Basic Information

Gene Symbol
-
Assembly
GCA_905333005.1
Location
HG995186.1:9435182-9448198[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 26 7.9e-07 6.6e-05 23.7 4.0 1 23 87 109 87 109 0.99
2 26 5.8e-07 4.8e-05 24.1 5.0 1 23 115 137 115 137 0.99
3 26 1.6e-05 0.0013 19.6 3.8 1 23 143 165 143 165 0.99
4 26 1.1e-07 8.7e-06 26.4 3.1 1 23 171 193 171 193 0.98
5 26 2.1e-07 1.8e-05 25.5 4.3 1 23 199 221 199 221 0.99
6 26 4.2e-06 0.00035 21.4 8.3 1 23 227 249 227 249 0.99
7 26 0.00061 0.051 14.6 7.3 1 23 255 277 255 277 0.98
8 26 1.6e-05 0.0013 19.6 6.0 1 23 283 305 283 305 0.99
9 26 3.3e-06 0.00027 21.7 6.6 1 23 311 333 311 333 0.98
10 26 3.3e-06 0.00027 21.7 6.6 1 23 339 361 339 361 0.98
11 26 2.1e-06 0.00017 22.4 6.6 1 23 394 416 394 416 0.99
12 26 4.5e-05 0.0038 18.1 8.3 1 23 422 444 422 444 0.97
13 26 0.0003 0.025 15.6 5.8 1 23 450 472 450 472 0.96
14 26 8.5e-07 7e-05 23.6 2.4 1 23 478 500 478 500 0.99
15 26 4.9e-07 4.1e-05 24.3 3.7 1 23 506 528 506 528 0.99
16 26 8.1e-07 6.7e-05 23.6 3.9 1 23 534 556 534 556 0.99
17 26 2.4e-05 0.002 19.0 6.1 1 23 562 584 562 584 0.99
18 26 1.5e-05 0.0012 19.7 6.9 1 23 590 612 590 612 0.99
19 26 0.0081 0.67 11.1 6.3 1 23 618 640 618 640 0.96
20 26 0.0031 0.26 12.4 8.5 1 23 646 668 646 668 0.99
21 26 0.00087 0.072 14.1 3.9 1 23 674 696 674 696 0.99
22 26 1e-07 8.6e-06 26.5 4.7 1 23 702 724 702 724 0.99
23 26 1.1e-06 9e-05 23.2 4.8 1 23 730 752 730 752 0.99
24 26 1e-06 8.6e-05 23.3 2.9 1 23 758 780 758 780 0.99
25 26 2.5e-05 0.0021 18.9 5.9 1 23 786 808 786 808 0.98
26 26 2.6e-06 0.00022 22.0 6.6 1 23 814 836 814 836 0.99

