Basic Information

Gene Symbol
-
Assembly
GCA_949709985.1
Location
OX453267.1:853103-855505[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.05 4.4 8.8 0.0 1 23 158 181 158 181 0.91
2 10 0.024 2.1 9.8 0.1 2 23 185 207 184 207 0.95
3 10 0.0053 0.46 11.9 2.7 1 23 209 232 209 232 0.96
4 10 0.00052 0.046 15.0 0.1 1 23 235 257 235 257 0.93
5 10 0.00066 0.057 14.7 1.3 2 20 261 279 260 281 0.93
6 10 2.3e-05 0.002 19.3 0.5 1 23 300 323 300 323 0.94
7 10 8.7e-05 0.0076 17.5 1.0 1 23 329 351 329 351 0.96
8 10 0.00034 0.029 15.6 0.8 1 23 357 379 357 379 0.97
9 10 0.0014 0.13 13.6 1.0 1 23 385 408 385 408 0.95
10 10 0.00012 0.01 17.0 2.5 2 23 414 435 413 436 0.94

Sequence Information

Coding Sequence
ATGTCAGATTCAGGTAAAGTAAATCTGGGTAGCGTTGTATCAGACATCCTAGCTGAAGCTCAAAACAGCTACTGTCGTTTATGCCTGTGTGAGATGGCTAATGAGTTTTTACATCTTGAAGATGCTGTGTGTATCGACACAGAGTCTGCTATTTTTAAACCACTTGAGGAGGTTTTGTCTGAAGTGCTGGGTGCACAGGTGTCCTGTGATGTGACTGGTTTAGACACTATATGTGTACTGTGTACAGAAATGGCTCTAAATagctataaatttataagtaaattccatgaaaataataaacttcttgaaaatgtatttaacaATCTTGCAGAAACATTAAGTACCAATATAAACAAAGTAACTACAGACCAAACTTTGTATAtcatactaaataataatgaaactaGATTGgttattatgaataaaaaacccaaaaaatataagaaaaataagtaTGTTTCAAAAAAGCTCTATGTGTGCGAAATATGTGGAGACAAACTGAACACACTGGGAGATCTAAAAGATCATGCCATATTGAATCATAGTTGTTTAGTTTGTGAGAAATGTCTTGTCACATTCTTAAATAATGAGGATTTAGAGACCCATATGAGCATAAACCACAAATTCAAATGCTCAAAGTGCTCACAAGTAAGAACATCTAAGGAAAGTTTACAAGAGCATCATGATAAAGCTCATGGCTTGTATGTCTGCAAAGACTGTGGAAAGTCATATGAAGGTATTGAAAAGTTAAAAGTCCATGAAGAAGCGCATAATAAGAAAACTTGTCCTAAATGTGGAAAGAGATACAATACAaaagatttctttttaaaacataaagagCTTTGTTTACAAGGTTTATTACAACCACATGCACCACGGCCGAAACTAAAATTTCCATTTACATGTGAGCAGTGTGGGAAAGGGTATAGCACTAAAGGGGGCCTTAGAGTCCACAATAGATTTGTTCACGGTGATGCTAAGCCGCACATCTGTGAATGGTGTAACAAGGGTTTTACGGCTCCTAGTTATCTAAAAACCCACACAATAAAACATACTGGCGAAAAGAATTTCGACTGTAAAATTTGTAATGGAAAATTTGTCTCCAAGGAGGCACTTTTGTATCACACTCGGAGACATACCGGAGAGAAACCTTATAACTGCACTCATTGCCCTGAGAAATTTGTAAATGCCTCTGCAAGGGCTGAgcacattaaatttaaacatattggacCAACGTTAATGTGTGACATATGCTCACGCAAATTTGTGACTCCATTCTTTTTGAAGAAACATATAAGCAGGCATCATGATCCTTGCAGTAAACTTTACAATAGATGGTCTGTGCTTAATGAGTCCAACCAAGATAATATTGACTAG
Protein Sequence
MSDSGKVNLGSVVSDILAEAQNSYCRLCLCEMANEFLHLEDAVCIDTESAIFKPLEEVLSEVLGAQVSCDVTGLDTICVLCTEMALNSYKFISKFHENNKLLENVFNNLAETLSTNINKVTTDQTLYIILNNNETRLVIMNKKPKKYKKNKYVSKKLYVCEICGDKLNTLGDLKDHAILNHSCLVCEKCLVTFLNNEDLETHMSINHKFKCSKCSQVRTSKESLQEHHDKAHGLYVCKDCGKSYEGIEKLKVHEEAHNKKTCPKCGKRYNTKDFFLKHKELCLQGLLQPHAPRPKLKFPFTCEQCGKGYSTKGGLRVHNRFVHGDAKPHICEWCNKGFTAPSYLKTHTIKHTGEKNFDCKICNGKFVSKEALLYHTRRHTGEKPYNCTHCPEKFVNASARAEHIKFKHIGPTLMCDICSRKFVTPFFLKKHISRHHDPCSKLYNRWSVLNESNQDNID

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-