Basic Information

Gene Symbol
RREB1
Assembly
GCA_002156465.1
Location
MVJL01009288.1:7609-32454[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.00041 0.057 14.0 0.2 1 23 110 132 110 132 0.98
2 16 2.1e-05 0.0029 18.1 0.7 1 23 145 167 145 167 0.97
3 16 2.9e-06 0.00039 20.8 3.1 1 23 173 196 173 196 0.98
4 16 2.2 3e+02 2.3 0.0 3 23 288 310 286 310 0.92
5 16 0.0014 0.19 12.4 0.5 2 23 316 338 315 338 0.93
6 16 3.5 4.7e+02 1.7 0.7 1 19 387 405 387 407 0.79
7 16 0.14 19 6.1 0.9 1 23 518 540 518 540 0.97
8 16 0.28 39 5.1 0.3 1 23 549 571 549 571 0.96
9 16 0.0002 0.027 15.0 2.5 1 23 577 600 577 600 0.97
10 16 4.1e-05 0.0056 17.2 1.3 1 23 948 971 948 971 0.97
11 16 0.00011 0.015 15.8 0.6 3 23 1224 1244 1223 1244 0.99
12 16 0.03 4 8.2 3.7 1 23 1250 1273 1250 1273 0.97
13 16 0.048 6.5 7.5 1.4 1 23 1308 1332 1308 1332 0.93
14 16 3.7 5.1e+02 1.6 5.0 1 23 1418 1441 1418 1441 0.90
15 16 0.0065 0.89 10.3 0.4 2 23 1487 1508 1486 1508 0.94
16 16 0.0015 0.21 12.2 5.3 1 23 1514 1536 1514 1536 0.98

Sequence Information

Coding Sequence
tTTAATAAATGTGTGGGTCGACGGGAGGCTGCGCAAGCGTTGGCTGCAGCTCGCTATTGGCGTTCGGAGGCGGGCCAATCATCGATGCTACTTCCCTTCTCCTGCAGAGATGTTGCAGAGCAGGTCCAGCCTTTCTCGAggGCATCTGCATGTTGGCTCGGCTCTGCGAGCTGTCAGATCTCGTGTGGACATCGTCGAAGCAGCTTCTCAGCTGCTGTTGGATCACAAATCTTCATCGTATCAGCGGCAAAGaTGACCATTGTAAGTGAGTCGAAGCGATCCAACGAGAGAACAGCCAATGCAACGACTTCAACGgcCAAGAACGAATTCTCATGTCCAGCCTGTCCAACAGTGCTGACGACGGCTCACGAGTTGACGAATCACATCCTCAGCCACAATTCGTCGGCAAACAGTGACTGCAGTGAGGACGAGTATACCTGCGGCGTCTGTCACAAAGTTCTCAGCTCAGCAAGTTCTCTGACTCGCCACGTCTACGTGCACTCGGGCGAGAAGCCATTCAAGTGCAAATATTGCGAAATGGCATTTTCAACCAATGGAAATATGAACAGACACCACAGAACGGCTCACCGTGAGATGCGCGATTGGCCATCAATGAGTTGTACAGACTCTGACAGCAGTGACGACTCAAATAAACCAGCGAGTCGCCGTCAGGCCGACGAGTACAACAACAACGAGGTGCGGAAAAGTATTTCGCCGCAAATCGCTGAAGATTACACCAAGCGAAAGCACTCGGACGACGAGGACGACGATACGagcactcgaaaaaaatctcgtatGGTTTTAAAAGACTCGAAACCACGTGCAAAAGCGAGACTTCCGAAAACTAATTCCAATCTCGCTTGTCCCGTGTGCGAGGATCTTGTTTTCGAGGCCAACGAGCAGCTAGATGATCACCTAAAAACCTATCACTCGACGTACGTGATAAAGTGCGACATGTGCGATCGAATATTCAACTCAAATCGTATGCTAAGCGTACACAAATTCATGGAACACTATGGCAATGGTCGTGGTGCAATTGAGACGTCTGTCGAGGGTTTCAACGATCTCACATTCGTCGATTTCTCGTCAGATAAATTCCCGGCGATTGCACGCGCAATGTGCGAACAGTCGCTTCACAGACCGGCCTCAGTGCCGGCATTTGAGTGTCCCAAGTGTGCGCGAGGTTTTCCGTGCAAGCAGGCGCTCGATTCGCACAAACTTGATTGCGGCAATCAGTTAGCAGCACCGCCAGCCGATATAAAAACCGCTGACCACTCGAAgcgcaatgatttttttgccgGACTTAATTTGCAAAATCGCGCGGCAGCCGTCGAAGCCCGTGAGGGCAAAGATTTGGCCGACATTCAGAGTATTATCTCGACAGCCTCGGAACCAATCTTTCCACGTTCCGACCGCAGCACTCCGGACCAACAGATCAAGCTCAATCCCAATGTGGGATCGTCCGGGTCGTCGGGCGGCGCGTCCGAGTACCAGGAGGAAACGCAGGACGCATTTGCCGTGGAATTTCGCAAGATGAAGCTAAAGGGCGAGTTTCCATGCCGACTGTGTGACTCAAAGTTCCAGAATTTGCGCGCACTCAAAGGCCACAATCGGCAGCACCTGAATGTGCCGAGTGGCATGCCCTTTCCGTGCTCCATGTGTCCGTACCAGCATCCTGAGCGCGGTGCTCTCATGAAGCACCTACGCGATCACAACGGCGATCGGCCGTACGAGTGTTCCATCTGCAACTACGCCTTCACCACCAAGGCCAATTGCGAGCGTCACGTGCGCAATCGCCACGGCAAGCAAACGCGTGAGGAGATCAAGAGCGTTCTGATTTATCATCCAAGCGAAGACATTACGAATGAGGGTGTGGATCGAGGCACCTCACCGAGACGCATCACTCGCGATGACGCGCGACGCACGATAATCTATCCCGAGGATATGCCGTCGTCGCAGCTGCCGTTTATCGAGCCAAATGACCTGTCGCTGCCCGACGAGGGCGCAAGAATGCGTCACCGATCACTTCCCACGCTCATCAACCCACCTATAAGTCATTACGATCACACGGGTATGTTTTCTCGACCTGTTCGCGCGCAGGAAATACCCCCGCGCACCGATGCTCCCGATGAGGACGACTCCAAGTCGTCAGACGGCAGCGTTTCTCTAGTCAGCGAACGCCAGACCGAGTTACACCAAAGACTGCACAGCCCTGTGAATCTACAGCGCGTCGAGGCGACCAATGACTCGCCCCTCGACCTCTCCATGGATGTGCTAGACCTGAGTAAAAAGTCCAGACCAGCGGAGGAAGAACGCAAACCCGCTCCGAGGCTTGCAGAAGAAAATGCCAGCGCAGAAGTCATCGAGGCGGCTCAACGGTTGCTGCTAGCTCAAGCAATCATTGCCGAGGGTGCTCAGGGACGACTTGGTTCTATTTATAATAATGCTCCGCTCATGTATTCGAGTGTGGCAGCGTTTCCCGGTGCACCGTCCGCCATACAGCCGTACTTGTACAATTCACCGCTATTTAATCCAAATTTGGCGGCGCGACGCGATCGCGCGCGCGATCTCGCTCTTCATCTGACGAGTGGTGGAAGTATGATTGAGCCTACGATAGCCAGTAGCAATTTTCCGGCTGCGTATCCACAACAAATTCCTGCTCGCGCTCGCAACGATCACGCGGAATCGTTTTCCAACACTGTGGCTCACTTGCACAACTCGACGACGAGCGAGCGTGGTAGCCGCCCGCCCAGCAGCAGCAATTCCTCGGTTAAAATGGTGATTAAAAATGGAGTGCTCATGCCAAAGCAAAAACAGCGGAGATACCGCACGGAGAAGCCGTATGTCTGTGAAATTTGTGATGCAAAATTCACACTAAGAAGCAATATGGAGCGACACATCAAGCACCAGCATCCGAAGCGTTGGAGTCAGCGCCCACGTGGAGGACACTCTACTCGTGGCCGACCCCCGGCGAATCCTGCTAGTCTCgtacaaaattcatcaatgcAGCCCAATCATCAGATGAATTTTTCCCAGTTTGACCAAGTGGAGAATGACAAACCCGTCATCTCAGCTGAGGTAAAGAATGCCATTCTTGCGCAGCATTTAAAAGGCACAAAACGCGAGAACGAGTCGGAGGACGAGGGATTAATCATTGACGAGGCGGCCGGAGATAAGGCATCGCCAGTGTCCGTCAAATTGCAGCCAACTACGAGTCTACTTCGGGGAAAACTCGAAGAACACGTGAattttgatattgaaaaaaagtacgACAGTGTGCCTCAGGATTTTTCAAAGATGGAGATACGAGTGAAGACTGAACCAGAGGCGAGTGAAGATGAAGAAGACACGGGGGAAAAATTGGAGAAGAAAATAGCTGTCAATGTAAAGCAAGAGGACAATGGCGCTGACCTTGCTAGTGTGTCTGAACTGCTGGATAATGCCTCGCAACAGTACCAGCAATTTCGGCCGCAGTACATCAGCGACGAGGAGGGACTAGTGGCCTCGACGAGCGACTGTAATATCTCGGGCAGCGATGACAAGTCAGACTCTATGACTTTTGGTAATTCCGGGGATTCGAGTATTGCTGGCAAgtggaaaaagaagaaaatgacaaaaaagaagaaaaagaagatgtCAGCATACTCCATGGCACCGAATAAGGTTCTTTGCACCTACTGCGAGCGCACCTTTCCCTGGCAGTCATCGCTGCGACGACATATCCTCACGCACACCGGCCACAAGCCCTTCCAATGCGCCTTCTGCGGCCTGCTCTTCACCACCAAGTCCAACTGCGATCGGCATCTCATGCGCAAGCACCGGACCAGCCTCGGGCGCTGCCGAATGAAGCACAGCTCGTCGCCTGAGGCTACCAACACAGACAACAACAAGTTCGCCATGCGAAATGTCCCTGAGAGACCGTACAAGTGTAATCGCTGTCCGAGTTCCACCTTCTCCACGATCGGCAACCTGAAAAAACACCGTTCAGCCAAGCACTCGGGCAACAGGTCGCGCCCAGAGAGCCCCGTCAGCGACACAAACTCGGAGCAGCAGGAAAACTCGACTGTGGCGAGCAAACAGCGCGAGGACAACAGCGGAGAGGACAGTCAGTCGTCGGTTTCCGAGCCTGCGGATAATTCCGCCGTTGCTGATCTGTCCAGCAAGAACAATAGTACAATCACACCGCCTGCGGAGGCTCCGCGTTCGCGCAGACCCTCTCCACGGTCATCACCCGGGCCTGCCGACGGGCCCTTTAAGTGCCACCTGTGCGACTGCGGCTTTGCCGAGCGCCAGGACTGTCTAGATCACATAAAAGAGAGCCACGTGAAGGCGTACGAGCTGCTGATGAACAAGGGTGCTCTCGACATGGACACAGAGAACGTCGATGAGCATCCGACGCAGCCGAGCGACCCCGAGGAGAGGCGCGGCAAGTTCCCCGACTACAGCAATCGAAAGGTCGTCTGTGCCTTTTGTATGCGGCGTTTTTGGTCGGCGGAAGATCTTCGCAGACACATGCGGACACACACGGGCGAACGTCCGTACTCTTGCGACATCTGCTCGCGCCGCTTCACGCTCAAGCACAGCATGCTTCGCCACCGCAAGAAACACGAGTCCGTCGACTCGACCATGTATGTGGGAACGAGCGGAGACGAGGAAACCGTGCCTGCACAGCTGTCCAATGCAACGCGAAGTCAGCAACAGGCCGCGGCCGTCGCTGTCGCGGCTGCAGCAGCCGTTTTTAACGCCACTACAACTGGTGGTGACTCGCGCGGACAGGAGAGGATGTCTCTGCCTACTGTGGCGACTGTCGCCACTGGTGATGCAGCTCCCAGTGGGCTCATGCGCTACAATCCGTACGAAAATCTCGCCTCATTTGCCGGGCGATTAAACAATACCAATAATTATGTATCTGATGCCACTGCTGCTGATGGTGATAGcgatttaatttcaaatttgttgGGTATCGGAgatagaaatattattgaacaGGTCCTACATGGATCTCCTGATGACGCGGCGAAAATATTGGGCGTCAATCGCAGTCacgattaa
Protein Sequence
FNKCVGRREAAQALAAARYWRSEAGQSSMLLPFSCRDVAEQVQPFSRASACWLGSASCQISCGHRRSSFSAAVGSQIFIVSAAKMTIVSESKRSNERTANATTSTAKNEFSCPACPTVLTTAHELTNHILSHNSSANSDCSEDEYTCGVCHKVLSSASSLTRHVYVHSGEKPFKCKYCEMAFSTNGNMNRHHRTAHREMRDWPSMSCTDSDSSDDSNKPASRRQADEYNNNEVRKSISPQIAEDYTKRKHSDDEDDDTSTRKKSRMVLKDSKPRAKARLPKTNSNLACPVCEDLVFEANEQLDDHLKTYHSTYVIKCDMCDRIFNSNRMLSVHKFMEHYGNGRGAIETSVEGFNDLTFVDFSSDKFPAIARAMCEQSLHRPASVPAFECPKCARGFPCKQALDSHKLDCGNQLAAPPADIKTADHSKRNDFFAGLNLQNRAAAVEAREGKDLADIQSIISTASEPIFPRSDRSTPDQQIKLNPNVGSSGSSGGASEYQEETQDAFAVEFRKMKLKGEFPCRLCDSKFQNLRALKGHNRQHLNVPSGMPFPCSMCPYQHPERGALMKHLRDHNGDRPYECSICNYAFTTKANCERHVRNRHGKQTREEIKSVLIYHPSEDITNEGVDRGTSPRRITRDDARRTIIYPEDMPSSQLPFIEPNDLSLPDEGARMRHRSLPTLINPPISHYDHTGMFSRPVRAQEIPPRTDAPDEDDSKSSDGSVSLVSERQTELHQRLHSPVNLQRVEATNDSPLDLSMDVLDLSKKSRPAEEERKPAPRLAEENASAEVIEAAQRLLLAQAIIAEGAQGRLGSIYNNAPLMYSSVAAFPGAPSAIQPYLYNSPLFNPNLAARRDRARDLALHLTSGGSMIEPTIASSNFPAAYPQQIPARARNDHAESFSNTVAHLHNSTTSERGSRPPSSSNSSVKMVIKNGVLMPKQKQRRYRTEKPYVCEICDAKFTLRSNMERHIKHQHPKRWSQRPRGGHSTRGRPPANPASLVQNSSMQPNHQMNFSQFDQVENDKPVISAEVKNAILAQHLKGTKRENESEDEGLIIDEAAGDKASPVSVKLQPTTSLLRGKLEEHVNFDIEKKYDSVPQDFSKMEIRVKTEPEASEDEEDTGEKLEKKIAVNVKQEDNGADLASVSELLDNASQQYQQFRPQYISDEEGLVASTSDCNISGSDDKSDSMTFGNSGDSSIAGKWKKKKMTKKKKKKMSAYSMAPNKVLCTYCERTFPWQSSLRRHILTHTGHKPFQCAFCGLLFTTKSNCDRHLMRKHRTSLGRCRMKHSSSPEATNTDNNKFAMRNVPERPYKCNRCPSSTFSTIGNLKKHRSAKHSGNRSRPESPVSDTNSEQQENSTVASKQREDNSGEDSQSSVSEPADNSAVADLSSKNNSTITPPAEAPRSRRPSPRSSPGPADGPFKCHLCDCGFAERQDCLDHIKESHVKAYELLMNKGALDMDTENVDEHPTQPSDPEERRGKFPDYSNRKVVCAFCMRRFWSAEDLRRHMRTHTGERPYSCDICSRRFTLKHSMLRHRKKHESVDSTMYVGTSGDEETVPAQLSNATRSQQQAAAVAVAAAAAVFNATTTGGDSRGQERMSLPTVATVATGDAAPSGLMRYNPYENLASFAGRLNNTNNYVSDATAADGDSDLISNLLGIGDRNIIEQVLHGSPDDAAKILGVNRSHD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-