Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.17 12 6.9 3.4 1 23 92 115 92 115 0.94

2 7 0.00022 0.015 16.0 3.2 2 23 136 157 135 157 0.97

3 7 0.55 39 5.3 5.6 2 23 165 187 164 187 0.93

4 7 0.015 1.1 10.2 6.6 1 23 195 217 195 217 0.97

5 7 8.2e-05 0.0058 17.3 1.3 2 23 224 245 223 245 0.98

6 7 0.017 1.2 10.0 0.7 1 23 251 275 251 275 0.95

7 7 0.00028 0.019 15.7 1.3 2 23 283 304 282 304 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.17	12	6.9	3.4	1	23	92	115	92	115	0.94
2	7	0.00022	0.015	16.0	3.2	2	23	136	157	135	157	0.97
3	7	0.55	39	5.3	5.6	2	23	165	187	164	187	0.93
4	7	0.015	1.1	10.2	6.6	1	23	195	217	195	217	0.97
5	7	8.2e-05	0.0058	17.3	1.3	2	23	224	245	223	245	0.98
6	7	0.017	1.2	10.0	0.7	1	23	251	275	251	275	0.95
7	7	0.00028	0.019	15.7	1.3	2	23	283	304	282	304	0.96

Coding Sequence: ATGAGTAAAAACGAGGAAGAGGAGGAAATAAAAATCGAATATTTCGAGTCTTTCGACACCGATCCTCTGTGTGAGAATAGGGAAAAACCAACATGTGCCACAAAAGATTACCTAACATCAAATATTTGTGATGAAAATATAAATCAACGAGACTCAAATGATAATAATGAGATCTTAGAATACCAAGAAAATGCAGTAAATGATGAAAATGAATACCCTGTTGAATCAGAAAATGAAGAAACTTGGTACAAATCTGTGGATAATCTAGGAAGATATCTCTGCAAATTCTGTGATAACTCATATTCTACTATCCAAACAGTACGTCACCATGTTAAGAACAAACACTTTGATGATTATAACCGCATAAAAGGCACCGCAAAAGACAAAATTAGAAAAAGAAAACTGAAATGCCATATTTGCAAGAAGAGGTTTAAAAATACCAACATTTTACAAGAACACATGCAAATTCATGGCATTAATGAAATACATAAATCTTGCTTCATATGCCATGCAACATTTCATACAGATACAGAATTGTTAACTCATATATCGCATAAACATGAATTGGTGAAAAGAAAGCTACATTACTGCTACACTTGCGGTTACATTACATCAAAATTATCACACTTCAAACAGCATGAAAAAACACATTCGCTCAACAATCAGATAAAATGTTCCTATTGTGAATATACAACATATCATCCACCCAATTTAAAGATACATGAACGGACACATACAAATGATAAGCCATATGCATGTACGTTCAATGGTTGTGGGTACCGATGTGCAGCTAAGTCAGGACTGTCCAGTCATTGGCTAAAACATGAGAAGAAGAAGAATATGATTTATTGTGATAAGTGCAGTTACAGTACTGTTTATAAACAGAGTTTGAAGAAACATATGGACAGCCATAAAAGAAATAGTGTGAGAACTAGATTTTAA
Protein Sequence: MSKNEEEEEIKIEYFESFDTDPLCENREKPTCATKDYLTSNICDENINQRDSNDNNEILEYQENAVNDENEYPVESENEETWYKSVDNLGRYLCKFCDNSYSTIQTVRHHVKNKHFDDYNRIKGTAKDKIRKRKLKCHICKKRFKNTNILQEHMQIHGINEIHKSCFICHATFHTDTELLTHISHKHELVKRKLHYCYTCGYITSKLSHFKQHEKTHSLNNQIKCSYCEYTTYHPPNLKIHERTHTNDKPYACTFNGCGYRCAAKSGLSSHWLKHEKKKNMIYCDKCSYSTVYKQSLKKHMDSHKRNSVRTRF

Sequence clustering based on sequence similarity using MMseqs2