Basic Information

Gene Symbol
-
Assembly
GCA_905333045.1
Location
HG995320.1:16950898-16951731[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 0.0023 0.19 12.9 4.3 1 23 85 107 85 107 0.98
2 7 0.00098 0.08 14.1 2.2 1 23 113 135 113 135 0.98
3 7 6.1e-05 0.005 17.9 1.0 1 23 141 163 141 163 0.98
4 7 2.5e-06 0.00021 22.2 1.2 1 23 169 191 169 191 0.98
5 7 2.9e-05 0.0024 18.9 2.1 1 23 197 219 197 219 0.97
6 7 9.1e-05 0.0075 17.3 5.0 1 23 225 247 225 247 0.98
7 7 0.0073 0.59 11.4 4.7 1 23 253 275 253 275 0.97

Sequence Information

Coding Sequence
ATGGAAGTTGTCAAGAGGAGAAAAATGGACCAAGAAAATGAAGATATAAAACCATTGATAAAAGCTCAGCCTCTTTGTACAACTAATGTGGTGTTCATTAAAACGGAAGACGGTGTAACAACACACGTAAAAGAGGAGGTCATAGTGTTCTCGTGTGTCGAAACAAACGACGTAAGAGAAGGCAGGGGCCGCCCCAAGAATAAGATTAAACTTCCCGATTGTGTCGAATACAACAGCGACGAAGACAAATGTTACCACTGCAAAGTTTGTAACTACAAATGTGCCGAGCGCAGTAGCATGATTAAACATGTGCGTATACACACTGGCGAAAAACCTTTTCAATGCGCCAATTGCACCTACAGATGTACAGAGAAAGGAAGTTTAGTTAAACATGAGCGTATTCACACTGGAGAGAAGCCTTTCATTTGTAGCATTTGCGAATACCGGTGCACGGAGCGGGGAAGCTTAGTCAAGCACATACGTATCCACACGGGCGAGAAGCCGTATGCCTGCCCCGAGTGCGAGTACAGGTGCACCGAAAAGGGAAGCTTAACAAAGCATATGCGAATCCACACAGGAGAAAGGCCATTTGCATGTGAATTCTGCGATTACAGATGCACAGAAAAGGGCAGTTTAACTAAACATATCAGGATTCACACGGGAGAGAAACCATACTCGTGTCCGATCTGCAGTTACAAATGTAATGATAAATGTGCATTGAACAAGCACCTCCGTTCACACTCATCCCACCCAACTTACTACTGCAGTTTGTGTGACTACACGTGTACTCATGAAAAGGTCTTAATGAAACATCTTGAAAATCATTCGGATTAA
Protein Sequence
MEVVKRRKMDQENEDIKPLIKAQPLCTTNVVFIKTEDGVTTHVKEEVIVFSCVETNDVREGRGRPKNKIKLPDCVEYNSDEDKCYHCKVCNYKCAERSSMIKHVRIHTGEKPFQCANCTYRCTEKGSLVKHERIHTGEKPFICSICEYRCTERGSLVKHIRIHTGEKPYACPECEYRCTEKGSLTKHMRIHTGERPFACEFCDYRCTEKGSLTKHIRIHTGEKPYSCPICSYKCNDKCALNKHLRSHSSHPTYYCSLCDYTCTHEKVLMKHLENHSD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00404178;
90% Identity
iTF_01248537;
80% Identity
iTF_00935161;