Basic Information

Gene Symbol
-
Assembly
GCA_948253155.1
Location
OX411815.1:22348192-22373654[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.0096 0.9 10.9 0.9 1 23 699 721 699 721 0.99
2 12 0.039 3.6 9.0 6.0 1 23 728 751 728 751 0.97
3 12 4.9 4.6e+02 2.3 2.4 1 23 755 777 755 777 0.93
4 12 0.0011 0.098 13.9 0.6 1 23 782 805 782 805 0.98
5 12 0.29 27 6.2 0.0 2 23 812 834 811 834 0.93
6 12 0.014 1.3 10.3 0.6 3 20 846 863 845 865 0.95
7 12 0.00062 0.058 14.6 1.8 3 23 875 896 875 896 0.97
8 12 0.065 6.1 8.2 0.2 3 23 908 929 906 929 0.96
9 12 1.4e-06 0.00013 22.9 0.7 1 23 950 972 950 972 0.98
10 12 0.0006 0.056 14.6 3.6 1 23 978 1000 978 1000 0.98
11 12 0.33 31 6.0 6.1 1 23 1006 1029 1006 1030 0.96
12 12 0.037 3.5 9.0 4.1 1 23 1035 1057 1035 1057 0.98

Sequence Information

Coding Sequence
ATGGGGAAGATTTGTGTTGTGAAAAGTTGTCCAAGTGGACGTAAAATGAAAAATAATGAAAATAATGCTCCTCAGTCTCTCTCTTTTTTCCGTCCAACACCGCAAAGATTAAAGAAGTGGACAATGTCTTTGGGCATTGAATTAAAACTATCTGATTATATTTGTCATCTTCATTTTAAAGAGGAGCATATAAACATGTATGATGTGTTCTACATTAAAGGAGAGCACAAAATTTTACCTAAAGGGAAAAAAGTACTGAAAGATGACGCTTTGCCCACAATTGGGCATCAGTTTATTCCTAAACCTGCACATGAGCTCCAAAAAAGTATGATCCATTTACTGCAACAGCCAAACTCATACAACAGTCACTCTATAAAAGCACAGCAGGATTTAGTACAACCAAGTAATATCAAGCAACAGGAAATATTAGTAAATGAGGAAGTTTCCAACAATTTCATGGATGACAATGTTCAAAGTGATCTAAATTTGGAAGATCAACTGTGTGATAGTGATCTAAAGAATCACCAGGAAAACGAAGCAACTATGCAATCAATACAGTATTTTAGGGATAATATAATAAAAAGTTCAATGCTGCCGCCATCTTGGCTGTATGAAGACAAACCAAATGGACTTGAATTTATGAGGATGGATGTCATCTTTCCCGATAACGAAGAATTGCCTTTAAATGAGAAAATCGAATTTAATAATATCTACAATTACTTAAAATTTGTAGAAAGATGGCCATTATGTGTTGGCACTCAAATTAACAGAAAAAAGTATTCAAAGCTTTGTAAAGGTGTCATTGTTGGTGATGATGCATACAAAAGAAGTCAAGCAAATCCAAGATGTAGTTCTTGTCGAATACTACGGAAATCCTTACAGACCCGTAAATTGACTTCAACTATACAAAAAAATACAAGTGCTTTGAATATAATAAAAAAATTCAAACATCTAAAAGGAATAAGTTTAAAAAAGTCTGAAAAGAAAATAAGTCTAAACAGATTGACAAAACAAGCAATTCATAATGTTGATATAGAGGTGAAAAACCTTGAATCCGATTTGAAAGTCAGTCCAGTAGAGTTGAGTGTTATATCTTCAAACATTGCCCCAAAAGCCAACCCAGAAATTCAATTGATATCTGATATAAAAACCTGGCAGGACAGTGAAGAAGATTATGAACGTGATGAGCTTGAATTAAAGGTAAAATGTGAAAGTCCAATTTCTGAAGATCATGAAAATGATATAAAATTAATAGAGGTTAAAATAAAAGAAGAATATGAAGATGACTATGAAGGGGATAGAATTGAATTAGAGATAAATCTTGAATCTGATGAAGAATCTGAAGTTTTCCTAGAAGGTCATAACTCTAATAATGATTCTTTTATAGACAAAAGAAAAATACTAACTTCCACACCACGTAAAGATTATAAACATGAAGTTGTAGTGGATCACAAATATAAAAAAGGGATAGAATATGTAAATATACTAGGGACTGAGATACCCATTCCTTTAAATATAGTTAATGCTGCTCTAGATAATTGTAATGATGATGATGATTTTATTCTTATATTAGTGGATAACAAACCACAAAATGTAGAAGATACAACAGGAAAAAATAAAACTAAAGTTATAGAGAAGTCAAAACCTAAAAAAATAAAAGACACTGTAGATAGTGATAATGACATACTTTTAAAAAGAGCTACTGAAGTCAAGAATACTGAAGTCACACATAAAATTGAAGTTAATAAAGGTAATGCTAAAGAAAATAGTCACTTTAGTGATAATGACATACCTTTAAAAAGAGCTAATAAAGTCAAAAGTACTAAAGTCACACATAAAAATGAAGTTAATAAAGGTAATGCTAAAGAAAAGCGTCGCTTTAGTGATAATAACATACATTTAAAAAGAGCTACTAAAGTCAAGAGTACTAAAGTCACACAAAAAAGTGAAGTTAATAAAGGTATTGCTAAAGAAAGGCGTCGCTTTAAAACAGAATATTTTGATGGTTTTGCAACAATTAAGACGCTTAGCGAGGATGATGCTAAGAAAGAGTTGCTTGCAAAAAAAACATCTAAAAATTATAAAATGTCACCATTCAAATGCGATTTTTGTTATAAAGGCTATGGTGTAAAAGCTGTATATGAAAATCATATGAGAAGGCATGATAAAAACTATGGTAAATTTGAATGCCATCTCTGCCAGTTGCGGTTTATTAAATTGCAACACTTGTACAAGCACCGGTATACTTTACATAAGAGAAAGTTCAGTTGCAAATTGTGTCAGTACATATGTTTCTCTACGAATCAAGCTAAGGCTCATGTCAGTCTTCATAAAGGGAAAAAATATGAATGTACAGATTGTGGGGTAATATTTCGTTTGCTTAACAGTCTACTCATGCACAAACGTAAGAAGCACCTCAATATAGCGGAGATGGTATGTGCACTATGTGGTGACACATTTAGGACAGCTATAGGGCTCAGCTTGCATGTTGCAAGATCACACGCTAAAGAAGAAAACAGACAACGTGGTCCCAACTGTAAGACGTGTAACGTGCACTTCTCCACGAATGAAGCCTGGAAGCGGCATTTAGTACTCTCCACCAGACATATAGTCAACAATGGATGCAAATTCTGCGGCGAGAGCTTCGCCAGCTTACGACAGCTAAAGTCTCACAAACGTCAGCAACACCCGCACTTGAAACGTGCTACAGTATCCACTGACTGTCCTGTTTGCAACACCAAGCTACCTACCTACGTCGAGTACAAGACTCACGTAAAATCTTCACATCCACAGTCAGATGAGGCACAGAAATTGTATGCCATTGAGCAAGATAATAATTTGCGACCCTTCATATGTGAAATATGCGGCCGTGGATTTAGGCACCCGTACAAACTGAATGATCACCTCCGCATTCATACTGATGAACGTCCCTACAAGTGCCACATATGCAACAAAGCCTTTAAATGGGCGGGCTCACTCTGCACGCATACTGAAACTCACACCCGGCAACGTGAATACAAATGTGACCTGTGCTTTAAACTGTTTTCGTCTCACAACTCACGGAGCAAACATATCAAGTTGTTGCATCACGGGACACGACCGCACAAATGCACGGTTTGCAACAAAGGGTTCCTTTATTTATGCGAGTTGAAGATGCATATCAAAGTGCACGACAAAGTCCGGATGAGAAAAACCAAAAAAGAATCCGATCCAGATGATAATATTACAGATAGTAATTAA
Protein Sequence
MGKICVVKSCPSGRKMKNNENNAPQSLSFFRPTPQRLKKWTMSLGIELKLSDYICHLHFKEEHINMYDVFYIKGEHKILPKGKKVLKDDALPTIGHQFIPKPAHELQKSMIHLLQQPNSYNSHSIKAQQDLVQPSNIKQQEILVNEEVSNNFMDDNVQSDLNLEDQLCDSDLKNHQENEATMQSIQYFRDNIIKSSMLPPSWLYEDKPNGLEFMRMDVIFPDNEELPLNEKIEFNNIYNYLKFVERWPLCVGTQINRKKYSKLCKGVIVGDDAYKRSQANPRCSSCRILRKSLQTRKLTSTIQKNTSALNIIKKFKHLKGISLKKSEKKISLNRLTKQAIHNVDIEVKNLESDLKVSPVELSVISSNIAPKANPEIQLISDIKTWQDSEEDYERDELELKVKCESPISEDHENDIKLIEVKIKEEYEDDYEGDRIELEINLESDEESEVFLEGHNSNNDSFIDKRKILTSTPRKDYKHEVVVDHKYKKGIEYVNILGTEIPIPLNIVNAALDNCNDDDDFILILVDNKPQNVEDTTGKNKTKVIEKSKPKKIKDTVDSDNDILLKRATEVKNTEVTHKIEVNKGNAKENSHFSDNDIPLKRANKVKSTKVTHKNEVNKGNAKEKRRFSDNNIHLKRATKVKSTKVTQKSEVNKGIAKERRRFKTEYFDGFATIKTLSEDDAKKELLAKKTSKNYKMSPFKCDFCYKGYGVKAVYENHMRRHDKNYGKFECHLCQLRFIKLQHLYKHRYTLHKRKFSCKLCQYICFSTNQAKAHVSLHKGKKYECTDCGVIFRLLNSLLMHKRKKHLNIAEMVCALCGDTFRTAIGLSLHVARSHAKEENRQRGPNCKTCNVHFSTNEAWKRHLVLSTRHIVNNGCKFCGESFASLRQLKSHKRQQHPHLKRATVSTDCPVCNTKLPTYVEYKTHVKSSHPQSDEAQKLYAIEQDNNLRPFICEICGRGFRHPYKLNDHLRIHTDERPYKCHICNKAFKWAGSLCTHTETHTRQREYKCDLCFKLFSSHNSRSKHIKLLHHGTRPHKCTVCNKGFLYLCELKMHIKVHDKVRMRKTKKESDPDDNITDSN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-