Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.011 0.82 10.6 5.0 2 23 154 174 153 174 0.97

2 6 6.4e-07 4.9e-05 23.9 0.8 1 23 180 202 180 202 0.98

3 6 0.00014 0.011 16.5 4.7 1 23 208 230 208 230 0.98

4 6 5.8e-05 0.0045 17.7 2.3 1 23 236 258 236 258 0.98

5 6 2.8e-06 0.00022 21.9 0.3 1 23 264 286 264 286 0.97

6 6 7.8e-05 0.0061 17.3 2.9 1 22 292 313 292 313 0.94

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.011	0.82	10.6	5.0	2	23	154	174	153	174	0.97
2	6	6.4e-07	4.9e-05	23.9	0.8	1	23	180	202	180	202	0.98
3	6	0.00014	0.011	16.5	4.7	1	23	208	230	208	230	0.98
4	6	5.8e-05	0.0045	17.7	2.3	1	23	236	258	236	258	0.98
5	6	2.8e-06	0.00022	21.9	0.3	1	23	264	286	264	286	0.97
6	6	7.8e-05	0.0061	17.3	2.9	1	22	292	313	292	313	0.94

Coding Sequence: ATGAATTCGACAATTGATTTTGCAAACAATCCATTTTTCATTCATGATATGGACAAGCTATGCGCTGTATGCCaaaagaaactggaaaagGACAAAACTCATTCGCTCTTCGCTGCCTTGCCAAACTTGGAACCCACTAAGAATGCGTTGGAAGTTCTTGCAACCATTTCAAATTTTAACAGTGAGAATGGTCCTCAAAACTTGTGCACGACATGTTTCAAGAACACAGCCGCTGCatataaattccaaaaaatatgtaacaaaGCAAAcgaatatatacaaaattatttgcgatATCAAGAGGAAATGAAGTTGAAAGCTCaggaaaatgtagaaattgtGATGAACAGTGTggaagttgaagaaaatgttACGATAGATGATACAGGTGTTTCAGATGGGAAAGTAGCTGATCCCGCAGTTGAATCCTCACATTTTTCTGGTGGAGCTACaagaataaaatgtaaattttgtcaTAAAATGTACAGACGTGATTATATGTCAGTACATAGAAGGACACACACTGGGGAGAAGCCATACAAATGTAACATATGCAACAAAAGATTCGCgCAACCCACAACGTTAAAGTTACATGAAATCACTCATACGGATAATAGAGcatatatttgcaaatattgcgGCAAGACATTTAAATTGCTACGAAATCTACGGTGTCATGAAAGGACTCATTCAGGAGAAAAGCCATATAAATGCGATTTGTGTGACAAGAGCTTTATTACTCATTCAGCGAGAAGAATGCACTACTTAGTTCACACTAAGGAAAAACGTTACCAATGTGAAGTGTGCTCGAAAAGTTTTGGAAGGCCATATGGTTTAACGCAGCATTTAGTATCACATTCTGATGTAAAGAAACATGAATGTCATCTATGTGGTAATCGTTTCACTCAGGCACATTCTTTAAGAACGCATTTAAAAATGAGTTGTCAAGCTCTGAAATAA
Protein Sequence: MNSTIDFANNPFFIHDMDKLCAVCQKKLEKDKTHSLFAALPNLEPTKNALEVLATISNFNSENGPQNLCTTCFKNTAAAYKFQKICNKANEYIQNYLRYQEEMKLKAQENVEIVMNSVEVEENVTIDDTGVSDGKVADPAVESSHFSGGATRIKCKFCHKMYRRDYMSVHRRTHTGEKPYKCNICNKRFAQPTTLKLHEITHTDNRAYICKYCGKTFKLLRNLRCHERTHSGEKPYKCDLCDKSFITHSARRMHYLVHTKEKRYQCEVCSKSFGRPYGLTQHLVSHSDVKKHECHLCGNRFTQAHSLRTHLKMSCQALK

Sequence clustering based on sequence similarity using MMseqs2