Basic Information

Gene Symbol
-
Assembly
GCA_032191425.1
Location
CM063450.1:28518432-28533827[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.52 62 5.7 0.4 3 23 112 132 110 132 0.96
2 17 0.017 2 10.4 0.1 2 23 136 158 135 158 0.96
3 17 0.0092 1.1 11.2 0.1 1 20 417 436 417 438 0.94
4 17 0.053 6.3 8.8 1.3 3 23 449 469 448 469 0.97
5 17 0.01 1.2 11.1 3.6 1 23 517 540 517 540 0.93
6 17 5.6 6.7e+02 2.5 1.4 8 23 590 606 581 606 0.83
7 17 0.068 8.1 8.5 0.3 2 23 617 639 616 639 0.85
8 17 6.6 7.9e+02 2.2 3.6 1 23 644 667 644 667 0.93
9 17 6.6e-05 0.0079 18.0 1.7 1 23 673 695 673 695 0.96
10 17 9.4e-07 0.00011 23.8 1.5 1 23 702 724 702 724 0.98
11 17 0.00011 0.013 17.3 2.3 1 23 729 751 729 751 0.96
12 17 0.00047 0.056 15.3 1.4 1 23 757 779 757 779 0.98
13 17 1.7e-06 0.0002 23.0 1.0 3 23 787 807 785 807 0.97
14 17 9.5e-05 0.011 17.5 1.7 2 23 814 835 814 835 0.98
15 17 0.00099 0.12 14.3 0.8 2 23 843 865 842 865 0.97
16 17 0.0023 0.27 13.1 0.5 1 23 870 892 870 892 0.96
17 17 0.045 5.4 9.1 4.2 2 23 899 921 898 921 0.96

