Lclr013921.1
Basic Information
- Insect
- Lordiphosa clarofinis
- Gene Symbol
- run
- Assembly
- GCA_018904275.1
- Location
- JAEIGQ010000215.1:224374-227083[+]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 5.6e-72 2.2e-68 227.9 0.0 2 129 31 158 30 158 0.99
Sequence Information
- Coding Sequence
- ATGCATTTGCCAGCCGGTCCCACCATGGTGGCCAACACCACGGCTCATACACAGATGCCCAGCTCCATGACGGACATGTTTGCCAGTCTACATGAAATGTTGCAAGAATATCATGGCGAATTGGCCCAAACGGGTTCCCCCTCTATACTGTGCAGTGCTTTGCCCAATCATTGGCGCTCCAACAAATCCCTGCCGGGTGCCTTCAAAGTGATCGCCCTGGATGATGTGCCCGATGGCACACTGGTGTCCATCAAATGCGGCAACGATGAGAACTATTGCGGGGAGCTGCGCAATTGCACAACCACCATGAAGAATCAGGTGGCCAAATTCAATGATCTACGCTTCGTGGGACGTTCGGGCAGGGGCAAATCCTTTACGCTGACGATCACCATTGCCACATATCCGGTGCAGATAGCCAGCTATAGCAAGGCGATTAAAGTGACAGTCGATGGGCCACGGGAGCCAAGAAGTAAGCAAAGCTATGGCTATCCACATCCCGGCGCCTTTAATCCCTTCATGCTGAATCCCGCCTGGCTAGATGCCGCCTATATGACCTATGGTTATGCGGATTATTTCCGTCATCAGGCCGCTGCCGCTGCCGTTCACCATCCAGCCTTGTCGAAATCCTCACCCGGTGCCGCACCCTCAGCCGCCACCTCAGCTAATGGGGGCAGTGGAGTTGGTGCTGGAGCTCCCAGCACTCCAAACGACTATCATCATCATGTGCCGCAAATAACACCACCGCCCGTGGGAGCTCCCGCTGCCCCAACAGCCGCCACACAGCCAGCGACCATGATGCCCTCGCCACCGGGTGCCGCTCCTGCTGCCGCCTATGCCATGCCACAGTTCCCCTTCAATCATGTGGCCGCTGCCGCTGCTGCCGCCGCTGCTCAAAAGTCCACACCTCATGCCTTCCATCCGTATAATTTTGCCGCCGCCGCCGGTCTGCGTGCGCGCAACGCGGCCGCCGTGGCCCTACATGGTGCTGGCAGTCCTGCCTCATCGCGTCCCTCCAGCTCCTCGCCCACGCAACAGCATGTTCTGGTCAAGCTGAACACGTCCATTGAAACCAGCTCCATACACGAACAGTCGGCCTCCGATGCGGATTCGGATGATGAGCAAATCGATGTGGTCAAGTCTGAATATGATCTGGACAAGTCCATTGATTCCACGCGCAGTTCACCCACGCAACATATCTCGGTGCCATTGCGTATGCGTTGCGATCTGAAAGCCCCGTCGGCTCTGAAGCCCCTGTTCCATGAGTCCACGGCGCCGACGACGCCGCGTCAAGCGTCACCCGAGACTACCACCCTGACGGCGGCCACCAAGCTGAAGAGCGCGTCCGTTCAGCAGAAGACCGTGTGGAGGCCTTACTAA
- Protein Sequence
- MHLPAGPTMVANTTAHTQMPSSMTDMFASLHEMLQEYHGELAQTGSPSILCSALPNHWRSNKSLPGAFKVIALDDVPDGTLVSIKCGNDENYCGELRNCTTTMKNQVAKFNDLRFVGRSGRGKSFTLTITIATYPVQIASYSKAIKVTVDGPREPRSKQSYGYPHPGAFNPFMLNPAWLDAAYMTYGYADYFRHQAAAAAVHHPALSKSSPGAAPSAATSANGGSGVGAGAPSTPNDYHHHVPQITPPPVGAPAAPTAATQPATMMPSPPGAAPAAAYAMPQFPFNHVAAAAAAAAAQKSTPHAFHPYNFAAAAGLRARNAAAVALHGAGSPASSRPSSSSPTQQHVLVKLNTSIETSSIHEQSASDADSDDEQIDVVKSEYDLDKSIDSTRSSPTQHISVPLRMRCDLKAPSALKPLFHESTAPTTPRQASPETTTLTAATKLKSASVQQKTVWRPY
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00471386;
- 90% Identity
- iTF_00918826; iTF_00919642;
- 80% Identity
- -