Basic Information

Transcription Factor Domain

TF Family: TEA
Domain: TEA domain
PFAM: PF01285
TF Group: Helix-turn-helix
Description: The TEA domain is a DNA-binding region of about 66 to 68 amino acids that has been named after the two proteins that originally defined the domain: TEF-1 and AbaA. The TEA domain is located toward the N terminus of eukaryotic transcription factors of the TEA/ATTS family. It shows a three-helix bundle with a homeodomain fold [3, 1]. Two α-helices are nearly anti-parallel and pack on either side of the third one, which is the DNA-recognition helix of the TEA domain. Phosphorylation of one or both of the two conserved serines found on the DNA-binding surface could interfere with DNA-binding activity, by introducing electrostatic repulsion and/or steric hindrance, and help regulate the transcription factor activity of the proteins [2, 1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 2.4e-11 3.3e-07 31.1 0.0 2 36 49 85 48 96 0.89

2 2 0.65 9.2e+03 -2.3 0.0 10 23 86 99 86 102 0.77

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	2.4e-11	3.3e-07	31.1	0.0	2	36	49	85	48	96	0.89
2	2	0.65	9.2e+03	-2.3	0.0	10	23	86	99	86	102	0.77

Coding Sequence: ATGATACAAGCCGGGTTGGGCAGCGTGGCGACCCCGTGGAGCGCCGCCGGGCCCCCGGAGGGCGGGGCGGCGGACCCCAGCAAGCAGCACCTGGACGTGGGCGACGCCAGCGATGACGAGAAGGACCTCAGCGCGGCGGACGCGGAGGGTGTCTGGAGCCCCGACATCGAGCAGAGCTTCCAGGAGGCTCTGGCCATCTACCCCCCCTGCGGCCGCCGGAAGATCATCCTGTCGGACGAGGGGAAGATGTACGGTGAGTCGACCATGCACAATGCACATACACAATACCCTCACCCTATAACTAATCACTAA
Protein Sequence: MIQAGLGSVATPWSAAGPPEGGAADPSKQHLDVGDASDDEKDLSAADAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGESTMHNAHTQYPHPITNH

Sequence clustering based on sequence similarity using MMseqs2