Basic Information

Transcription Factor Domain

TF Family: AP-2
Domain: TF_AP-2 domain
PFAM: PF03299
TF Group: Basic Domians group
Description: Activator protein-2 (AP-2) transcription factors constitute a family of closely related and evolutionarily conserved proteins that bind to the DNA consensus sequence GCCNNNGGC and stimulate target gene transcription [PMID: 2010091, PMID: 1998122]. Four different isoforms of AP-2 have been identified in mammals, termed AP-2 alpha, beta, gamma and delta. Each family member shares a common structure, possessing a proline/glutamine-rich domain in the N-terminal region, which is responsible for transcriptional activation [PMID: 2010091], and a helix-span-helix domain in the C-terminal region, which mediates dimerisation and site-specific DNA binding [PMID: 199812]. http://www.ebi.ac.uk/interpro/entry/IPR013854
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 4.7e-24 2e-19 71.5 0.1 1 45 73 117 73 122 0.98

2 2 7.3e-37 3.1e-32 113.3 0.0 84 196 139 249 134 250 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	4.7e-24	2e-19	71.5	0.1	1	45	73	117	73	122	0.98
2	2	7.3e-37	3.1e-32	113.3	0.0	84	196	139	249	134	250	0.96

Coding Sequence: ATGCGCTGCGTATGCCAAAACACGGACGTGGACGACTCTGCCGGCTTCATCAACGACCTGCCTCTACTCAAGAGCGAATATTGCATCGCGGCGCTCGGGAAAAACCGACGCTCGCTGCTCGGCGTCGTAGACGTCGGCGTCGGCATCAAACCACGGAACAACGAGAACATCTCCAAGGACATCGTGTTGTCCGGCGCCGCGACGCCCTCCGACGTCTTCTGCTCGGTGCCGGGGCGTCTCTCGCTGCTGTCGTCGACGAGCAAGTACAAGGTGACGGTGGGCGAGGTGCAGCGGCGCCTCTCACCGCCAGAGTGTCTCAACGCCTCCCTCCTCGGCGGCGTCCTCAGGAGGATAATGGAGGCTCGACGAGACTGTTGGTCGCGGACGCTCGCGTGTCCTGAACCTTGCGTTTCAGGAGGCGAGGCGATCCATTTGGCTCGGGACTTCGGCTACGTGTGCGAGACGGAGTTCCCCGCGCGACAAGTGGCCGAGTACCTCAGCCGGCAACACACCGACCCCTCCGAGTCATACAGGCGCAAGGAGCTCATACACGCCACCAAACAAGTGACCAAAGAACTGATGGACCTGCTGAATCAAGACCGCTCTCCGCTGTGCAACACGAGACCGCAGCACATCCTGGACCCCAGCATCCAGCGCCATCTCACACACTTCTCGCTCATCTCACACGGCTTCGGCTCGCCGGCCATCGTCGCAGCGCTCACGGCCATTCAGAACTTCCTGTCTGAATCGCTGAAGCACCTGGACAAGATGTATCCCGGCGGCGGCTCGCAGCAGCTGGACAACAAGAAGGACCTGAGTCAGGAGCTCCACGGGAAGAAGTGA
Protein Sequence: MRCVCQNTDVDDSAGFINDLPLLKSEYCIAALGKNRRSLLGVVDVGVGIKPRNNENISKDIVLSGAATPSDVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRIMEARRDCWSRTLACPEPCVSGGEAIHLARDFGYVCETEFPARQVAEYLSRQHTDPSESYRRKELIHATKQVTKELMDLLNQDRSPLCNTRPQHILDPSIQRHLTHFSLISHGFGSPAIVAALTAIQNFLSESLKHLDKMYPGGGSQQLDNKKDLSQELHGKK

Sequence clustering based on sequence similarity using MMseqs2