Sequence Information

Coding Sequence
ATGTCATATAATGATGTGGAGATCAAACAGGAACAAGTGGATTATCTGGTGCTGCCTGATGGAGATGATTTTATAAAAATTGAAATAAGAGAAGAAAATCAACCATATTCTGAACAAAACTTGGACGAACAAAATGTTACCGCCAAAGCAAAAAGTAAAAACAAGACTGAAGAGATTCAAAGCAAATGTGAAGATCCATTAATGGACGACGAACATAATTTAGAAAAGCATAATAAAACACATACGGGCGAAAAACCGTACAGCTGCGAATACTGTAATAAGAAATTTACTCAATACGGTAATTTAAAGACTCATAAGAGAACACACACGGGGGAGAAACCGTACAGCTGCGAATACTGTAATAAGAAATTTTCTGCTTCCCATAGTTTAAAGAGGCACATGAGAACACACACGGGGGAGAAACCGTACAGCTGCGAATACTGTGATAAGAAATTTTTGACTTCCAATAATTTAAGAAAGCACAAGAGAACACACACTGGGGAAAAACCGTACAACTGCGAATACTGTGATAAGAAATTTTCTGATAGTAGTTATTTAAAGAATCATACGAGAACACACACGGGTGAGAAACCGTACAGCTGCGAATACTGTAATAAGAAATTTGACCATCCCAGTGATTTAAAGAGACATACGAGAACACACACGGGGGAAAAACCGTACAGCTGCGAATACTGTAATAAGAAATTTTCTGATTGCAGTCATTTAAAAACTCATACGAGAACACACACGGGGGAGAAACCGTACTGCTGTGAATACTGTAATAAGAATTTTCCTGATTGCAGTAGATTAAACACTCATAAGAGAACACACACAGGGGAGACACCGTACAGCTGCGAATACTGTAATAAGAAATTTTCTTATGGTAGTCATTTAAAGACTCATAAGAGAACACACACGGGGGAGAAACCGTACTGCTGCGAATACTGTAATAAGAAATTTTCTGATCGCAGTAGTTTAAAATCTCATAAGAGAACACACACGGGGGAGAAACCGTACTGCTGCGAATACTGTAATAAGAAATTTTCTGATCGCAGTAGTTTAAAATCTCATAAGAGAACACATACGGGGGAGAAACCGTACAGCTGCGAATACTATCTATTAAAGGACGACGAAGGTAATTTAAAGACTCATAAGAGAAGGAACACAGGGGAGGAACCGTACAGCTGCGAATACTGTAATAAGAAATTTTGTAATCGCAGTGATTTAAAAAGACATAATAGAACACACACAGGGGAGAAACCGCATTGCTGCGAATACTGTAATAAGAAATTTTATAATAGCAGTGATTTAAAAAGACATAATAGAACACACACAGGGGAGAAACCGCATTGCTGCGAATACTGTAATAAGAAATTTTCTGTTTTAAATAATTTAAAGATTCATAAGAGAATACACACAGGGAAGCAACCGTACAGCTGCGAATACTGTAATAAGAAATTTTCTAATGGCAGTTCTTTAAAGGCGCATAAGAGAACACACACGGGGGAGAAACCGTACAGCTGCGAATACTGTGGTAAGACATTTTTTACTTCCAATAGTTTAACGAAGCACAAGAGAACACACACGCGGGAAAAACCGTACAGCTGCGAATACTGTAATAAGAAATTTTCTGCTTCCTATAATTTAAAGAGGCACAAGAGAACACACACGGGGGAGAAACCGTACAGCTGCGAATACTGTTATAAGAAATTTTCTGCTTCCCATAATTTAAAGAGGCACAAGAGAACACATACGGGGGAGAAACCGTACAGCTGCGAATACTGTTATAAGAAATTTTGTAATCGCAGTGATTTAAAAAGACATAATAGAACACACACAGGGGAGAAACCGCATTGCTGCGAATACTGTAATAAGAAATTTTCTATTTTAAATAAATTAAAGATTCATAAGAGAATACACACAGGGGAGAAACCGTACAGCTGCGAATACTGTTGTAAGAAATTTTCTGCTTCCCATAATTTAAAGAGGCACAAGAGAACACACACGGGGGAGAAACCGTACAGCTGCGAATACTGTGATAAGACATTTTTTGCTTTCAATAGATTAACGAAGCACAAGAGAACACACACGGAGGAGAAATCGTACAGCTGTGAATACTGTGATAAGAAATTTTCTGATAGTAGTCATTTAACGACTCATACGAGAACACACACGGGAGAGAAACCGTACAGCTGCGAATACTGTACTAAGAAATTTGATCATCCTAGTGATTTAAAGAGACATAAGAGAACACACACGGAGGAAAAGCCATACAGCTGCGAATACTGTGATAAGAAATTTTCAGCTTCAGATTATTTAAAGAGACACAAGAGAACACACACGGGGGAGAAACCGTACAGCTGCGAATACTGTAATAAGAAATTTTCTGCTTCCCATAATTTAAAGACTCATAAGAGAAAACACACGGGGGAAAAACCGTACAGTTGTGAATACTGTAATAAGAAATTTTGTACTTCCAATAGTCTTACGAGGCACACGAGAACACACACGGGGGAGAAACCGTAG
Protein Sequence
MSYNDVEIKQEQVDYLVLPDGDDFIKIEIREENQPYSEQNLDEQNVTAKAKSKNKTEEIQSKCEDPLMDDEHNLEKHNKTHTGEKPYSCEYCNKKFTQYGNLKTHKRTHTGEKPYSCEYCNKKFSASHSLKRHMRTHTGEKPYSCEYCDKKFLTSNNLRKHKRTHTGEKPYNCEYCDKKFSDSSYLKNHTRTHTGEKPYSCEYCNKKFDHPSDLKRHTRTHTGEKPYSCEYCNKKFSDCSHLKTHTRTHTGEKPYCCEYCNKNFPDCSRLNTHKRTHTGETPYSCEYCNKKFSYGSHLKTHKRTHTGEKPYCCEYCNKKFSDRSSLKSHKRTHTGEKPYCCEYCNKKFSDRSSLKSHKRTHTGEKPYSCEYYLLKDDEGNLKTHKRRNTGEEPYSCEYCNKKFCNRSDLKRHNRTHTGEKPHCCEYCNKKFYNSSDLKRHNRTHTGEKPHCCEYCNKKFSVLNNLKIHKRIHTGKQPYSCEYCNKKFSNGSSLKAHKRTHTGEKPYSCEYCGKTFFTSNSLTKHKRTHTREKPYSCEYCNKKFSASYNLKRHKRTHTGEKPYSCEYCYKKFSASHNLKRHKRTHTGEKPYSCEYCYKKFCNRSDLKRHNRTHTGEKPHCCEYCNKKFSILNKLKIHKRIHTGEKPYSCEYCCKKFSASHNLKRHKRTHTGEKPYSCEYCDKTFFAFNRLTKHKRTHTEEKSYSCEYCDKKFSDSSHLTTHTRTHTGEKPYSCEYCTKKFDHPSDLKRHKRTHTEEKPYSCEYCDKKFSASDYLKRHKRTHTGEKPYSCEYCNKKFSASHNLKTHKRKHTGEKPYSCEYCNKKFCTSNSLTRHTRTHTGEKP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-