Basic Information

Gene Symbol
RREB1
Assembly
GCA_963971575.1
Location
OZ020617.1:40020642-40025947[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 8e-05 0.019 17.3 1.2 1 23 70 92 70 92 0.98
2 16 6.2e-05 0.015 17.6 0.3 1 23 104 126 104 126 0.97
3 16 5.2e-06 0.0012 21.0 3.7 1 23 132 154 132 154 0.98
4 16 1.2 2.9e+02 4.1 0.0 1 20 226 246 226 250 0.72
5 16 0.011 2.7 10.5 2.3 2 23 256 278 255 278 0.95
6 16 1 2.5e+02 4.3 0.0 1 20 331 350 331 352 0.93
7 16 0.075 18 7.9 0.1 1 23 485 507 485 507 0.96
8 16 1.5e-05 0.0037 19.5 0.7 1 23 517 539 517 539 0.99
9 16 0.00086 0.21 14.0 3.1 1 23 545 568 545 568 0.97
10 16 0.00074 0.18 14.2 2.8 1 23 957 980 957 980 0.96
11 16 0.00019 0.047 16.0 0.4 2 23 1223 1244 1222 1244 0.97
12 16 0.13 31 7.1 6.3 1 23 1250 1273 1250 1273 0.97
13 16 0.2 49 6.5 3.0 1 20 1304 1324 1304 1328 0.94
14 16 0.16 39 6.9 0.5 1 23 1381 1404 1381 1404 0.94
15 16 0.017 4.1 9.9 0.5 3 23 1451 1471 1449 1471 0.93
16 16 0.017 4.1 9.9 7.9 1 23 1477 1499 1477 1499 0.98

Sequence Information

Coding Sequence
ATGGAAGACTCATTTAACGAGACCAAAGAAAGCCAAAGACGTACGGATACCGAAGAAAGTATGTTGGAGAGTAGTTCTGCAGTATCCGAAAATTTGCACACGACAGCATCAACGAATGAGTCGGATTTAGAGCCTATGGACATTAGCAAAACTGCATCAGACAGCGATAACGCTAGCAACTGCAGCTCACCATCAAGTGACACTAAATATTTCTGCCCGATATGCGATATCACCCTTACTTCTCAACACGAATTTACATTGCATATTCGTTCTCATAACAATGATAACGAAATAATATCAGAAAAAGGTTTTATTTGTAGAATTTGCTCAAAAGTATTGAGTTCTAGTTCGAGTTTAGACAGGCATATGCTTGTTCATAGTGGTGAACGACCATTTAGTTGTAAAATTTGTTCAGTTACTTTTACAACAAACGGAAATATGCATAGACACATGAGAACACATACTCATAAAGGAGGTGAAAATTATGAATCGGATGGAAGTACAGATAGCAATAACAGTAATAACTCAGGAAGAAGGAAAAGAAGGTTGgaatttaacaacaataaattagtaGATAACAAAAGAAAGTCTGATAATTATAACGAAGATGAAGCAACAccgagaaaaacaaaaaatttaaacaataataatatcaacGAAAATCTAACCCAAAAATTCCGCTGTCCTGTTTGTGGTAGAGAAGATTTTGCTTCCCTAAATGTTCTTGAATTACATCTCGAAGATAATCATCCAGATTTTGAAGTTAAGTGTACATCGTGTAATTTGAGTTTTAAAAACCATCGTGCTCTGAATCTCCACCGTTATATGGTACATtcatctgaaaaaaataatattaataacaaaaatttaaggAACTCTGTTGTTGGCTTTAAGGATTTGACTTTTGTAGATTTTTCTAGTGAAAAATTCCCACATATAGCAAGATATGCCTGTGAGAAAAGTCTTCATAAACCAGTAACAGGACAGAAGTTCATTTGCGACAATTGTACATTAGCCTTTCCATGTGCTAGTGCTTTGGAAATTCACCAAGAAGCTTGTCTGAGAAAGAGAGATGAAAGCTTTAATGACAGTGAAAATCCAACTGATTTATCCAGAAAATCCGAATCTTCTGAGGAAGACATTCGACGTGAAAACTTCTTTGCTCACTTGGACTTGCAAAACAAGTCCCCTCCATGTTCTCCAACTAACGAAGAAActaaaatcaaagaaaaaccAGCTGAAGTAAAAGCTCCAATAGATTCCAAAGACCTAGCTGATATCCAGTCTATCATTTCAATGACCTCTAATGGAAGTCTTCTTCAGCACCTTCGCGCTAAACCATCTCCTGAACTATTACCAGTTCCCACTGAAACTCCTCCAAGAGAACCCCAGGAAGAAGAAAGTCAAGATGTTTTCGCTGCTGAATTTAGAAAGATGAAACTTCGCGGAGAGTTTCCATGTAGGCTCTGCACTGCAGTATTTCCAAACTTACGTGCTTTGAAGGGGCACAACAGGGCCCATTTAACAGGGACTGGTAATACAGGGCCTTATCGCTGTAATATGTGCCCTCATAGTTCTGTGGACAAAGCAGCTTTAATAAGACATATGAGATCTCACAATGGTGACCGTCCTTATGAGTGTTCACTTTGCAATTATGCGTTTACTACAAAAGCAAATTGCGAGAGACATTTGAGGAATAGACACGCAAAAGTTACTCGCGAAGAAGTTAAAAAGGCTATCATCTATCATCCATCTGAAGACCCAACTAATGATGATAATAAACTTAACACTTCTCGTGATGAGATGAAGAGATCTTTCTTCAATAGTTCTAACGAAGAAGAACATCAAGAAAGAATAAATAGCTCCACGCCAAAAGAAAATAGAATCGCACCTGAGGCAATGGGACTTTTGATGCCTAAAGACTTGGGAATTAAAATACCACCTACTCTGCTCCCTCCAGATTTACCAATAAGCTTCCCAATGCATAAGGAACATGCCCCATTTATTCAAGTAAACAAAGAATTGGCTGtacttaaagaaaaaattatgccCAAAGATGAGATTATGAAACCTTTCAATATTCTCCGTGAAAAAATGGAAGAGTCTTTCAACATCAAGAATAATTTCCAGAGTGTGGATGGGTTGAAACAAATCCCTGAATACGATATTCCATCGGATGATGAAACAGAAGAATCTTCTCAGAATCATTCCTCGAGTTATGAAGATTATAAGAGTGAGCATCCAATTGATTTGAGCATGGATGTATTGGATTTAAGTAAAAAGAAATCTCCACCACCTGTGAAGAAAGACGAACCGGTAGATTGCACTAAAAAGACACTTGAAGCAAGCATACCTCCTGCGATGACCCAAGCAGCTTTATCGCAATTATTTGCTCAACAACTCCTCAAAAATCCCTTCTACGCAACACAACTTTCCCAATATTATCAAAATCCAGCTGTTTTTCCCTCTCTACAAAATTTGGCAATGCCTCAAATGCCATTATCACCTTTTCTATTTCCACATACTTTCCTCAATTCAAATGCTGCTCAAGAGATGAAAGATAGGATGCTTCGCATACAGTTGCAAAGTGGAGGAACGATCATCAGCGATCAGTTTTCTCCTGACAGGCTACAATCATTCCAACCACAACCTGTAAATGAAATGAAGTTTTCaccaaaagaagaagaaattaaACCACCCCTACATATTAATACACATTTAGGGGATTCTGTGAACAAAATGCATTCCCCTAAACCACAGCAAAAGACACCAGACATGTCTCATAGTCCTaatagtgtgaaaatggtgaTTAAAAACGGGGTACTGATGCCAAAACAAAAGCAACGAAGGTACAGAACTGAAAGGCCGTTTTCCTGCGAGCATTGCTCTGCTAGATTCACACTTAGATCTAATATGGAACGTCATATTAAGCAACAACATCCACAATTTTGGTCTCAGAGACAAAGATCTGGAATCTCCACCGCTGGGAGGAAGCCGTCAGGGCCAACCCCAACACCACCTCTAACTACTAACAATAAACCACCTTATTACGACCTAAATATACCAAATTATGATATGTATGTACCAAAGATGCAAGATACGTTAGTCAACGATACCAAAGAAAAAGTTAAATTCGCTATTTTAGCTCAACAGTTAAAAGCTAAAGACTTTTATAACGAGCAATGTTATCCCTCACCCACCAAAGATAAACCAGATGAAGATGAAGATGCTCTTGTTATTGATGAAGAAGATGATAAGAGTTCTGTAAAGCAAGAAACCAAAGAAGAAcctaaaaatgatgaaaaaccAAAAACTCTTGAGGAAAAAATGTTTGAATTGAGACAAATGAGAGAGAATGAAATCAAAAAAGTTGGTGATTTGTTGAAGATTGCCAAGACTGAAGAGGGACAGGATCTTGTTCCAGTTTCCCGATTGCTTGATAATGCTAATAGTTCTATGCCCTTTCGCGAGTTTTTTCGCCGCGAAGGAGAAGACCATGAAGGTGGGGGCGTAAGCGAAGAAGACGAAGAAGGATTGGTAGCGAGCGGCAGTACTAGCGAAGGAAATGGATCTAGTGGAGATGAAAATAAATCTGAAAATGAGCAGACTTCAACCAGCGAAGCTACAAAAAAGAAGTCCGCATACTCCCTGGCTCCGAACCGTGTGAGTTGCCCATACTGCAACCGTAAATTCCCCTGGACATCTTCACTGCGTCGTCACATTTTGACCCATACCGGacagaaacctttcaaatgttcacATTGTCCACTTCTCTTTACCACCAAATCAAACTGTGACAGACATCTCCTTCGTAAACACGGCAATGTCAATCTCCAAAATTCCGAATCTTCAACTCAACCGaataacaaaaatcaaaactaTATGATGAGAAACGTGCCAGAAAGACCATACAAATGTTCCAGTTGCCCAAGTTCGACTTTTGCAACTTTAAGTAATCTCAATAAACACATGTCTTGCAAACATACGCAAAATGATAGACCTCCTAGTATTGAATATGAAAGTCATGGAAGTTCTGAGGATGAAAGAGCTAAAGAAATGAAGACAGATAAAGATTGGGAAACTCAAATATCCCAAAGTAAAGTTCTCAATGACCAAACACCCCAAAATGCTGATTTACCATTCAAATGCCACCTTTGTGAAGGTTCTTTTTCGGAAAGACAGGAAGCTTTGGATCATATCAAAGACATTCATGTTTCTGAGTTTGAATTGTTGATGTCTAAAGGTGCTTTAGATCAGACTGTAACGGAAGAGGTGCAGCAGAATCATGAGACAGAAGATGATGATCATTTACGGGGAAAATTCCCGGATTACGCGAATCGGAAGGTGATGTGTGCCTTTTGTATGCGTCGTTTTTGGTCTGCTGAAGACTTGCGTCGTCACATGAGAACACATACTGGAGAACGACCATTTTCTTGTGATGTATGTCACAGAAAATTCACCCTTAAACACAGCATGTTGCGTCACCGGAAAAAACATAACCTCACAAATCCCGTTGAAGAAAATGTAATGGTAAGTGGGGACGAAGAACCCACCCAAGTTCTCTATGACAgacttaatattaataataacaatatagaAGGAAAGAGAGAAGAGAAATCAGATGATTCAGAAGGTAATGAAGGAAATGATTTAATCGGTAACTTATTAGGTATACGTGATAAATCGATTATAGATCAAGTACTTGTTTCATCAGCGGATGATGCTGCTAAGTTACTTGGTGTGAATAATGGACAAGAGTGA
