Basic Information

Gene Symbol
topi
Assembly
GCA_018904235.1
Location
JAEIFU010000057.1:151988-153943[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 6e-05 0.0026 17.9 1.4 1 23 225 247 225 247 0.97
2 9 0.66 29 5.2 0.0 2 23 275 296 274 296 0.87
3 9 0.052 2.3 8.7 0.2 2 23 357 378 356 378 0.96
4 9 0.01 0.44 10.9 2.5 1 20 425 444 425 447 0.95
5 9 2 86 3.7 0.5 2 21 464 483 463 486 0.86
6 9 5.2e-07 2.2e-05 24.4 1.9 1 23 507 529 507 529 0.95
7 9 0.00039 0.017 15.4 1.2 1 23 535 560 535 560 0.97
8 9 0.077 3.3 8.2 1.8 1 23 566 588 566 588 0.88
9 9 2.5e-08 1.1e-06 28.6 0.2 1 23 594 616 594 616 0.98

Sequence Information

Coding Sequence
ATGATGGAGAATATGAAGAAGACAAACGAGGAGATATTTGGCGAGTACACGCTAGCCGAGATTTTGGTGGATGCGGACTTACAGTTGACGCTTAATGAACTGCAGCCTGGAGCTACTGTTCTGGCCAGCAACGTCGGCTCTGACAATTCTGACATCGTTAGATACGAAGGGCTGTCCAAGATTTTTCCTTCAGCTCCGTCTGCTAGCATCCAAATGCCCACGGAGGTGGTCGTGCAGCACACTCTGGCCGATCCGGCTCTGATGCAGATTCTACAGGAAGCCGACGGTAAGTCGGGCTTTGATCCCGGGGCGGAGCAAATGAAAATATGCGACTACTTGGCTGGTGTCAGCAACACCAAGATGACCACCAAAGAGAGCGTATTTCAGGGTAAGTACCGACAGGTATCGGCTCTTTGGCTTTATGTTATGTTATTGTATGTATTCTTCTTCAATCATGCATGCAAAGGTCATGCCGTTCAAAAACCCGTCCAGTCCAAAAATTCACAACAGGACAAACAACCGGCGGCTCCCTCATCCCAGCCACCTACTGGCAGCGAACGTTTACTTATGGAGAATCAAATTCGACTACGCCGGTATATGAAGGATGAGTTTAAATTCGATCTGACCACTGAATCTGATAACTCGCTATCCAAAAAGTCCTCAAAAGAACCACACGAATGTACCATGTGCGATCGAAAGTTTGTGTACGACTCTGGTCTGGTTCGTCACATGGAGAAGCATGCCCTGTATCTGATCCCCAGCCGGGTCAATGTACAGATTAATGCCAATCCGCCAGCAGATCCTGGCCTTCATCTGGTGCTTAAGTGCAATGCCTGTGGTCGCATTTTCTACGACGTTAAACTGGCTTTGGACCATGCCCTGGTTCATTACTCCAAGCAGCCCGAACTAAGCGAGGCCACCATAGTGGACATAGAACCGAGTGTGGACCTGGCCCAACTCTTACCAGAGGGTGAGCAACTGCTAGCCTCCCTCCTACAGGATAACCATGCGAACGATTCACAATTGGAGTCAGATATGTTCACAACCCTAATCCTCGGCAGCGTTTTGCAGTGCGAATTCTGCGACTTTAATTTTGCGGGTATATCGGAGCTTCTGCTTCACTCGTCTACACATGCGCCTGAGCGGCGCGCCGAGTGCACCGCCTGCGACATAACCATGAAGACGGCCATGGATGCCAGCGTACACTTCCAGACCGATTGCACCTTTATGCGCGATGGTTTGAGGCAGCTAAATGTCTCGCTGGATCGCTATTTCGTTTGCAATGTGTGCGAACAAAAATTTTCAAGCACTGAGCTGCTGCAAGAGCATCGGTATTGCCATCATCACTATTTCCCGCGTCTTAGTGAGAACAGGAAGCGGCTGCTTCTTTCCTGTGATTTTTGCGATGTAATCTTCGAATTCGCCCACGAGATTCAGTCGCACAATGAAGAGAAGCATATAAATAAGAAAAAACGTGTGAAGGAGCACAAAAACACTTCAGCCGGACGCCTGCGCCAATATCTGTGCGATATCTGTGGCAAATCATACACCCAGTCTAGTCATCTGTGGCAGCACTTGCGTTTCCATCAAGGCGTGAAGCCGTTCGTATGCACCGAGGAGAATTGCGGCCGCAAGTTTACTATACGTCCGGATCTAAATGATCACATTCGCAAGTGTCATACGGGAGAGCGACCCTATCACTGCCAGGTGTGTGGCAAGAGCTTTCTTACGGGATCAGTCTTCTATCAGCATCGGCTCATCCATCGTGGTGAGCGTCGTTACGAGTGCGAGGAGTGTGGCAAGCGTTTCTCTCGCGCTGATGCCCTGAAGAAACATCAGCTTATCCATACCGAAGAGGAACTGTACAGTTGCCAGCTTCTGTCCCCTATATAA
Protein Sequence
MMENMKKTNEEIFGEYTLAEILVDADLQLTLNELQPGATVLASNVGSDNSDIVRYEGLSKIFPSAPSASIQMPTEVVVQHTLADPALMQILQEADGKSGFDPGAEQMKICDYLAGVSNTKMTTKESVFQGKYRQVSALWLYVMLLYVFFFNHACKGHAVQKPVQSKNSQQDKQPAAPSSQPPTGSERLLMENQIRLRRYMKDEFKFDLTTESDNSLSKKSSKEPHECTMCDRKFVYDSGLVRHMEKHALYLIPSRVNVQINANPPADPGLHLVLKCNACGRIFYDVKLALDHALVHYSKQPELSEATIVDIEPSVDLAQLLPEGEQLLASLLQDNHANDSQLESDMFTTLILGSVLQCEFCDFNFAGISELLLHSSTHAPERRAECTACDITMKTAMDASVHFQTDCTFMRDGLRQLNVSLDRYFVCNVCEQKFSSTELLQEHRYCHHHYFPRLSENRKRLLLSCDFCDVIFEFAHEIQSHNEEKHINKKKRVKEHKNTSAGRLRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCTEENCGRKFTIRPDLNDHIRKCHTGERPYHCQVCGKSFLTGSVFYQHRLIHRGERRYECEECGKRFSRADALKKHQLIHTEEELYSCQLLSPI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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