Basic Information

Gene Symbol
-
Assembly
GCA_036365455.1
Location
JAWQUS010000020.1:5017154-5025074[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.00061 0.051 14.8 5.3 2 23 157 178 156 178 0.97
2 12 0.0017 0.14 13.4 0.5 1 23 185 208 185 208 0.93
3 12 0.00055 0.046 14.9 0.2 3 23 234 254 232 254 0.97
4 12 0.00069 0.057 14.6 1.9 3 20 263 280 261 283 0.92
5 12 7.2e-07 6e-05 24.0 1.7 1 23 289 311 289 311 0.99
6 12 8.5e-07 7.1e-05 23.8 3.2 1 23 317 339 317 339 0.96
7 12 9.6e-08 8e-06 26.8 1.4 1 23 345 367 345 367 0.96
8 12 1.6e-05 0.0013 19.8 0.3 1 23 373 395 373 395 0.97
9 12 2.2e-05 0.0018 19.4 1.7 1 23 401 423 401 423 0.98
10 12 0.028 2.4 9.6 6.9 1 23 429 451 429 451 0.98
11 12 2e-06 0.00017 22.6 0.7 1 23 457 479 457 479 0.99
12 12 0.00033 0.028 15.6 1.4 1 23 485 507 485 507 0.95

Sequence Information

Coding Sequence
atgACCAGTGCGTTAGGTTGTAAAAACTTCGAAACCTGTTGCCGGACTTGTATGAATGATACTTCTATAAAAATGTATGATATTTTTGCTGAAATCGAAGACTCACTGAGTCTAGCTAATATTTTAGTCTCATGCACGAATATAAACATACTCAAAGACGATACATTACCAAAGAAAATATGTGGCAGCTGCTACAATTGTCTAATGAGTTTTCACGATTTCCGCAAGTTGGCTGAAAAAGTGGATTTGCAGATAAGAGTGGATCTAAATAACATTGGATCAGATGATCACATGTCCGAGTCAGACAAAGAAGCATTTGATATCAAAAGTGAGGTCTGCGTGCATATAGATGATACATTTCTAAgagacattgatgttaaatctGAACAATTTGATATAAACGATAACACACAATCCTGCGATGATATTTCTGAATCAAAATCACTAGAagatgtaaaatataatttgacctGTGATATTTGtgataagaaatttaaaaaactttcaaaatatAGTCATCATAGACAAAAACATGAAgctgaaaaaaacatttttatgtgtaaattGTGTCCGCAGACATTTAGCCAAGTAGTGAAGTACACACAACATATAATAGACTCGCATACTGAGGAAAATAAGTGCTTATCAAAAAGTATTGAAAGAGATGTGAGTGATGCAAAGGCGATGGAAGAAGTAATATGTAGTGTATGTTCTGCTAGTTATAAATCAGTCAATTCTCTTTCTGCGCATATGCGGAAGCACACAGACAAAGCCAGAGTGCTAGCATGTGGTATATGCAATAAAGTTTTTGCAAAAGTTAGCCATTTAAAAAGACATGAACTGTGTCATGAAGATAACCGTCCATTCAAATGTTCTCAATGCACAAAATCGTTTGCAACTGAAAGTTTATTAACTGATCATATGAACAAACACAATGGATTGAAGCCTCATGCTTGTCCGGTTTGTACAAAATCATTTTCCCATTCTTCAACATTGACGTCCCATCTGAGAATACATACAAGAGAAAAGCCATTTCTGTGTCCAACTTGTGGAAAGAGGTTTGATTCTAGTACGAATTTGAATCAGCATATGAGAAGGCATGCAGGATTAAAAACATTCTCGTGTGACTTATGCCCGAGATCTTTTGTAAGCAAAGGAGAACTCAAATCCCACAGCATAACACATACGGGCGAGCGTTTGTACACTTGTGACCAATGCGGCAGCTCGTTCACGAAACGCAGCTCGCTTGTGAAACACAAGCTATCTCATCTCGGGCTGAGGCCGCATCAATGCGACGCTTGCCCCATGAAATTTTTAAGCAAGCACCACCTAAAGCGCCACTACCGCATCCACACGGGCGAGAAGCCGTATCGCTGCGACTTGTGCGAGCGAGCCTTCACGCAGAGCAACGATCTGGTCAAACACCGCCGGGTGCATCTTGGTGATAAACTTTACAAGTGCGACCAATGTACACAAAGTTTTCGTTTGAAGACCGAGCTCAGGCAGCACGCGTCGGAGCACTTCATATCTTCCCAACTGGAGGCGTTACGGATGACGACCAAACCAAATGAGGTGGCAGGAAATAATGTAGTCAAGGTGCTAAGCGATGTGGGAAACTGCGGAGTAGAAAGGAAAGATGTCGGTATGAGTGGCGAAAATTGTGTTAATATGAATGCAAACAATGTAAAGCTAACTTAG
Protein Sequence
MTSALGCKNFETCCRTCMNDTSIKMYDIFAEIEDSLSLANILVSCTNINILKDDTLPKKICGSCYNCLMSFHDFRKLAEKVDLQIRVDLNNIGSDDHMSESDKEAFDIKSEVCVHIDDTFLRDIDVKSEQFDINDNTQSCDDISESKSLEDVKYNLTCDICDKKFKKLSKYSHHRQKHEAEKNIFMCKLCPQTFSQVVKYTQHIIDSHTEENKCLSKSIERDVSDAKAMEEVICSVCSASYKSVNSLSAHMRKHTDKARVLACGICNKVFAKVSHLKRHELCHEDNRPFKCSQCTKSFATESLLTDHMNKHNGLKPHACPVCTKSFSHSSTLTSHLRIHTREKPFLCPTCGKRFDSSTNLNQHMRRHAGLKTFSCDLCPRSFVSKGELKSHSITHTGERLYTCDQCGSSFTKRSSLVKHKLSHLGLRPHQCDACPMKFLSKHHLKRHYRIHTGEKPYRCDLCERAFTQSNDLVKHRRVHLGDKLYKCDQCTQSFRLKTELRQHASEHFISSQLEALRMTTKPNEVAGNNVVKVLSDVGNCGVERKDVGMSGENCVNMNANNVKLT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-