Protein Sequence
MEDSFNETKESQRRTDTEESMLESSSAVSENLHTTASTNESDLEPMDISKTASDSDNASNCSSPSSDTKYFCPICDITLTSQHEFTLHIRSHNNDNEIISEKGFICRICSKVLSSSSSLDRHMLVHSGERPFSCKICSVTFTTNGNMHRHMRTHTHKGGENYESDGSTDSNNSNNSGRRKRRLEFNNNKLVDNKRKSDNYNEDEATPRKTKNLNNNNINENLTQKFRCPVCGREDFASLNVLELHLEDNHPDFEVKCTSCNLSFKNHRALNLHRYMVHSSEKNNINNKNLRNSVVGFKDLTFVDFSSEKFPHIARYACEKSLHKPVTGQKFICDNCTLAFPCASALEIHQEACLRKRDESFNDSENPTDLSRKSESSEEDIRRENFFAHLDLQNKSPPCSPTNEETKIKEKPAEVKAPIDSKDLADIQSIISMTSNGSLLQHLRAKPSPELLPVPTETPPREPQEEESQDVFAAEFRKMKLRGEFPCRLCTAVFPNLRALKGHNRAHLTGTGNTGPYRCNMCPHSSVDKAALIRHMRSHNGDRPYECSLCNYAFTTKANCERHLRNRHAKVTREEVKKAIIYHPSEDPTNDDNKLNTSRDEMKRSFFNSSNEEEHQERINSSTPKENRIAPEAMGLLMPKDLGIKIPPTLLPPDLPISFPMHKEHAPFIQVNKELAVLKEKIMPKDEIMKPFNILREKMEESFNIKNNFQSVDGLKQIPEYDIPSDDETEESSQNHSSSYEDYKSEHPIDLSMDVLDLSKKKSPPPVKKDEPVDCTKKTLEASIPPAMTQAALSQLFAQQLLKNPFYATQLSQYYQNPAVFPSLQNLAMPQMPLSPFLFPHTFLNSNAAQEMKDRMLRIQLQSGGTIISDQFSPDRLQSFQPQPVNEMKFSPKEEEIKPPLHINTHLGDSVNKMHSPKPQQKTPDMSHSPNSVKMVIKNGVLMPKQKQRRYRTERPFSCEHCSARFTLRSNMERHIKQQHPQFWSQRQRSGISTAGRKPSGPTPTPPLTTNNKPPYYDLNIPNYDMYVPKMQDTLVNDTKEKVKFAILAQQLKAKDFYNEQCYPSPTKDKPDEDEDALVIDEEDDKSSVKQETKEEPKNDEKPKTLEEKMFELRQMRENEIKKVGDLLKIAKTEEGQDLVPVSRLLDNANSSMPFREFFRREGEDHEGGGVSEEDEEGLVASGSTSEGNGSSGDENKSENEQTSTSEATKKKSAYSLAPNRVSCPYCNRKFPWTSSLRRHILTHTGQKPFKCSHCPLLFTTKSNCDRHLLRKHGNVNLQNSESSTQPNNKNQNYMMRNVPERPYKCSSCPSSTFATLSNLNKHMSCKHTQNDRPPSIEYESHGSSEDERAKEMKTDKDWETQISQSKVLNDQTPQNADLPFKCHLCEGSFSERQEALDHIKDIHVSEFELLMSKGALDQTVTEEVQQNHETEDDDHLRGKFPDYANRKVMCAFCMRRFWSAEDLRRHMRTHTGERPFSCDVCHRKFTLKHSMLRHRKKHNLTNPVEENVMVSGDEEPTQVLYDRLNINNNNIEGKREEKSDDSEGNEGNDLIGNLLGIRDKSIIDQVLVSSADDAAKLLGVNNGQE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-