Basic Information

Insect: Liodrosophila aerea
Gene Symbol: zfh2
Assembly: GCA_035045005.1
Location: JAWNNL010000591.1:269565-290581[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 11 0.34 25 5.7 0.3 2 23 151 173 150 173 0.95

2 11 0.00012 0.0089 16.6 1.4 2 23 660 682 659 682 0.96

3 11 3e-05 0.0022 18.5 0.7 1 23 714 738 714 738 0.92

4 11 0.002 0.15 12.7 0.4 1 22 835 856 835 859 0.91

5 11 7.9 5.8e+02 1.4 0.4 1 20 1014 1034 1014 1036 0.82

6 11 1.2 87 4.0 1.9 1 23 1057 1081 1057 1081 0.91

7 11 1.5 1.1e+02 3.7 0.5 2 21 1183 1202 1182 1206 0.89

8 11 0.061 4.5 8.1 0.4 1 23 1321 1344 1321 1344 0.98

9 11 0.038 2.8 8.7 2.5 2 23 1600 1622 1599 1623 0.93

10 11 5.7e-05 0.0042 17.6 2.3 1 23 1674 1696 1674 1696 0.98

11 11 0.0018 0.14 12.8 3.6 2 23 1703 1725 1702 1725 0.94

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	11	0.34	25	5.7	0.3	2	23	151	173	150	173	0.95
2	11	0.00012	0.0089	16.6	1.4	2	23	660	682	659	682	0.96
3	11	3e-05	0.0022	18.5	0.7	1	23	714	738	714	738	0.92
4	11	0.002	0.15	12.7	0.4	1	22	835	856	835	859	0.91
5	11	7.9	5.8e+02	1.4	0.4	1	20	1014	1034	1014	1036	0.82
6	11	1.2	87	4.0	1.9	1	23	1057	1081	1057	1081	0.91
7	11	1.5	1.1e+02	3.7	0.5	2	21	1183	1202	1182	1206	0.89
8	11	0.061	4.5	8.1	0.4	1	23	1321	1344	1321	1344	0.98
9	11	0.038	2.8	8.7	2.5	2	23	1600	1622	1599	1623	0.93
10	11	5.7e-05	0.0042	17.6	2.3	1	23	1674	1696	1674	1696	0.98
11	11	0.0018	0.14	12.8	3.6	2	23	1703	1725	1702	1725	0.94

