5 7 8.1e-05 0.11 17.0 0.8 1 23 209 231 209 231 0.96

6 7 0.089 1.2e+02 7.4 0.5 1 23 242 265 242 265 0.92

7 7 6.7e-05 0.089 17.2 2.8 1 20 269 288 269 290 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	2.3e-05	0.031	18.7	0.8	1	23	79	101	79	101	0.97
2	7	7.5	1e+04	1.4	1.1	1	9	107	115	107	126	0.78
3	7	0.7	9.2e+02	4.6	2.7	1	13	130	142	130	144	0.87
4	7	0.0081	11	10.7	1.1	2	23	183	203	183	203	0.85
5	7	8.1e-05	0.11	17.0	0.8	1	23	209	231	209	231	0.96
6	7	0.089	1.2e+02	7.4	0.5	1	23	242	265	242	265	0.92
7	7	6.7e-05	0.089	17.2	2.8	1	20	269	288	269	290	0.92

Coding Sequence: ATGTCCACTGATACAAGTATTTGTACAAATGAGGTTGTAATTAAAGAAATATATGACATAAATGACGAAAATGACTCTGTTAGTGATACAACAGATTCGCTGAGTGTATCGGAGTTACCGAGACTGAAGAAAGCGTATGAGAAAGAATCTGGTGAAAACAAGTTTGACATACAAAACAAATCTGTTAATGTGTCAGTTTCTGTATCAAACCATAAAACAACCGACGTTAATAAGTATAAGTGTGATAAATGTAATATGGCGTTCGCAACACGTGTATTATTGACAAGTCACAGATTCATTCATAGAGATTTTCAAACGTACCAATGTGATGTATGCGAATACATTGCGTCTTATCtgttgttaaaacacaaaaagtatAGCAAGAAATACCATTGTACTGTATGTAATAAGGATTTCGAAAGTGCATGTCATTCGTTAAAACAAAAGTCAGATGATTGTGAAGAAAAACAGGACTCAAGTAAACGCAAGTTAAATGATTGTGGAAAAAAACGAAACCGAAGTAAGGAGAAGCAGTGTAAGACGAGGCAATGTGATATATGCAAGAAGACTTTTTCCAGAGGTTATTTACCTACACACAAATTAACTCACAGTGATACTAAAAACTTCAAGTGTAATGTTTGTGATAAGGCATTTAATCAGTTTCGTGGTTTGGCACTCCATAAATTTGTTCATACTGATATCGGAAAACGTCTTACGAGATATTATCAGTGTGATGTATGTAGTGATATTTTCAAAAGCGAATATGAGAGGCGGGTACACAAATTAGAATCCCACACAAAGCACCACATATGTAACGTATGCGGCAAGAGTTTCACTAcatattttcatttccaagaacaCAAGTTGTCGGTGCCCGGGTGTAACACCAGTGAATTTCCAGTTGTAATACTTAGTGTTATAACACCTGTCCACAGTGTAATAACCTCTGGAAAGTAA
Protein Sequence: MSTDTSICTNEVVIKEIYDINDENDSVSDTTDSLSVSELPRLKKAYEKESGENKFDIQNKSVNVSVSVSNHKTTDVNKYKCDKCNMAFATRVLLTSHRFIHRDFQTYQCDVCEYIASYLLLKHKKYSKKYHCTVCNKDFESACHSLKQKSDDCEEKQDSSKRKLNDCGKKRNRSKEKQCKTRQCDICKKTFSRGYLPTHKLTHSDTKNFKCNVCDKAFNQFRGLALHKFVHTDIGKRLTRYYQCDVCSDIFKSEYERRVHKLESHTKHHICNVCGKSFTTYFHFQEHKLSVPGCNTSEFPVVILSVITPVHSVITSGK

Sequence clustering based on sequence similarity using MMseqs2