Basic Information

Gene Symbol
topi
Assembly
GCA_905147385.1
Location
LR990233.1:11265463-11266966[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 8.6e-05 0.0077 17.3 0.7 1 23 149 172 149 172 0.95
2 9 0.0024 0.21 12.8 4.3 1 23 190 212 190 212 0.98
3 9 7.9e-06 0.00071 20.6 2.9 5 23 221 239 219 239 0.96
4 9 3.9e-06 0.00035 21.6 3.2 1 23 245 267 245 267 0.97
5 9 0.00024 0.021 15.9 3.2 1 23 272 294 272 294 0.98
6 9 7.3e-06 0.00065 20.7 2.1 1 23 300 322 300 322 0.98
7 9 0.004 0.35 12.1 4.3 2 23 329 350 328 350 0.97
8 9 5.1e-05 0.0046 18.0 3.1 1 23 356 378 356 378 0.99
9 9 5.2e-05 0.0046 18.0 1.1 1 23 384 407 384 407 0.97

Sequence Information

Coding Sequence
ATGGCTTTGATCCCAGAACCTGGGAACATAGAAACATTAATATGTCGAATATGTATGCAAACAGTTCAAAAGCCCACATATTTATTTTCTGATGACAAACATTCAAAAGAAATATTAGATAAAATATTCACATGTTTTCAATTTATTTTGAAATATAAGGATTATTTTCCTTCAGTAATTTGTGAGAACTGCATATTAGAATTAAATAATGCTTATAAATTCCATCAGAACTGTGAAAATTTTGAAAAACGTTTCTTAGCTGTTTATCAAGTAAATCTTACAAAAAATAAATTGAATAATGAAGGTAATGAAACCCTTGGGACCCAACCACAATATGACGTAGACTCCCAAGGTTGTTTAGATAAAATTGATGATGATGATAAAATTATTGCCGAAGGTGCAATAAACATAAGCAACACAAAACATGTTAATAAGGATGGATATTTTTCATGTCCCATTTGTAAGAAGAAACTAAAAACAGAGGAATCATTAATTAAGCATAAAATTTCTATGCATCAAAAGAGAAAACATGTAGGTAAAATTACAGGCTACGGTGTGAATCGTCGATACCATTGTACAAAATGTCCATATAATACTCCGCACAGCCAAACTTTAGTGAATCATATCAGGAAACACAATGGAGATCGTCCATTCCATTGTGAATGTGGAAAATCCTTTAGTCAGTCTTCAAGTCTGAATGCACATAGAAAAACTCACGATAACACAACATACTTTACTTGTTCTATGTGTGGAAAGCAATTTAAACATGCTTTTTCATTAAAGAAACATCTAGATGTTCATGAAACTGGAAAGTTTGAATGTGAAATATGTCACAAGCAGTTAAAATCCAGGCAGACTCTGCAGGACCATATGTATCGTCACTATAATATTAGGAATTACAACTGTGAAGATTGTGGCAACACATTTGTGACACATTCCGAATTACTAAACCACAAAAGGAGGCATAATATAATAAAGAGTGTGGAGTGTCATCTTTGTGGGTACAAAACGCATACTAAAAAATCCTTAATATTACATTTGAAAAGACATGCCGGTGATAAGGCTTATAAATGTGATCTTTGTCATTTATCTTTCTTTATTAGTAGTGATTTGCAACGGCATAAGAGAGTGCACACAAGAGAAAAGCCTTTTCCCTGCCCTGCTTGCACTCAAAGATTCACTCACAGTCCTAGTTTAAATAAGCACTTGAAATCAGTCCATGGAATAAATTGGAAATGGTCAGATATCAAAATGAAGATTCTAAATAAAGAAAAAATTTTAAAAGATCTACAAGGAAGAGTAAAATAA
Protein Sequence
MALIPEPGNIETLICRICMQTVQKPTYLFSDDKHSKEILDKIFTCFQFILKYKDYFPSVICENCILELNNAYKFHQNCENFEKRFLAVYQVNLTKNKLNNEGNETLGTQPQYDVDSQGCLDKIDDDDKIIAEGAINISNTKHVNKDGYFSCPICKKKLKTEESLIKHKISMHQKRKHVGKITGYGVNRRYHCTKCPYNTPHSQTLVNHIRKHNGDRPFHCECGKSFSQSSSLNAHRKTHDNTTYFTCSMCGKQFKHAFSLKKHLDVHETGKFECEICHKQLKSRQTLQDHMYRHYNIRNYNCEDCGNTFVTHSELLNHKRRHNIIKSVECHLCGYKTHTKKSLILHLKRHAGDKAYKCDLCHLSFFISSDLQRHKRVHTREKPFPCPACTQRFTHSPSLNKHLKSVHGINWKWSDIKMKILNKEKILKDLQGRVK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-