Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00054 0.035 14.9 3.7 1 21 143 162 143 164 0.93

2 6 0.015 0.94 10.4 5.1 1 23 175 197 175 197 0.95

3 6 0.00073 0.046 14.5 2.8 1 22 206 227 206 230 0.90

4 6 0.00011 0.0068 17.2 7.3 1 23 249 271 249 271 0.97

5 6 9.9 6.3e+02 1.5 5.4 2 23 281 302 280 302 0.94

6 6 5.6e-06 0.00036 21.2 1.1 1 23 308 332 308 332 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00054	0.035	14.9	3.7	1	21	143	162	143	164	0.93
2	6	0.015	0.94	10.4	5.1	1	23	175	197	175	197	0.95
3	6	0.00073	0.046	14.5	2.8	1	22	206	227	206	230	0.90
4	6	0.00011	0.0068	17.2	7.3	1	23	249	271	249	271	0.97
5	6	9.9	6.3e+02	1.5	5.4	2	23	281	302	280	302	0.94
6	6	5.6e-06	0.00036	21.2	1.1	1	23	308	332	308	332	0.93

Coding Sequence: ATGTCAGAGCTGTGCCGTACTTGCGGCAGAGGCATTAATGCTTTAAATGTCAAGGATGTCTTTGACAAAGATAACAGTGAAATCCTTAGCAACATTCATAAACTGACTGGCTTGTGGCTAACCCATAAACTGAATATGCCAAAAAACATATGTTCGACGTGCCTTTTGGACTTAAATAACGCCTTGTCTTTTCGAGAGCGTTGCATCAAGACCCAAAGTCTTTTGGAGTTTGCAGCAGTAACTAATAATACGACTGACTCCAAAGCGCCCGCCGCCTCTgttaaaccaacaacaaatgtcGAACTTGAGCCAATTGATATTAAACAAGAGCAGGTATCCGAGTCTGACGATTGCGGTGACTCTGAACTTTTGGAGCAATTGGAAGCCCTGTCCAATGAACAGGATTCACAGCCAGAGGATAAACTATATACCTGCAAATATTGTGGAAAGATGTTTAACAGCAGCAACGCTGCGCAACATCAACGGTGTCATAAAGTTCACTTGGCCCAGAGCGATCAATCTCATAATTGCAAATACTGTAATAAATCTTGTGCCAATAGCagcatttggaaaaaacatcaATTAGAGCACACGGTGGCCGCCGGTGATCGCCCATTTCGATGTGATATCTGTGACATGGCTTTTACTCGAGGTTTCCATCTAAAAACTCATTTTCTCTCCTACTTTCATCGTAAGAAAGTTGATGCCCTAAACGAACAGGCCTCGGACAACgaaagcaaacaatttttctgtAAATATTGTCCAAGAAGTTTCAACAGCAAGAGCACACGATTTCATCATCAAAGGACGCACTCGGAGTATATGCTGAACAAATCTTTGAATTGCCGATTTTGTAATCACCTATGCCAAAACAAGCAAAGCCTAAAAGAACACGAGCTTATGCACACTGAAGAGCGTCGATATCGATGTGACATCTGCGATGTGGCCTTCAATCGAATTTCTAGTTTGCATAATCATATGCGCTCCAATTCGCACAGATTTAAGGCACAACAAGCGGAAGAGAAGAATGTGTCTGAAGAGGAACAGGACGAAGCACCGGATAGTATATTGTCCACTTAA
Protein Sequence: MSELCRTCGRGINALNVKDVFDKDNSEILSNIHKLTGLWLTHKLNMPKNICSTCLLDLNNALSFRERCIKTQSLLEFAAVTNNTTDSKAPAASVKPTTNVELEPIDIKQEQVSESDDCGDSELLEQLEALSNEQDSQPEDKLYTCKYCGKMFNSSNAAQHQRCHKVHLAQSDQSHNCKYCNKSCANSSIWKKHQLEHTVAAGDRPFRCDICDMAFTRGFHLKTHFLSYFHRKKVDALNEQASDNESKQFFCKYCPRSFNSKSTRFHHQRTHSEYMLNKSLNCRFCNHLCQNKQSLKEHELMHTEERRYRCDICDVAFNRISSLHNHMRSNSHRFKAQQAEEKNVSEEEQDEAPDSILST

Sequence clustering based on sequence similarity using MMseqs2