Sequence Information

Coding Sequence: ATGTCCAGTCCTGATGTTGAAACTTTTAATGGCAAAATAGTTTATAATCTTGATGGCAGTGCGTTTATTATTGATGCAGGAAATGCGACTGTTTCCAGCATTGGCTTGAGCTCATGCGGCGTAACACCAACAGccacaccaacaccaacagccaCATCCACtgcgactccgactccgacgcccacgcccacgagCAAAGTAGCGTGCTCATTGAGGCAAACTGCGAGAGGATCAGAGACATTGCTACAATCTGGTGACGATTACGGCAAGAACAAAGACGGCCTAAGATACAGCTTCAATACAACAATTGGCTCAAGTGGCTGCCCACTAGATAGGCAGGTAGCGAGCCCAAAGATTCACTCATTCCGTGTAGTATCAGCGCAAGATGCAAGCACACATTGTCAGCAGCCAGGAAATGCCTTTCAGACGCACAAGCACAAGCCAATATTGATGTGCTTTATATGCAAGCTGTCCTTTGGCAACGTCAACTCGTTTAGCTTGCATGCGAATACGGAGCACAAGTTGAATCTGCTGGAGTtggagcaacagctgctgaatCGTGAATATTCTAGTGCCATCATACAGCGTAACATGGATGAGAAGCCGCAGATATCGTTTCTGCAGCCGCTGGATGTCAATGCTGTGAGCAGTGGCAGTAATGCTGATGCTGACCAGGAGTCTACAGCAGCCGAGACCAGATCGCAAATTTCATCACTCTCCGAGCATATAGAAAACACCGTTGAGCCGTTGCAAAGCGATATTAATGATAACGACGATAATGAaggcaatgacaatgacagtGCTAAGGATAAATTTCAGGATAACTACGGCCGTGGTAGCCAGCTGACTGTGGCTATGGCTCCACCTAATCTCGCTAGCTCATCCTCGTCATTATCCACAACAGTGAAAGTAGCAGTGAAATCAGCTGTGAAATTTGGTTCCTTAAGTTCAGCAACAATAAAGACTAATAAACTCTTAAATACACCCGCATCCGAGACGTTAACATGTAATTCACCTGCATCtccatccgcatccgcatcagcatctgcatctgcatcggCAACAGCTTCTGAGTCGGCATCagcttctgcctctgcctctgcatcAACACCAGTTCAAACGCCATTGCCCTCACCAGCAAACACAGTGGACATTGTCGCGGCCACTTCTGGTCAAGATAACTCCTCTCCGGCGTGTGTGAAGACAACTAGTACTGATAAAATAAGTAGCAATAAGTCAACTAAACAAAATCAAGGTTCGGAGTCAGCGGAGATGAATCCACGTAGTCCATTTATTTCGGCATCTGCCTCGGCATGCGGCTCGTCGGACAGTCCAAATCCTCACAACCCCCTAGATTCAGATGCTACGCCAACTGCTGCCGACATACTGCAACAGCACCTATTGTCCCTACAGCATCAAGTATCTAGCGCCGGCCCCGACGATTTCCCACCAACACAGGCCCAGGTGCAGGCCCAACTCAGTTCCTTTCACGCATCTCTTGCTGCTCTGGCGAACGAACAGAACGCAAGGGGTGTTAAACTCCTCACAGACTtcctgcagcaacaacttcaacagcagcagcagcagcaacagcagcagcaacagcaacagcttttCCCCACCAACTGCTTGGAACATCCAGATGCTAAGGGTGTAGACTGCAAAACATGCGAACTGATCGATATTCaacatcaaatcaaatcacCAGCTATGCCACAAATTCCTCCCCAGAGATCTCCTAATGCCCAGACCTGTAGTGGAGCCCTATCAGCATCAATGCCCATCTCGCCAAGCGCCTCATCAGTTGCCAGCTTACCAGGAAATACAACTTCTTCAAGCTTTACCATTGGCGCCTGTTCTGAGCACGTCAACGGCCGGCCACAAGGAATCGATTGCGCTAGgtGTGAGCTGTTGCTTAACTCGGCGCGCCTTAACAGTGGCGTCCAGATGTCCACTCGAAACTCATGCAAAACCCTTAAGTGTCCACAGTGCAATTGGCATTATAAGTATCAAGAGACATTAGAAATCCATATGCGGGAGAAACATCCGGATGGAGAGAGTGCCTGTGGGTATTGCTTGGCAGGCCAGCAGCATCCACGCCTTGCACGCGGAGAGTCGTACTCATGCGGATACAAGCCGTACCGGTGTGAAATATGCAACTACTCGACCACCACAAAGGGCAACCTATCCATACACATGCAGTCGGATAAGCACTTGAACAACATGCAGGAGCTGAACAGTTCGCAGAATATGGTggctgccgcagcagcagctgcagcaagtgCCAAGCTACTATTGCCCAGCCCGTCGCCACAAGGTGTAGGTGGCCCAGTGGCTAGTGTGGGGacgcatcagcatcagcatcagcagacAGGCTCCACCAGTATGAGCAGCGgttccagcaacagcaatagcaacagcattaGCACCGGGAACACCGTGGAGCGATCGTTGGCAACAGCTGCGGCCTCTACATCGGCATCCTTGAAGCCAAAGCCTTCCTTTCGCTGTGACATATGCAACTATGAAACTTCCGTCGCACGTAATCTTCGTATCCATATGACCAGTGAGAAGCACACTCACAACATGGCAGTGCTCCAGAACAACATTAAGCAGATCCAGGCGTTTAAttttctgcagcagcagcagcagcagcagcaacagcagcaacatagtGCCAGTACAAATGCCAGCAGTTTTTTACCCGTATCAGAAGTGGCTCTCGCCGATCTGGCCTACAACCAGGCACTGATGATACAGCTCTTGCAGCAGAATGCCGCTGCCTCcagtcaacaacagcagcagcagcaaacaactAATACTATGGGCAAACTATCGCCCCCGTCACCAACGTCAGTGATCACACCGGATCAATTGCCAGCggcgttttcattttcgccAAAGCCTTTAAAGCTATCACAGAGTAtaggcatgggcatgggcatgggcatgggcatggtgCACGGCGGAGCGGATGCCGGTGAAACAATGGACAACAGTCAGGCAATTAGCGTGCCGGATCTATGGCCCGCAGCGCTGTACAGTTGTCTCATCTGTGACTGTTTTAGCACAAACAATATGGATGAGCTGAATCAGCATCTGCTCTTGGATCGTTCCAGACAATCCTCGAACGTTTCGTCGGACATCATGGTCATAcacaacaataattatatttgtcgTCTTTGCAACTACAAGACGAACCTGAAGGCCAACTTTCAGCTGCACAGCAAAACCGATAAGCACTTGCAGAAGCTTAATTTCATCAATCACATTCGCGAGGGAGGTGCCCGCAATGAGTATAAGATGCAATACCAGCCCCAACTGGCCACAAATGTGGTTCAACTGAAGTGTAACTGCTGTGACTTTCACACCAATTCGATACAAAAGCTATCGTTGCATACACAGCAGATGCGGCACGACACCATGCGTTTGATCTTCCAGCATCTCATCTTTCTCATACAGCAGCATCGACTCGGACTCGGTCTCGTCTCGGAGCCATCGATGGAGCAAGAACACCAGGAACACCAGCAGCCACAAAAGGCGCTATACTGCCAGCTATGTAATTACGTTGCCAAACATCTCTATGATATGATCCAGCATGTGAAGGGATTGCGGCACATGCAAGTGGAGCAGTTCATCTGCATGCAACGACGTAACGACAACTTGGACATGCTTGCCCTCACCGAGGTATTCAAGATCACCGAAAAGTTGCCCGGCCGCATTGAAGACTCAATTCTGGACGGTGGATTAAATTTGACAGGTACTGTTTGTGCTGGAGCTAACACCGAGAGCAGAGGACATGATGTGCCGAGTGCATCGTCAGCAGACAGTAACATATTTTCACCTGCCTCAGCGTCCAGCTGCTCCACATCGTATGGCAAGACGCAGATAACGCGTATTTTGTCTCCAGTACCAGCTATGGGTGATTCCTGCGCGAATCTCAGCGCTTCCACTACAGTTTACAAATGCAATCTCTGCGAGTTCTTTGCGCAGTCTAAAACGAATATCACAGCACACATGGAAACTGCGCATCCATCTGCGGAAATCGATGACTATATCAGCATTCCCACCAATGCAGCAGCCCTACAAGCTTTCCAaacagctgtggcagctgccgcTTTTGCGGCGGTGCAGCGCTGTAATGCCACCAGGCACGAGGAGGGAAATGCAGTACAAGATTGTGATAGGGCCGGAGATCAAGAtgctgatggtgatggtgatggagAGGGAGATGCGGATGGTACAAGTGATATTCACAACGATTGCCCAATTGATATTAAACGCGAGCGACTGGAAGATAGCTTTGAAGGCAATACGGATCGAAATGAAGAACAGAATAGTAACATTTTTCTGCCATCAGTGTCAGTTGAGGACAgcacatcagcatcagcatcgacATCAACAGCGACACATCAGGTCAAGCTTGAATCCCGTACACCCGCACCGTCAACGGGTGTTTCTTGCCCTCTGTGTTTGGAGTCTGGATATTGTGAGAAATCCTTGCTAGAAGCCCACCTTATGAGCGTGCACAGCGTTACACGAGACGGTCTGGCCAGGCTCCTTCAGCTGGTGGACCACAAGGCCTGGCGTTCATCTCAGGGCTCGAATTCGGTATGCAGCGATGCTAATGAATCTCTACTGGATGAGAGTGAAAAATGTGCGCCGCAAAaatcatcagcaacatcagccaaagcaacaaaatcagcgacaataacaacagccacaacgccgactccaactccaacttcaacttcaacttccaTGCCGGCCATCTGTGCCACCTCTATGCAGGGTATTTCGTGCCAGCAATGCGAGGCCAGTTTTAAGCACGAGGAGCAATTGCTCCAACACGCCAAACAAACTCATCATTATCCAATGCAAAACAATGAGTACCTCTGCTTAGCCGTTAGCCACGTTAGCTGTCCCTGCTATATGACATTCGTCAAGTTGTCCGACATGCTGTCGCACTTTGAGGATGCACACCAGAGTTTGGTCATATCGGAACGACACGTCTACAAATATCGCTGCAAGCAGTGCTCGCTGGCCTTTAAAACTCAAGAAAAGCTAACCACCCATATGCTCTACCATACAATGCGAGATGCTACCAAATGCTCTCTCTGCCATCGCAATTTCCGCAGCACTCAGGCCCTACAGAAACATATGGAACAGAATCATGCAGAGGCCTATGCTGCACCATCGACCAGTGACAGCCCACGCGGCTCCTCTCCTAGCTCAAACTGTAATGAAGCAGATAAGGTGCCAGCTGAGAAGACTATATTTGACTTTACGACGAACCCTTCAACTGAAACTGcCGCGAAAACCAGTGAAACTTCAATGCAGTGCTCCCCTCAATCTAGATCCCCTCTGCAGCTGGAGGGCCAGTCTAAAGAAGGGCATAGAATGTCACCTCCATTATCAGTAgaagcgacagcagcagcaacagagcagcagcaacatcttgCCGTGTTAACTGCAGCGTTActaaaacagcagcagtgccaaGCGGACTCTCTTGACCTAGAGGTGGATCCAAGAGGCCTCTCATCGGATGAATTGCAGTTAAAGATGCATCAAGGTGCGATGGGAGCTATGAATTCGCAACCAATGCACGGCCTACAGAGCCTGCAGAACTTAcagcaaatgcagcagcaactaggCGTGGCAGCAGCTACATCAGGAATGCCAATAAATCCTGTTGACATGCTTAATCTAATGCAATTCCATCATTTGATGTCACTCAACTTTATGAATCTGGCGCCTCCATTGATATTTGGGGCCAATGCATCCGCCAATAGCTCCGTTGTGTCTGCAGCTGGAGTAGCCGGAGTAGCTAATAACGGCACAGCATCTGCTCTAACAGCAGCAGATGGCAttgcagccgctgctgctgcagcacttCCAGCTGATGTTTCCAGCATTAGTATGCTCCCAAAGTCGAATGCCAACAATACCAATCAGcaacaaatctCAAATAACCAGAAGCGTGCTCGTACCCGCATCACAGATGACCAGCTGAAGATTCTGCGTGCTCATTTCGACATCAATAACTCGCCCAGCGAAGAAAGCATAATGGAAATGTCACAGAAAGCGAATCTTCCGATGAAGcttctgcaaaagtcgttgaaaggggcctggAATCTATCAGCGTGGGAGCCTATGAGCCAGTGTCCGGTCAAGGGTCTGATCACCAGTGAGCAGGAGGATCTATTaagtccgcaaagctcagAGGAGCGTTTTGGGCAGAAAGCGGGCTAA
