Basic Information

Transcription Factor Domain

TF Family: HPD
Domain: HPD domain
PFAM: PF05044
TF Group: Helix-turn-helix
Description: Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. Homologues of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here [1]. This homeo-prospero domain binds to DNA.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00023 8.3 7.2 0.1 107 139 142 174 120 176 0.80

2 6 0.00061 22 5.8 0.0 109 139 172 202 168 204 0.90

3 6 0.00051 18 6.1 0.0 109 139 200 230 194 232 0.88

4 6 0.00021 7.7 7.3 0.1 107 140 226 259 209 264 0.82

5 6 0.00028 10 7.0 0.1 107 139 254 286 238 288 0.82

6 6 0.00019 6.9 7.5 0.1 107 140 282 315 264 322 0.82

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00023	8.3	7.2	0.1	107	139	142	174	120	176	0.80
2	6	0.00061	22	5.8	0.0	109	139	172	202	168	204	0.90
3	6	0.00051	18	6.1	0.0	109	139	200	230	194	232	0.88
4	6	0.00021	7.7	7.3	0.1	107	140	226	259	209	264	0.82
5	6	0.00028	10	7.0	0.1	107	139	254	286	238	288	0.82
6	6	0.00019	6.9	7.5	0.1	107	140	282	315	264	322	0.82

Coding Sequence: ATGACGGACACGTGGGATAAGGACCAGACCTTGAAGCTTATATCATTATTGCGTTTGTGTCCGCAGTTGTACAATCCTACGGATAAAGATTTCACAAATAAAGTTAAGCGGAGTGAGAAATATAATTTTATATTAAATGGACTAAAAGATTACAAAGAAAATATGACGGTGCCACTGATAAAAAAAAAAATTCGCACGTTACAAAGCCAACTATCTAAAGAAAAAAACAAAGAGCGATCAACAAGGAAAAGCGGTGCGGGGTTGGAGGACATATATGAACCTAGCTATGGTGCTACAGGGATTTGCAATTTCTATTGCACTGCAACGATGCAACCCCCTCTTCATCTACTATTGAGTTTTCTGTGCGCCACGATCGGCATCAACACCGATACCGATTCCGAGCACCACAAACGAATATTCGCCAATATTCAACAACTGCAGAGGTTCTTCAAGCCGATCGCCATCAACACCGATACCGATTCCGAGCACCACAAACGAATATTCGCCAATATTCAACAATTACAGAGGTTCTTCAAGCCGATCGCCATCAACACCGATACCGATTCCGAGCACCACAAACGAATATTCGCCAATATTCAACAACTGCAGAGGTTCTTCAAGCCGATCGCCATCAACACCGATACCGATTCCGAGCACCACAAACGAATATTCGCCAATATTCAACAATTACAGAGGTTCTTCAAGCCGATCGCCATCAACACCGATACCGATTCCGAGCACCACAAACGAATATTCGCCAATATTCAACAATTACAGAGGTTCTTCAAGCCGATCGCCATCAACACCGATACCGATTCCGAGCACCACAAACGAATATTCGCCAATATTCAACAACTGCAGAGGTTCTTCAAGCCGATCGCCATCAACACCGATACCGATTCCGAGCACCACAAACGAATATTCGCCAATATTCAACAATTACAGAGGTTGTTCAAGCTCAACAGAAAATTCCTATGCGGAAGCTCATGCTGCTTCGTCGCTACAATCAACTGA
Protein Sequence: MTDTWDKDQTLKLISLLRLCPQLYNPTDKDFTNKVKRSEKYNFILNGLKDYKENMTVPLIKKKIRTLQSQLSKEKNKERSTRKSGAGLEDIYEPSYGATGICNFYCTATMQPPLHLLLSFLCATIGINTDTDSEHHKRIFANIQQLQRFFKPIAINTDTDSEHHKRIFANIQQLQRFFKPIAINTDTDSEHHKRIFANIQQLQRFFKPIAINTDTDSEHHKRIFANIQQLQRFFKPIAINTDTDSEHHKRIFANIQQLQRFFKPIAINTDTDSEHHKRIFANIQQLQRFFKPIAINTDTDSEHHKRIFANIQQLQRLFKLNRKFLCGSSCCFVATIN

Sequence clustering based on sequence similarity using MMseqs2