Basic Information

Insect: Magicicada septendecula
Gene Symbol: -
Assembly: GCA_034769895.1
Location: CM068371.1:459945174-459956166[+]

Transcription Factor Domain

TF Family: ETS
Domain: Ets domain
PFAM: PF00178
TF Group: Helix-turn-helix
Description: Transcription factors are protein molecules that bind to specific DNA sequences in the genome, resulting in the induction or inhibition of gene transcription [3]. The ets oncogene is such a factor, possessing a region of 85-90 amino acids known as the ETS (erythroblast transformation specific) domain [3, 5, 4]. This domain is rich in positively-charged and aromatic residues, and binds to purine-rich segments of DNA. The ETS domain has been identified in other transcription factors such as PU.1, human erg, human elf-1, human elk-1, GA binding protein, and a number of others [3, 5, 2]. It is generally localized at the C terminus of the protein, with the exception of ELF-1, ELK-1, ELK-3, ELK-4 and ERF where it is found at the N terminus. NMR-analysis of the structure of the Ets domains revealed that it contains three α-helices (1-3) and four-stranded β-sheets (1-4) arranged in the order α1-β1-β2-α2-α3-β3-β4 forming a winged helix-turn-helix (wHTH) topology [1]. The third α-helix is responsive to contact to the major groove of the DNA. Different members of the Ets family proteins display distinct DNA binding specificities. The Ets domains and the flanking amino acid sequences of the proteins influence the binding affinity, and the alteration of a single amino acid in the Ets domain can change its DNA binding specificities.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.59 1.9e+04 0.1 0.0 42 61 164 183 163 194 0.87

2 9 0.028 9e+02 4.3 0.0 31 61 181 213 173 214 0.86

3 9 0.032 1e+03 4.1 0.0 32 61 212 243 209 245 0.86

4 9 0.03 9.6e+02 4.2 0.0 32 61 242 273 235 274 0.86

5 9 0.029 9.2e+02 4.3 0.0 32 61 272 303 270 313 0.85

6 9 0.11 3.4e+03 2.5 0.0 32 61 302 333 294 344 0.82

7 9 0.1 3.3e+03 2.5 0.0 32 61 332 363 324 379 0.80

8 9 0.22 7e+03 1.5 0.0 31 60 361 392 353 395 0.80

9 9 0.01 3.3e+02 5.7 0.0 31 61 391 423 383 436 0.83

#	of	c-Evalue	i-Evalue	score	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.59	1.9e+04	0.1	42	61	164	183	163	194	0.87
2	9	0.028	9e+02	4.3	31	61	181	213	173	214	0.86
3	9	0.032	1e+03	4.1	32	61	212	243	209	245	0.86
4	9	0.03	9.6e+02	4.2	32	61	242	273	235	274	0.86
5	9	0.029	9.2e+02	4.3	32	61	272	303	270	313	0.85
6	9	0.11	3.4e+03	2.5	32	61	302	333	294	344	0.82
7	9	0.1	3.3e+03	2.5	32	61	332	363	324	379	0.80
8	9	0.22	7e+03	1.5	31	60	361	392	353	395	0.80
9	9	0.01	3.3e+02	5.7	31	61	391	423	383	436	0.83

Sequence Information

Coding Sequence: ATGCCTCGACCGAAATCTTCACGCCGATTAGGAAGAGGAATAGCTGTGAGAAGCCAAAGTAAATGTATCATAAAGAACGTGTTTAATAAGATTAACGGAGAAAATCCGGAGCAGCGCATGGGAAACTCGTGTGTTCGTCGACTGAAACGCTTCACGCCGGGCGATTTGGTAATCAGATGGCACCCAACGTGGGACCCAGGTCATCGAGCGGACGGCAGATGCAGCCACATCGACAAGCTACGACCCGGTCCACAGCACTATATGTCGCTTAGCCACTACAACCAGCGGGACACAGCAGAGCGATATATAACGCAATTCGTAGTAGCCCTGCGGTCTACGCTGACACCGGTGATCACCGTCACACACCACGGCCTCAAGTACAAAGACCCGAAGCGCCATCTGCAACAGTTGGAGCTACAGCCGTTGTACTTACAGAGTTCCACTAGATCAGTTGGAAGACTACGCACTGCGACAGCTCCGAGGGGAAGCGGCAAACGGAAAAGTAAACAGAGAGGTACTGCAGATCAACTGGCACGAGTTTTGCGGGACACAGATTTGCTGGCCGAGGTATACGGACAAACACAGCGGCAAAGTAAACAGAGAGGTACTGCAGATCAACTGGCACGAGTTTTGCGGGACACAGATTTGCTGGCCGAGGTATACGGACAAACACAGCGGCAAAGTAAACAGAGAGGTACTGCAGATCAACTGGCACGAGTTTTGCGGGACACAGATTTGCTGGCCGAGGTATACGGACAAACACAGCGGCAAAGTAAACAGAGAGGTACTGCAGATCAACTGGCACGAGTTTTGCGGGACACAGATTTGCTGGCCGAGATATACGGACAAACACAGCGGCAAAGTAAACAGAGAGGTACTGCAGATCAACTGGCACGAGTTTTGCGGGACACAGATTTGCTGGCCGAGGTACACGGACAAACACAGCGGCAAAGTAAACAGAGAGGTACTGCAGATCAACTGGCACGAGTTTTGCGGGACACAGATTTGCTGGCCGAGGTACACGGACAAACACAGCGGCAAAGTAAACAGAGAGGTACTGCAGATCAACTGGCACGAGTTTTGCGGGACACAGATTTGCTGGCCGAGGTATACGGACAAACACAGCGGCAAAGTAAACAGAGAGGTACTGCAGATCAACTGGCACAAATTTTGCGGGACACAGATTTGCTGGCCGAGGTATACGGACAAACACAGCGGAAAAGTAAACAGAGAGGTACTGCAGATCAACTGGCACGAATTTTGCGGGACACAGATTTGCTGGCCGATGTATACGGACAAACACTGCGGCAGAGCTGCAGTGACGGTAGAGCTGTTTCTTCTAAGGAAAACAAACCTGCTTCGCGACTGTGCTCGTGA
Protein Sequence: MPRPKSSRRLGRGIAVRSQSKCIIKNVFNKINGENPEQRMGNSCVRRLKRFTPGDLVIRWHPTWDPGHRADGRCSHIDKLRPGPQHYMSLSHYNQRDTAERYITQFVVALRSTLTPVITVTHHGLKYKDPKRHLQQLELQPLYLQSSTRSVGRLRTATAPRGSGKRKSKQRGTADQLARVLRDTDLLAEVYGQTQRQSKQRGTADQLARVLRDTDLLAEVYGQTQRQSKQRGTADQLARVLRDTDLLAEVYGQTQRQSKQRGTADQLARVLRDTDLLAEIYGQTQRQSKQRGTADQLARVLRDTDLLAEVHGQTQRQSKQRGTADQLARVLRDTDLLAEVHGQTQRQSKQRGTADQLARVLRDTDLLAEVYGQTQRQSKQRGTADQLAQILRDTDLLAEVYGQTQRKSKQRGTADQLARILRDTDLLADVYGQTLRQSCSDGRAVSSKENKPASRLCS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -