Basic Information

Gene Symbol
ush
Assembly
GCA_905147385.1
Location
LR990227.1:14441918-14444601[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.0058 0.52 11.6 0.2 1 20 125 144 125 146 0.94
2 9 8.7e-05 0.0077 17.3 0.9 1 23 183 205 183 205 0.98
3 9 0.042 3.7 8.9 0.4 3 19 236 252 235 254 0.94
4 9 0.0067 0.6 11.4 2.5 2 21 495 514 494 515 0.95
5 9 0.0059 0.53 11.5 0.2 3 20 544 561 542 563 0.91
6 9 0.12 11 7.5 0.1 2 23 591 612 590 612 0.96
7 9 0.0085 0.76 11.0 1.3 1 23 618 640 618 640 0.99
8 9 0.32 29 6.1 0.7 1 23 677 700 677 700 0.96
9 9 1.2 1.1e+02 4.3 0.7 3 20 733 750 732 752 0.93

Sequence Information

Coding Sequence
ATGTATGCCTCGACCGAAGCCCTGATCTGTCTGACGTACACAGATAGTGAGGACGAGGAATGGGGAAACGAGAGCGAGGCGATGCCAGCAGAACCGCGCACGCCAAGCTCAGGTGGAGAACGACCGGCCTCGAGTGGAGAAGCTTCGCCTACATCAGAAGGATCGGCAGCTGCTTCTCCACCACGCTTACGTCTGAATACTAGTCTAGCTACAGATCCGGCTCTTGCGCCTCAAGCCACATCTTTGAAGCATGAGCCGCCGTCACCATCACCTCCTCCGCCACCAGCGCAGCAACCTAGAGATTACGGTTTGGCACTTACGCCAGCAAGTTTTTCAACATTATTTCCAGCTGCTGCAGCGACACCGCCTGGTTATATGTGTAAGCCCTGTGGTATCAGATATAGTTCATTGAGTACTCTTCAGGCACATCAAGAACACTATTGTTCCAAACGCAGAACTAAACCTGATGGCACTGAAACGCCAACAGATGCAAATGCTGATGAATCTAGCGGTGACTCCAAAACACCGCGTCCGCCAGGAAAGCAGTATGCATGCACTTACTGCTCCTATAGCGCTGATAAAAAAGTTAGTTTGAATCGGCATATGAGAATGCATTCTTCGTCTCCTGTCGGCAGTGGAACTCCAGTACCGCCACCTGTGTCAAACGGCGATTCTGTAGAAAGCACACAGACTCAAGACCGCTATTGCGCAGATTGTGATATTCATTTTACGTCACTCAAGACATACCGAGCGCACAAAGTTTACTATTGTAATACACGACAAGTTGTCAAGCAAGCACTAGCTGCGGCTAGAACTGGATCTGCTACTTCAGGATCTGCACCACCATCCCCAGGGGCTACTCCTCCTGCACAAAATCAATATGCACTAGCTTTACCGACGAACCCAATACTGATAGTTCCATACTCAATATTACAAGGTGCTAGTAGACTTCCAGGTGCTACATTGCCAGACCCAGACACTCCGTGTTTTTTGTTACCAAATGGTACTCTGCAACCGATTAGTCGAGCATTGCCCAACATAAATTCAGAAGTGAAAGAACCTGAAGTGTTAAAATCAGCAAATAGACCACGTGAGCCATCAAGAGATGGTGCTACACCCTTAGATCTGAGCGTCCGACGTACCCCCGAGTCTGTAACGACGGATGAACATGAAAAGGAAAATAGGATGCGTTCCACTACACCGGAGCAAATAGTTTGCGCTCCATCATTACCTGGTTCACCTGGAACGCCATCTCCTACGAGGAGATCCTCTTCTCCTAGTGTAGAAAGTTCTCCCAAACGTCGCCGACGGAACTCAAGAGGTCCTACTCCTAAACCACCTTCCATACCTTCTCCTCCGGAAGAAAAATTTACACCTATAGTACCTCCTCCAGTTATGCCACCTGCTCTAGCCTTACGACTAGCTACAGAGTTACCTGTGTCGACATCTTCACCTCAAGTACTGGTAAAACAAGGAGTGTCAAAATGTAAAGAGTGCAATATAGTGTTTTGCAAGTATGAAAATTACCGTATACATAAACGATACTACTGTTCTGCTGGAGGAGGAGAGGAGAGAGCTAGTCCTGCACCCCCCGAGCCTGGTCCACCTCCACAGTATCGACAATTAATTTGCTTGGCATGTGGTATACACTTTAGTTCACTAGACAATTTAACAACTCATCAATTATTTTACTGTACAAAGAGAGAGACTCGGTCGCCACGCAGTTTACCAGAAGCGCCTAGGCCTGCGTCTGGATCTGATGGCGGTTGGAAATGCCCATGCTGTGATGTGGTTTCCCCGACTGCCTCAGCGGCACAGCGACACATGGAGTCTCACGCTGGAGTGAAAGCATTCCGGTGTACGATCTGCCGATACAGAGGAAATACGCTGAGAGGCATGCGAACTCATATACGCATGCATTTTAGGGAGAAACCAGCTGACTTACAGGAGGAGAGTTATATCTCATGCGTGGTTGAAGATGACAATCGGGAGACTACGTCACCAAGCCCGGCCGTGGGGGATCGAGTCCACAAGTGCGGATCCTGCGCCTACACCTCCACGTACCGCGGGAATGTAGTGCGACACGCGCGTCTTGTCCACGCAACCGAAGACCCAGAACCAGAAGAGCAGACCTCCCCTATCCCCCCTGTCGATATTAAGAAAGAACCTGACACTGAAGAGGATACTCCTAACTTCTGCAAGTCCTGCAACATACCTTTCAAATACGTGAACACGTATAAGGCTCACAAACAGTTCTACTGTACAGCCAACCAGGATACTGCAGCCAATAACAACGTGCCGGCGAGGATCAGTGACGCACCTGTTGTATGA
Protein Sequence
MYASTEALICLTYTDSEDEEWGNESEAMPAEPRTPSSGGERPASSGEASPTSEGSAAASPPRLRLNTSLATDPALAPQATSLKHEPPSPSPPPPPAQQPRDYGLALTPASFSTLFPAAAATPPGYMCKPCGIRYSSLSTLQAHQEHYCSKRRTKPDGTETPTDANADESSGDSKTPRPPGKQYACTYCSYSADKKVSLNRHMRMHSSSPVGSGTPVPPPVSNGDSVESTQTQDRYCADCDIHFTSLKTYRAHKVYYCNTRQVVKQALAAARTGSATSGSAPPSPGATPPAQNQYALALPTNPILIVPYSILQGASRLPGATLPDPDTPCFLLPNGTLQPISRALPNINSEVKEPEVLKSANRPREPSRDGATPLDLSVRRTPESVTTDEHEKENRMRSTTPEQIVCAPSLPGSPGTPSPTRRSSSPSVESSPKRRRRNSRGPTPKPPSIPSPPEEKFTPIVPPPVMPPALALRLATELPVSTSSPQVLVKQGVSKCKECNIVFCKYENYRIHKRYYCSAGGGEERASPAPPEPGPPPQYRQLICLACGIHFSSLDNLTTHQLFYCTKRETRSPRSLPEAPRPASGSDGGWKCPCCDVVSPTASAAQRHMESHAGVKAFRCTICRYRGNTLRGMRTHIRMHFREKPADLQEESYISCVVEDDNRETTSPSPAVGDRVHKCGSCAYTSTYRGNVVRHARLVHATEDPEPEEQTSPIPPVDIKKEPDTEEDTPNFCKSCNIPFKYVNTYKAHKQFYCTANQDTAANNNVPARISDAPVV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00050390;
90% Identity
iTF_00214014;
80% Identity
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