Protein Sequence: MSSPDVETFNGKIVYNLDGSAFIIDAGNATVSSIGLSSCGVTPTATPTPTATSTATPTPTPTPTSKVACSLRQTARGSETLLQSGDDYGKNKDGLRYSFNTTIGSSGCPLDRQVASPKIHSFRVVSAQDASTHCQQPGNAFQTHKHKPILMCFICKLSFGNVNSFSLHANTEHKLNLLELEQQLLNREYSSAIIQRNMDEKPQISFLQPLDVNAVSSGSNADADQESTAAETRSQISSLSEHIENTVEPLQSDINDNDDNEGNDNDSAKDKFQDNYGRGSQLTVAMAPPNLASSSSSLSTTVKVAVKSAVKFGSLSSATIKTNKLLNTPASETLTCNSPASPSASASASASASATASESASASASASASTPVQTPLPSPANTVDIVAATSGQDNSSPACVKTTSTDKISSNKSTKQNQGSESAEMNPRSPFISASASACGSSDSPNPHNPLDSDATPTAADILQQHLLSLQHQVSSAGPDDFPPTQAQVQAQLSSFHASLAALANEQNARGVKLLTDFLQQQLQQQQQQQQQQQQQQLFPTNCLEHPDAKGVDCKTCELIDIQHQIKSPAMPQIPPQRSPNAQTCSGALSASMPISPSASSVASLPGNTTSSSFTIGACSEHVNGRPQGIDCARCELLLNSARLNSGVQMSTRNSCKTLKCPQCNWHYKYQETLEIHMREKHPDGESACGYCLAGQQHPRLARGESYSCGYKPYRCEICNYSTTTKGNLSIHMQSDKHLNNMQELNSSQNMVAAAAAAAASAKLLLPSPSPQGVGGPVASVGTHQHQHQQTGSTSMSSGSSNSNSNSISTGNTVERSLATAAASTSASLKPKPSFRCDICNYETSVARNLRIHMTSEKHTHNMAVLQNNIKQIQAFNFLQQQQQQQQQQQHSASTNASSFLPVSEVALADLAYNQALMIQLLQQNAAASSQQQQQQQTTNTMGKLSPPSPTSVITPDQLPAAFSFSPKPLKLSQSIGMGMGMGMGMVHGGADAGETMDNSQAISVPDLWPAALYSCLICDCFSTNNMDELNQHLLLDRSRQSSNVSSDIMVIHNNNYICRLCNYKTNLKANFQLHSKTDKHLQKLNFINHIREGGARNEYKMQYQPQLATNVVQLKCNCCDFHTNSIQKLSLHTQQMRHDTMRLIFQHLIFLIQQHRLGLGLVSEPSMEQEHQEHQQPQKALYCQLCNYVAKHLYDMIQHVKGLRHMQVEQFICMQRRNDNLDMLALTEVFKITEKLPGRIEDSILDGGLNLTGTVCAGANTESRGHDVPSASSADSNIFSPASASSCSTSYGKTQITRILSPVPAMGDSCANLSASTTVYKCNLCEFFAQSKTNITAHMETAHPSAEIDDYISIPTNAAALQAFQTAVAAAAFAAVQRCNATRHEEGNAVQDCDRAGDQDADGDGDGEGDADGTSDIHNDCPIDIKRERLEDSFEGNTDRNEEQNSNIFLPSVSVEDSTSASASTSTATHQVKLESRTPAPSTGVSCPLCLESGYCEKSLLEAHLMSVHSVTRDGLARLLQLVDHKAWRSSQGSNSVCSDANESLLDESEKCAPQKSSATSAKATKSATITTATTPTPTPTSTSTSMPAICATSMQGISCQQCEASFKHEEQLLQHAKQTHHYPMQNNEYLCLAVSHVSCPCYMTFVKLSDMLSHFEDAHQSLVISERHVYKYRCKQCSLAFKTQEKLTTHMLYHTMRDATKCSLCHRNFRSTQALQKHMEQNHAEAYAAPSTSDSPRGSSPSSNCNEADKVPAEKTIFDFTTNPSTETAAKTSETSMQCSPQSRSPLQLEGQSKEGHRMSPPLSVEATAAATEQQQHLAVLTAALLKQQQCQADSLDLEVDPRGLSSDELQLKMHQGAMGAMNSQPMHGLQSLQNLQQMQQQLGVAAATSGMPINPVDMLNLMQFHHLMSLNFMNLAPPLIFGANASANSSVVSAAGVAGVANNGTASALTAADGIAAAAAAALPADVSSISMLPKSNANNTNQQQISNNQKRARTRITDDQLKILRAHFDINNSPSEESIMEMSQKANLPMKLLQKSLKGAWNLSAWEPMSQCPVKGLITSEQEDLLSPQSSEERFGQKAG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00901412;
90% Identity: iTF_00901412;
80% Identity: iTF_00901412;