Basic Information

Gene Symbol
-
Assembly
GCA_905220515.1
Location
HG992114.1:447489-450143[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 19 0.027 2.2 9.5 3.1 1 23 81 104 81 104 0.96
2 19 0.0099 0.84 10.9 0.1 2 23 130 152 129 152 0.90
3 19 0.0039 0.33 12.1 3.6 3 23 177 197 175 197 0.96
4 19 8.2e-05 0.0069 17.4 0.3 1 23 201 223 201 223 0.98
5 19 0.0051 0.44 11.7 0.1 1 23 230 253 230 253 0.97
6 19 0.0038 0.32 12.2 1.5 2 23 261 283 260 283 0.94
7 19 4.9e-06 0.00041 21.3 0.7 2 23 289 311 288 311 0.97
8 19 0.23 20 6.5 1.3 1 23 317 340 317 340 0.93
9 19 9.4e-06 0.0008 20.4 1.6 1 23 346 369 346 369 0.98
10 19 0.075 6.4 8.1 3.1 1 23 429 452 429 452 0.92
11 19 0.057 4.8 8.5 0.0 2 23 480 502 479 502 0.96
12 19 0.47 40 5.6 2.3 2 23 525 546 524 546 0.96
13 19 0.00059 0.05 14.7 0.3 1 23 550 572 550 572 0.98
14 19 0.00072 0.061 14.4 0.9 1 23 577 600 577 600 0.94
15 19 0.18 15 6.9 6.6 1 23 607 630 607 630 0.98
16 19 0.038 3.2 9.0 1.4 1 23 636 659 636 659 0.97
17 19 0.0027 0.23 12.6 2.1 1 23 665 687 665 687 0.97
18 19 2.2e-05 0.0018 19.2 0.4 1 23 693 715 693 715 0.99
19 19 6.7e-05 0.0057 17.7 3.9 1 23 721 744 721 744 0.98

