Basic Information

Gene Symbol
ttk
Assembly
GCA_905333005.1
Location
HG995167.1:9232163-9277409[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 6 0.29 24 6.2 0.0 2 23 467 489 467 489 0.90
2 6 0.00031 0.025 15.5 0.9 1 23 500 523 500 523 0.94
3 6 0.00033 0.028 15.4 2.7 1 23 533 555 533 555 0.97
4 6 3.8e-06 0.00032 21.5 2.1 1 23 709 731 709 731 0.97
5 6 4.8e-06 0.0004 21.2 0.2 1 23 737 759 737 759 0.98
6 6 3e-05 0.0025 18.7 3.3 1 23 765 787 765 787 0.98

Sequence Information

Coding Sequence
ATGGGAAGTGAGCACTATTGCCTGAGGTGGAACAATCATCAGAGCAACCTGCTGGGAGTTTTCAGCCAGTTGCTACACGACGAGAGTTTGGTGGACGTTACGCTCGCCTGTTCCGAAGGAGCCTCCATTCGGGCTCACAAGGTAGTATTGTCTGCGTGTTCATCCTACTTCCGTTCGCTTTTCGTGGATCACCCTTCACGCCATCCAATAGTTATCCTGAAGGACGTGGGTTTAGAGGAGCTCCGCACACTCGTTGACTTCATGTACAAGGGCGAGGTGAACGTCCAGTACTGCCAACTGCCAGCACTCCTCAAAACTGCTGAGAGTCTTCAGGTCAAGGGCCTAGCTGAAATGACGACTTTAAGCGCAGCTGGCATTACAACAAGGAACGTTCCAGAGCCAATGGAGGAGTGTCAGCCACAAGACAATAAAGAGGGCACTGACTCACACGAAAGGTTAGAAGAACGCGACTGTCGGGAGAAAGAAGACAGACGCGATACTAAAGAGTTGCGCGAAATACGTGAAAGAGAGAGCAAAGACACGAGGGAACGAGAACCTCGAGAACCCAGGGAACGGGACCGGGAGCGTGAAATAAGAGATACTCGCGAGATAATTAGAGATACACGAGAAACTAGAGATATAAGAGACTCTCGTGAAACGCGAGAACTAAGAGAACAAAGAGATAGCAGAGAAAATAGAGATACCAGAGACATCAGGGACCTGCGAGATTTAAGAGATACTCATAGAGAAACAACGGAAACTTCTCCTCCTCGAATGTCCCCCCTACTGTCTATACGTCGATTTAGGCCTGAAACGTCAATTGAAGCTCCAACTCTAACGCATCCACCCATCCCAAAGGATGAGCCTCCTGATGAGCCAATGCGACCGTCATCGCCAGAAGAAGACACAGTTTCGATTAGATCCAACGGTGCTAATGATAACATTGGTCTCAATATGACTATAAACAGTCATGGCACTGGGCTGGGATCTCGGTATTCTCCTGTAGAGCAAAGGCTGAGCGTATTAAGTACATTATCACATCCAGGCCTTCCGCATCCTCACAGCACTTTAACAAGCCCAAGAAATGAACCTATTGCTGGCCCATCTGGACTACCACCAGTTCAGCAAGTACCCCTTTCATTGAAAAAGGAGGCAGATTGGGACAGAAGTAATGATGATAAAGGCATGGAGGCGGAGTATAGATTGCAACATGAGTCTATGTGCCTGGACATGTCATGCGGCTCGCCAAGCTTACCCACCCCGATACCGACAAGAAGCCCCACTGCACTGCCGCTGTGGTCCCCTCTGTTGGCACTGCAAGCCTGCCGCCTGCGCAGGTATTTGAGCGACGATTGTATGGCTTACCAAAGTCGCCATTTACTGCATTCAGAGAGACGTCGTTGTGGCGTTTGTCTCGCCTCGTTTCCATCCACATGGCTCCTAGAACGCCATGCTGCATTGCAACATTCATCACAAGCACCCGGCGAAGACAAACCGTTTGTGTGTGAACAGTGCGGGCAGAGCTATCGATATAGGTCAGCTTACGTAAAACACAGAGAACAAAACCACCGAGCAAGACTGCCAGCAGATAAGTTATTCACTTGTGACGTGTGCGGAATGCAGTTCCGATATTTAAAATCCTTCAAAAAACATCGCCTAAATCACACACTTGAGAGATTACACACAAAGAACACCGATCCTCCGGAAGCAATAGACCAGGTTTCCAGTACAAATGAAGTACAGATCGGTCAGTGCGGTGAAATGGATTTATCCATGAAAAAGAAAAATAAGGCAGAAGATACGAGAACTTCCCCGATTGAAGCGATCGGTGACGCCGAACAAGATAGTACAGTCGACTCAAATGGCCCCACTGATTCGATCGTGACGGTCGATGATTCCACTGAATGCCGTAACTCTAGCGTCGAAGGAGAGACAAAACGGGAAGATCTATCGTCTAATTACGAACGGAGACGAATTCCCGTATCTTTTGCTAGCGTAAGCTCCATTGCTGACAGTTCAGAGAGTGAACGAGGCGATAGCAGCAAACTGGAGAGTCCAAGCTCACATTCCGGAATACTGGGATTCTTACAAAACGACGATCGACAAAGGGAGAGGGAGAGAAGGTTCGCTTGTCCCTTCTGCGGCAAATGCGTTAGGTCCAAAGAAAATTTGAAGCTACATGTTAGAAAGCACACAGGAGAACGTCCGTTTGTTTGTCTATTCTGTGGGCGTGCGTTTGGCGGGAAGAGCGACTTGACCCGCCACCTGCGGATCCACACGGGCGAGCGGCCCTACCACTGCGAGGCCTGCGGCAAGTGCTTCGCCCGCGCTGACTACTTGTCCAAGCACCTCACGACACACGTACACAACGCTCGCTGA
Protein Sequence
MGSEHYCLRWNNHQSNLLGVFSQLLHDESLVDVTLACSEGASIRAHKVVLSACSSYFRSLFVDHPSRHPIVILKDVGLEELRTLVDFMYKGEVNVQYCQLPALLKTAESLQVKGLAEMTTLSAAGITTRNVPEPMEECQPQDNKEGTDSHERLEERDCREKEDRRDTKELREIRERESKDTREREPREPRERDREREIRDTREIIRDTRETRDIRDSRETRELREQRDSRENRDTRDIRDLRDLRDTHRETTETSPPRMSPLLSIRRFRPETSIEAPTLTHPPIPKDEPPDEPMRPSSPEEDTVSIRSNGANDNIGLNMTINSHGTGLGSRYSPVEQRLSVLSTLSHPGLPHPHSTLTSPRNEPIAGPSGLPPVQQVPLSLKKEADWDRSNDDKGMEAEYRLQHESMCLDMSCGSPSLPTPIPTRSPTALPLWSPLLALQACRLRRYLSDDCMAYQSRHLLHSERRRCGVCLASFPSTWLLERHAALQHSSQAPGEDKPFVCEQCGQSYRYRSAYVKHREQNHRARLPADKLFTCDVCGMQFRYLKSFKKHRLNHTLERLHTKNTDPPEAIDQVSSTNEVQIGQCGEMDLSMKKKNKAEDTRTSPIEAIGDAEQDSTVDSNGPTDSIVTVDDSTECRNSSVEGETKREDLSSNYERRRIPVSFASVSSIADSSESERGDSSKLESPSSHSGILGFLQNDDRQRERERRFACPFCGKCVRSKENLKLHVRKHTGERPFVCLFCGRAFGGKSDLTRHLRIHTGERPYHCEACGKCFARADYLSKHLTTHVHNAR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00943167;
90% Identity
iTF_00289143;
80% Identity
iTF_00925870;