Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.57 34 5.8 5.9 1 23 114 137 114 137 0.94

2 5 8.3e-05 0.0049 17.9 0.8 1 20 143 162 143 166 0.95

3 5 1.2e-06 7e-05 23.7 0.6 1 23 179 201 179 201 0.98

4 5 0.0012 0.071 14.2 1.5 2 23 207 228 206 228 0.97

5 5 0.00095 0.056 14.5 0.3 2 23 235 257 234 257 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.57	34	5.8	5.9	1	23	114	137	114	137	0.94
2	5	8.3e-05	0.0049	17.9	0.8	1	20	143	162	143	166	0.95
3	5	1.2e-06	7e-05	23.7	0.6	1	23	179	201	179	201	0.98
4	5	0.0012	0.071	14.2	1.5	2	23	207	228	206	228	0.97
5	5	0.00095	0.056	14.5	0.3	2	23	235	257	234	257	0.95

Coding Sequence: ATGTTGGATGCTTCAATCAAGTCTGAATCCAAAACCTCAGAAGTAAAGCTAATCCTGCGCATGCGCACTCAATTCTGTTTGGCTCGTACTATGTATGAAATTTCCGATGCAGTTTTACGAAAGGAGATTGAAGCCAGCAGTATTGAAGGCTGCACGGACTTGGAATGGTTGCTAGAGACAGAGTCATTGGATGGCAAAGTCGGCGCTTCAAAAGATCTAAAGAACACTATCAAAGAAAAGGAATTAAACCATAAAGTCGGCATTACCagAACAAATAACCGCGGCCTGACCTACACCACCGACTCTCCCAACTTCATCCTGAAGAAGGCCAGCGGTGTGTACGAGTGCGCCGTCTGCCACAGGTCTTTCCATCATGGCTACCGGGCGGAGCACCACGTCCGCTCCGTCCACACCAACGAGAAGCCCTTCTCGTGCCAAGTGTGCCGTAAAGGGTTTGTTGGGGCCTCTAATCTCAATAGACACATCTTGTGTGTCCACGAAAAGGGCAAGTTTATATGCGATGTAAgTCTGAAATTTGTATGCGAGCAATGTGGCAAGGCATTTCGTACAAAAATTCGTCTAACAAATCATATCCTGAGGCATGGCGATAAGAACATCCAGTGTCCTCACTGCCCCAAAATGTTCTACATAAAGACTGACCGGCTACTTCACATGAAGTACCACAAAGACGACCTTCCATGGAGATGCGGGAACTGTGACATGTACTTTAAGACAACTCGGGGACTTCAGAATCACCTGTCAGTAGCGCATGAAGAGAAAGTTAGCAAGGTTGACCTGTACAAGCGAAATACTGCtaaatcaattaaatga
Protein Sequence: MLDASIKSESKTSEVKLILRMRTQFCLARTMYEISDAVLRKEIEASSIEGCTDLEWLLETESLDGKVGASKDLKNTIKEKELNHKVGITRTNNRGLTYTTDSPNFILKKASGVYECAVCHRSFHHGYRAEHHVRSVHTNEKPFSCQVCRKGFVGASNLNRHILCVHEKGKFICDVSLKFVCEQCGKAFRTKIRLTNHILRHGDKNIQCPHCPKMFYIKTDRLLHMKYHKDDLPWRCGNCDMYFKTTRGLQNHLSVAHEEKVSKVDLYKRNTAKSIK

Sequence clustering based on sequence similarity using MMseqs2