Basic Information

Gene Symbol
-
Assembly
GCA_948253155.1
Location
OX411826.1:4576093-4577601[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.006 0.56 11.5 1.4 1 23 184 207 184 207 0.91
2 10 0.027 2.5 9.5 0.1 2 23 234 256 233 256 0.96
3 10 0.39 37 5.8 2.1 2 23 279 300 278 300 0.96
4 10 0.00015 0.014 16.6 0.1 1 23 304 326 304 326 0.96
5 10 0.092 8.6 7.8 1.4 1 14 331 344 331 354 0.79
6 10 0.0067 0.63 11.4 0.4 2 23 362 384 361 384 0.96
7 10 8.7e-05 0.0081 17.3 1.9 2 23 392 414 392 414 0.96
8 10 0.00024 0.023 15.9 4.7 1 23 420 442 420 442 0.97
9 10 1e-05 0.00096 20.2 1.2 1 23 448 470 448 470 0.98
10 10 0.00027 0.025 15.7 6.9 1 23 475 498 475 498 0.98

Sequence Information

Coding Sequence
ATGAGCGAAAAAAGACCATCGTCAGAAAGTGATCTAGAAGGCCCAGACACTGATTTGGTGAAAGTGCGATCTAATTTTAAAGAGATACTAATAAATTCAAACGCGATGTCTAGTAAAATAACACAATTGTCAGAAAGTGGTCAAGAAGACACAGCCACAGTCATCAAAAATAAAGCACGTAGAAAAGAATTGGTAAAAGGTCGATTTGATGTAATATTTAAAAATGTAGTAATAAATTCGAACGTGATGCAAACTAGCAAAATAACACAATCAGAAAGTCATCAAGAGGTCACAGCCACGTGCATCAAAAATAAAGCAAGTAGAAAAGAATCGGTAAAAGATCGATCTAATATTAATGAAATACTAATAAACACTAATGCAACGCCAAGCGAAATAACACAATCTTCAGAAAGTGACGAAGAGGACATAGACACAGGCGTTAAAAATAACAAAGCACCTAGAACTGAATTGGTAAAACATCGATCTAATATTAAAGAAATATTAATAAAttctaacgcaacgccaattaggcggtatggtggtattggctatacttgttgttattgtgaagagcagtatgcagaaccatcacttttaaagaagcattcactagaatctcataaaaatgtgtctgaagcgaattttatgaaaaacatgaacatgtctgagtatgtcataaaacttgacattactggtcttagttgcaatctttgtgacgtggaaatcgatactctagataatttgctggaacatttgaaaaaaaagcacgagaagaatatatttactgatgttaaaaaccatatatttcctttcaaattcaaagacaatgtactaaaatgtacaatgtgcttaagttcctttaataagtttcgaatgttagtcggccacatgcatgtccattacaggaattttatttgcactatttgtgatgctggcttcgttaaccgcaatgcattaacacagcacttggagaaccataaaattggcgagtttacttgcaattattgccccaaaatttacaaaactgaggtaaaaaagagatttcacgagagaaatgctcatacacattcagattctatgaataaatgtggatactgtaaagaaacattcaaagactattggaagaaggaagttcatttagcaactgtgcatggtgttaaatctcttgtccctaaatgtcaggcctgtgataaaacatttagctctagaagactgctcaccactcacgtcaaaagagatcatttaatggaacggccacataagtgttccgaatgtgaaatggcgtttttctcgtcgactcacctaaagaaccatatggtgaagcacacggggtcgagggcattccgctgcgctatttgtttaaagtcttatggtagaaaaaagactttaaattcccatatgcgtattcacgaaacgcataggtttaaatgtgaacattgcagcaaggattttgttcagaagtgtagttggaggagtcatatgcgtagtaaacatggaaaaattgtgtaA
Protein Sequence
MSEKRPSSESDLEGPDTDLVKVRSNFKEILINSNAMSSKITQLSESGQEDTATVIKNKARRKELVKGRFDVIFKNVVINSNVMQTSKITQSESHQEVTATCIKNKASRKESVKDRSNINEILINTNATPSEITQSSESDEEDIDTGVKNNKAPRTELVKHRSNIKEILINSNATPIRRYGGIGYTCCYCEEQYAEPSLLKKHSLESHKNVSEANFMKNMNMSEYVIKLDITGLSCNLCDVEIDTLDNLLEHLKKKHEKNIFTDVKNHIFPFKFKDNVLKCTMCLSSFNKFRMLVGHMHVHYRNFICTICDAGFVNRNALTQHLENHKIGEFTCNYCPKIYKTEVKKRFHERNAHTHSDSMNKCGYCKETFKDYWKKEVHLATVHGVKSLVPKCQACDKTFSSRRLLTTHVKRDHLMERPHKCSECEMAFFSSTHLKNHMVKHTGSRAFRCAICLKSYGRKKTLNSHMRIHETHRFKCEHCSKDFVQKCSWRSHMRSKHGKIV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-