Basic Information

Gene Symbol
SMS
Assembly
GCA_949987735.1
Location
OX465296.1:227573959-227610985[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.00019 0.02 17.1 0.4 1 23 257 280 257 280 0.97
2 17 0.0053 0.57 12.5 1.3 1 23 286 308 286 308 0.99
3 17 0.00021 0.022 16.9 5.3 3 23 317 337 315 337 0.96
4 17 0.0076 0.8 12.0 0.2 1 23 343 365 343 365 0.97
5 17 0.0039 0.42 12.9 0.3 1 23 481 504 481 504 0.94
6 17 0.0025 0.26 13.5 0.6 1 23 510 532 510 532 0.98
7 17 0.001 0.11 14.8 0.2 1 23 657 680 657 680 0.93
8 17 0.059 6.3 9.2 1.1 1 23 686 708 686 708 0.97
9 17 0.00014 0.014 17.5 4.8 3 23 717 737 715 737 0.96
10 17 0.013 1.3 11.3 0.2 1 23 743 765 743 765 0.97
11 17 0.00034 0.036 16.2 2.5 2 23 772 794 771 794 0.96
12 17 5.1e-05 0.0054 18.8 1.2 1 23 927 950 927 950 0.97
13 17 0.001 0.11 14.8 1.6 2 23 957 978 956 978 0.97
14 17 0.0014 0.15 14.3 8.1 3 23 987 1007 985 1007 0.96
15 17 0.00083 0.087 15.0 0.6 1 23 1013 1035 1013 1035 0.99
16 17 0.00071 0.075 15.3 2.0 2 23 1042 1064 1041 1064 0.95
17 17 0.0016 0.16 14.2 2.4 1 23 1073 1096 1073 1096 0.96

