Basic Information

Gene Symbol
-
Assembly
GCA_905163515.1
Location
LR991105.1:19073317-19087369[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 7.3e-06 0.0008 20.9 1.2 1 23 309 332 309 332 0.97
2 9 2.5 2.8e+02 3.5 4.4 2 23 340 361 339 361 0.96
3 9 0.008 0.87 11.3 3.7 2 23 393 414 393 414 0.98
4 9 0.00033 0.036 15.7 1.1 1 23 418 441 418 441 0.96
5 9 0.096 10 7.9 1.0 2 20 458 476 457 478 0.93
6 9 0.83 90 5.0 8.1 2 23 558 580 557 580 0.93
7 9 3.9 4.2e+02 2.9 0.0 1 23 592 613 592 613 0.80
8 9 0.0022 0.24 13.1 1.5 1 23 619 641 619 641 0.97
9 9 1.9e-05 0.0021 19.6 1.9 1 23 647 670 647 670 0.97

Sequence Information

Coding Sequence
atgtctgaattaaaaatatgtagaatATGTCTTCAAACAGAGACGAAAATgtataatttcaatttatatcaACTGAAATTTTACTATGAAGAAGTCATGGCTTTACAAGTGAATGAAGCAGACGGCCTACCCCAGTACTTTTGTTATGAATGTGCTCCAATGCTTCATAAATTCCACAAGTTCAAGGAGAAATGTTACACAGGGCAGAAAATACTTAAAGAAATTATGTGGAGAGGACCGattacatatgaatcaatatataaaattgatcgCAAATGTGAAATGCTCAAGTCGCCTCTATCAATTGATTCATTCCATATTTCTATAGAAGAACACACAACAGAAGATATCACAAATTCTAAACCGAAAACAAAAAGTAATGTTATAACAAAAACAGAACTAGATTCTTTTAGTGATACATCTTTAACAGACATAGAAGATGGTATAGATGAATTAGCtgatgaagaaaatataacaGATGATGAAAAAACAAACTTATCAgtcaaagaaaataatatgatttaCATATCAGTGGAAAAAGATAAAACTGACAGTAGTAATGGTAAGCAAAATATAACAGATGAGGGAATCTTCATTAATGATTCAGTTAGCAAACGAAATATTAACAGTGATGAGAAGGTACTTACTGATTCATTTGATGATCAAATCAATGGTAGTGATgaaaaagaattaaaagatgataATGCAACTAGCAGTTCTATTGTTTTCGTTGatgctaaaaatatattaaaaaaagatatcaaagagaaaaaaggaaaaaataatcttaaacaGGAAAGTAATACTTTAAAAGCTAGACATTTGGAGAATAATAAAGATTGGAAAATAATAACTTTGAGCGAAGAGGATGCATTGAAAGAATTTAGAGCTAGAGCTgaggataaaaaatatttggatgCGGCATATAAATGTACAGATTGTGTCAAAGGATTCTCTAAAAAAGAAATGTTGAATAGGCATATTCAATTACGGCAtgttaaagagCTTGGAAATATTGAATGCCGTTTTTGTAAATTCCGTTATCGTTTAGATTGTTATTTAACTAAACACATTAAACAGCATTATATACGATATGAATGTTTGAGATGTAACCGTTTGTGCCCTTTAGAaaaTACAGCCATTATGCATGAAGAATATCACAGAGGAATCACAAGGAAGTGTCCATTTTGTAATGATGTATTTAAaCACACGTCTACGTACTATACGCATTTGCGTACTCATCGTAGCGAGCACGTGTGCACTTTATGCGGCGCTTCATTCGTCAGTAAACTTGGATTGAAACAACATAAACGAATAAAACATGTCATCATTGAAattGAAAGtccagatgatgatgaagaagtgAATACGTATTGCAAACGATGTGATATCCGCTTCGACACACGAAAAGCTTATGAGGAACATTTGTTTCATTCAGCTCGGCATAGTGatgaagaagaaaagaaaaatgaagGGCAATCTAATGTTGAGAGAAACGCTTCACCGCCAATGAAATTATCAGCAAGTAAGAAAATACTAGGCAAGAGGGACCAAGCAAAGatcacGAAAGAACTAAGAAAACGCAAAAATGAAGATGATCAGTTCAATTTTAATCAGAATTTTGGtcgtaaaatatacaaaagagGGCGGCGACTTCGAATTAAACCTACTACATGCCATCATtgcgGTGAGCATTTTGAGACTCAAGCTGCTTGTATGAAACACCATAGTGTGGCACATCCTCGTACATCCTTCTTTCCACCGGGCGAGAGATACATATGTGAGATATGCGGTTCTTCCCTTGCGCCGGGTAGTATATTAACACATCAGAATATGCATACCAGGGAGAAACTCCACACCTGTAACACATGTGGGAAGCAGTTCTACGCTATGATAGGTCTGAAGCGACATCTAGTGACTCACACCGGTGAAAAGCCGTACGCTTGTCCGTCATGCGATAAAAGATTCACGCAAAGCAATAGTATGAAACTACATTATAGGACTTATCATCTGAAACAGCCGTATCCAAAAAGGAATAGACAAAAGAAGGGTCCGAAGGTAGCAGTTAATGCGGAGGAGTCGAATAGTGAAGCATCATCAGACGAGAGCTCGCCTGAAGCAGACCCTCAAAAGAAGCCGGGTGTCGAATCTAATTTCGTTCAGCTCGCTGACGAGAGCATGCATTTTTTGACACTTACATAA
Protein Sequence
MSELKICRICLQTETKMYNFNLYQLKFYYEEVMALQVNEADGLPQYFCYECAPMLHKFHKFKEKCYTGQKILKEIMWRGPITYESIYKIDRKCEMLKSPLSIDSFHISIEEHTTEDITNSKPKTKSNVITKTELDSFSDTSLTDIEDGIDELADEENITDDEKTNLSVKENNMIYISVEKDKTDSSNGKQNITDEGIFINDSVSKRNINSDEKVLTDSFDDQINGSDEKELKDDNATSSSIVFVDAKNILKKDIKEKKGKNNLKQESNTLKARHLENNKDWKIITLSEEDALKEFRARAEDKKYLDAAYKCTDCVKGFSKKEMLNRHIQLRHVKELGNIECRFCKFRYRLDCYLTKHIKQHYIRYECLRCNRLCPLENTAIMHEEYHRGITRKCPFCNDVFKHTSTYYTHLRTHRSEHVCTLCGASFVSKLGLKQHKRIKHVIIEIESPDDDEEVNTYCKRCDIRFDTRKAYEEHLFHSARHSDEEEKKNEGQSNVERNASPPMKLSASKKILGKRDQAKITKELRKRKNEDDQFNFNQNFGRKIYKRGRRLRIKPTTCHHCGEHFETQAACMKHHSVAHPRTSFFPPGERYICEICGSSLAPGSILTHQNMHTREKLHTCNTCGKQFYAMIGLKRHLVTHTGEKPYACPSCDKRFTQSNSMKLHYRTYHLKQPYPKRNRQKKGPKVAVNAEESNSEASSDESSPEADPQKKPGVESNFVQLADESMHFLTLT*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-