Sequence Information

Coding Sequence
ATGTATAAAAAACTTAGAAGATTTTATGAAGACTTATGGCGAGTGAAACGTTATTTTTCTTTTATAGGCCTTACCGGAGCTGTAAGTGAATGGCACTGGGAGCCAAGTGGACTGAATGAGACAGTGAATGATGTAGTGGTAGAGAAGCATCTGCCGGAGATGCGAAAACAGTGTCACAACTTGATGACGCTCCTCAAATACTCTAACGCGACTCCCTTCAAAGATAGGAACGACGCCGGATACGTTTGCGCGTACTGCTTTAAAACATATCCCGACTGCGACGTGCTTAGAAGTCACACGCACGTGCAACACGAAAATGAAAAGCGAACATACAAAGCCGGCTCGGGAGTCAGTAGTTTCGTAGTATTCCTAGATATAGTCGATCTCAAATGTACTATCTGTGATAAAAGTATTGACAGTATTAACGAGCTCGCCCGACACTTGGTCGAGGAGCACGACAAAAAGTACCACATGGGTGTCACCGACTACTTCCAGCCGTTCAAGCTGACGAACGACCAGCAGATGAACTGCTGCCTGTGCGGGGAGACATTCCACAATATGAAGCTCCTGATGCAGCACATGAACGTGCACTACCGAAATTTTATCTGTACAATATGCGGCGCTGGATTCGTGAACAGCTTCAGACTGAAGAGGCACGAGATGACCCACGAAAAGAAAAAATCCAACTACCCGTGCAAACAGTGCGGTCTGGTGTTCGAAGCGGAGTCCAAGAAGAAGGCGCACGTGAACACCGAACATAAAGGGATCGCCGGAGATAGTGTCTGTCAGATTTGCAAAGCGAGATTCAAGAATTACTACCAGAAGACCAGGCACATGACCCAAGTTCACAATTTGGAAGGCATCAAATGTGACTTTTGCGATAAGAAGTTTAATCTGAAGTCGAATTTAATACTCCACATTCGAAGCGTTCATTTGAAGGAGAGGCCGTACCAGTGTTCGGTTTGTAGCATGGGATTCTTTGTGAAGCGACACATGCTGGGACATTATATGGCTACCCATACCAACGAAAGAAAATTCAAATGTGAAGTGTGCGGCAAAGCGTACGCGACGCAGAACAGCCGACGGAAACATATGAAGAAGAATCATGGGATCACTAAAACCACCTTGATGGTCCAGAACAAGGAGAAGGATACACTCAAGGAGAGTAGAATAAAACTGAAGACCCTTCGGCCGAGCGGGGAACTTCACAAGCATTACAACAACATTAAACAGATACTCACTTGCACGAACGCGACCCCCATACGGCAGTGTGGAGATTTTGGCTACGCGTGCTGCTACTGCGAGAGCCAGTTCCATCAGCCAGCTGACCTGAAAAAACACACACTAGACAGCCACGACGACCCTATCAAAAACGCTTCGTTTACCAAGAGACCAGATCTCTGTGGTTTGCTCATAAAGCTCGACATAACGGCACTTCAGTGCAAACTTTGTGATGCAGATCTCGATAACTTAGAAGATTTATTTTCACATCTTAACATTGTGCACGATCGCCCGATACATACGGACGTAAAAAATCAAATAGTCCCTTTCAAATTTGAAGGTGAAAAGTTAAAGTGTTTTATATGCCACAACGAATTTAATAGATTTAAAATTTTACTGTCCCACATGTCCGTCCATTATAGGAATTTCGTGTGCGGGGTGTGCGACGCCGGCTACGTTAATAGGAGACAGTTCAAGACTCACATTAAAAATCACGATACTGGCTCATACAAATGTGACGAGTGTGATAAAGTTTTCGATACGCTGACCAAGAAAAAATCGCACGCCAAACTCGTCCACGACAAAAAGAATAAGGTGTACAAGTGCAGCTACTGCCACGAAATGCTATGCAACTATCGCCAGAAGGTGACCCACATGAAGCGAGTACACGGCATCTACACCAAGTTTAAATGCAACGCCTGCGACCAAATATTTTGGAGCCAGCATTCGCTGAGTATACACACGCAGCGAGACCATCTGATGGAGAGGCGTCACAAGTGTACAGAGTGTGATAGTACATTTTTTGCCTCGACGGACTTAAAGGAGCATATGGTTAAGCACACGGGTGAACGCACTTACCAATGTGCTGTGTGTTTGAAAAGCTACGGCAGGAAGTGGACACTTCGCGAGCATATGCGAATACATGCGAACGATAGACGCTTCAAGTGCGAGCACTGTGGACAGGCATTTGTGCAGAAGTGCAGTTGGCGGGGACATATGAGGTCGCAGCACGGAGAGGATGTTTAA
Protein Sequence
MYKKLRRFYEDLWRVKRYFSFIGLTGAVSEWHWEPSGLNETVNDVVVEKHLPEMRKQCHNLMTLLKYSNATPFKDRNDAGYVCAYCFKTYPDCDVLRSHTHVQHENEKRTYKAGSGVSSFVVFLDIVDLKCTICDKSIDSINELARHLVEEHDKKYHMGVTDYFQPFKLTNDQQMNCCLCGETFHNMKLLMQHMNVHYRNFICTICGAGFVNSFRLKRHEMTHEKKKSNYPCKQCGLVFEAESKKKAHVNTEHKGIAGDSVCQICKARFKNYYQKTRHMTQVHNLEGIKCDFCDKKFNLKSNLILHIRSVHLKERPYQCSVCSMGFFVKRHMLGHYMATHTNERKFKCEVCGKAYATQNSRRKHMKKNHGITKTTLMVQNKEKDTLKESRIKLKTLRPSGELHKHYNNIKQILTCTNATPIRQCGDFGYACCYCESQFHQPADLKKHTLDSHDDPIKNASFTKRPDLCGLLIKLDITALQCKLCDADLDNLEDLFSHLNIVHDRPIHTDVKNQIVPFKFEGEKLKCFICHNEFNRFKILLSHMSVHYRNFVCGVCDAGYVNRRQFKTHIKNHDTGSYKCDECDKVFDTLTKKKSHAKLVHDKKNKVYKCSYCHEMLCNYRQKVTHMKRVHGIYTKFKCNACDQIFWSQHSLSIHTQRDHLMERRHKCTECDSTFFASTDLKEHMVKHTGERTYQCAVCLKSYGRKWTLREHMRIHANDRRFKCEHCGQAFVQKCSWRGHMRSQHGEDV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00164600;
90% Identity
iTF_00164600;
80% Identity
-