Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00029 0.051 15.3 0.2 1 21 116 136 116 137 0.97

2 6 2.7e-06 0.00048 21.7 1.6 2 23 151 172 151 172 0.98

3 6 0.001 0.18 13.6 0.9 2 23 179 200 178 200 0.98

4 6 0.17 30 6.6 1.0 1 11 229 239 229 241 0.94

5 6 0.0025 0.44 12.4 0.1 1 20 251 270 251 272 0.94

6 6 0.00012 0.021 16.6 0.5 1 20 279 298 279 298 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00029	0.051	15.3	0.2	1	21	116	136	116	137	0.97
2	6	2.7e-06	0.00048	21.7	1.6	2	23	151	172	151	172	0.98
3	6	0.001	0.18	13.6	0.9	2	23	179	200	178	200	0.98
4	6	0.17	30	6.6	1.0	1	11	229	239	229	241	0.94
5	6	0.0025	0.44	12.4	0.1	1	20	251	270	251	272	0.94
6	6	0.00012	0.021	16.6	0.5	1	20	279	298	279	298	0.97

Coding Sequence: ATGAACGTTAAACAGGAAAAATATACCGTGGAAGATGAAGTGGTACCGGTTGTTTTGCACGACGGTGCTTACGGCACTTACACTATACAAACGTTTCAGCCATCACAAGAAGTTGCCGCTGCAGTGGCAACGCTGGAAGCCAATCATCTTCATCAGATCGGAGAAATTGATAGTGAACAGCAAATAATTCATCTGAATGAAGGCGACTGTGTCGAAATTGCTACGGTTACAAATACAACCCCTTCAGGACCGGGTGCTGTGGGGTCAATCATGTCGGACACTTCATACCACAGCGATAATTCGGCCGAATACAGCATGGTCCCAGAAACCAGTCGTGCCAAGACTTACTATTGCCCCAACTGTGGCAATTGCTATAGTGCAGCCGGCAGTCTTAAGTTGCACATTCGAGCGTGCACTCGTGAGAAGGAAACCTCTTCGAATGATAGCAGAAAATGTGAGATTTGCCAGAGAACTTTCAACTCAAGCACCTATTTGCGGGAACATATGCTGCGACACTCTGGGAAGGGCCCAAAGAAATGCCCCAAATGCTATCGCAAATTCATTGACGATACAAAGTACGAAGCTCACTTGGAAACACACAAACTAGAAGAAAGAATTGCCATTGAAGCTGGCACCCCAATCAATGCAGATGGGGCACCCAGCGAAAAGAAAATTATCAAAGAGTATGTTTGCTCGTTCTGCTCAAAAAGCTTTACAGTAGTATTTGATTCTCGCCACACCAAGCGCCGCTATGCCTGTGACGAATGCAGAGAGAAATATTCCAACGAGGAGATGCTCAAGCAGCATAAAGCTCAGCTCGAAGAGAAGCGCGAATTCCGTTGCGAGAAGTGTGGACGAAAGTTCGTTTTCGAGGGTTTCCTGCAAAGGCATATTCCCTCTTGTGATGGAACAATTCGAAGACGACGTGACCGTCAGTAA
Protein Sequence: MNVKQEKYTVEDEVVPVVLHDGAYGTYTIQTFQPSQEVAAAVATLEANHLHQIGEIDSEQQIIHLNEGDCVEIATVTNTTPSGPGAVGSIMSDTSYHSDNSAEYSMVPETSRAKTYYCPNCGNCYSAAGSLKLHIRACTREKETSSNDSRKCEICQRTFNSSTYLREHMLRHSGKGPKKCPKCYRKFIDDTKYEAHLETHKLEERIAIEAGTPINADGAPSEKKIIKEYVCSFCSKSFTVVFDSRHTKRRYACDECREKYSNEEMLKQHKAQLEEKREFRCEKCGRKFVFEGFLQRHIPSCDGTIRRRRDRQ

Sequence clustering based on sequence similarity using MMseqs2