Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00076 0.071 14.3 2.5 1 22 155 176 155 176 0.93

2 6 3.6e-05 0.0034 18.5 0.3 1 23 185 207 185 207 0.97

3 6 0.096 8.9 7.7 4.8 3 23 219 238 218 238 0.98

4 6 3.2e-07 3e-05 24.9 0.8 1 23 244 266 244 266 0.97

5 6 1.1e-06 0.0001 23.3 1.7 1 23 272 294 272 294 0.96

6 6 1.7e-07 1.6e-05 25.8 1.3 1 23 300 322 300 322 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00076	0.071	14.3	2.5	1	22	155	176	155	176	0.93
2	6	3.6e-05	0.0034	18.5	0.3	1	23	185	207	185	207	0.97
3	6	0.096	8.9	7.7	4.8	3	23	219	238	218	238	0.98
4	6	3.2e-07	3e-05	24.9	0.8	1	23	244	266	244	266	0.97
5	6	1.1e-06	0.0001	23.3	1.7	1	23	272	294	272	294	0.96
6	6	1.7e-07	1.6e-05	25.8	1.3	1	23	300	322	300	322	0.98

Coding Sequence: ATGCAGAACAACCCCCAGGAGCTTTCATGGCAGGCGATTCAGGCTATAGTTGGTGTTAAACTTCCTTCAAATGTACTACGATTTGATGATATCGGATTTCATTTAGTTAATAACGCAGTTTCAAGTGCCGAAGACTCCGATTCGGACGTAGAAATTGTTGAAAATGAATGGGAATCTGATAATAATGTGTCCTCCAGACATGATCATTCTGACAATGAAAAAACTACTTCCCCGGATAGGGAACAGAGTGAGTCACCAGTTTTACATCTCGTAGAACCTGATAATAACAATTCAGGTAAAGATTCGTTAGATTACAGACATTATGTCGAAAAAATGGATACTAAAGATATTTCGCCAAAGGAGCGAATGATTCATATAGACGACGTAGATAGTTCCAATGGTAATGTCATGTCCATTGAAAATTACTTGGAGGTCACACTATCCACAGACTCTGAGGCTAGTCATACTTGCAACCAATGTAATCAAATATTTTCTAATGAAAGTTTACTTGCCTCGCACAAATGCACTGCTAAACCCACCGAAGAAAAGAAGTATCCCTGTAATGTCTGTTCAGAAAGGTTTCCAAGCTACTGGGACCTCAGAAAACACCTTAGCAATCACTTTCCTGGAATGTTGGAATCTAAGTCAAGTTTTTGTCACCTATGTCAAAAGGACTATACTAAAACGGGTTTTATGAATCACTTACGCAAGCACACAGGTGAGCGACCATTTGTCTGTGAACTTTGCAATAAGGCATTTTCACAATCCAGCTCACTCTCAATACACATGAAATTTCACCTCAATGTTCGTAAACATGCATGCACAGTTTGTGAAAAGAAATTTGTTACTAAAAGTGAATTATCACGTCATATGACTGTGCATACTAAACAGAAGTCATATTACTGTGGTGTTTGTGACAAAGCTTTTACTCGCTCTGATAATATGAAGAAGCATGAGAAGACTCATGGGTAA
Protein Sequence: MQNNPQELSWQAIQAIVGVKLPSNVLRFDDIGFHLVNNAVSSAEDSDSDVEIVENEWESDNNVSSRHDHSDNEKTTSPDREQSESPVLHLVEPDNNNSGKDSLDYRHYVEKMDTKDISPKERMIHIDDVDSSNGNVMSIENYLEVTLSTDSEASHTCNQCNQIFSNESLLASHKCTAKPTEEKKYPCNVCSERFPSYWDLRKHLSNHFPGMLESKSSFCHLCQKDYTKTGFMNHLRKHTGERPFVCELCNKAFSQSSSLSIHMKFHLNVRKHACTVCEKKFVTKSELSRHMTVHTKQKSYYCGVCDKAFTRSDNMKKHEKTHG

Sequence clustering based on sequence similarity using MMseqs2