Basic Information

Gene Symbol
-
Assembly
GCA_905333005.1
Location
HG995166.1:4074482-4095313[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 1.2 1e+02 4.2 0.1 2 23 469 490 468 490 0.89
2 18 0.0003 0.025 15.5 0.2 1 23 500 523 500 523 0.96
3 18 0.62 51 5.1 0.7 1 21 637 657 637 658 0.92
4 18 0.036 3 9.0 3.8 2 23 718 739 717 739 0.95
5 18 0.88 73 4.7 0.1 1 23 751 775 751 775 0.90
6 18 0.00019 0.015 16.2 0.3 2 23 782 805 781 805 0.96
7 18 0.071 5.9 8.1 0.2 1 23 811 833 811 833 0.93
8 18 0.0022 0.18 12.8 3.3 1 23 839 861 839 861 0.98
9 18 1.2 1e+02 4.2 0.0 2 20 872 890 871 892 0.87
10 18 0.013 1.1 10.4 0.3 1 23 969 991 969 991 0.98
11 18 2.1 1.7e+02 3.5 7.2 1 23 998 1020 998 1020 0.95
12 18 0.0014 0.12 13.5 1.8 1 23 1054 1077 1054 1077 0.95
13 18 0.0091 0.75 10.9 2.7 1 23 1084 1107 1084 1107 0.97
14 18 0.018 1.5 9.9 0.1 2 23 1127 1149 1126 1149 0.95
15 18 0.0019 0.15 13.1 0.3 2 23 1168 1190 1168 1190 0.94
16 18 0.00044 0.037 15.0 0.0 1 23 1208 1230 1208 1230 0.98
17 18 0.00013 0.011 16.7 0.1 1 23 1236 1258 1236 1258 0.97
18 18 5.2e-05 0.0043 18.0 0.5 3 23 1266 1287 1264 1287 0.95

Sequence Information

Coding Sequence
ATGACGGACACTCCACAACCACTGATAGTTTGCATGGAGAATATAGATGGAGAAGAAGTTTCGTTGAGAATAAACCGGACAGATACTTTCCAGATATTCTTGGATAACGCCAAGAGTTTATTGGGTTATGACGTTGACATAGACTCTGTAACTGGTAATCGACCAGTTGCACTTGATGATAACATTTACGATTTTTTAATACACGTGGAAGAAAATTTGAATGAATCTAACATAGACGAAAATAAGTATACTAAAACAAATAATATTCACGACCGGGAATACGTTTTGGATGATGGAACTCAAATAAAAGCATCACAAATACAGTTTGACAATGATGATCCTATTATAGATCTAACATCTTTAAAGATTCCATTCGTTAAGTATATAGATGATGGCATAACTGATATTGAAAGTGAAGAAACGTTCACTATGAAAGATTTTAATATACCTGAAAGTCCTAAATCACGGGAAGCAATCATGGAAACTTCAAGCCCAAGACGTGATTTTGCAAATAGTCTTCCATTTAAACTTTTCTGCAACAACGTTTCAAATTTCGAAGCTCAATTCACTAAATATTTAGAGTCCAATACCAGTTCATCAATAAATTTAACATTGCCAAATAAAAGTAAGCCACAGAAGGATTATAACTATGATATTGCCATGAAGAATCGTAAAGAAGTTTTAACTCGCGAAGATGTACTTAATATGTTCAAAGATTCGCCTGTTACTTCGCTTCCATATGATGCAAACAAAAATTATGATAAACGTAAACATGCTCGAAAATCTGATCCCTCGAGATTAGGACATAAAAATTCTAATTGTAAAACAGACACTGTGGCAAATACTACTAATAATGATCATATATGTTGTATTTGTGATAAAATAACTACTAATGAAATAGAGAAAACGTACATATTCGATAAAGAAGACCAAATGAATCACAGCTCTGATCAGGGAGGTGGCGCAACGCAATTAAAAAATATATGTTCTCATTGTTTAGGTAATAATTTTCAACCGAGCTTAATGAAGAGTCCTAGCCAATCTTTAAACACCGACGAATACTTAGTATTACAAAATAGCCAGCAGCTTATTTATCAAAAAATAACAGCGGTAGTTTTAAAGAAATCTAGTGTCGACTTAGAAACAATTATAGGCAATAGCAGAAACAAAGAGAGTGTTGAGCTCGTAAAAGTGGAAATTGGACCGGATGGAGAGATTATAACAAAACCTGTAGATAACGATGAAGGATCTGATGATATTATATTCATCGATGATAAGACGAAAGATTGTTATAGTGATGTTGAAATTATTGAACCAGACCAGGATTGCGAAGATATAGACATAGAGGACGAAGCACTTAAGGAGTTTCTAGGAAAATATGAATGTAGAGAAATTGATGAATTGAAATGCAGATTTTGTGAACGAATATTCGAGAACGTGTCCCAAGTGGTGGATCACGGGGAGGAACATAAGCACGACCTGGAGGACGGGCCGGTTTATCCCTGCCCATTGTGTGATTACGGGTATGAACATAGTAAGTGGCTTAAAGCTCATCTGAAAGCAGCACACGACACAGTACATGAAAAGAAGAACGTCGATGGCGGACAAGAAAACAAAGATAAAACTTCTCCTAGTCCATCTCCGGTAGCCAAAAGGACAAGAAGTTCACAAAAAAAGAACGACTCTGGATCAGAAAAAGGTACTAAAGACACCCAGGAGACTGAAGACAACACGAATGAATCGGTAAAATTGCCACCGTTATTAATCACGGAGGTCAAACAAGAATGCTTAGACAGCAGCGACGAAGAAGCCATATGGATCGTCCAAGCAGAGGACGGGAGCTCGGAGCAGCCACAGCACTTGGGAAAAAAGAAGGTTGACGATAATGCAGACAGAGCAGAAGAGGTTCACAAATGTTTTAACTGCAATGAAGTCGTAAGTTCAGCCGAAGTGTTGGCAGCTCACAAATGTAAAAAACGAGGCAGAAAAAGAAAAAGTCTGTCTAAAGATGCGAATGTCTTAGTGCCATCCCGAGAGGATTTTCTCAAGCGCGCCCAAGGAAGACCTCGCAAGTCGAACAAGTCAAGCGAAAAAGAATCGGTGAAACTTCGCAAAAAGAGGAGCAAAGGTTCGTCTAACTCCCTCATAGTAACGTGCCATAACTGCAATGAATCGTTCACCTCTAAAGTCAGATTGAAGTTTCACATGCAGTTCCACGAGGCGAGCAGCATGCTCACGGCGGGGGGAGAGTACGCTTGCCCGGAGTGCGAGGGCGCCACTTTCCCCACCGAGACGGCGCTGTTTGACCACATACACTTCCAGCACGACAAGCAGAAGCGCTGGCAGTGCCCCGTCAACGACTGCGGCAAGACCTTTTTTTTGAGAGCGACCCTGACGAAACACAGCCGCATCCACACGGACACGCGGCGCTACGTGTGCGTCACGTGCGGCAAGCGGTTCCTCGACAAACAGACGCTGGACGAACACGGAGTCACGCATCTGCAGATCAAACCGTTCCAATGCCACATCTGCCTGAAGCAGCTGACGCGGCGCTCCCGGCTACGGATGCACCTGCGGGCCCACGAGGAAGAGCTGTCCCTGAAACTGGTGCTTGTGTGTGCGGTCTGTAGCAGAGCCTTTAGAGACCACATAGATGCCCAGGAGCACGTGGCGAGATCAGGCGAATGCTTGGAGGTGTTCACCGACGAGCTGAAGGAAGACACGGAGTCGGAGCGGCTGTCGCCCACCACCGGGATCGTCATGCCCAAGGACACGCACAAGAAGGCGTCAGTGCTGAGCGCGCCGATCGAGCGCGAGGTGCGGTCCGGCGAGAGCGCGGCGCTGCTGGCGCGCGTGGCGGACGGCGCGCGGTGCGTGCTGCGCGTCGTCAACATCGAGAAGGCCTTCCGCTGCGAGTACTGCGAGGATGTGTTCTACTTGGAGGAGGCGCTAAACAAGCACCGGATGATTCATAAGGGCGTGAAGAACCCCTTCACCTGCCACATCTGTAAAGTAAGCTTCGCGACCTACTCAAGATGCACCACCCACAAGACGACCCACGGGTTCTACAAGCGTACGGCGGAGGCGCCGGGCGGGGAGGCGCGCGGGCCGGCCAACGCGGGCATCCTCGGCTACGGCGGCTTCCCCGTCGTCAAACACTTCTTGTGCGAGGACTGCGGGCGGTCGTACCTGCACTGGACGTACCTGCAGGTGCACCGGCGGATGAAGCACGCCAACGAGCGGTACCTGTTCCGCTGCGACCACTGCCAGCTGACTTTCAACAACAGTTGGAGCATCGCCTATCACAGAAAGAAAATTCACGGTAAAAGCGGCAGCGACGAGGGCATTACCAAAATAATCAGGGAGGACTTAAAGATCCCCTGTCGCGACTGCGAGGAGGTGTTGCCGAACAAGACTGCGCTGTACAAACACAGGCAGATGGAGCACTGCGTACGACCAGGGAACGAAGATTATATCGCAGAGTATAAAGAAGACACGGAGACTTGCGCCAAGTGTGGACTCGACTTTCGTACGTCTCTGGCGTTACAGAAACATCTCAAGGATGTCCACGGAGCTGAGGGGTCTGTGGGGGAGGAGGAGACGAATGGGGTGAAGGGCCAGTTCCCGTGCGATGGCTGCGGACGGGCGTTCCGGTCGGCGGGAGCGCGGGCGGAACACGTGCGCGTGCACACGGGCGAACGGCCCTTCCCCTGCGACGTGTGCGGTGCCGCCTTCCGCAGATCGACGGCGATGCGCAACCACCGCCTGATCCACGGGGGCGTGCGCGCGTGGGCGTGTCCGCGCTGTCCGCGGCGGTTCCGCGTGCGCTCCGACCTGCGGACGCACCTGCGGCTCAAGCACCCTGCACACCTCGCTGTTATCGAGATCGAAGGTCTGAACCCCACTCCCGAGGAGGTGCTCGGCTACCTGAAGAGGAACAACATTAACCAGAACAAGGTCCTGGAGATCACAATGATTTCATTTCCGAAGGGAACCACAAACATAGTACCAAACTCGGCGCGAGCGCTATCGATGCTGAGCGACGTACGCAGGACGCCAGTCGCATTCGAGACCACGCCCTCTCAGTCGCTCGACGTTTTCCAACCAACACATCACAGTCGGGGCATATTGATGGGAAGCAGACCTAGTATACTTCAGCGCGGCGCGGATATGGCACAAAACTATTTACCTATCACATTCAACGATCCAGAACGGTTATCGGCATTGAACGTGGAGTTGTTATTGCCTGAAGGCGGACTCGTCAACGGCAACCAGATGGTTCAGTTGCAGCTGGACGGTGCACTTGGCTTAGAATAA
Protein Sequence
MTDTPQPLIVCMENIDGEEVSLRINRTDTFQIFLDNAKSLLGYDVDIDSVTGNRPVALDDNIYDFLIHVEENLNESNIDENKYTKTNNIHDREYVLDDGTQIKASQIQFDNDDPIIDLTSLKIPFVKYIDDGITDIESEETFTMKDFNIPESPKSREAIMETSSPRRDFANSLPFKLFCNNVSNFEAQFTKYLESNTSSSINLTLPNKSKPQKDYNYDIAMKNRKEVLTREDVLNMFKDSPVTSLPYDANKNYDKRKHARKSDPSRLGHKNSNCKTDTVANTTNNDHICCICDKITTNEIEKTYIFDKEDQMNHSSDQGGGATQLKNICSHCLGNNFQPSLMKSPSQSLNTDEYLVLQNSQQLIYQKITAVVLKKSSVDLETIIGNSRNKESVELVKVEIGPDGEIITKPVDNDEGSDDIIFIDDKTKDCYSDVEIIEPDQDCEDIDIEDEALKEFLGKYECREIDELKCRFCERIFENVSQVVDHGEEHKHDLEDGPVYPCPLCDYGYEHSKWLKAHLKAAHDTVHEKKNVDGGQENKDKTSPSPSPVAKRTRSSQKKNDSGSEKGTKDTQETEDNTNESVKLPPLLITEVKQECLDSSDEEAIWIVQAEDGSSEQPQHLGKKKVDDNADRAEEVHKCFNCNEVVSSAEVLAAHKCKKRGRKRKSLSKDANVLVPSREDFLKRAQGRPRKSNKSSEKESVKLRKKRSKGSSNSLIVTCHNCNESFTSKVRLKFHMQFHEASSMLTAGGEYACPECEGATFPTETALFDHIHFQHDKQKRWQCPVNDCGKTFFLRATLTKHSRIHTDTRRYVCVTCGKRFLDKQTLDEHGVTHLQIKPFQCHICLKQLTRRSRLRMHLRAHEEELSLKLVLVCAVCSRAFRDHIDAQEHVARSGECLEVFTDELKEDTESERLSPTTGIVMPKDTHKKASVLSAPIEREVRSGESAALLARVADGARCVLRVVNIEKAFRCEYCEDVFYLEEALNKHRMIHKGVKNPFTCHICKVSFATYSRCTTHKTTHGFYKRTAEAPGGEARGPANAGILGYGGFPVVKHFLCEDCGRSYLHWTYLQVHRRMKHANERYLFRCDHCQLTFNNSWSIAYHRKKIHGKSGSDEGITKIIREDLKIPCRDCEEVLPNKTALYKHRQMEHCVRPGNEDYIAEYKEDTETCAKCGLDFRTSLALQKHLKDVHGAEGSVGEEETNGVKGQFPCDGCGRAFRSAGARAEHVRVHTGERPFPCDVCGAAFRRSTAMRNHRLIHGGVRAWACPRCPRRFRVRSDLRTHLRLKHPAHLAVIEIEGLNPTPEEVLGYLKRNNINQNKVLEITMISFPKGTTNIVPNSARALSMLSDVRRTPVAFETTPSQSLDVFQPTHHSRGILMGSRPSILQRGADMAQNYLPITFNDPERLSALNVELLLPEGGLVNGNQMVQLQLDGALGLE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-