Sequence Information

Coding Sequence
ATGTCTTCTGACGACTCTGATGATGAACCACTATCAGTACTTGCAGCTAACAAAAAGCTTCATCCCGAGAACTACGAAGATGAAACACCAATAGCCTTAAACTTAACAGTtccaaagaaaaagaaaagaaaatatcaaCCAAAACGTCTTTCGATTACTATAAAACTGCAGAAAACTGAACAGAATCCTGTAATCGAGCGCCCCGATGACGTCTGGCTTTACCTTAAGGATTTTAATCCTGCTGGACCATACAGTTGCTTATTATGCCCTGATTGGTTTATTAACAGGTCAAAGATGATACTACACTACTGTCTTGAtcacaaaaaagatttttgtgGTATTTGTAGGTATTTTGTACCAGACAGGGATACTTGGAAGAGTCACTTAAAATTTCACACACCATGGCCTTGCTCACAATGTGTTCTCAATTTTCAATCGGAAGCAGAATTACGCACACATCTTAAAACCGTTCATCAGTTAGTGCATTGCCGACTTTGCCATTTTAGAGTATCTGATGGTGAGTTATATGAGTcacatttattacaaaaacatGTTATATCGAATCTAGAAAATAAGGATGAAGAATTTTTATGGGCTTTGGAGGATGAAGGGTGTACAACATTCTCATGTATACTTTGTTCTAAGTCAGATAACACTATGAATATGTTCTTTAGTCACTATATGGGTTACCATCATTTTACTTTGAAATGCATTGCTGCCTTAATAGCAGGCAGAGATTTACCTTTTATAGTGCATGGAGCTAATATTAGACCGGAATTTATAGAAGAACAGTTGAAGCGCCATCCACAGTTTGGATATATAGATTTTCAATTAAAAGTTCGTAATTGCATAGAATCTGATCCTTCTATGACTGAAACTAGAGATTTGCTACGAGCGCTAATACCGGAGATTAAACAAGAGACAACAAGCACCGAAGAGATAAAAGTCAATACTGAATCAAATTTGAAGGATGAAGCAATCCTTAAAGCTTATGACGGTGATGAAGATTATGATGTAACATCAACAGAACTTGTTGTTTTAGAAAAATGTTACTtcgattatataaatttaattaaatccaGAATTGACACAAATAATGTTCATGAGAGTTCTAACATAAATTATCAGAAGGTTGCATCAGAACTTGCCATGGATATAACATGTGCACTATGTCAAGATGTATATCTTAATGTACAAAGTTTTGTTACACATATGATTAAAATGCATTGTCTTAAATATATGCCGATATTTTCATGTAGAGTCTGTGGAGCGACATTTGATACTATGAATGAATTGAACAATCATGTATCTCAAGAGTTGGGCGACTTTGAGGATTTGTGGCTTTGTCAATTTTGTGATAAAGAGTTTGACAACAGAGAGCAGTCAAGGAAGCATTTAAATGAACACTGGGACTTGTTGGAATATGACAATTGTTTTAGTCCACATTTGGGTTTCAAGTGTATGTTTTGTCCGACTTTGTTTTGGCATGAGACAGATAGAGAAGCTCATCAAGTGAGAGTACATTTTTCTAAGAATATGGATGGTTACTACAAGTGTTGTATTTGCACTGAGGTTTTTAGTGATAAGATTTGGTTCATTCATCACTACTTGGACAAACACACTACTTCAGAATTAGTTCCTCTCTACCTCATGAAGTGTTCCATATGCTGCTTAGTGCTGTCTGATGTTGATGATATGAGAACTCATTTTATGGCTGATCATCCAGAAGCTAAAAAGTTGTTTTGTTCTTTAGGATTGTGTAAATATAGACCTCTTAGTCACAGGAAAAGTCTTAAGCTTCATTTACGGTCGATCCATAATCCACGCTTTCGAAATGAACGCGGCCTGGAATGCCCCACATGTGGCCGAGAGTTTGCTACCTCCCGGGCTTGTGGTACGCACATGGCTCAAGCACATGGCTCCGGTAAGTTCAAGTGTAAACTGTGCGATGAACATTTGCATACTATGGACGAAAGaAAACTACACTATCTCATCAGTCATCCTGGCCAGCATCCATTTGTTTGTTCAGAATGTGGCAAATCATTCCAATACAAGTCTTCGCTGTATATGCACAAACAAGACCATGTACCAAACAAACAGAGCTACACTTGCTCTTACTGTGGCAAAGTTTTCAAGAAACGGGATTCGTATCGAGAGCACATCCAAATTCACGAAGGTCCGCGACATGCGTGTTCGTATTGTCCAATGCGGTTTGTTCAGCGCTCCAATATGCTGCGACACGAACGCCGGCATACAGGCGAGCGCCCATACGCGTGCCCACATTGTCCGCGTACCTTCGCCGATAAAGGCGCTTGCAACTCTCATGCCAGaACACATTCAAGAGATACTTCCTACGGATGCGTGTATTGTGGAAAGACATTTGTACAAAAATCTAAGCTCACTTATCACATAAGGAAACATACAGGAGAGAATTTAGAAACGTGCCCGATCTGCTCTAAGTTATTCACCAGCGCTTGTTCCCTGCGCGAGCATATGAAGATACACAATtctaagaagaatacaattaaatgtCCATTATGTGATCGTAAATATCAAGATGAAAGGTACATGTTGCGACATCTACGAACGTCTCACACACAAGGTACTCATGCGTGTCCGATATGTGGCAAGTTGATGACGAGTCCAACCGCACTACGACATCATGTCATTACGCATAGCAAATATAAGACGCTTAGTTGCAAAATGTGCCCTAAAGTATGCTCAGTGAAAAGAACAATGTTAAAACATTTTCGAAGACGCCACGGTTTCAAAGGTACAGAATCTATGAAGGAGTATTATACTCGATTGGATCCCAGAGAATGTGAACTAGGTCTCGATGAAGAAACTATGACAAATATATTTGGTCCTCCAAAGAAAATTACGAATACTGTCATTACTGACTTTGTTACAGTTACTAATAAAGTATTAGACCAAATAAAGAAGAATAAGGCGAAAAAGAGTAAAAAGGCTAAGAAGGCTAAAAAGTCTAAAAAAGAGAAAGATGATGGAGAAGAACAAAATGAGACCGCAAAATCTAATTCCGAAGAAGAGAAGAGTGAAAAAGATAATCTACAATCGGAGAGTGAAAatgataaaaacattaaaacttGTAATATCAAAACTGAAGTGACAGATTATAATAGTGATCACGGTGAAAATGAACTTGAACCTACTGATTTTGTGAGTGTCAAAATAGAACCTTTGGAAGATGATGAAGCTGTTGAAAATTAA
Protein Sequence
MSSDDSDDEPLSVLAANKKLHPENYEDETPIALNLTVPKKKKRKYQPKRLSITIKLQKTEQNPVIERPDDVWLYLKDFNPAGPYSCLLCPDWFINRSKMILHYCLDHKKDFCGICRYFVPDRDTWKSHLKFHTPWPCSQCVLNFQSEAELRTHLKTVHQLVHCRLCHFRVSDGELYESHLLQKHVISNLENKDEEFLWALEDEGCTTFSCILCSKSDNTMNMFFSHYMGYHHFTLKCIAALIAGRDLPFIVHGANIRPEFIEEQLKRHPQFGYIDFQLKVRNCIESDPSMTETRDLLRALIPEIKQETTSTEEIKVNTESNLKDEAILKAYDGDEDYDVTSTELVVLEKCYFDYINLIKSRIDTNNVHESSNINYQKVASELAMDITCALCQDVYLNVQSFVTHMIKMHCLKYMPIFSCRVCGATFDTMNELNNHVSQELGDFEDLWLCQFCDKEFDNREQSRKHLNEHWDLLEYDNCFSPHLGFKCMFCPTLFWHETDREAHQVRVHFSKNMDGYYKCCICTEVFSDKIWFIHHYLDKHTTSELVPLYLMKCSICCLVLSDVDDMRTHFMADHPEAKKLFCSLGLCKYRPLSHRKSLKLHLRSIHNPRFRNERGLECPTCGREFATSRACGTHMAQAHGSGKFKCKLCDEHLHTMDERKLHYLISHPGQHPFVCSECGKSFQYKSSLYMHKQDHVPNKQSYTCSYCGKVFKKRDSYREHIQIHEGPRHACSYCPMRFVQRSNMLRHERRHTGERPYACPHCPRTFADKGACNSHARTHSRDTSYGCVYCGKTFVQKSKLTYHIRKHTGENLETCPICSKLFTSACSLREHMKIHNSKKNTIKCPLCDRKYQDERYMLRHLRTSHTQGTHACPICGKLMTSPTALRHHVITHSKYKTLSCKMCPKVCSVKRTMLKHFRRRHGFKGTESMKEYYTRLDPRECELGLDEETMTNIFGPPKKITNTVITDFVTVTNKVLDQIKKNKAKKSKKAKKAKKSKKEKDDGEEQNETAKSNSEEEKSEKDNLQSESENDKNIKTCNIKTEVTDYNSDHGENELEPTDFVSVKIEPLEDDEAVEN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00932964;
90% Identity
iTF_00932964;
80% Identity
-