Sequence Information

Coding Sequence
ATGGCCGCACAAACCATATTATTTGATTTTACCGTCGAAAAAGAACGTACAGGTAATGCCAAAGAACGTCAAGAAATTGCCAAATTATTACGCCATGAATTGGAGCACATTTTTCCCCAATTGGAAATGGCCTTTCAAATGCCTATGGATGATGGTTACTTTGCCGTTTTGGCTGAAAATAAAGAAACCTTTGTAACTGTGCGTATATTCCCACAAGGTTTGGTAACAATTAATGTGGAATACTATTTGGAAGATGGCAAAGAACAATTGATGTCGTTTGATACCATGCGTGCAATGGAATTAATATTACAACAAAAGTTAAATTCCGATCGTTCCAAATATTTGCCGCCTATTAAACGTGGTGGATATATTGATATTTACATGACTAGTTCAGTGTATAATCAAAAGATTTGTAAACTGGAAGAAGATGTTATTGAAAATGAGTCCGAAGATAACTATTTTGTGCACTATGATCCTCTTGACTCAGCACAAATTGAAATAAAAGAAGAATTACCTAAAATCGAAAATGATGAAGATCAAGATGAAGATGACATACCTCTTATACATCGAAAAAAATTGTATGATGACAGAAATAAGAAAAAACGCAAAAAGTCTAAAGATAAAACTcaagcaaaagaaaaaaagcCTAAAGCTAAAGGCCCATCTAAAAATAATTCTTCTAAAGCACACAATACTGAACAAATGTCGAGCACTGCAGAAGACAATAAGACCGATAAAAGAATACCTAAAAAAAGTTCATACAGAAAACATCCATGTGGAGTTTGTGATAAGATCTTCGAATTCCAGTTTAATCTTGTCGAGCATATACAAACACTGCATCCAAATGGAAATGGTTATAAATGTCGAAATTGCAGTGAAAGCTTTGCTAGCATTAGATTATTGTATAGTCATAGAAAAATTCACAGAAAATCGCTGAGAGCACATCTTTGTGAGTTTTGTTCCAAGACTTTTAATAGCAAGAACCATTTAGCTCGTCACTTACGTGTGCACACTAATGAACGGCCCTACGCATGTGATTTGTGTGGAAACGCttataaagaaaataaagaCTTGACGCTGCATAAAATGTCTCACACCAATGAACTACCCGTTTCATGTGAATTGTGTGGAAAAGtgAAAAATCAAAAGTTTTGTAAACTAGAAAAAGATGTTGCCGAAAATGATTCCGAAGAGGACCATATTGATGACAATGACCCACTTGACTCACCGCAAATTGAAACGAAAGAAGAATTCCCTAAAATTGTGTATAATGAAGATGACTTACCTATTTTTAAACGAAAAAAGACTTCTGTTAGCAAAATGCAAACGAAATCTAATAAATTAAAACTCAATGCTATTTCTTCAAAAGCTGTCAATACTAAACACATATCGAGCGATAAGACCAATAGAAgaaattcaaagcaaaattCCAATGGTAGACATCGATGTGGAGTTTGTGATAAGATATTTGATTTACAGTCTAAACTTGTCGAACATGTGCAAGAACTTCACCCCAATGAAAATGCCTATAAATGCAGGGATTGTCCTGAAATGTTCCAAAGCATCAAGTTATTATATCGTCATAGAATAGTTCATAGCAAATCATTGAAAGCACATCTTTtgAATAATCAAAAGTTTTGCAAACTAGAAGAAGATGTTATCGAAAATGATTCAGAAGAAGGTTATTTTTTGTACAATGACCCGCTTGACTCACCGGAAGTTGAAATAAAAGAAGAATTGCATAAAATAGAATTTAGTGAAGATGAAGATGACATACCTCTAATTCAACGAAAGAAATCTTCTGaagacaatttaaaaaaaaagcgAAACAAATCTATTAAAGCAAAGCCAAAAAAACCCAAAGCTAAAATTCAGTCTAAAGATATTGCTTCCAAAACAGCTGATACTGAACAAATGTCAGGCAATGTGTGTGTTaggaaaaaatcaaaaaagaaatCAAATGGAAAACATCCATGTGGAATTTGTGATAAGatatttgATTTCCAGAGTTATCTTGTCGAACATGTGCAAGAACTTCATCCAAACGAAAATGCGTTTAAATGCCGGGACTGTGCTGAAATGTTCCAAAGCATAAAATTATTATATCGCCATAGAACAATTCATAGAAAATCATTGAATGCACATCTTTGTGAATTTTGTTCCAAGGCCTTTAATGATAAGCAACATTTGACACGTCACTTGAGAGTACACACTAATGAACGCCCCTACGCCTGTGATTTATGTGGAAACGCttataaagaaaataaagaTTTGATGCTGCATAAAATGTCTCACACCAATGAACGTCCGGTCTCATGTGAATTGTGTGGAAAAtcttttaaagaaaataaaaccCTAAAACTTCATCATCAAAAGGATCATATGGCACTAACCATTGAACGTCCCTATTCATGTTCCTTGTGTGTGTATAATCAAAAATTTTGCAAACTAGAAGAGGATGTTATTGAAAATGATTCCGAAGAGGATTTTTTTGTGGACAATGATCCTCTTGACTCGCTGCTAATTGAAATGAAAAAGGAAAGTTCTGAAACTGAGCATGATGATGATGACATTCCTCTAATACAGCGGAAAAAAATGTATGATGGAATAAAcaaaaaacgtaaaaaaccTAAAGCAAAACGAAAAAAACCCGAAGTAACTCGAAAAACTCGATCTTTTGAAAACCCCGCCAAAGCCGACGATACAGACGAAATGCCTAGCGATGAATTTATCAATAAGACTAATAAAAGAAATCGAGAAAAGAAATTCATCAGAAAACATACATGTGGAGTTTGTGATAAGatattCGAATTCCAGTTTGATCTTATTAAACACATAAAAACACTTCATCCCAACGAAAGTGCCATAAAATGTCGAAATTGTAATGAAAGTTTTGCTACCACTAAATTATTATATCGTCACAGAAAAGTGcataaaaaatcaattaaacCACATCTTTGTGAATTTTGTTCCAAGACATTTGGGTACAAGCACCATTTGGAACGCCACTTAAGAACACACACTAATGAACGTCCCTACAAATGTGAGTTGTGTGGAAACGCCTATAAGGAGAATAAAGACTTGAGGCTTCATAGAATGTCTCATACCAATGAACGACCCGTCTCATGCGAAGTGTGCGGTAAAGgttttaaagaaaataaaacattaaaacTTCATCATCAAAGGACACATATGCTACAACCACACGAACGACCCTATTCATGTGTTTTGTGTGGAAGAACTTATAAAGAAAAGAAAGACTTGAAGCTTCATCATAAAAACGCTCATTTGGAACCAGTATTAGATTTTTTTGCAGCACCTCTTTTTCcataa
Protein Sequence
MAAQTILFDFTVEKERTGNAKERQEIAKLLRHELEHIFPQLEMAFQMPMDDGYFAVLAENKETFVTVRIFPQGLVTINVEYYLEDGKEQLMSFDTMRAMELILQQKLNSDRSKYLPPIKRGGYIDIYMTSSVYNQKICKLEEDVIENESEDNYFVHYDPLDSAQIEIKEELPKIENDEDQDEDDIPLIHRKKLYDDRNKKKRKKSKDKTQAKEKKPKAKGPSKNNSSKAHNTEQMSSTAEDNKTDKRIPKKSSYRKHPCGVCDKIFEFQFNLVEHIQTLHPNGNGYKCRNCSESFASIRLLYSHRKIHRKSLRAHLCEFCSKTFNSKNHLARHLRVHTNERPYACDLCGNAYKENKDLTLHKMSHTNELPVSCELCGKVKNQKFCKLEKDVAENDSEEDHIDDNDPLDSPQIETKEEFPKIVYNEDDLPIFKRKKTSVSKMQTKSNKLKLNAISSKAVNTKHISSDKTNRRNSKQNSNGRHRCGVCDKIFDLQSKLVEHVQELHPNENAYKCRDCPEMFQSIKLLYRHRIVHSKSLKAHLLNNQKFCKLEEDVIENDSEEGYFLYNDPLDSPEVEIKEELHKIEFSEDEDDIPLIQRKKSSEDNLKKKRNKSIKAKPKKPKAKIQSKDIASKTADTEQMSGNVCVRKKSKKKSNGKHPCGICDKIFDFQSYLVEHVQELHPNENAFKCRDCAEMFQSIKLLYRHRTIHRKSLNAHLCEFCSKAFNDKQHLTRHLRVHTNERPYACDLCGNAYKENKDLMLHKMSHTNERPVSCELCGKSFKENKTLKLHHQKDHMALTIERPYSCSLCVYNQKFCKLEEDVIENDSEEDFFVDNDPLDSLLIEMKKESSETEHDDDDIPLIQRKKMYDGINKKRKKPKAKRKKPEVTRKTRSFENPAKADDTDEMPSDEFINKTNKRNREKKFIRKHTCGVCDKIFEFQFDLIKHIKTLHPNESAIKCRNCNESFATTKLLYRHRKVHKKSIKPHLCEFCSKTFGYKHHLERHLRTHTNERPYKCELCGNAYKENKDLRLHRMSHTNERPVSCEVCGKGFKENKTLKLHHQRTHMLQPHERPYSCVLCGRTYKEKKDLKLHHKNAHLEPVLDFFAAPLFP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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