Basic Information

Gene Symbol
-
Assembly
GCA_949709985.1
Location
OX453265.1:4766112-4772872[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 0.23 20 6.7 1.6 1 23 36 59 36 59 0.94
2 18 0.012 1.1 10.7 0.1 2 23 84 106 83 106 0.93
3 18 0.031 2.7 9.4 0.9 2 23 129 150 128 150 0.97
4 18 0.0051 0.44 11.9 0.9 1 23 154 177 154 177 0.92
5 18 0.23 20 6.7 0.3 3 19 182 198 181 203 0.88
6 18 0.17 14 7.1 1.0 1 20 213 232 213 236 0.82
7 18 0.046 4 8.9 1.8 1 23 243 266 243 266 0.93
8 18 0.02 1.7 10.1 2.9 1 23 272 294 272 294 0.97
9 18 1.3 1.2e+02 4.3 4.7 1 23 353 376 353 376 0.95
10 18 0.33 29 6.2 0.1 2 23 401 423 400 423 0.92
11 18 0.00086 0.075 14.3 3.3 1 23 444 466 444 466 0.99
12 18 0.047 4.1 8.9 1.6 1 23 470 492 470 492 0.98
13 18 0.012 1 10.7 1.6 1 19 497 515 497 515 0.98
14 18 0.035 3 9.3 0.1 2 23 527 549 526 549 0.93
15 18 0.18 16 7.0 5.7 1 23 556 579 556 579 0.97
16 18 1.1e-05 0.00097 20.3 0.7 3 23 587 607 586 607 0.99
17 18 8e-05 0.007 17.6 2.7 1 23 613 635 613 635 0.97
18 18 3e-05 0.0026 18.9 2.3 2 23 642 663 641 664 0.94

Sequence Information

Coding Sequence
ATGAAGATAGCAGAAATCAGGGGTAACGGACCGATTCTGAGAGAAAACTCTTTGAAACTCCTAGCTAACTCGACGATATGCGTTTTCCAATGGAACAGGAGTCGGTATCGATGTTTTTGCTGTCAAGAACCGTTCTCTGATATGCCTTCCTTGAGAGATCACACGAACAATGAGCACACGCTGAAAGATATagaaaaaatgataataaaccAACAGAATCGTCTGGTGAAAGTGGAGATTTCCACTTTATCCTGCAAGATATGTTCTACGCAAGTGCCAGACTTGGAGAATCTGAAGAACCACTTGTCGGAAATCCACGATTTGGAATTCGGTCTGGTGTCGGACGATTTGCTCGTGCCTTTTAAATTGGAATCTGGGACCCTCAAATGCCAACTGTGTTTGGAAGACTTTAAACTGTTTCGACTGCTAAACATCCACATGAATAAGCATTTTCAGAAGCACGTTTGCCACGTATGCGGTGCCGGTTTCTCGAATCTCGTCTTTTTGAACATGCACAAAGTTAGGATTCACAAACCCCAACTTTGTAAAGAGTGCGGTGTGAAGTTCTCCAACAGGATCGAGAAAAGGGACCACGATGTTACAATCCACAACGTGAAAGTTGAAAGGAAACTGAGATTCCCGTGTCCGTATTGCCAAGAGCGTTTCTTCCAGGAATACTTCAGGGTACAGCATTTAGTCGACAAGCACGGCTTAGCGAAGCCCGAATATAAATGTCCCGTTTGTGATAAgatttatttgaccaaaagcTTGTGCACGAACCATGTGAAGAATGTGCATATGAAGGAAAAAAATCACGAGTGTGATTTGTGTGCGATGAGGTTTTATACGAAATCCGATAAAAATAGGCACAGGGTGACGCACACAGGCGAAAAGAATTTCGTGTgtacaaGTGACAATGGCTCTTCAAAAGAAAAAACGTCAAAGCGGATGTTTGTGCGCACCACCCTCGATGAGAAGAAGGCCACCATCCGAAATACGTTCAAACTCATACAGTATTCGAACATGTGTCTATTCCGTTGGAATCTGCAGTACCAATACAAATGTTTCTGCTGTCAAAAAATCTTTCAGAATATCGTATTGTTgaaaaatcacacaaaaaacAGGCACACTTTAGATGAAATCCGTACAAGAATCAGTAGATATTACCATGGATTGCACAATGTTGATATATCTTCTCTACAATGCAGTATCTGTACTGAAGGAACGGACGACATAGTTATGCTGAAAACGCATTTGTCCGAAAAACATTTTGTGGTCATAGAACCGGGTGAAGATATCCTTGTACCTTTTAGACTGGAAAAGGAAGGTTACAAGTGCGTTCTTTGCCCTGAAGAGTTCCAACATCTGCATTCCTTCAACATCCATATGAACACGCATTTCAAGAACTTCGTCTGCTACATCTGCGGTGCCGGATTTAGGTGTTCCAGTCGGATGAACGTGCATCTAAAGAGGCACAACATGAAAGAGTACAAATGTGAACAGTGCGAAACAACTTTCGCATCATCTTACCAGAAACAGAAACACGATGTGGCGATCCACAACAAGAATCTGAGAATGAAGTGTCCGCTGTGCCCGGAAAGGTTCAGTGAGTATTACGCACGCTTGGCTCATCAAATTAACGTCCATAACACCGAACAGCCCAGACACGAATGCGAATTCTGCAACAGGATATTCCTTTTCAAACACAGACTGAAACAGCATATCCGCAGGGAGCATCTGAAGGAGAAGAACCACGGTTGCAACGAGTGCGGTCAGAACTTCTTTTCCAAAGACATGCTGAAAAGGCACATGATCAGTCACAACGGGGAGAAGGTGCACGAGTGTTCGTTCTGTAAGAAAAGCTACGCCCGACGCGGCACTTTGAGGGAGCACTTGAAAATACATCTAAACATAAGAAAATGGGTGTGCAGTGTGTGTGGGGAGGCGTTCGTTCAGAATTGCAGTTTGAAAAATCATCTAAAGAAACACCATCCAGATTGA
Protein Sequence
MKIAEIRGNGPILRENSLKLLANSTICVFQWNRSRYRCFCCQEPFSDMPSLRDHTNNEHTLKDIEKMIINQQNRLVKVEISTLSCKICSTQVPDLENLKNHLSEIHDLEFGLVSDDLLVPFKLESGTLKCQLCLEDFKLFRLLNIHMNKHFQKHVCHVCGAGFSNLVFLNMHKVRIHKPQLCKECGVKFSNRIEKRDHDVTIHNVKVERKLRFPCPYCQERFFQEYFRVQHLVDKHGLAKPEYKCPVCDKIYLTKSLCTNHVKNVHMKEKNHECDLCAMRFYTKSDKNRHRVTHTGEKNFVCTSDNGSSKEKTSKRMFVRTTLDEKKATIRNTFKLIQYSNMCLFRWNLQYQYKCFCCQKIFQNIVLLKNHTKNRHTLDEIRTRISRYYHGLHNVDISSLQCSICTEGTDDIVMLKTHLSEKHFVVIEPGEDILVPFRLEKEGYKCVLCPEEFQHLHSFNIHMNTHFKNFVCYICGAGFRCSSRMNVHLKRHNMKEYKCEQCETTFASSYQKQKHDVAIHNKNLRMKCPLCPERFSEYYARLAHQINVHNTEQPRHECEFCNRIFLFKHRLKQHIRREHLKEKNHGCNECGQNFFSKDMLKRHMISHNGEKVHECSFCKKSYARRGTLREHLKIHLNIRKWVCSVCGEAFVQNCSLKNHLKKHHPD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-